Details for: COX5B

Gene ID: 1329

Symbol: COX5B

Ensembl ID: ENSG00000135940

Description: cytochrome c oxidase subunit 5B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 676.0735
    Cell Significance Index: -105.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 424.3359
    Cell Significance Index: -107.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 348.1996
    Cell Significance Index: -143.4400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 298.4818
    Cell Significance Index: -140.9200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 273.4138
    Cell Significance Index: -140.6400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 211.2300
    Cell Significance Index: -141.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 103.6534
    Cell Significance Index: -127.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 35.2099
    Cell Significance Index: -138.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 34.2965
    Cell Significance Index: -105.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 31.8643
    Cell Significance Index: -85.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.6833
    Cell Significance Index: -40.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 6.4007
    Cell Significance Index: 336.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 6.1632
    Cell Significance Index: 142.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.7630
    Cell Significance Index: 268.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.9535
    Cell Significance Index: 134.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.9508
    Cell Significance Index: 130.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.6065
    Cell Significance Index: 85.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.0738
    Cell Significance Index: 734.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.9612
    Cell Significance Index: 543.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.9469
    Cell Significance Index: 178.9000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.8263
    Cell Significance Index: 30.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.6449
    Cell Significance Index: 448.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.5895
    Cell Significance Index: 1960.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.5882
    Cell Significance Index: 253.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.4543
    Cell Significance Index: 162.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.3766
    Cell Significance Index: 334.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.2714
    Cell Significance Index: 1446.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.2611
    Cell Significance Index: 30.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.0948
    Cell Significance Index: 230.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.0650
    Cell Significance Index: 34.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.0229
    Cell Significance Index: 88.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.8370
    Cell Significance Index: 334.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.8216
    Cell Significance Index: 61.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.6988
    Cell Significance Index: 348.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2467
    Cell Significance Index: 116.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1322
    Cell Significance Index: 137.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.9615
    Cell Significance Index: 251.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.5417
    Cell Significance Index: 32.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.3812
    Cell Significance Index: 109.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.3225
    Cell Significance Index: 969.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1637
    Cell Significance Index: 69.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9050
    Cell Significance Index: 57.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8115
    Cell Significance Index: 154.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8078
    Cell Significance Index: 28.0700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7982
    Cell Significance Index: 11.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7401
    Cell Significance Index: 126.3800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6989
    Cell Significance Index: 12.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6487
    Cell Significance Index: 17.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5618
    Cell Significance Index: 112.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3748
    Cell Significance Index: 25.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3369
    Cell Significance Index: 66.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3096
    Cell Significance Index: 234.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3036
    Cell Significance Index: 3.3000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2628
    Cell Significance Index: 3.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0608
    Cell Significance Index: 21.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0487
    Cell Significance Index: 0.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0206
    Cell Significance Index: -0.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0264
    Cell Significance Index: -49.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0339
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0420
    Cell Significance Index: -31.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0640
    Cell Significance Index: -3.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0711
    Cell Significance Index: -131.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0933
    Cell Significance Index: -143.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1097
    Cell Significance Index: -68.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1160
    Cell Significance Index: -157.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1531
    Cell Significance Index: -97.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1729
    Cell Significance Index: -97.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1979
    Cell Significance Index: -6.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2071
    Cell Significance Index: -33.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2298
    Cell Significance Index: -104.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2773
    Cell Significance Index: -58.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2919
    Cell Significance Index: -11.9600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3685
    Cell Significance Index: -5.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4022
    Cell Significance Index: -115.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5099
    Cell Significance Index: -14.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5300
    Cell Significance Index: -60.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6492
    Cell Significance Index: -49.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7359
    Cell Significance Index: -18.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7682
    Cell Significance Index: -111.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7874
    Cell Significance Index: -91.7600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0673
    Cell Significance Index: -121.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0863
    Cell Significance Index: -31.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.1265
    Cell Significance Index: -15.3700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.2821
    Cell Significance Index: -7.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.3235
    Cell Significance Index: -137.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.3810
    Cell Significance Index: -39.7900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.3842
    Cell Significance Index: -16.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.6122
    Cell Significance Index: -40.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.6352
    Cell Significance Index: -34.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.7234
    Cell Significance Index: -96.7100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.7981
    Cell Significance Index: -37.5000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.8586
    Cell Significance Index: -26.0700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -2.0992
    Cell Significance Index: -16.1800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.2816
    Cell Significance Index: -19.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.2921
    Cell Significance Index: -140.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.5120
    Cell Significance Index: -67.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.5130
    Cell Significance Index: -74.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.5751
    Cell Significance Index: -44.1300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -3.0095
    Cell Significance Index: -51.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -3.0427
    Cell Significance Index: -106.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** COX5B is a mitochondrial protein that belongs to the cytochrome c oxidase family. It is a subunit of the mitochondrial respiratory chain complex IV, which is responsible for the transfer of electrons from cytochrome c to oxygen. COX5B is characterized by its ability to bind metals, specifically copper and iron, which are essential for its enzymatic activity. The protein is highly conserved across species, suggesting its critical role in maintaining mitochondrial function. **Pathways and Functions** COX5B is involved in several cellular pathways, including: 1. **Cellular Respiration**: COX5B plays a crucial role in the electron transport chain, facilitating the production of ATP through chemiosmotic coupling. 2. **Cytochrome-c Oxidase Activity**: COX5B is responsible for the transfer of electrons from cytochrome c to oxygen, which is essential for the production of ATP. 3. **Mitochondrial Electron Transport**: COX5B is a key component of the mitochondrial respiratory chain complex IV, which is responsible for the transfer of electrons from cytochrome c to oxygen. 4. **Proton Transmembrane Transport**: COX5B is involved in proton transmembrane transport, which is essential for maintaining the proton gradient across the mitochondrial inner membrane. 5. **Heat Production by Uncoupling Proteins**: COX5B is also involved in heat production by uncoupling proteins, which are essential for regulating cellular temperature. **Clinical Significance** Dysregulation of COX5B has been implicated in various diseases, including: 1. **Mitochondrial Myopathies**: Mutations in the COX5B gene have been associated with mitochondrial myopathies, which are characterized by muscle weakness and fatigue. 2. **Neurodegenerative Disorders**: COX5B has been implicated in neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease, where mitochondrial dysfunction plays a key role. 3. **Cancer**: COX5B has been shown to be overexpressed in various types of cancer, including breast cancer and lung cancer, suggesting its potential role in tumorigenesis. 4. **Cardiovascular Disease**: COX5B has been implicated in cardiovascular disease, where mitochondrial dysfunction plays a key role in the development of atherosclerosis and cardiac hypertrophy. In conclusion, COX5B is a critical component of the mitochondrial respiratory chain complex IV, playing a vital role in the production of ATP and maintaining mitochondrial function. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in human health and disease.

