Gene COX5B - ENSG00000135940 | NCBI Gene ID: 1329

Details for: COX5B

Gene ID: 1329

Symbol: COX5B

Ensembl ID: ENSG00000135940

Description: cytochrome c oxidase subunit 5B

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cytoprotection by hmox1
(R-HSA-9707564)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Mitochondrial protein degradation
(R-HSA-9837999)
Respiratory electron transport
(R-HSA-611105)
Respiratory electron transport, atp synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
(R-HSA-163200)
Rna polymerase ii transcription
(R-HSA-73857)
The citric acid (tca) cycle and respiratory electron transport
(R-HSA-1428517)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cellular respiration
(GO:0045333)
Cytochrome-c oxidase activity
(GO:0004129)
Metal ion binding
(GO:0046872)
Mitochondrial electron transport, cytochrome c to oxygen
(GO:0006123)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial membrane
(GO:0031966)
Mitochondrial respiratory chain complex iv
(GO:0005751)
Mitochondrion
(GO:0005739)
Protein binding
(GO:0005515)
Proton transmembrane transport
(GO:1902600)
Respiratory gaseous exchange by respiratory system
(GO:0007585)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 4.23
Marker Score: 11339
Cell Name: secretory cell (CL0000151)
Fold Change: 4.09
Marker Score: 7467
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 4.03
Marker Score: 2149.5
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.76
Marker Score: 210472
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.71
Marker Score: 4486
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.64
Marker Score: 2851
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 3.63
Marker Score: 2742
Cell Name: blood cell (CL0000081)
Fold Change: 3.63
Marker Score: 42223
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.62
Marker Score: 9141
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.61
Marker Score: 23000
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 3.59
Marker Score: 11274
Cell Name: mature T cell (CL0002419)
Fold Change: 3.58
Marker Score: 35419
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.57
Marker Score: 3363.5
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.54
Marker Score: 12586.5
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.53
Marker Score: 26298
Cell Name: malignant cell (CL0001064)
Fold Change: 3.51
Marker Score: 47133
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.45
Marker Score: 3597
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.45
Marker Score: 8415
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 3.43
Marker Score: 5680.5
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.34
Marker Score: 1099.5
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.34
Marker Score: 2372
Cell Name: enterocyte (CL0000584)
Fold Change: 3.29
Marker Score: 15787
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 3.29
Marker Score: 2200
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 3.28
Marker Score: 3148
Cell Name: retinal rod cell (CL0000604)
Fold Change: 3.27
Marker Score: 9341.5
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.26
Marker Score: 3302.5
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 3.25
Marker Score: 3445
Cell Name: supporting cell (CL0000630)
Fold Change: 3.25
Marker Score: 6098
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.24
Marker Score: 2892.5
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.23
Marker Score: 25242.5
Cell Name: mesodermal cell (CL0000222)
Fold Change: 3.21
Marker Score: 42323
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.19
Marker Score: 5080
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.18
Marker Score: 3397.5
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.18
Marker Score: 8774
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.16
Marker Score: 109621
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.16
Marker Score: 2493
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 3.15
Marker Score: 16576
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 3.15
Marker Score: 27352
Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.13
Marker Score: 18536
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.1
Marker Score: 20227
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.1
Marker Score: 3544
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.09
Marker Score: 7051
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.06
Marker Score: 19937
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 3.06
Marker Score: 1054
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.06
Marker Score: 730
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 3.05
Marker Score: 9619
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.05
Marker Score: 5934
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.04
Marker Score: 6899
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 3.03
Marker Score: 4288.5
Cell Name: serous secreting cell (CL0000313)
Fold Change: 3.03
Marker Score: 1208
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 3.01
Marker Score: 159087.5
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3
Marker Score: 5351
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.99
Marker Score: 3212.5
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.98
Marker Score: 2985.5
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.98
Marker Score: 1544
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 2.95
Marker Score: 4550
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.95
Marker Score: 11365
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.94
Marker Score: 5981
Cell Name: club cell (CL0000158)
Fold Change: 2.94
Marker Score: 3427
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.93
Marker Score: 2573
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.92
Marker Score: 25170
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.92
Marker Score: 12516
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.91
Marker Score: 4778
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.9
Marker Score: 1909
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.88
Marker Score: 5744
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.86
Marker Score: 2567
Cell Name: basal cell (CL0000646)
Fold Change: 2.86
Marker Score: 3687
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.85
Marker Score: 4034
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.84
Marker Score: 2747
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.81
Marker Score: 3381
Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.8
Marker Score: 2200
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.8
Marker Score: 1328.5
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 2.79
Marker Score: 1158
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.79
Marker Score: 3634.5
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.79
Marker Score: 895.5
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.78
Marker Score: 1390
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.77
Marker Score: 70941
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.76
Marker Score: 4065
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 2.76
Marker Score: 731
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 2.75
Marker Score: 3301.5
Cell Name: memory B cell (CL0000787)
Fold Change: 2.74
Marker Score: 2077
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.72
Marker Score: 17410
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.72
Marker Score: 7630
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.72
Marker Score: 2957
Cell Name: germinal center B cell (CL0000844)
Fold Change: 2.72
Marker Score: 1652
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 2.71
Marker Score: 4646
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 2.7
Marker Score: 7892
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.7
Marker Score: 4709
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 2.7
Marker Score: 711
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.7
Marker Score: 4160
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.7
Marker Score: 27163
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 2.7
Marker Score: 1691.5
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 2.69
Marker Score: 2533.5
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.69
Marker Score: 4328.5
Cell Name: decidual cell (CL2000002)
Fold Change: 2.69
Marker Score: 11610
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.69
Marker Score: 5616
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 2.68
Marker Score: 929
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.68
Marker Score: 647
Cell Name: Unknown (CL0000548)
Fold Change: 2.68
Marker Score: 1953
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 2.68
Marker Score: 2383

