Details for: COX4I1
Gene ID: 1327
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: COX4I1
Ensembl ID: ENSG00000131143
Description: cytochrome c oxidase subunit 4I1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 137.65rCSI 91.49%PRS 3.05
-
CSI 123.94rCSI 86.54%PRS 2.7
-
CSI 122.18rCSI 82.32%PRS 3.12
-
CSI 119.54rCSI 83.96%PRS 7.84
-
CSI 113.59rCSI 98.36%PRS 2.87
-
CSI 113.37rCSI 100%PRS 2.57
-
CSI 113.14rCSI 94.84%PRS 3.09
-
CSI 112.28rCSI 90.78%PRS 2.52
-
CSI 109.61rCSI 82.19%PRS 7.8
-
CSI 107.29rCSI 96.89%PRS 2.26
-
CSI 107.16rCSI 84.3%PRS 3.05
-
CSI 105.46rCSI 73.31%PRS 3.02
-
CSI 103.6rCSI 90.06%PRS 3.16
-
CSI 101.17rCSI 88.85%PRS 2.87
-
CSI 100.23rCSI 83.1%PRS 2.41
-
CSI 99.96rCSI 100%PRS 4.66
-
CSI 97.34rCSI 73.14%PRS 2.64
-
CSI 96.79rCSI 85.11%PRS 1.86
-
CSI 96.45rCSI 56.96%PRS 3.59
-
CSI 95.71rCSI 63.78%PRS 7.29
-
CSI 93.54rCSI 77.46%PRS 2.57
-
CSI 92.71rCSI 97.12%PRS 2.4
-
CSI 91.91rCSI 96.06%PRS 2.76
-
CSI 91.04rCSI 68.87%PRS 3.6
-
CSI 90.61rCSI 87.37%PRS 0.94
-
CSI 89.67rCSI 91.39%PRS 3.73
-
CSI 88.95rCSI 76.29%PRS 8.19
-
CSI 87.78rCSI 86.69%PRS 11.4
-
CSI 87.67rCSI 68.19%PRS 3.72
-
CSI 87.4rCSI 84.13%PRS 2.68
-
CSI 86.31rCSI 69.74%PRS 6.7
-
CSI 86.1rCSI 68.97%PRS 4.82
-
CSI 85.17rCSI 61.14%PRS 3.52
-
CSI 84.77rCSI 67.31%PRS 4.57
-
CSI 84.38rCSI 88.04%PRS 2.63
-
CSI 84.31rCSI 99.02%PRS 3.14
-
CSI 84.23rCSI 77.86%PRS 4.74
-
CSI 84.2rCSI 65.28%PRS 2.43
-
CSI 83.96rCSI 77.09%PRS 2.91
-
CSI 83.7rCSI 62.48%PRS 4.35
-
CSI 83.1rCSI 65.68%PRS 1.78
-
CSI 82.95rCSI 67.4%PRS 2.7
-
CSI 82.76rCSI 82.59%PRS 2.17
-
CSI 80.01rCSI 59.45%PRS 3.83
-
CSI 79.26rCSI 69.43%PRS 3.46
-
CSI 78.31rCSI 60.33%PRS 2.31
-
CSI 74.86rCSI 85.69%PRS 5.35
-
CSI 74.15rCSI 70.07%PRS 2.68
-
CSI 73.9rCSI 89.26%PRS 2.97
-
CSI 73.43rCSI 94.18%PRS 2.97
-
CSI 72.47rCSI 54.23%PRS 4.21
-
CSI 70.42rCSI 88.38%PRS 3.25
-
CSI 67.34rCSI 78.1%PRS 3.84
-
CSI 66.36rCSI 68.27%PRS 4.17
-
CSI 65.13rCSI 81.12%PRS 3.8
-
CSI 64.78rCSI 67.1%PRS 3.01
-
CSI 64.68rCSI 88.37%PRS 2.84
-
CSI 64.6rCSI 81.18%PRS 14.17
-
CSI 64.56rCSI 62.09%PRS 5.62
-
CSI 64.53rCSI 63.47%PRS 2.84
-
CSI 64.42rCSI 72.51%PRS 4.35
-
CSI 64.23rCSI 63.08%PRS 4.13
-
