Details for: COX4I1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 950.5274
Cell Significance Index: -147.8500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 526.6844
Cell Significance Index: -133.5900 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 463.6026
Cell Significance Index: -190.9800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 441.1246
Cell Significance Index: -179.2100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 391.0425
Cell Significance Index: -184.6200 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 375.9828
Cell Significance Index: -193.4000 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 277.1406
Cell Significance Index: -185.9700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 191.2243
Cell Significance Index: -182.5700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 138.6424
Cell Significance Index: -170.9400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 47.0884
Cell Significance Index: -144.6300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 46.8722
Cell Significance Index: -184.9600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 29.9605
Cell Significance Index: -80.2600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 26.5559
Cell Significance Index: -58.1200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 8.5318
Cell Significance Index: 228.2200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 7.9427
Cell Significance Index: 417.0200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 7.2608
Cell Significance Index: 341.2500 - Cell Name: peg cell (CL4033014)
Fold Change: 7.0345
Cell Significance Index: 162.5200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 6.6089
Cell Significance Index: 308.1400 - Cell Name: lactocyte (CL0002325)
Fold Change: 5.9562
Cell Significance Index: 769.5000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 5.5589
Cell Significance Index: 1002.1000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 5.5243
Cell Significance Index: 390.7000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 5.3907
Cell Significance Index: 662.8400 - Cell Name: granulosa cell (CL0000501)
Fold Change: 5.3645
Cell Significance Index: 141.0600 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 5.2222
Cell Significance Index: 96.5200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 5.0223
Cell Significance Index: 689.7000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 4.9775
Cell Significance Index: 2718.3500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 4.9243
Cell Significance Index: 2177.1300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 4.8219
Cell Significance Index: 359.3700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.7035
Cell Significance Index: 128.0300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 4.6485
Cell Significance Index: 136.5200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 4.4830
Cell Significance Index: 528.6800 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 4.1486
Cell Significance Index: 47.1300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 4.1206
Cell Significance Index: 37.9500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.8984
Cell Significance Index: 251.5100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 3.3577
Cell Significance Index: 332.1500 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 3.2423
Cell Significance Index: 57.3000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 3.0268
Cell Significance Index: 137.2000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.9431
Cell Significance Index: 102.2700 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 2.9362
Cell Significance Index: 18.0700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.2948
Cell Significance Index: 119.2100 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.1840
Cell Significance Index: 279.9800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 2.0122
Cell Significance Index: 343.5900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.9229
Cell Significance Index: 40.2500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.6769
Cell Significance Index: 48.0700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.5924
Cell Significance Index: 42.5200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.4162
Cell Significance Index: 73.7700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.2070
Cell Significance Index: 196.3000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.8958
Cell Significance Index: 656.8000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7149
Cell Significance Index: 141.8700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6993
Cell Significance Index: 140.2800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6498
Cell Significance Index: 123.6600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.6079
Cell Significance Index: 460.1200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5208
Cell Significance Index: 470.2300 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.3291
Cell Significance Index: 4.2200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1879
Cell Significance Index: 2.2400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0779
Cell Significance Index: 27.9300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0185
Cell Significance Index: 0.3100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.0044
Cell Significance Index: 0.3500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0328
Cell Significance Index: -61.7300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0384
Cell Significance Index: -3.9300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0591
Cell Significance Index: -43.7900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0948
Cell Significance Index: -174.8900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1167
