Details for: MAP3K8

Gene ID: 1326

Symbol: MAP3K8

Ensembl ID: ENSG00000107968

Description: mitogen-activated protein kinase kinase kinase 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 208.5567
    Cell Significance Index: -32.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.2663
    Cell Significance Index: -31.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.2919
    Cell Significance Index: -18.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 65.7192
    Cell Significance Index: -33.8100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 50.8180
    Cell Significance Index: -34.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.2969
    Cell Significance Index: -31.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.5541
    Cell Significance Index: -32.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.1241
    Cell Significance Index: -29.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.3571
    Cell Significance Index: -28.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.5402
    Cell Significance Index: -33.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.2924
    Cell Significance Index: -15.9600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 4.8832
    Cell Significance Index: 39.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.6490
    Cell Significance Index: 48.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.3516
    Cell Significance Index: 122.1600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.9362
    Cell Significance Index: 34.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5046
    Cell Significance Index: 40.1800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.3174
    Cell Significance Index: 8.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2867
    Cell Significance Index: 151.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.2204
    Cell Significance Index: 32.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1861
    Cell Significance Index: 88.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1780
    Cell Significance Index: 152.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1664
    Cell Significance Index: 54.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1264
    Cell Significance Index: 131.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7985
    Cell Significance Index: 158.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7212
    Cell Significance Index: 19.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7124
    Cell Significance Index: 20.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7009
    Cell Significance Index: 13.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6769
    Cell Significance Index: 66.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6055
    Cell Significance Index: 330.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5465
    Cell Significance Index: 493.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3780
    Cell Significance Index: 19.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3501
    Cell Significance Index: 63.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3498
    Cell Significance Index: 43.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3379
    Cell Significance Index: 64.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3283
    Cell Significance Index: 16.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3201
    Cell Significance Index: 52.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2242
    Cell Significance Index: 99.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2118
    Cell Significance Index: 23.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1762
    Cell Significance Index: 11.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1127
    Cell Significance Index: 15.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1021
    Cell Significance Index: 192.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0772
    Cell Significance Index: 49.0600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0726
    Cell Significance Index: 0.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0394
    Cell Significance Index: 7.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0315
    Cell Significance Index: 58.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0176
    Cell Significance Index: 2.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0085
    Cell Significance Index: 13.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0003
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0025
    Cell Significance Index: -1.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0211
    Cell Significance Index: -3.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0228
    Cell Significance Index: -30.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0347
    Cell Significance Index: -23.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0363
    Cell Significance Index: -2.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0376
    Cell Significance Index: -2.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0383
    Cell Significance Index: -17.4000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0389
    Cell Significance Index: -0.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0425
    Cell Significance Index: -31.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0441
    Cell Significance Index: -32.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0493
    Cell Significance Index: -1.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0558
    Cell Significance Index: -31.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0564
    Cell Significance Index: -35.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0588
    Cell Significance Index: -16.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0592
    Cell Significance Index: -1.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0757
    Cell Significance Index: -1.6400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0784
    Cell Significance Index: -0.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0820
    Cell Significance Index: -29.4000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0942
    Cell Significance Index: -0.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1014
    Cell Significance Index: -7.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1040
    Cell Significance Index: -3.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1369
    Cell Significance Index: -23.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1403
    Cell Significance Index: -6.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1481
    Cell Significance Index: -2.0200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1710
    Cell Significance Index: -1.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1748
    Cell Significance Index: -36.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1904
    Cell Significance Index: -6.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1918
    Cell Significance Index: -14.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2023
    Cell Significance Index: -23.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2298
    Cell Significance Index: -23.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2375
    Cell Significance Index: -13.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2587
    Cell Significance Index: -15.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2616
    Cell Significance Index: -6.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2940
    Cell Significance Index: -3.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3403
    Cell Significance Index: -7.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3648
    Cell Significance Index: -17.0100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3688
    Cell Significance Index: -5.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3800
    Cell Significance Index: -10.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4188
    Cell Significance Index: -33.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4312
    Cell Significance Index: -13.8100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4484
    Cell Significance Index: -10.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4679
    Cell Significance Index: -31.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5361
    Cell Significance Index: -32.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5520
    Cell Significance Index: -34.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5543
    Cell Significance Index: -14.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6241
    Cell Significance Index: -32.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6280
    Cell Significance Index: -20.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6891
    Cell Significance Index: -22.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6985
    Cell Significance Index: -20.5800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.7144
    Cell Significance Index: -7.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7151
    Cell Significance Index: -24.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7201
    Cell Significance Index: -31.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAP3K8 is a member of the MAP3K family, which is involved in the regulation of various cellular processes, including cell growth, differentiation, and survival. This gene is characterized by its ability to phosphorylate and activate downstream kinases, such as MAPK1 and MAPK3, which are crucial for the regulation of immune responses. MAP3K8 is also known to interact with various proteins, including CD28, which is a key co-stimulatory molecule for T cells. **Pathways and Functions:** MAP3K8 is involved in multiple signaling pathways that regulate immune responses, including: 1. **Adaptive Immune System:** MAP3K8 is essential for the regulation of T cell activation, proliferation, and differentiation. It interacts with CD28 to enhance T cell responses and is required for the activation of downstream signaling cascades, including the NF-κB pathway. 2. **Cytokine Signaling:** MAP3K8 is involved in the regulation of cytokine signaling, including the production of pro-inflammatory cytokines, such as IL-1β and TNF-α. 3. **TLR Signaling:** MAP3K8 is required for the activation of Toll-like receptors (TLRs), which are crucial for the recognition of pathogens and the activation of immune responses. 4. **Costimulation by the CD28 Family:** MAP3K8 is involved in the regulation of costimulation by the CD28 family, which is essential for the activation of T cells. **Clinical Significance:** MAP3K8 has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases:** MAP3K8 has been shown to contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** MAP3K8 has been implicated in the regulation of cancer cell growth and survival, and its expression has been associated with poor prognosis in various types of cancer. 3. **Infectious Diseases:** MAP3K8 has been shown to play a critical role in the regulation of immune responses to infections, including the activation of T cells and the production of cytokines. In conclusion, MAP3K8 is a critical gene involved in the regulation of immune responses, including cytokine signaling, costimulation, and the activation of downstream signaling cascades. Its dysregulation has been implicated in various immune-related disorders, including autoimmune diseases, cancer, and infectious diseases. Further research is necessary to fully understand the mechanisms of MAP3K8 and its role in the immune system. **References:** * [Insert references here] **Recommendations:** 1. **Future Research Directions:** Further research is necessary to fully understand the mechanisms of MAP3K8 and its role in the immune system. 2. **Therapeutic Applications:** MAP3K8 inhibitors may have therapeutic potential in the treatment of autoimmune diseases and cancer. 3. **Immunological Applications:** MAP3K8 may have applications in the development of novel immunotherapies, including checkpoint inhibitors and cytokine-based therapies. **Conclusion:** MAP3K8 is a critical gene involved in the regulation of immune responses, including cytokine signaling, costimulation, and the activation of downstream signaling cascades. Its dysregulation has been implicated in various immune-related disorders, including autoimmune diseases, cancer, and infectious diseases. Further research is necessary to fully understand the mechanisms of MAP3K8 and its role in the immune system.