CSI 64.2rCSI 87.78%PRS 4.74
-
CSI 64.06rCSI 55.22%PRS 4.3
-
CSI 63.79rCSI 53.25%PRS 8.55
-
CSI 63.73rCSI 77.58%PRS 3.25
-
CSI 63.57rCSI 86.62%PRS 2.34
-
CSI 63.27rCSI 91.26%PRS 3.56
-
CSI 63.17rCSI 93.88%PRS 3.42
-
CSI 63rCSI 90.8%PRS 4.18
-
CSI 62.29rCSI 83.24%PRS 4.91
-
CSI 61.93rCSI 94.72%PRS 4.21
-
CSI 61.38rCSI 93.78%PRS 3.21
-
CSI 60.93rCSI 75.38%PRS 2.27
-
CSI 60.91rCSI 73.12%PRS 2.57
-
CSI 60.67rCSI 86.97%PRS 3.61
-
CSI 60.08rCSI 45.7%PRS 3.43
-
CSI 59.17rCSI 84.44%PRS 2.94
-
CSI 59.05rCSI 90.74%PRS 3.74
-
CSI 58.46rCSI 94.26%PRS 4.18
-
CSI 58.31rCSI 90.1%PRS 2.43
-
CSI 57.95rCSI 60.52%PRS 8.35
-
CSI 57.53rCSI 52.4%PRS 4.04
-
CSI 57.17rCSI 66.1%PRS 1.86
-
CSI 57.09rCSI 42.28%PRS 2.44
-
CSI 54.81rCSI 38.15%PRS 3.75
-
CSI 54.34rCSI 83.46%PRS 2.97
-
CSI 54rCSI 73.56%PRS 6.49
-
CSI 53.88rCSI 49.71%PRS 2.6
-
CSI 52.69rCSI 64.92%PRS 8.58
-
CSI 52.56rCSI 77.92%PRS 30.67
-
CSI 52.29rCSI 83.81%PRS 8.59
-
CSI 51.98rCSI 89.06%PRS 3.43
-
CSI 50.15rCSI 58.91%PRS 26.14
-
CSI 50.03rCSI 50.68%PRS 17.22
-
CSI 49.56rCSI 64.93%PRS 3.59
-
CSI 49.31rCSI 52.85%PRS 2.36
-
CSI 49.02rCSI 61.62%PRS 3.95
-
CSI 48.48rCSI 70.93%PRS 2.72
-
CSI 46.51rCSI 92.71%PRS 4.39
-
CSI -47.2rCSI -55.3%PRS 4.3%
-
CSI -41.8rCSI -79.8%PRS 4.2%
-
CSI -35.2rCSI -43.8%PRS 1.5%
-
CSI -30.2rCSI -52.9%PRS 2.0%
-
CSI -29.0rCSI -37.4%PRS 1.7%
-
CSI -25.6rCSI -30.6%PRS 1.6%
-
CSI -25.2rCSI -100.0%PRS 3.4%
-
CSI -22.8rCSI -51.1%PRS 1.7%
-
CSI -22.2rCSI -83.8%PRS 5.9%
-
CSI -17.5rCSI -49.7%PRS 3.6%
-
CSI -16.9rCSI -27.2%PRS 1.9%
-
CSI -15.9rCSI -67.4%PRS 6.5%
-
CSI -14.4rCSI -37.4%PRS 3.2%
-
CSI -13.8rCSI -63.3%PRS 10.2%
-
CSI -13.5rCSI -37.3%PRS 3.0%
-
CSI -13.2rCSI -49.3%PRS 2.3%
-
CSI -13.1rCSI -84.4%PRS 7.2%
-
CSI -13.1rCSI -52.9%PRS 3.0%
-
CSI -13.0rCSI -69.0%PRS 17.6%
-
CSI -12.5rCSI -39.9%PRS 1.8%
-
CSI -12.2rCSI -28.1%PRS 2.5%
-
CSI -11.1rCSI -26.9%PRS 1.6%
-
CSI -10.8rCSI -33.8%PRS 1.7%
-
CSI -10.8rCSI -35.0%PRS 4.5%
-
CSI -9.6rCSI -48.1%PRS 20.7%
-
CSI -8.6rCSI -32.6%PRS 1.7%
-
CSI -8.0rCSI -84.8%PRS 35.3%
-
CSI -7.3rCSI -30.3%PRS 8.1%
-
CSI -7.0rCSI -11.7%PRS 1.6%
-
CSI -6.8rCSI -100.0%PRS 22.4%
-
CSI -6.3rCSI -68.5%PRS 18.5%
-
