Genular: Defining Cellular Identity and Function

Details for: Ddx3x

Gene ID: 13205

Symbol: Ddx3x

Ensembl ID: ENSMUSG00000000787

Description: DEAD box helicase 3, X-linked

Associated with

Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cell differentiation
(GO:0030154)
Cell leading edge
(GO:0031252)
Cell projection
(GO:0042995)
Cellular response to arsenic-containing substance
(GO:0071243)
Cellular response to osmotic stress
(GO:0071470)
Cellular response to virus
(GO:0098586)
Centrosome
(GO:0005813)
Chromosome segregation
(GO:0007059)
Ctpase activity
(GO:0043273)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Cytosolic ribosome assembly
(GO:0042256)
Cytosolic small ribosomal subunit
(GO:0022627)
Dna binding
(GO:0003677)
Dna helicase activity
(GO:0003678)
Eukaryotic initiation factor 4e binding
(GO:0008190)
Eukaryotic translation initiation factor 3 complex
(GO:0005852)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Gamete generation
(GO:0007276)
Gamma-tubulin binding
(GO:0043015)
Gtpase activity
(GO:0003924)
Helicase activity
(GO:0004386)
Hydrolase activity
(GO:0016787)
Immune system process
(GO:0002376)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Intracellular signal transduction
(GO:0035556)
Intrinsic apoptotic signaling pathway
(GO:0097193)
Lipid homeostasis
(GO:0055088)
Membrane
(GO:0016020)
Mrna 5'-utr binding
(GO:0048027)
Mrna binding
(GO:0003729)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043154)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902042)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of intrinsic apoptotic signaling pathway
(GO:2001243)
Negative regulation of non-canonical nf-kappab signal transduction
(GO:1901223)
Negative regulation of protein-containing complex assembly
(GO:0031333)
Negative regulation of translation
(GO:0017148)
Nucleic acid binding
(GO:0003676)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
P granule
(GO:0043186)
Plasma membrane
(GO:0005886)
Poly(a) binding
(GO:0008143)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interferon-alpha production
(GO:0032727)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of nlrp3 inflammasome complex assembly
(GO:1900227)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of protein acetylation
(GO:1901985)
Positive regulation of protein autophosphorylation
(GO:0031954)
Positive regulation of protein k63-linked ubiquitination
(GO:1902523)
Positive regulation of protein serine/threonine kinase activity
(GO:0071902)
Positive regulation of toll-like receptor 7 signaling pathway
(GO:0034157)
Positive regulation of toll-like receptor 8 signaling pathway
(GO:0034161)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of translation
(GO:0045727)
Positive regulation of translational initiation
(GO:0045948)
Positive regulation of translation in response to endoplasmic reticulum stress
(GO:0036493)
Positive regulation of type i interferon production
(GO:0032481)
Positive regulation of viral genome replication
(GO:0045070)
Primary mirna binding
(GO:0070878)
Primary mirna processing
(GO:0031053)
Protein binding
(GO:0005515)
Protein localization to cytoplasmic stress granule
(GO:1903608)
Protein serine/threonine kinase activator activity
(GO:0043539)
Regulation of translation
(GO:0006417)
Response to virus
(GO:0009615)
Ribonucleoside triphosphate phosphatase activity
(GO:0017111)
Ribosomal small subunit binding
(GO:0043024)
Ribosome biogenesis
(GO:0042254)
Rna binding
(GO:0003723)
Rna helicase activity
(GO:0003724)
Rna secondary structure unwinding
(GO:0010501)
Rna stem-loop binding
(GO:0035613)
Rna strand annealing activity
(GO:0033592)
Signaling adaptor activity
(GO:0035591)
Stress granule assembly
(GO:0034063)
Transcription factor binding
(GO:0008134)
Translational initiation
(GO:0006413)
Translation initiation factor binding
(GO:0031369)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

ATP-dependent RNA helicase DDX3X

Genular Protein ID: 4021044202

Symbol: DDX3X_MOUSE

Name: ATP-dependent RNA helicase DDX3X

UniProtKB Accession Codes:

Q62167 O09060 O09143

Database IDs:

Citations:

PubMed ID: 8948440

Title: The embryonic RNA helicase gene (ERH): a new member of the DEAD box family of RNA helicases.

