Details for: CORT

Gene ID: 1325

Symbol: CORT

Ensembl ID: ENSG00000241563

Description: cortistatin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2000.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7683
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4822
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 506
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.04
    Marker Score: 431
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.8
    Marker Score: 463.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1192
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 442
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.65
    Marker Score: 233
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 488
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.57
    Marker Score: 345
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.35
    Marker Score: 613
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.33
    Marker Score: 6543
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.31
    Marker Score: 312
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.28
    Marker Score: 536
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.27
    Marker Score: 122
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.26
    Marker Score: 140.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.23
    Marker Score: 468.5
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.22
    Marker Score: 233
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.19
    Marker Score: 122.5
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.18
    Marker Score: 120
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 160
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.18
    Marker Score: 2625
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.17
    Marker Score: 2713
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.17
    Marker Score: 6199
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.16
    Marker Score: 59
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.16
    Marker Score: 244.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.15
    Marker Score: 92
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.15
    Marker Score: 94
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.14
    Marker Score: 38
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.14
    Marker Score: 198
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.13
    Marker Score: 46
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.13
    Marker Score: 36
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.12
    Marker Score: 67
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.12
    Marker Score: 246
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.11
    Marker Score: 128
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.11
    Marker Score: 7043
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.11
    Marker Score: 55
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.11
    Marker Score: 106
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.11
    Marker Score: 672
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.11
    Marker Score: 1024
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.11
    Marker Score: 1016
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.1
    Marker Score: 834
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.09
    Marker Score: 351
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.09
    Marker Score: 86
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.09
    Marker Score: 87
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.09
    Marker Score: 36
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.08
    Marker Score: 154
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.08
    Marker Score: 75
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.08
    Marker Score: 85
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.08
    Marker Score: 74
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.08
    Marker Score: 79
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.08
    Marker Score: 328
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.08
    Marker Score: 82
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.08
    Marker Score: 96
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.08
    Marker Score: 309
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.07
    Marker Score: 48
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.07
    Marker Score: 551
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.07
    Marker Score: 62.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.07
    Marker Score: 121
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.07
    Marker Score: 277
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 31.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.05
    Marker Score: 31

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * It is a protein of the immunoglobulin superfamily. * It is expressed in high levels in the colon. * It is a key regulator of cell migration in the colon. * It is involved in the regulation of inflammation. **Pathways and functions:** * It is a key regulator of cell migration by binding to G protein-coupled receptors (GPCRs) on epithelial cells. * It inhibits the activity of GCRs, which leads to the inhibition of cell migration. * It is also involved in the regulation of inflammation by binding to GPCRs on immune cells. * It helps to regulate the development and function of the colon. **Clinical significance:** * Mutations in the CORT gene have been linked to a number of diseases, including colorectal cancer, inflammatory bowel disease, and obesity. * Targeting the CORT gene has been shown to be a promising strategy for treating these diseases. **Additional information:** * The gene is located on chromosome 15q21.1. * It is a secreted protein. * It is a member of the immunoglobulin superfamily. * It is a key regulator of cell migration and inflammation.

Genular Protein ID: 2233170570

Symbol: CORT_HUMAN

Name: Cortistatin

UniProtKB Accession Codes:

O00230 Q5T6G0 Q6UX11

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 2 Ensembl 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9125122

Title: Identification and characterization of a novel human cortistatin-like peptide.

PubMed ID: 9125122

DOI: 10.1006/bbrc.1997.6252

PubMed ID: 9205124

Title: Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.

PubMed ID: 9205124

DOI: 10.1006/geno.1997.4763

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

Sequence Information:

  • Length: 105
  • Mass: 11532
  • Checksum: 09578F4520201551
  • Sequence:
    • MPLSPGLLLL LLSGATATAA LPLEGGPTGR DSEHMQEAAG IRKSSLLTFL AWWFEWTSQA 
SAGPLIGEEA REVARRQEGA PPQQSARRDR MPCRNFFWKT FSSCK

Genular Protein ID: 2858329919

Symbol: Q8IUV6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IUV6

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 122
  • Mass: 13369
  • Checksum: A1279CA09CB0CB44
  • Sequence:
    • GRKSSSRVGE KLQSAHKMPL SPGLLLLLLS GATATAALPL EGGPTGRDSE HMQEAAGIRK 
SSLLTFLAWW FEWTSQASAG PLIGEEAREV ARRQEGAPPQ QSARRDRMPC RNFFWKTFSS 
CK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.