COX5B | ENSG00000135940 | NCBI 1329

Details for: COX5B

Gene ID: 1329

Symbol: COX5B

Ensembl ID: ENSG00000135940

Description: cytochrome c oxidase subunit 5B

Associated with

Aerobic respiration and respiratory electron transport
(R-HSA-1428517)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Complex iv assembly
(R-HSA-9864848)
Cytoprotection by hmox1
(R-HSA-9707564)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Mitochondrial protein degradation
(R-HSA-9837999)
Respiratory electron transport
(R-HSA-611105)
Rna polymerase ii transcription
(R-HSA-73857)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cellular respiration
(GO:0045333)
Cytochrome-c oxidase activity
(GO:0004129)
Metal ion binding
(GO:0046872)
Mitochondrial electron transport, cytochrome c to oxygen
(GO:0006123)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial membrane
(GO:0031966)
Mitochondrion
(GO:0005739)
Protein binding
(GO:0005515)
Proton transmembrane transport
(GO:1902600)
Respiratory chain complex iv
(GO:0045277)
Respiratory gaseous exchange by respiratory system
(GO:0007585)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cell in vitro (CL0001034)
Fold Change: 2.19
Cell Significance Index: 4
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.69
Cell Significance Index: 2
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.46
Cell Significance Index: 2
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.28
Cell Significance Index: 1
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.28
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.24
Cell Significance Index: 1
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.18
Cell Significance Index: 1
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.12
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.12
Cell Significance Index: 1
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: lactocyte (CL0002325)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.09
Cell Significance Index: 1
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: kidney cell (CL1000497)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: peg cell (CL4033014)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 1
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1
Cell Significance Index: 1
Cell Name: granulosa cell (CL0000501)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: germ cell (CL0000586)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: neuron associated cell (CL0000095)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: enterocyte (CL0000584)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: stem cell (CL0000034)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: odontoblast (CL0000060)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: precursor cell (CL0011115)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: granular cell of epidermis (CL0002189)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 0.97
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** COX5B is a mitochondrial protein that belongs to the cytochrome c oxidase family. It is a subunit of the mitochondrial respiratory chain complex IV, which is responsible for the transfer of electrons from cytochrome c to oxygen. COX5B is characterized by its ability to bind metals, specifically copper and iron, which are essential for its enzymatic activity. The protein is highly conserved across species, suggesting its critical role in maintaining mitochondrial function. **Pathways and Functions** COX5B is involved in several cellular pathways, including: 1. **Cellular Respiration**: COX5B plays a crucial role in the electron transport chain, facilitating the production of ATP through chemiosmotic coupling. 2. **Cytochrome-c Oxidase Activity**: COX5B is responsible for the transfer of electrons from cytochrome c to oxygen, which is essential for the production of ATP. 3. **Mitochondrial Electron Transport**: COX5B is a key component of the mitochondrial respiratory chain complex IV, which is responsible for the transfer of electrons from cytochrome c to oxygen. 4. **Proton Transmembrane Transport**: COX5B is involved in proton transmembrane transport, which is essential for maintaining the proton gradient across the mitochondrial inner membrane. 5. **Heat Production by Uncoupling Proteins**: COX5B is also involved in heat production by uncoupling proteins, which are essential for regulating cellular temperature. **Clinical Significance** Dysregulation of COX5B has been implicated in various diseases, including: 1. **Mitochondrial Myopathies**: Mutations in the COX5B gene have been associated with mitochondrial myopathies, which are characterized by muscle weakness and fatigue. 2. **Neurodegenerative Disorders**: COX5B has been implicated in neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease, where mitochondrial dysfunction plays a key role. 3. **Cancer**: COX5B has been shown to be overexpressed in various types of cancer, including breast cancer and lung cancer, suggesting its potential role in tumorigenesis. 4. **Cardiovascular Disease**: COX5B has been implicated in cardiovascular disease, where mitochondrial dysfunction plays a key role in the development of atherosclerosis and cardiac hypertrophy. In conclusion, COX5B is a critical component of the mitochondrial respiratory chain complex IV, playing a vital role in the production of ATP and maintaining mitochondrial function. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.