CSI -6.2rCSI -100.0%PRS 14.0%
-
CSI -6.2rCSI -24.5%PRS 6.9%
-
CSI -5.8rCSI -83.9%PRS 30.8%
-
CSI -4.5rCSI -15.1%PRS 2.6%
-
CSI -4.2rCSI -30.6%PRS 1.2%
-
CSI -4.1rCSI -20.8%PRS 17.6%
-
CSI -4.1rCSI -24.3%PRS 1.8%
-
CSI -4.1rCSI -22.4%PRS 6.9%
-
CSI -3.5rCSI -6.6%PRS 2.1%
-
CSI -3.5rCSI -21.6%PRS 2.2%
-
CSI -3.4rCSI -22.8%PRS 6.0%
-
CSI -3.4rCSI -8.0%PRS 3.5%
-
CSI -3.4rCSI -5.9%PRS 1.6%
-
CSI -3.2rCSI -9.2%PRS 3.7%
-
CSI -3.1rCSI -15.8%PRS 13.6%
-
CSI -2.7rCSI -3.5%PRS 3.4%
-
CSI -2.3rCSI -8.4%PRS 1.4%
-
CSI -2.1rCSI -7.1%PRS 12.0%
-
CSI -1.3rCSI -4.0%PRS 1.9%
-
CSI -1.3rCSI -18.0%PRS 2.1%
-
CSI -1.3rCSI -6.2%PRS 4.9%
-
CSI -1.2rCSI -4.9%PRS 12.8%
-
CSI -1.1rCSI -6.8%PRS 13.4%
-
CSI -0.6rCSI -4.1%PRS 5.7%
-
CSI -0.5rCSI -12.6%PRS 1.8%
-
CSI -0.5rCSI -2.7%PRS 13.6%
-
CSI -0.3rCSI -3.3%PRS 32.9%
-
CSI -0.3rCSI -0.9%PRS 3.6%
-
CSI -0.3rCSI -0.6%PRS 0.9%
-
CSI -0.2rCSI -5.5%PRS 45.3%
-
CSI 0.2rCSI 0.3%PRS 2.3%
-
CSI 0.7rCSI 2.6%PRS 4.5%
-
CSI 0.7rCSI 14.7%PRS 58.5%
-
CSI 0.8rCSI 4.1%PRS 6.8%
-
CSI 0.9rCSI 1.9%PRS 1.9%
-
CSI 1.2rCSI 25.4%PRS 47.5%
-
CSI 1.3rCSI 16.3%PRS 24.1%
-
CSI 1.3rCSI 26.8%PRS 3.1%
-
CSI 1.5rCSI 29.5%PRS 3.3%
-
CSI 1.7rCSI 23.2%PRS 30.4%
-
CSI 2.0rCSI 4.5%PRS 3.7%
-
CSI 2.0rCSI 32.8%PRS 29.6%
-
CSI 2.1rCSI 22.6%PRS 36.4%
-
CSI 2.1rCSI 15.2%PRS 35.5%
-
CSI 2.1rCSI 11.8%PRS 10.0%
-
CSI 2.2rCSI 3.8%PRS 2.0%
-
CSI 2.3rCSI 17.9%PRS 32.9%
-
CSI 2.3rCSI 70.8%PRS 34.9%
-
CSI 2.3rCSI 6.3%PRS 2.7%
-
CSI 2.4rCSI 53.3%PRS 15.4%
-
CSI 2.4rCSI 4.3%PRS 2.8%
-
CSI 2.4rCSI 34.5%PRS 35.4%
-
CSI 2.5rCSI 33.3%PRS 31.6%
-
CSI 2.7rCSI 30.1%PRS 10.2%
-
CSI 2.8rCSI 5.8%PRS 3.1%
-
CSI 2.9rCSI 37.5%PRS 17.6%
-
CSI 3.0rCSI 17.2%PRS 15.6%
-
CSI 3.1rCSI 81.4%PRS 14.9%
-
CSI 3.2rCSI 78.5%PRS 25.4%
-
CSI 3.2rCSI 94.7%PRS 6.5%
-
CSI 3.3rCSI 14.6%PRS 10.7%
-
CSI 3.4rCSI 4.7%PRS 2.9%
-
CSI 3.4rCSI 19.8%PRS 4.0%
-
CSI 3.5rCSI 6.3%PRS 2.2%
-
CSI 3.5rCSI 84.1%PRS 9.9%
-
CSI 3.6rCSI 39.3%PRS 4.8%
-
CSI 3.6rCSI 92.6%PRS 16.0%
-
CSI 3.7rCSI 92.9%PRS 9.1%
-
CSI 3.7rCSI 86.2%PRS 2.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2422795391
Symbol: COX41_HUMAN
Name: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2444497