Genular Protein ID: 3806203648

Symbol: M3K8_HUMAN

Name: Mitogen-activated protein kinase kinase kinase 8

UniProtKB Accession Codes:

P41279 A8K2Q5 D3DRX1 Q14275 Q5T855 Q9HC81

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 7 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2072910

Title: Structure and transforming potential of the human cot oncogene encoding a putative protein kinase.

PubMed ID: 2072910

DOI: 10.1128/mcb.11.8.4088-4096.1991

PubMed ID: 8226782

Title: The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation.

PubMed ID: 8226782

DOI: 10.1016/s0021-9258(18)41587-6

PubMed ID: 8479752

Title: Expression cDNA cloning of a serine kinase transforming gene.

PubMed ID: 8479752

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10896655

Title: COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation.

PubMed ID: 10896655

DOI: 10.1074/jbc.m000382200

PubMed ID: 1833717

Title: Identification and characterization of protein products of the cot oncogene with serine kinase activity.

PubMed ID: 1833717

PubMed ID: 9950430

Title: TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105.

PubMed ID: 9950430

DOI: 10.1038/16946

PubMed ID: 11342626

Title: p27kip protein levels and E2F activity are targets of Cot kinase during G1 phase progression in T cells.

PubMed ID: 11342626

DOI: 10.4049/jimmunol.166.10.6084

PubMed ID: 12975377

Title: Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling.

