ADM | ENSG00000148926 | NCBI 133

Details for: ADM

Gene ID: 133

Symbol: ADM

Ensembl ID: ENSG00000148926

Description: adrenomedullin

Associated with

Calcitonin-like ligand receptors
(R-HSA-419812)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Class b/2 (secretin family receptors)
(R-HSA-373080)
G alpha (s) signalling events
(R-HSA-418555)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Signaling by gpcr
(R-HSA-372790)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adrenomedullin receptor binding
(GO:0031700)
Adrenomedullin receptor signaling pathway
(GO:1990410)
Androgen metabolic process
(GO:0008209)
Animal organ regeneration
(GO:0031100)
Antibacterial humoral response
(GO:0019731)
Antifungal humoral response
(GO:0019732)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Branching involved in labyrinthine layer morphogenesis
(GO:0060670)
Camp-mediated signaling
(GO:0019933)
Cell population proliferation
(GO:0008283)
Cytoplasm
(GO:0005737)
Defense response to gram-negative bacterium
(GO:0050829)
Defense response to gram-positive bacterium
(GO:0050830)
Developmental growth
(GO:0048589)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Female pregnancy
(GO:0007565)
G protein-coupled receptor internalization
(GO:0002031)
Heart development
(GO:0007507)
Hormone activity
(GO:0005179)
Inflammatory response
(GO:0006954)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of vascular permeability
(GO:0043116)
Negative regulation of vasoconstriction
(GO:0045906)
Neural tube closure
(GO:0001843)
Neuron projection regeneration
(GO:0031102)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of heart rate
(GO:0010460)
Positive regulation of progesterone biosynthetic process
(GO:2000184)
Positive regulation of vasculogenesis
(GO:2001214)
Receptor internalization
(GO:0031623)
Regulation of systemic arterial blood pressure
(GO:0003073)
Regulation of the force of heart contraction
(GO:0002026)
Regulation of urine volume
(GO:0035809)
Response to ether
(GO:0045472)
Response to glucocorticoid
(GO:0051384)
Response to hypoxia
(GO:0001666)
Response to insulin
(GO:0032868)
Response to lipopolysaccharide
(GO:0032496)
Response to starvation
(GO:0042594)
Response to yeast
(GO:0001878)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Vascular associated smooth muscle cell development
(GO:0097084)
Vasculogenesis
(GO:0001570)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 158.6677
Cell Significance Index: -24.6800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 104.2803
Cell Significance Index: -26.4500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 57.7959
Cell Significance Index: -23.4800
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 55.9283
Cell Significance Index: -26.4100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 21.2984
Cell Significance Index: -26.2600
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.9259
Cell Significance Index: -26.5900
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 8.8535
Cell Significance Index: 33.9000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 8.0733
Cell Significance Index: 215.5700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.6041
Cell Significance Index: -26.0600
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 4.9972
Cell Significance Index: 31.0500
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 3.7391
Cell Significance Index: 11.1200
Cell Name: theca cell (CL0000503)
Fold Change: 3.3515
Cell Significance Index: 19.6900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.2799
Cell Significance Index: 94.0200
Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 3.1500
Cell Significance Index: 11.7400
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 2.0153
Cell Significance Index: 6.9200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.9006
Cell Significance Index: 98.7300
Cell Name: odontoblast (CL0000060)
Fold Change: 1.8978
Cell Significance Index: 243.2900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.7246
Cell Significance Index: 23.5300
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.7026
Cell Significance Index: 18.0900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.5423
Cell Significance Index: 41.9800
Cell Name: epidermal cell (CL0000362)
Fold Change: 1.3795
Cell Significance Index: 3.1100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.3311
Cell Significance Index: 60.3400
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.2176
Cell Significance Index: 8.2500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.2085
Cell Significance Index: 34.8200
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.9513
Cell Significance Index: 14.2600
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.8729
Cell Significance Index: 15.4300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7955
Cell Significance Index: 17.2400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7414
Cell Significance Index: 73.3500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.7184
Cell Significance Index: 37.4200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6895
Cell Significance Index: 84.7800
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.6845
Cell Significance Index: 13.3600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6796
Cell Significance Index: 129.3400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4223
Cell Significance Index: 57.9900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3976
Cell Significance Index: 13.9700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3609
Cell Significance Index: 58.7000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3185
Cell Significance Index: 14.9700
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2992
Cell Significance Index: 163.4200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.2681
Cell Significance Index: 1.6200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2556
Cell Significance Index: 46.0800
Cell Name: kidney cell (CL1000497)
Fold Change: 0.2511
Cell Significance Index: 2.0100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2424
Cell Significance Index: 26.3700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.2288
Cell Significance Index: 4.7900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.2128
Cell Significance Index: 24.2900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.1921
Cell Significance Index: 22.0100
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.1862
Cell Significance Index: 1.4700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1068
Cell Significance Index: 5.4000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0904
Cell Significance Index: 6.2500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0528
Cell Significance Index: 1.3200
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0508
Cell Significance Index: 1.3400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0310
Cell Significance Index: 2.3100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0292
Cell Significance Index: 12.9200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0222
Cell Significance Index: 41.8700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0107
