Details for: Ddit3

Gene ID: 13198

Symbol: Ddit3

Ensembl ID: ENSMUSG00000025408

Description: DNA-damage inducible transcript 3

Associated with

  • Anterior/posterior axis specification
    (GO:0009948)
  • Apoptotic process
    (GO:0006915)
  • Artery development
    (GO:0060840)
  • Blood vessel maturation
    (GO:0001955)
  • Camp response element binding protein binding
    (GO:0008140)
  • Cell cycle
    (GO:0007049)
  • Cell redox homeostasis
    (GO:0045454)
  • Chop-c/ebp complex
    (GO:0036488)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna binding
    (GO:0003677)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Er overload response
    (GO:0006983)
  • Establishment of protein localization to mitochondrion
    (GO:0072655)
  • Gene expression
    (GO:0010467)
  • Identical protein binding
    (GO:0042802)
  • Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
    (GO:0070059)
  • Intrinsic apoptotic signaling pathway in response to nitrosative stress
    (GO:1990442)
  • Late endosome
    (GO:0005770)
  • Leucine zipper domain binding
    (GO:0043522)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cold-induced thermogenesis
    (GO:0120163)
  • Negative regulation of creb transcription factor activity
    (GO:0032792)
  • Negative regulation of determination of dorsal identity
    (GO:2000016)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of fat cell differentiation
    (GO:0045599)
  • Negative regulation of interleukin-4 production
    (GO:0032713)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of myoblast differentiation
    (GO:0045662)
  • Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051898)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of autophagy in response to er overload
    (GO:0034263)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Proteasome-mediated ubiquitin-dependent protein catabolic process
    (GO:0043161)
  • Protein-dna complex
    (GO:0032993)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of autophagy
    (GO:0010506)
  • Regulation of cell cycle
    (GO:0051726)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Release of sequestered calcium ion into cytosol
    (GO:0051209)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Response to platelet-derived growth factor
    (GO:0036119)
  • Response to starvation
    (GO:0042594)
  • Response to unfolded protein
    (GO:0006986)
  • Response to wounding
    (GO:0009611)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sensory perception of sound
    (GO:0007605)
  • Sequence-specific dna binding
    (GO:0043565)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription corepressor activity
    (GO:0003714)
  • Transcription factor binding
    (GO:0008134)
  • Transcription regulator activator activity
    (GO:0140537)
  • Transcription regulator inhibitor activity
    (GO:0140416)
  • Vascular associated smooth muscle cell migration
    (GO:1904738)
  • Vascular associated smooth muscle cell proliferation
    (GO:1990874)
  • Wnt signaling pathway
    (GO:0016055)

Other Information

Genular Protein ID: 3393435003

Symbol: DDIT3_MOUSE

Name: DNA damage-inducible transcript 3 protein

UniProtKB Accession Codes:

P35639 Q91YW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 69 Gene3D 1 GeneTree 1 Genevisible 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 1547942

Title: CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

PubMed ID: 1547942

DOI: 10.1101/gad.6.3.439

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8650547

Title: Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase.

PubMed ID: 8650547

DOI: 10.1126/science.272.5266.1347

PubMed ID: 12706815

Title: C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform.

PubMed ID: 12706815

DOI: 10.1016/s0014-5793(03)00283-7

PubMed ID: 12876286

Title: CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation.

PubMed ID: 12876286

DOI: 10.1074/jbc.m306404200

PubMed ID: 14684614

Title: CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation.

PubMed ID: 14684614

DOI: 10.1210/en.2003-0868

PubMed ID: 15601821

Title: CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum.

PubMed ID: 15601821

DOI: 10.1101/gad.1250704

PubMed ID: 15775988

Title: TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.

PubMed ID: 15775988

DOI: 10.1038/sj.emboj.7600596

PubMed ID: 16670335

Title: C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation.

PubMed ID: 16670335

DOI: 10.4049/jimmunol.176.10.6245

PubMed ID: 19752026

Title: Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis.

PubMed ID: 19752026

DOI: 10.1083/jcb.200904060

PubMed ID: 19855386

Title: Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling.

PubMed ID: 19855386

DOI: 10.1038/ncb1996

PubMed ID: 19919955

Title: Molecular mechanisms of the LPS-induced non-apoptotic ER stress-CHOP pathway.

PubMed ID: 19919955

DOI: 10.1093/jb/mvp189

PubMed ID: 21159964

Title: Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA.

PubMed ID: 21159964

DOI: 10.1523/jneurosci.1598-10.2010

PubMed ID: 21285359

Title: Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation.

PubMed ID: 21285359

DOI: 10.1074/jbc.m110.216093

PubMed ID: 22242125

Title: Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation.

PubMed ID: 22242125

DOI: 10.1371/journal.pone.0029498

PubMed ID: 22265908

Title: C/EBP homologous protein-10 (CHOP-10) limits postnatal neovascularization through control of endothelial nitric oxide synthase gene expression.

PubMed ID: 22265908

DOI: 10.1161/circulationaha.111.041830

PubMed ID: 23624402

Title: ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.

PubMed ID: 23624402

DOI: 10.1038/ncb2738

Sequence Information:

  • Length: 168
  • Mass: 19189
  • Checksum: CA423B79512F33AB
  • Sequence:
    • MAAESLPFTL ETVSSWELEA WYEDLQEVLS SDEIGGTYIS SPGNEEEESK TFTTLDPASL 
AWLTEEPGPT EVTRTSQSPR SPDSSQSSMA QEEEEEEQGR TRKRKQSGQC PARPGKQRMK 
EKEQENERKV AQLAEENERL KQEIERLTRE VETTRRALID RMVSLHQA

Genular Protein ID: 830478934

Symbol: Q3V405_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3V405

Database IDs:

AGR 1 ARBA 17 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 9 Gene3D 1 Genevisible 1 InterPro 3 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 2 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 168
  • Mass: 19117
  • Checksum: 0C577B5B512D1388
  • Sequence:
    • MAAESLPFTL ETVSSWGLEA WYEDLQEVLS SDEIGGTYIS SPGNEEEESK TFTTLDPASL 
AWLTEEPGPT EVTRTSQSPR SPDSSQSSMA QEEEEEEQGR TRKRKQSGQC PARPGKQRMK 
EKEQENERKV AQLAEENERL KQEIERLTRE VETTRRALID RMVSLHQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.