Details for: MAP3K8
Associated with
Other Information
Genular Protein ID: 3806203648
Symbol: M3K8_HUMAN
Name: Mitogen-activated protein kinase kinase kinase 8
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2072910
Title: Structure and transforming potential of the human cot oncogene encoding a putative protein kinase.
PubMed ID: 2072910
PubMed ID: 8226782
Title: The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation.
PubMed ID: 8226782
PubMed ID: 8479752
Title: Expression cDNA cloning of a serine kinase transforming gene.
PubMed ID: 8479752
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10896655
Title: COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation.
PubMed ID: 10896655
PubMed ID: 1833717
Title: Identification and characterization of protein products of the cot oncogene with serine kinase activity.
PubMed ID: 1833717
PubMed ID: 9950430
Title: TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105.
PubMed ID: 9950430
DOI: 10.1038/16946
PubMed ID: 11342626
Title: p27kip protein levels and E2F activity are targets of Cot kinase during G1 phase progression in T cells.
PubMed ID: 11342626
PubMed ID: 12975377
Title: Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling.
PubMed ID: 12975377
PubMed ID: 12667451
Title: NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase.
PubMed ID: 12667451
PubMed ID: 15466476
Title: Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.
PubMed ID: 15466476
PubMed ID: 15169888
Title: ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.
PubMed ID: 15169888
PubMed ID: 15699325
Title: Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.
PubMed ID: 15699325
PubMed ID: 16371247
Title: TRAF6 and Src kinase activity regulates Cot activation by IL-1.
PubMed ID: 16371247
PubMed ID: 17472361
Title: Characterization of phosphorylation sites on Tpl2 using IMAC enrichment and a linear ion trap mass spectrometer.
PubMed ID: 17472361
DOI: 10.1021/pr0700293
PubMed ID: 19001140
Title: Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii.
PubMed ID: 19001140
DOI: 10.1084/jem.20081461
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19754427
Title: IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.
PubMed ID: 19754427
DOI: 10.1042/bj20091271
PubMed ID: 24325551
Title: Retraction. IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.
PubMed ID: 24325551
DOI: 10.1042/bj4570227
PubMed ID: 19808894
Title: Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.
PubMed ID: 19808894
DOI: 10.2337/db09-0470
PubMed ID: 22988300
Title: IkappaB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400.
PubMed ID: 22988300
DOI: 10.1128/mcb.01065-12
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 467
- Mass: 52925
- Checksum: 7728969EA3E4E8EC
- Sequence:
MEYMSTGSDN KEEIDLLIKH LNVSDVIDIM ENLYASEEPA VYEPSLMTMC QDSNQNDERS KSLLLSGQEV PWLSSVRYGT VEDLLAFANH ISNTAKHFYG QRPQESGILL NMVITPQNGR YQIDSDVLLI PWKLTYRNIG SDFIPRGAFG KVYLAQDIKT KKRMACKLIP VDQFKPSDVE IQACFRHENI AELYGAVLWG ETVHLFMEAG EGGSVLEKLE SCGPMREFEI IWVTKHVLKG LDFLHSKKVI HHDIKPSNIV FMSTKAVLVD FGLSVQMTED VYFPKDLRGT EIYMSPEVIL CRGHSTKADI YSLGATLIHM QTGTPPWVKR YPRSAYPSYL YIIHKQAPPL EDIADDCSPG MRELIEASLE RNPNHRPRAA DLLKHEALNP PREDQPRCQS LDSALLERKR LLSRKELELP ENIADSSCTG STEESEMLKR QRSLYIDLGA LAGYFNLVRG PPTLEYG
Genular Protein ID: 3543529875
Symbol: Q6FG25_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 467
- Mass: 52915
- Checksum: 7728969EA3E4EA3C
- Sequence:
MEYMSTGSDN KEEIDLLIKH LNVSDVIDIM ENLYASEEPA VYEPSLMTMC QDSNQNDERS KSLLLSGQEV PWLSSVRYGT VEDLLAFANH ISNTAKHFYG QRPQESGILL NMVITPQNGR YQIDSDVLLI PWKLTYRNIG SDFIPRGAFG KVYLAQDIKT KKRMACKLIP VDQFKPSDVE IQACFRHENI AELYGAVLWG ETVHLFMEAG EGGSVLEKLE SCGPMREFEI IWVTKHVLKG LDFLHSKKVI HHDIKPSNIV FMSTKAVLVD FGLSVQMTED VYFPKDLRGT EIYMSPEVIL CRGHSTKADI YSLGATLIHM QTGTPPWVKR YPRSAYPSYL YIIHKQAPPL EDIADDCSPG MRELIEASLE RNPNHRPRAA DLLKHEALNP PREDQPRCQS LDSALLERKR LLSRKELELP ENIADSSCTG STEESEMLKR QRSLYIDLGA LAGYFNLVRG SPTLEYG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.