Details for: ADK

Gene ID: 132

Symbol: ADK

Ensembl ID: ENSG00000156110

Description: adenosine kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 5.68
    Marker Score: 23677.5
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 4.5
    Marker Score: 3692
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 4.48
    Marker Score: 3977
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 4.37
    Marker Score: 5439.5
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 4.19
    Marker Score: 4750
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.95
    Marker Score: 133279
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.73
    Marker Score: 12208
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.36
    Marker Score: 2590
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.3
    Marker Score: 2293
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.21
    Marker Score: 2777
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.17
    Marker Score: 70896.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.96
    Marker Score: 47566
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.91
    Marker Score: 13463
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.81
    Marker Score: 1480
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.74
    Marker Score: 3153
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.62
    Marker Score: 52107
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.58
    Marker Score: 755
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.56
    Marker Score: 38266
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.48
    Marker Score: 94131
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.47
    Marker Score: 903
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.47
    Marker Score: 10334
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.46
    Marker Score: 1222
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.44
    Marker Score: 4264
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.43
    Marker Score: 10086.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.42
    Marker Score: 1014
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.4
    Marker Score: 18424
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.4
    Marker Score: 691
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.38
    Marker Score: 2882
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.37
    Marker Score: 5945
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.34
    Marker Score: 86377.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.34
    Marker Score: 49896
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.33
    Marker Score: 3129
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.32
    Marker Score: 2559
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 2.3
    Marker Score: 1002
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.26
    Marker Score: 818
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.25
    Marker Score: 11804
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.25
    Marker Score: 1314.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.24
    Marker Score: 14615
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.22
    Marker Score: 2391
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.2
    Marker Score: 1234
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.18
    Marker Score: 8421.5
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.18
    Marker Score: 1639
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.14
    Marker Score: 4115
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.13
    Marker Score: 11467
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.13
    Marker Score: 1054
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.11
    Marker Score: 5047.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.09
    Marker Score: 37182
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.09
    Marker Score: 19697
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.07
    Marker Score: 1206
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.07
    Marker Score: 2910
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.03
    Marker Score: 124796
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.99
    Marker Score: 8095
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.98
    Marker Score: 7055.5
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.96
    Marker Score: 4106
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.96
    Marker Score: 3286
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.95
    Marker Score: 20115
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.92
    Marker Score: 10314
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.89
    Marker Score: 596
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.88
    Marker Score: 17885
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.88
    Marker Score: 6682
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.88
    Marker Score: 6305
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.88
    Marker Score: 16189
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.86
    Marker Score: 5295
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.85
    Marker Score: 15900
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.85
    Marker Score: 691
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.85
    Marker Score: 683
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.84
    Marker Score: 502
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.82
    Marker Score: 662
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.8
    Marker Score: 477
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.79
    Marker Score: 7033
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.75
    Marker Score: 849.5
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.75
    Marker Score: 11227
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.73
    Marker Score: 1651
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.72
    Marker Score: 2122
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.71
    Marker Score: 3752.5
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.7
    Marker Score: 3918
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.7
    Marker Score: 2403
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.69
    Marker Score: 1664
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.68
    Marker Score: 1766
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.68
    Marker Score: 1577
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.67
    Marker Score: 7185.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.66
    Marker Score: 2725.5
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.64
    Marker Score: 12396
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.64
    Marker Score: 980.5
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.64
    Marker Score: 1758
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.64
    Marker Score: 1419
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.63
    Marker Score: 2101
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.63
    Marker Score: 461
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.61
    Marker Score: 870
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.6
    Marker Score: 2569
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.59
    Marker Score: 8371
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.59
    Marker Score: 888
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.58
    Marker Score: 2446
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.56
    Marker Score: 589
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.56
    Marker Score: 600
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.56
    Marker Score: 865.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.55
    Marker Score: 1021
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.54
    Marker Score: 1013
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.52
    Marker Score: 2773
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.52
    Marker Score: 481

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Other Information

**Key characteristics:** - ADK is a serine/threonine kinase that is highly expressed in various tissues. - It is a key regulator of cellular metabolism, cell cycle, and apoptosis. - It is involved in the regulation of inflammation, cell growth, and differentiation. **Pathways and functions:** - ADK is involved in multiple cellular pathways, including the purine salvage pathway, the AMP-activated protein kinase (AMPK) pathway, and the Deoxyadenosine kinase (DAK) pathway. - In the purine salvage pathway, ADK phosphorylates purine nucleotides to form deoxyadenosine, which is used in various cellular processes, including DNA repair and RNA synthesis. - In the AMPK pathway, ADK phosphorylates AMPK, which is a key regulator of cellular metabolism. - In the DAK pathway, ADK is involved in the regulation of cell cycle progression and apoptosis. **Clinical significance:** - Mutations in the ADK gene have been linked to various human diseases, including cancer, cardiovascular disease, and metabolic disorders. - Inhibition of ADK has been shown to have anti-tumor effects in preclinical models. - Therefore, ADK is a potential therapeutic target for the treatment of human diseases. **Additional information:** - The ADK gene is located on chromosome 15q21.1. - It is a highly conserved gene, with a similar gene found in mammals. - ADK is a highly active enzyme that is regulated by various hormones and growth factors.

