Details for: ADM

Gene ID: 133

Symbol: ADM

Ensembl ID: ENSG00000148926

Description: adrenomedullin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.5
    Marker Score: 6143
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.08
    Marker Score: 1301
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.03
    Marker Score: 1160
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.97
    Marker Score: 4810
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.9
    Marker Score: 64699
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.74
    Marker Score: 1455
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.72
    Marker Score: 3040
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.7
    Marker Score: 908.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.67
    Marker Score: 2458
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 1.65
    Marker Score: 534
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.56
    Marker Score: 1231
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.48
    Marker Score: 5832
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168214
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.41
    Marker Score: 350
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.4
    Marker Score: 475
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.4
    Marker Score: 2837
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.39
    Marker Score: 350
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.39
    Marker Score: 946
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.38
    Marker Score: 1453
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.38
    Marker Score: 2613
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.37
    Marker Score: 1368.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.36
    Marker Score: 3571
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.35
    Marker Score: 560
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.28
    Marker Score: 409
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.28
    Marker Score: 294
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.28
    Marker Score: 4004
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.23
    Marker Score: 1052
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.2
    Marker Score: 1132
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.19
    Marker Score: 855
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.15
    Marker Score: 671
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.15
    Marker Score: 6965
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.13
    Marker Score: 17682
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.12
    Marker Score: 1112.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.11
    Marker Score: 2811
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.1
    Marker Score: 266
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.1
    Marker Score: 1058
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.08
    Marker Score: 8399.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.07
    Marker Score: 1185
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.06
    Marker Score: 1370.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.06
    Marker Score: 618
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.06
    Marker Score: 1758
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.06
    Marker Score: 3768
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.06
    Marker Score: 1210
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.01
    Marker Score: 227
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.01
    Marker Score: 2435
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1
    Marker Score: 365
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71755
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47980
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.99
    Marker Score: 979
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.96
    Marker Score: 2273
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.95
    Marker Score: 235
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.93
    Marker Score: 896
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.93
    Marker Score: 360
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.9
    Marker Score: 467
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.9
    Marker Score: 1237
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.9
    Marker Score: 4407
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.89
    Marker Score: 1255
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.87
    Marker Score: 1073
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5263
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4900
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.85
    Marker Score: 423
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.83
    Marker Score: 411
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.83
    Marker Score: 220
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 627
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.82
    Marker Score: 300
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.82
    Marker Score: 1007
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.81
    Marker Score: 234
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.81
    Marker Score: 860
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.81
    Marker Score: 201
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.81
    Marker Score: 532
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.81
    Marker Score: 855
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.8
    Marker Score: 1164
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.8
    Marker Score: 414
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.8
    Marker Score: 3332
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.8
    Marker Score: 756
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.79
    Marker Score: 1332
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.78
    Marker Score: 839
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.77
    Marker Score: 3332
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.76
    Marker Score: 989
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.76
    Marker Score: 6644
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.76
    Marker Score: 592
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.75
    Marker Score: 456
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.74
    Marker Score: 1551
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.74
    Marker Score: 494
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.74
    Marker Score: 454
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.74
    Marker Score: 1832.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.73
    Marker Score: 144
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.73
    Marker Score: 1477
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 663
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.73
    Marker Score: 169
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464

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Other Information

**Key characteristics:** * It is a type of G protein-coupled receptor (GPCR). * It is expressed in the central nervous system, where it is involved in blood pressure regulation. * It is also expressed in the periphery, where it plays a role in vascular function. * It is a key regulator of systemic arterial blood pressure by binding to angiotensin II. **Pathways and functions:** * Adrenomedullin binds to angiotensin II, a hormone produced by the kidneys. * Binding of ADM to angiotensin II activates the G protein-coupled receptor (GPCR), which leads to the activation of downstream signaling pathways. * These pathways include the Gpcr downstream signaling pathway, the Gpcr ligand binding pathway, and the hormone activity pathway. * The Gpcr downstream signaling pathway leads to the inhibition of angiotensin-induced vasodilation, which helps to regulate blood pressure. * The Gpcr ligand binding pathway leads to the activation of the enzyme angiotensin-converting enzyme (ACE), which converts angiotensin I to angiotensin II. * The hormone activity pathway leads to the release of various hormones and factors that promote vasoconstriction or vasodilation, depending on the specific pathway activated. **Clinical significance:** * Mutations in the ADM gene have been linked to hypertension and heart disease. * Targeting ADM with drugs is a promising therapeutic strategy for these conditions. * ADML inhibitors are currently being investigated as potential treatments for hypertension and vascular diseases. **Additional notes:** * ADM is also known as ADMR (angiotensin-converting enzyme-related protein). * It is a highly conserved protein across species. * It is a key regulator of blood pressure and vascular function, and its dysfunction can lead to a variety of cardiovascular diseases.

Genular Protein ID: 1017360539

Symbol: ADML_HUMAN

Name: Pro-adrenomedullin

UniProtKB Accession Codes:

P35318 B2R793 D3DQV3 Q6FGW2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 8 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7688224

Title: Cloning and characterization of cDNA encoding a precursor for human adrenomedullin.

PubMed ID: 7688224

DOI: 10.1006/bbrc.1993.1881

PubMed ID: 8074714

Title: Genomic structure of human adrenomedullin gene.

PubMed ID: 8074714

DOI: 10.1006/bbrc.1994.2229

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8387282

Title: Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma.

PubMed ID: 8387282

DOI: 10.1006/bbrc.1993.1451

PubMed ID: 9578982

Title: Proadrenomedullin-derived peptides.

PubMed ID: 9578982

DOI: 10.1006/frne.1998.0164

PubMed ID: 10588445

Title: Structure-activity relationships of adrenomedullin in the circulation and adrenal gland.

PubMed ID: 10588445

DOI: 10.1016/s0167-0115(99)00025-7

PubMed ID: 16315141

Title: NMR conformational analysis of proadrenomedullin N-terminal 20 peptide, a proangiogenic factor involved in tumor growth.

PubMed ID: 16315141

DOI: 10.1002/bip.20418

Sequence Information:

  • Length: 185
  • Mass: 20420
  • Checksum: 64C7D2A0B4654DFE
  • Sequence:
    • MKLVSVALMY LGSLAFLGAD TARLDVASEF RKKWNKWALS RGKRELRMSS SYPTGLADVK 
AGPAQTLIRP QDMKGASRSP EDSSPDAARI RVKRYRQSMN NFQGLRSFGC RFGTCTVQKL 
AHQIYQFTDK DKDNVAPRSK ISPQGYGRRR RRSLPEAGPG RTLVSSKPQA HGAPAPPSGS 
APHFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.