Cell Significance Index: -179.6300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1451
Cell Significance Index: -197.2600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1607
Cell Significance Index: -100.3500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.2253
Cell Significance Index: -143.0700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2305
Cell Significance Index: -130.0100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3219
Cell Significance Index: -9.0000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.3298
Cell Significance Index: -149.6700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3302
Cell Significance Index: -20.8100 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.3857
Cell Significance Index: -5.7800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3948
Cell Significance Index: -83.1600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.4819
Cell Significance Index: -28.9300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.5482
Cell Significance Index: -157.7500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.8091
Cell Significance Index: -20.6700 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.8187
Cell Significance Index: -8.9000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.8308
Cell Significance Index: -95.1800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.8876
Cell Significance Index: -28.4300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -1.0986
Cell Significance Index: -128.0300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.1015
Cell Significance Index: -160.1200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -1.1344
Cell Significance Index: -129.4900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.1387
Cell Significance Index: -24.6700 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.4038
Cell Significance Index: -24.2000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.4193
Cell Significance Index: -108.9100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.4769
Cell Significance Index: -90.7800 - Cell Name: kidney cell (CL1000497)
Fold Change: -1.5718
Cell Significance Index: -12.5500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.7420
Cell Significance Index: -181.3800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.8546
Cell Significance Index: -104.0700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -1.9440
Cell Significance Index: -68.3100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -2.1743
Cell Significance Index: -146.2000 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -2.2212
Cell Significance Index: -13.4200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -2.3645
Cell Significance Index: -32.2600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.6799
Cell Significance Index: -164.3000 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -3.1445
Cell Significance Index: -65.5800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -3.2112
Cell Significance Index: -80.2700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -3.2263
Cell Significance Index: -55.2900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -3.2976
Cell Significance Index: -95.0100 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -3.6157
Cell Significance Index: -31.0700 - Cell Name: theca cell (CL0000503)
Fold Change: -3.6885
Cell Significance Index: -21.6700 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -3.7000
Cell Significance Index: -108.9800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2422795391
Symbol: COX41_HUMAN
Name: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2444497
Title: Isolation of a cDNA clone encoding subunit IV of human cytochrome c oxidase.
PubMed ID: 2444497
PubMed ID: 2157630
Title: Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome c oxidase subunit IV.
PubMed ID: 2157630
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10337626
Title: The 5-prime region of the COX4 gene contains a novel overlapping gene, NOC4.
PubMed ID: 10337626
PubMed ID: 1311608
Title: Subunit IV of human cytochrome c oxidase, polymorphism and a putative isoform.
PubMed ID: 1311608
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26759378
Title: The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits.
PubMed ID: 26759378
DOI: 10.1042/bj20151029
PubMed ID: 28766551
Title: Mutation in the COX4I1 gene is associated with short stature, poor weight gain and increased chromosomal breaks, simulating Fanconi anemia.
PubMed ID: 28766551
PubMed ID: 31290619
Title: Biallelic variants in COX4I1 associated with a novel phenotype resembling Leigh syndrome with developmental regression, intellectual disability, and seizures.
PubMed ID: 31290619
DOI: 10.1002/ajmg.a.61288
PubMed ID: 28844695
Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.
PubMed ID: 28844695
PubMed ID: 30030519
Title: Structure of the intact 14-subunit human cytochrome c oxidase.
PubMed ID: 30030519
Sequence Information:
- Length: 169
- Mass: 19577
- Checksum: F6382FFDCF3BE4ED
- Sequence:
MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA HVKHLSASQK ALKEKEKASW SSLSMDEKVE LYRIKFKESF AEMNRGSNEW KTVVGGAMFF IGFTALVIMW QKHYVYGPLP QSFDKEWVAK QTKRMLDMKV NPIQGLASKW DYEKNEWKK
Genular Protein ID: 2226600151
Symbol: Q86WV2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 83
- Mass: 9291
- Checksum: 8DB8AE40FDAE8909
- Sequence:
MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA HVKHLSASQK ALKEKEKASW SSLSMDEKVE CGY
Genular Protein ID: 1621839967
Symbol: H3BNV9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 139
- Mass: 15725
- Checksum: 13EBD2AFE2084F8C
- Sequence:
MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA HVKHLSASQK ALKEKEKASW SSLSMDEKVE LYRIKFKESF AEMNRGSNEW KTVVGGAMFF IGFTALVIMW QKHYGHLGLC LSDPVIHSL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.