Title: Isolation of a cDNA clone encoding subunit IV of human cytochrome c oxidase.
PubMed ID: 2444497
PubMed ID: 2157630
Title: Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome c oxidase subunit IV.
PubMed ID: 2157630
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10337626
Title: The 5-prime region of the COX4 gene contains a novel overlapping gene, NOC4.
PubMed ID: 10337626
PubMed ID: 1311608
Title: Subunit IV of human cytochrome c oxidase, polymorphism and a putative isoform.
PubMed ID: 1311608
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26759378
Title: The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits.
PubMed ID: 26759378
DOI: 10.1042/bj20151029
PubMed ID: 28766551
Title: Mutation in the COX4I1 gene is associated with short stature, poor weight gain and increased chromosomal breaks, simulating Fanconi anemia.
PubMed ID: 28766551
PubMed ID: 31290619
Title: Biallelic variants in COX4I1 associated with a novel phenotype resembling Leigh syndrome with developmental regression, intellectual disability, and seizures.
PubMed ID: 31290619
DOI: 10.1002/ajmg.a.61288
PubMed ID: 28844695
Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.
PubMed ID: 28844695
PubMed ID: 30030519
Title: Structure of the intact 14-subunit human cytochrome c oxidase.
PubMed ID: 30030519
Sequence Information:
- Length: 169
- Mass: 19577
- Checksum: F6382FFDCF3BE4ED
- Sequence:
MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA HVKHLSASQK ALKEKEKASW SSLSMDEKVE LYRIKFKESF AEMNRGSNEW KTVVGGAMFF IGFTALVIMW QKHYVYGPLP QSFDKEWVAK QTKRMLDMKV NPIQGLASKW DYEKNEWKK
Genular Protein ID: 2226600151
Symbol: Q86WV2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 83
- Mass: 9291
- Checksum: 8DB8AE40FDAE8909
- Sequence:
MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA HVKHLSASQK ALKEKEKASW SSLSMDEKVE CGY
Genular Protein ID: 1621839967
Symbol: H3BNV9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 139
- Mass: 15725
- Checksum: 13EBD2AFE2084F8C
- Sequence:
MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA HVKHLSASQK ALKEKEKASW SSLSMDEKVE LYRIKFKESF AEMNRGSNEW KTVVGGAMFF IGFTALVIMW QKHYGHLGLC LSDPVIHSL