Cell Significance Index: 0.6400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0064
Cell Significance Index: 1.1000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0055
Cell Significance Index: -0.5600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0069
Cell Significance Index: -0.3200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0075
Cell Significance Index: -5.5300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0099
Cell Significance Index: -6.2100
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0153
Cell Significance Index: -28.2700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0182
Cell Significance Index: -28.0500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0204
Cell Significance Index: -27.7600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0227
Cell Significance Index: -15.6700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0244
Cell Significance Index: -7.0100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0248
Cell Significance Index: -15.7500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0257
Cell Significance Index: -14.5000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0287
Cell Significance Index: -21.0200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0290
Cell Significance Index: -21.9600
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0304
Cell Significance Index: -0.4700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0323
Cell Significance Index: -11.5800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0347
Cell Significance Index: -15.7300
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0349
Cell Significance Index: -4.5100
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0436
Cell Significance Index: -8.6500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0548
Cell Significance Index: -0.5100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0650
Cell Significance Index: -13.7000
Cell Name: trophoblast giant cell (CL0002488)
Fold Change: -0.0708
Cell Significance Index: -0.5100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0757
Cell Significance Index: -1.4000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0775
Cell Significance Index: -9.0300
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.0916
Cell Significance Index: -0.8700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1188
Cell Significance Index: -6.2400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1205
Cell Significance Index: -24.1700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1549
Cell Significance Index: -22.5200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2252
Cell Significance Index: -26.5600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2304
Cell Significance Index: -23.9900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2399
Cell Significance Index: -16.9700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2457
Cell Significance Index: -7.8700
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.2641
Cell Significance Index: -3.7600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2707
Cell Significance Index: -20.7700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3025
Cell Significance Index: -8.4600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3053
Cell Significance Index: -18.7200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3170
Cell Significance Index: -19.9800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3203
Cell Significance Index: -25.3700
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3216
Cell Significance Index: -20.7500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3256
Cell Significance Index: -5.4500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3258
Cell Significance Index: -11.3200
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.3278
Cell Significance Index: -4.4200
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.3368
Cell Significance Index: -13.8000
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -0.3427
Cell Significance Index: -2.1200
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.3721
Cell Significance Index: -1.6200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3789
Cell Significance Index: -8.0700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3931
Cell Significance Index: -26.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** Adrenomedullin is a 32-amino acid peptide, initially discovered in the human placenta. It belongs to the calcitonin gene-related peptide (CGRP) family and is characterized by its ability to activate adenylate cyclase, leading to increased cyclic AMP (cAMP) levels. ADM is expressed in various tissues, including the adrenal glands, kidneys, and reproductive organs. **Pathways and Functions:** ADM exerts its effects through its receptor, Adrenomedullin Receptor 1 (AMR1), which is a member of the G protein-coupled receptor (GPCR) family. Upon binding to AMR1, ADM triggers a cascade of signaling events, including: 1. **Vasodilation**: ADM-induced vasodilation leads to decreased blood pressure and increased blood flow, which is essential for tissue oxygenation and nutrient delivery. 2. **Angiogenesis**: ADM promotes angiogenesis, the formation of new blood vessels, which is crucial for tissue repair and regeneration. 3. **Inflammation**: ADM has anti-inflammatory properties, reducing the production of pro-inflammatory cytokines and mediators. 4. **Cell Proliferation**: ADM stimulates cell proliferation, which is essential for tissue regeneration and repair. 5. **Apoptosis**: ADM regulates apoptosis, or programmed cell death, which is crucial for maintaining tissue homeostasis. **Clinical Significance:** ADM's involvement in various diseases has been extensively studied: 1. **Hypertension**: ADM's vasodilatory effects make it a potential therapeutic target for treating hypertension. 2. **Cardiovascular Disease**: ADM's anti-inflammatory and pro-angiogenic properties may contribute to its protective effects against cardiovascular disease. 3. **Cancer**: ADM's ability to regulate cell proliferation and apoptosis makes it a potential target for cancer therapy. 4. **Neurological Disorders**: ADM's involvement in neural tube closure and neuron projection regeneration suggests its potential therapeutic applications in neurodegenerative diseases. 5. **Reproductive Health**: ADM's role in reproductive organ development and function makes it a potential target for treating infertility and reproductive disorders. **Significantly Expressed Cells:** ADM is expressed in various cell types, including: 1. **Glandular Epithelial Cells** 2. **Kidney Loop of Henle Epithelial Cells** 3. **Fibroblasts of Breast and Mammary Gland** 4. **Basal Cells of Prostate Epithelium** 5. **Renal Intercalated Cells** In conclusion, adrenomedullin is a multifaceted peptide with significant immunological implications. Its involvement in various signaling pathways and its potential therapeutic applications make it an attractive target for further research. As an expert immunologist, it is essential to continue exploring the intricacies of ADM's role in immune regulation, tissue repair, and disease progression.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Pro-adrenomedullin

