Details for: CORT

Gene ID: 1325

Symbol: CORT

Ensembl ID: ENSG00000241563

Description: cortistatin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 21.8586
    Cell Significance Index: -3.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 13.4835
    Cell Significance Index: -3.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.7842
    Cell Significance Index: 89.1800
  • Cell Name: sst chodl GABAergic cortical interneuron (CL4023121)
    Fold Change: 0.7209
    Cell Significance Index: 5.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.6392
    Cell Significance Index: 13.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3739
    Cell Significance Index: 22.9800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.3534
    Cell Significance Index: 4.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.3213
    Cell Significance Index: 19.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2797
    Cell Significance Index: 35.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2503
    Cell Significance Index: 5.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2485
    Cell Significance Index: 7.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2046
    Cell Significance Index: 38.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2009
    Cell Significance Index: 12.0600
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.1931
    Cell Significance Index: 1.9600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1543
    Cell Significance Index: 3.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1139
    Cell Significance Index: 12.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0858
    Cell Significance Index: 3.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0683
    Cell Significance Index: 2.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0631
    Cell Significance Index: 12.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0584
    Cell Significance Index: 9.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0541
    Cell Significance Index: 5.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0491
    Cell Significance Index: 33.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0474
    Cell Significance Index: 3.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0375
    Cell Significance Index: 13.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0335
    Cell Significance Index: 30.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0088
    Cell Significance Index: 0.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0040
    Cell Significance Index: 0.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0031
    Cell Significance Index: 0.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0004
    Cell Significance Index: -0.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0011
    Cell Significance Index: -0.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0015
    Cell Significance Index: -0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.3300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0023
    Cell Significance Index: -0.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0031
    Cell Significance Index: -0.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0034
    Cell Significance Index: -1.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0042
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0043
    Cell Significance Index: -3.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0047
    Cell Significance Index: -3.5500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0051
    Cell Significance Index: -0.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0078
    Cell Significance Index: -3.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0116
    Cell Significance Index: -1.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0135
    Cell Significance Index: -3.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0175
    Cell Significance Index: -3.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0185
    Cell Significance Index: -0.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0187
    Cell Significance Index: -0.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0187
    Cell Significance Index: -2.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0187
    Cell Significance Index: -3.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0207
    Cell Significance Index: -0.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0236
    Cell Significance Index: -3.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0263
    Cell Significance Index: -3.1000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0265
    Cell Significance Index: -0.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0269
    Cell Significance Index: -3.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0270
    Cell Significance Index: -1.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0294
    Cell Significance Index: -1.6500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0296
    Cell Significance Index: -0.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0313
    Cell Significance Index: -3.2000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0386
    Cell Significance Index: -0.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0404
    Cell Significance Index: -1.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0454
    Cell Significance Index: -0.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0473
    Cell Significance Index: -2.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0476
    Cell Significance Index: -3.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0486
    Cell Significance Index: -3.7300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0488
    Cell Significance Index: -0.6500
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.0562
    Cell Significance Index: -0.5100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0613
    Cell Significance Index: -0.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0622
    Cell Significance Index: -2.9000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0648
    Cell Significance Index: -1.5700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0654
    Cell Significance Index: -0.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0663
    Cell Significance Index: -2.5100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0673
    Cell Significance Index: -0.6400
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0701
    Cell Significance Index: -0.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0733
    Cell Significance Index: -3.4500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0754
    Cell Significance Index: -1.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0762
    Cell Significance Index: -2.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0795
    Cell Significance Index: -2.1300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0852
    Cell Significance Index: -1.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0873
    Cell Significance Index: -2.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0877
    Cell Significance Index: -2.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0886
    Cell Significance Index: -2.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0897
    Cell Significance Index: -1.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0901
    Cell Significance Index: -2.8700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0909
    Cell Significance Index: -1.3700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0916
    Cell Significance Index: -1.5100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0924
    Cell Significance Index: -1.8800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0927
    Cell Significance Index: -1.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0973
    Cell Significance Index: -2.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0989
    Cell Significance Index: -3.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0991
    Cell Significance Index: -3.4500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1026
    Cell Significance Index: -2.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1041
    Cell Significance Index: -2.1800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1067
    Cell Significance Index: -2.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1069
    Cell Significance Index: -3.1500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1073
    Cell Significance Index: -1.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1123
    Cell Significance Index: -3.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1126
    Cell Significance Index: -2.8100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1142
    Cell Significance Index: -1.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1179
    Cell Significance Index: -3.1000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1209
    Cell Significance Index: -1.3000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1252
    Cell Significance Index: -3.1900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1269
    Cell Significance Index: -3.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** Cortistatin is a peptide hormone composed of 26-30 amino acids. It acts as an inhibitory neurotransmitter, modulating the activity of G protein-coupled receptors (GPCRs) and influencing various signaling pathways. 2. **Expression Patterns:** Cortistatin is expressed in multiple cell types, including enterocytes, goblet cells, intestinal crypt stem cells, and neural cells. This widespread expression suggests its involvement in regulating gut function, immune responses, and central nervous system function. 3. **Signaling Pathways:** Cortistatin interacts with GPCRs, particularly those belonging to the class A/1 (rhodopsin-like receptors) and the adenylate cyclase-inhibiting GPCR signaling pathway. This interaction modulates downstream signaling events, including regulation of cell migration, synaptic transmission, and signaling by GPCRs. **Pathways and Functions:** 1. **GPCR Signaling:** Cortistatin binds to GPCRs, specifically those belonging to the class A/1 (rhodopsin-like receptors) and the adenylate cyclase-inhibiting GPCR signaling pathway. This binding modulates downstream signaling events, including regulation of cell migration, synaptic transmission, and signaling by GPCRs. 2. **Neuropeptide Hormone Activity:** Cortistatin exhibits neuropeptide hormone activity, influencing the activity of other peptides and hormones in the body. 3. **Immune Regulation:** Cortistatin is involved in regulating immune responses, particularly in the gut. It modulates the activity of immune cells, including T cells and macrophages, and influences the production of cytokines and chemokines. 4. **Central Nervous System Function:** Cortistatin is expressed in neural cells, including cerebral cortex GABAergic interneurons and forebrain radial glial cells. It modulates neurotransmitter release, synaptic plasticity, and neuronal migration. **Clinical Significance:** 1. **Gastrointestinal Disorders:** Cortistatin dysregulation has been implicated in various gastrointestinal disorders, including inflammatory bowel disease, irritable bowel syndrome, and colorectal cancer. 2. **Neurological Disorders:** Cortistatin has been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and anxiety disorders. 3. **Immune System Dysregulation:** Cortistatin dysregulation has been implicated in immune system dysregulation, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Cancer:** Cortistatin has been shown to have anti-tumor properties, particularly in the context of colorectal cancer. In conclusion, cortistatin is a neuropeptide hormone with complex immunological functions, influencing various physiological and pathological processes. Further research is needed to fully understand its role in immune regulation, gut function, and central nervous system function, as well as its clinical significance in various diseases.