PubMed ID: 12975377

DOI: 10.1074/jbc.m306002200

PubMed ID: 12667451

Title: NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase.

PubMed ID: 12667451

DOI: 10.1016/s1097-2765(03)00070-4

PubMed ID: 15466476

Title: Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.

PubMed ID: 15466476

DOI: 10.1074/jbc.m403716200

PubMed ID: 15169888

Title: ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.

PubMed ID: 15169888

DOI: 10.1128/mcb.24.12.5235-5248.2004

PubMed ID: 15699325

Title: Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.

PubMed ID: 15699325

DOI: 10.1073/pnas.0409856102

PubMed ID: 16371247

Title: TRAF6 and Src kinase activity regulates Cot activation by IL-1.

PubMed ID: 16371247

DOI: 10.1016/j.cellsig.2005.10.016

PubMed ID: 17472361

Title: Characterization of phosphorylation sites on Tpl2 using IMAC enrichment and a linear ion trap mass spectrometer.

PubMed ID: 17472361

DOI: 10.1021/pr0700293

PubMed ID: 19001140

Title: Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii.

PubMed ID: 19001140

DOI: 10.1084/jem.20081461

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19754427

Title: IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.

PubMed ID: 19754427

DOI: 10.1042/bj20091271

PubMed ID: 24325551

Title: Retraction. IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.

PubMed ID: 24325551

DOI: 10.1042/bj4570227

PubMed ID: 19808894

Title: Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.

PubMed ID: 19808894

DOI: 10.2337/db09-0470

PubMed ID: 22988300

Title: IkappaB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400.

PubMed ID: 22988300

DOI: 10.1128/mcb.01065-12

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 467
  • Mass: 52925
  • Checksum: 7728969EA3E4E8EC
  • Sequence:
    • MEYMSTGSDN KEEIDLLIKH LNVSDVIDIM ENLYASEEPA VYEPSLMTMC QDSNQNDERS 
KSLLLSGQEV PWLSSVRYGT VEDLLAFANH ISNTAKHFYG QRPQESGILL NMVITPQNGR 
YQIDSDVLLI PWKLTYRNIG SDFIPRGAFG KVYLAQDIKT KKRMACKLIP VDQFKPSDVE 
IQACFRHENI AELYGAVLWG ETVHLFMEAG EGGSVLEKLE SCGPMREFEI IWVTKHVLKG 
LDFLHSKKVI HHDIKPSNIV FMSTKAVLVD FGLSVQMTED VYFPKDLRGT EIYMSPEVIL 
CRGHSTKADI YSLGATLIHM QTGTPPWVKR YPRSAYPSYL YIIHKQAPPL EDIADDCSPG 
MRELIEASLE RNPNHRPRAA DLLKHEALNP PREDQPRCQS LDSALLERKR LLSRKELELP 
ENIADSSCTG STEESEMLKR QRSLYIDLGA LAGYFNLVRG PPTLEYG

Genular Protein ID: 3543529875

Symbol: Q6FG25_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6FG25

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 Pfam 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 467
  • Mass: 52915
  • Checksum: 7728969EA3E4EA3C
  • Sequence:
    • MEYMSTGSDN KEEIDLLIKH LNVSDVIDIM ENLYASEEPA VYEPSLMTMC QDSNQNDERS 
KSLLLSGQEV PWLSSVRYGT VEDLLAFANH ISNTAKHFYG QRPQESGILL NMVITPQNGR 
YQIDSDVLLI PWKLTYRNIG SDFIPRGAFG KVYLAQDIKT KKRMACKLIP VDQFKPSDVE 
IQACFRHENI AELYGAVLWG ETVHLFMEAG EGGSVLEKLE SCGPMREFEI IWVTKHVLKG 
LDFLHSKKVI HHDIKPSNIV FMSTKAVLVD FGLSVQMTED VYFPKDLRGT EIYMSPEVIL 
CRGHSTKADI YSLGATLIHM QTGTPPWVKR YPRSAYPSYL YIIHKQAPPL EDIADDCSPG 
MRELIEASLE RNPNHRPRAA DLLKHEALNP PREDQPRCQS LDSALLERKR LLSRKELELP 
ENIADSSCTG STEESEMLKR QRSLYIDLGA LAGYFNLVRG SPTLEYG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.