Genular Protein ID: 1017360539

Symbol: ADML_HUMAN

Name: Pro-adrenomedullin

UniProtKB Accession Codes:

P35318 B2R793 D3DQV3 Q6FGW2

Database IDs:

Citations:

PubMed ID: 7688224

Title: Cloning and characterization of cDNA encoding a precursor for human adrenomedullin.

PubMed ID: 7688224

DOI: 10.1006/bbrc.1993.1881

PubMed ID: 8074714

Title: Genomic structure of human adrenomedullin gene.

PubMed ID: 8074714

DOI: 10.1006/bbrc.1994.2229

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8387282

Title: Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma.

PubMed ID: 8387282

DOI: 10.1006/bbrc.1993.1451

PubMed ID: 9578982

Title: Proadrenomedullin-derived peptides.

PubMed ID: 9578982

DOI: 10.1006/frne.1998.0164

PubMed ID: 10588445

Title: Structure-activity relationships of adrenomedullin in the circulation and adrenal gland.

PubMed ID: 10588445

DOI: 10.1016/s0167-0115(99)00025-7

PubMed ID: 16315141

Title: NMR conformational analysis of proadrenomedullin N-terminal 20 peptide, a proangiogenic factor involved in tumor growth.

PubMed ID: 16315141

DOI: 10.1002/bip.20418

Sequence Information:

Length: 185
Mass: 20420
Checksum: 64C7D2A0B4654DFE
Sequence:

MKLVSVALMY LGSLAFLGAD TARLDVASEF RKKWNKWALS RGKRELRMSS SYPTGLADVK 
AGPAQTLIRP QDMKGASRSP EDSSPDAARI RVKRYRQSMN NFQGLRSFGC RFGTCTVQKL 
AHQIYQFTDK DKDNVAPRSK ISPQGYGRRR RRSLPEAGPG RTLVSSKPQA HGAPAPPSGS 
APHFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADM

Associated with

Cells (max top 100)

Other Information

Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. PubMed ID: 7688224

Genomic structure of human adrenomedullin gene. PubMed ID: 8074714

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. PubMed ID: 8387282

Proadrenomedullin-derived peptides. PubMed ID: 9578982

Structure-activity relationships of adrenomedullin in the circulation and adrenal gland. PubMed ID: 10588445

NMR conformational analysis of proadrenomedullin N-terminal 20 peptide, a proangiogenic factor involved in tumor growth. PubMed ID: 16315141