Genular Protein ID: 3820169466

Symbol: ADK_HUMAN

Name: Adenosine kinase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8577746

Title: Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases.

PubMed ID: 8577746

DOI: 10.1073/pnas.93.3.1232

PubMed ID: 8917457

Title: Cloning and characterization of cDNA for adenosine kinase from mammalian (Chinese hamster, mouse, human and rat) species. High frequency mutants of Chinese hamster ovary cells involve structural alterations in the gene.

PubMed ID: 8917457

DOI: 10.1111/j.1432-1033.1996.00564.x

PubMed ID: 9070863

Title: Cloning and expression of the adenosine kinase gene from rat and human tissues.

PubMed ID: 9070863

DOI: 10.1006/bbrc.1997.6157

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19635462

Title: Subcellular localization of adenosine kinase in mammalian cells: The long isoform of AdK is localized in the nucleus.

PubMed ID: 19635462

DOI: 10.1016/j.bbrc.2009.07.106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9843365

Title: Structure of human adenosine kinase at 1.5-A resolution.

PubMed ID: 9843365

DOI: 10.1021/bi9815445

PubMed ID: 12112843

Title: Identification of the phosphotyrosine proteome from thrombin activated platelets.

PubMed ID: 12112843

DOI: 10.1002/1615-9861(200206)2:6<642::aid-prot642>3.0.co;2-i

PubMed ID: 21963049

Title: Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function.

PubMed ID: 21963049

DOI: 10.1016/j.ajhg.2011.09.004

Sequence Information:

  • Length: 362
  • Mass: 40545
  • Checksum: 48AA4925865BFE70
  • Sequence:
  • MAAAEEEPKP KKLKVEAPQA LRENILFGMG NPLLDISAVV DKDFLDKYSL KPNDQILAED 
    KHKELFDELV KKFKVEYHAG GSTQNSIKVA QWMIQQPHKA ATFFGCIGID KFGEILKRKA 
    AEAHVDAHYY EQNEQPTGTC AACITGDNRS LIANLAAANC YKKEKHLDLE KNWMLVEKAR 
    VCYIAGFFLT VSPESVLKVA HHASENNRIF TLNLSAPFIS QFYKESLMKV MPYVDILFGN 
    ETEAATFARE QGFETKDIKE IAKKTQALPK MNSKRQRIVI FTQGRDDTIM ATESEVTAFA 
    VLDQDQKEII DTNGAGDAFV GGFLSQLVSD KPLTECIRAG HYAASIIIRR TGCTFPEKPD 
    FH

Genular Protein ID: 3645166431

Symbol: A0A5F9ZHJ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

Sequence Information:

  • Length: 270
  • Mass: 30167
  • Checksum: 50BEFE2973A11254
  • Sequence:
  • MIQQPHKAAT FFGCIGIDKF GEILKRKAAE AHVDAHYYEQ NEQPTGTCAA CITGDNRSLI 
    ANLAAANCYK KEKHLDLEKN WMLVEKARVC YIAGFFLTVS PESVLKVAHH ASENNRIFTL 
    NLSAPFISQF YKESLMKVMP YVDILFGNET EAATFAREQG FETKDIKEIA KKTQALPKMN 
    SKRQRIVIFT QGRDDTIMAT ESEVTAFAVL DQDQKEIIDT NGAGDAFVGG FLSQLVSDKP 
    LTECIRAGHY AASIIIRRTG CTFPEKPDFH

Genular Protein ID: 913775614

Symbol: A0A5F9ZH72_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

Sequence Information:

  • Length: 229
  • Mass: 25942
  • Checksum: 4F72B2BE7E9DC2FE
  • Sequence:
  • MTSVRENILF GMGNPLLDIS AVVDKDFLDK YSLKPNDQIL AEDKHKELFD ELVKKFKVEY 
    HAGGSTQNSI KVAQWMIQQP HKAATFFGCI GIDKFGEILK RKAAEAHVDA HYYEQNEQPT 
    GTCAACITGD NRSLIANLAA ANCYKKEKHL DLEKNWMLVE KARVCYIAGF FLTVSPESVL 
    KVAHHASENN RIFTLNLSAP FISQFYKESL MKVMPYVDIL FGNETTYHI

Genular Protein ID: 2346542517

Symbol: A0A140VJE0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 345
  • Mass: 38703
  • Checksum: 7DC20F364E63D944
  • Sequence:
  • MTSVRENILF GMGNPLLDIS AVVDKDFLDK YSLKPNDQIL AEDKHKELFD ELVKKFKVEY 
    HAGGSTQNSI KVAQWMIQQP HKAATFFGCI GIDKFGEILK RKAAEAHVDA HYYEQNEQPT 
    GTCAACITGD NRSLIANLAA ANCYKKEKHL DLEKNWMLVE KARVCYIAGF FLTVSPESVL 
    KVAHHASENN RIFTLNLSAP FISQFYKESL MKVMPYVDIL FGNETEAATF AREQGFETKD 
    IKEIAKKTQA LPKMNSKRQR IVIFTQGRDD TIMATESEVT AFAVLDQDQK EIIDTNGAGD 
    AFVGGFLSQL VSDKPLTECI RAGHYAASII IRRTGCTFPE KPDFH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.