Genular Protein ID: 2233170570

Symbol: CORT_HUMAN

Name: Cortistatin

UniProtKB Accession Codes:

O00230 Q5T6G0 Q6UX11

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 3 Ensembl 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9125122

Title: Identification and characterization of a novel human cortistatin-like peptide.

PubMed ID: 9125122

DOI: 10.1006/bbrc.1997.6252

PubMed ID: 9205124

Title: Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.

PubMed ID: 9205124

DOI: 10.1006/geno.1997.4763

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

Sequence Information:

  • Length: 105
  • Mass: 11532
  • Checksum: 09578F4520201551
  • Sequence:
    • MPLSPGLLLL LLSGATATAA LPLEGGPTGR DSEHMQEAAG IRKSSLLTFL AWWFEWTSQA 
SAGPLIGEEA REVARRQEGA PPQQSARRDR MPCRNFFWKT FSSCK

Genular Protein ID: 2858329919

Symbol: Q8IUV6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IUV6

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 122
  • Mass: 13369
  • Checksum: A1279CA09CB0CB44
  • Sequence:
    • GRKSSSRVGE KLQSAHKMPL SPGLLLLLLS GATATAALPL EGGPTGRDSE HMQEAAGIRK 
SSLLTFLAWW FEWTSQASAG PLIGEEAREV ARRQEGAPPQ QSARRDRMPC RNFFWKTFSS 
CK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.