Genular: Defining Cellular Identity and Function

Details for: Gadd45a

Gene ID: 13197

Symbol: Gadd45a

Ensembl ID: ENSMUSG00000036390

Description: growth arrest and DNA-damage-inducible 45 alpha

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Rna polymerase ii transcription
(R-MMU-73857)
Tp53 regulates transcription of cell cycle genes
(R-MMU-6791312)
Tp53 regulates transcription of genes involved in g2 cell cycle arrest
(R-MMU-6804114)
Transcriptional regulation by tp53
(R-MMU-3700989)
Cell cycle
(GO:0007049)
Cellular response to ionizing radiation
(GO:0071479)
Centrosome cycle
(GO:0007098)
Cytoplasm
(GO:0005737)
Dna damage response
(GO:0006974)
Kinase binding
(GO:0019900)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of blood vessel endothelial cell migration
(GO:0043537)
Negative regulation of peptidyl-serine phosphorylation of stat protein
(GO:0033140)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of protein serine/threonine kinase activity
(GO:0071901)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear speck
(GO:0016607)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of p38mapk cascade
(GO:1900745)
Positive regulation of reactive oxygen species metabolic process
(GO:2000379)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of cell cycle
(GO:0051726)
Signal transduction in response to dna damage
(GO:0042770)

Other Information

Proteins

Growth arrest and DNA damage-inducible protein GADD45 alpha

Genular Protein ID: 3732628744

Symbol: GA45A_MOUSE

Name: Growth arrest and DNA damage-inducible protein GADD45 alpha

UniProtKB Accession Codes:

P48316

Database IDs:

Citations:

PubMed ID: 8139541

Title: The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

PubMed ID: 8139541

DOI: 10.1128/mcb.14.4.2361-2371.1994

PubMed ID: 7509226

Title: Cloning and characteristics of murine genes coding for the human GADD45 analog -- a protein induced in response to DNA damage.

PubMed ID: 7509226

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15735649

Title: The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.

PubMed ID: 15735649

DOI: 10.1038/ni1176

Sequence Information:

Length: 165
Mass: 18339
Checksum: C96BAB354A84770F
Sequence:

MTLEEFSAAE QKTERMDTVG DALEEVLSKA RSQRTITVGV YEAAKLLNVD PDNVVLCLLA 
ADEDDDRDVA LQIHFTLIRA FCCENDINIL RVSNPGRLAE LLLLENDAGP AESGGAAQTP 
DLHCVLVTNP HSSQWKDPAL SQLICFCRES RYMDQWVPVI NLPER

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gadd45a

Associated with

Other Information

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. PubMed ID: 8139541

Cloning and characteristics of murine genes coding for the human GADD45 analog -- a protein induced in response to DNA damage. PubMed ID: 7509226

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway. PubMed ID: 15735649

Database document:

PubMed ID: 8139541

PubMed ID: 7509226

PubMed ID: 15489334

PubMed ID: 15735649