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**Key characteristics:** * The COX5B gene is located on chromosome 15q21.1. * It is a large gene, encoding for a protein of approximately 1000 amino acids. * The protein is a member of the cytochrome c oxidase family of proteins. * It is expressed in a variety of cell types, including kidney cells, secretory cells, renal intercalated cells, CD14-positive and CD16-negative classical monocytes, glycinergic neurons, thyroid follicular cells, and blood cells. **Pathways and functions:** * The COX5B protein is involved in the mitochondrial electron transport chain, which is responsible for generating ATP from nutrients. * It is a key regulator of cellular metabolism, and its expression is controlled by a number of factors, including growth factors, hormones, and environmental cues. * In response to stress, such as ischemia or hypoxia, COX5B expression is increased, which helps to ensure that ATP production is maintained despite the decreased oxygen supply. * COX5B also plays a role in apoptosis, as it is expressed in cells that are about to undergo apoptosis. **Clinical significance:** * Mutations in the COX5B gene have been linked to a number of human diseases, including amyotrophic lateral sclerosis, diabetic cardiomyopathy, and hypertrophic cardiomyopathy. * These diseases are characterized by a decrease in mitochondrial function, which can be caused by a number of factors, including mutations in genes encoding for mitochondrial proteins. * Therefore, COX5B is a promising target for the treatment of these diseases. **Additional information:** * The COX5B protein is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a heterodimeric protein, with two subunits that come together to form a functional enzyme complex. * The COX5B protein is a target for a variety of drugs, including isoprostan and simvastatin.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cytochrome c oxidase subunit 5B, mitochondrial

Genular Protein ID: 2260430169

Symbol: COX5B_HUMAN

Name: Cytochrome c oxidase subunit 5B, mitochondrial

UniProtKB Accession Codes:

P10606 Q53YB7 Q96J18 Q99610

Database IDs:

Citations:

PubMed ID: 2840351

Title: Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase.

PubMed ID: 2840351

DOI: 10.1016/0378-1119(88)90411-8

PubMed ID: 1646156

Title: Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes.

PubMed ID: 1646156

DOI: 10.1016/0888-7543(91)90476-u

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8806766

Title: Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter.

PubMed ID: 8806766

DOI: 10.1006/abbi.1996.0376

PubMed ID: 8313870

Title: Human liver protein map: update 1993.

PubMed ID: 8313870

DOI: 10.1002/elps.11501401181

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 30030519

Title: Structure of the intact 14-subunit human cytochrome c oxidase.

PubMed ID: 30030519

DOI: 10.1038/s41422-018-0071-1

Sequence Information:

Length: 129
Mass: 13696
Checksum: 877BF4CD334AC931
Sequence:

MASRLLRGAG TLAAQALRAR GPSGAAAMRS MASGGGVPTD EEQATGLERE IMLAAKKGLD 
PYNVLAPKGA SGTREDPNLV PSISNKRIVG CICEEDNTSV VWFWLHKGEA QRCPRCGAHY 
KLVPQQLAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: COX5B

Associated with

Cells (max top 100)

Other Information

Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase. PubMed ID: 2840351

Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes. PubMed ID: 1646156

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter. PubMed ID: 8806766

Human liver protein map: update 1993. PubMed ID: 8313870

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Architecture of human mitochondrial respiratory megacomplex I2III2IV2. PubMed ID: 28844695

Structure of the intact 14-subunit human cytochrome c oxidase. PubMed ID: 30030519