Genular Protein ID: 2260430169

Symbol: COX5B_HUMAN

Name: Cytochrome c oxidase subunit 5B, mitochondrial

UniProtKB Accession Codes:

P10606 Q53YB7 Q96J18 Q99610

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2840351

Title: Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase.

PubMed ID: 2840351

DOI: 10.1016/0378-1119(88)90411-8

PubMed ID: 1646156

Title: Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes.

PubMed ID: 1646156

DOI: 10.1016/0888-7543(91)90476-u

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8806766

Title: Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter.

PubMed ID: 8806766

DOI: 10.1006/abbi.1996.0376

PubMed ID: 8313870

Title: Human liver protein map: update 1993.

PubMed ID: 8313870

DOI: 10.1002/elps.11501401181

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 30030519

Title: Structure of the intact 14-subunit human cytochrome c oxidase.

PubMed ID: 30030519

DOI: 10.1038/s41422-018-0071-1

Sequence Information:

  • Length: 129
  • Mass: 13696
  • Checksum: 877BF4CD334AC931
  • Sequence:
    • MASRLLRGAG TLAAQALRAR GPSGAAAMRS MASGGGVPTD EEQATGLERE IMLAAKKGLD 
PYNVLAPKGA SGTREDPNLV PSISNKRIVG CICEEDNTSV VWFWLHKGEA QRCPRCGAHY 
KLVPQQLAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.