PubMed ID: 8948440

DOI: 10.1042/bj3080839

PubMed ID: 8144024

Title: Mouse erythroid cells express multiple putative RNA helicase genes exhibiting high sequence conservation from yeast to mammals.

PubMed ID: 8144024

DOI: 10.1016/0378-1119(94)90541-x

PubMed ID: 10859333

Title: An N-acetylated natural ligand of human histocompatibility leukocyte antigen (HLA)-B39. Classical major histocompatibility complex class I proteins bind peptides with a blocked NH(2) terminus in vivo.

PubMed ID: 10859333

DOI: 10.1084/jem.191.12.2083

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 25050112

Title: DDX3X regulates cell survival and cell cycle during mouse early embryonic development.

PubMed ID: 25050112

DOI: 10.7555/jbr.27.20130047

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 27179789

Title: Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis.

PubMed ID: 27179789

DOI: 10.1093/hmg/ddw143

PubMed ID: 31511697

Title: DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.

PubMed ID: 31511697

DOI: 10.1038/s41586-019-1551-2

PubMed ID: 30475900

Title: The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity.

PubMed ID: 30475900

DOI: 10.1371/journal.ppat.1007397

PubMed ID: 30613052

Title: An azoospermic factor gene, Ddx3y and its paralog, Ddx3x are dispensable in germ cells for male fertility.

PubMed ID: 30613052

DOI: 10.1262/jrd.2018-145

Sequence Information:

Length: 662
Mass: 73101
Checksum: 216515CB00324017
Sequence:

MSHVAVENAL GLDQQFAGLD LNSSDNQSGG STASKGRYIP PHLRNREATK GFYDKDSSGW 
SSSKDKDAYS SFGSRGDSRG KSSFFGDRGS GSRGRFDDRG RGDYDGIGGR GDRSGFGKFE 
RGGNSRWCDK SDEDDWSKPL PPSERLEQEL FSGGNTGINF EKYDDIPVEA TGNNCPPHIE 
SFSDVEMGEI IMGNIELTRY TRPTPVQKHA IPIIKEKRDL MACAQTGSGK TAAFLLPILS 
QIYADGPGEA LRAMKENGRY GRRKQYPISL VLAPTRELAV QIYEEARKFS YRSRVRPCVV 
YGGAEIGQQI RDLERGCHLL VATPGRLVDM MERGKIGLDF CKYLVLDEAD RMLDMGFEPQ 
IRRIVEQDTM PPKGVRHTMM FSATFPKEIQ MLARDFLDEY IFLAVGRVGS TSENITQKVV 
WVEEIDKRSF LLDLLNATGK DSLTLVFVET KKGADSLEDF LYHEGYACTS IHGDRSQRDR 
EEALHQFRSG KSPILVATAV AARGLDISNV KHVINFDLPS DIEEYVHRIG RTGRVGNLGL 
ATSFFNERNI NITKDLLDLL VEAKQEVPSW LENMAFEHHY KGSSRGRSKS SRFSGGFGAR 
DYRQSSGASS SSFSSSRASS SRSGGGGHGG SRGFGGGGYG GFYNSDGYGG NYNSQGVDWW 
GN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ddx3x

Associated with

Other Information

The embryonic RNA helicase gene (ERH): a new member of the DEAD box family of RNA helicases. PubMed ID: 8948440

Mouse erythroid cells express multiple putative RNA helicase genes exhibiting high sequence conservation from yeast to mammals. PubMed ID: 8144024

An N-acetylated natural ligand of human histocompatibility leukocyte antigen (HLA)-B39. Classical major histocompatibility complex class I proteins bind peptides with a blocked NH(2) terminus in vivo. PubMed ID: 10859333

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

DDX3X regulates cell survival and cell cycle during mouse early embryonic development. PubMed ID: 25050112

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. PubMed ID: 27179789

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. PubMed ID: 31511697

The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity. PubMed ID: 30475900

An azoospermic factor gene, Ddx3y and its paralog, Ddx3x are dispensable in germ cells for male fertility. PubMed ID: 30613052