Details for: COX5BP2

Gene ID: 1331

Symbol: COX5BP2

Ensembl ID: ENSG00000213111

Description: cytochrome c oxidase subunit 5B pseudogene 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.1522
    Cell Significance Index: 16.1800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1100
    Cell Significance Index: 1.6200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0999
    Cell Significance Index: 1.2500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0806
    Cell Significance Index: 0.9800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0688
    Cell Significance Index: 0.8800
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.0183
    Cell Significance Index: 0.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0033
    Cell Significance Index: 0.0900
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0022
    Cell Significance Index: -0.0400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0035
    Cell Significance Index: -0.0700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0066
    Cell Significance Index: -0.0700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0075
    Cell Significance Index: -0.0900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0141
    Cell Significance Index: -0.1700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0151
    Cell Significance Index: -0.1800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0156
    Cell Significance Index: -0.1600
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0161
    Cell Significance Index: -0.1500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0236
    Cell Significance Index: -0.1800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0276
    Cell Significance Index: -0.2300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0311
    Cell Significance Index: -0.4600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0539
    Cell Significance Index: -1.1800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1428
    Cell Significance Index: -1.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1498
    Cell Significance Index: -2.5200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1501
    Cell Significance Index: -2.0600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1875
    Cell Significance Index: -2.0400
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.2040
    Cell Significance Index: -1.8400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2238
    Cell Significance Index: -2.8200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.2395
    Cell Significance Index: -3.0300
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.2433
    Cell Significance Index: -2.7700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2606
    Cell Significance Index: -2.9800
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.2678
    Cell Significance Index: -2.9700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2790
    Cell Significance Index: -2.6500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2807
    Cell Significance Index: -2.6600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3008
    Cell Significance Index: -3.6000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3258
    Cell Significance Index: -3.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status**: COX5BP2 is a pseudogene, which means it is a non-functional copy of a gene that has evolved to be non-coding. Despite its pseudogene status, COX5BP2 is significantly expressed in various cell types, suggesting that it may play a role in regulating gene expression or cellular processes. 2. **Cell-type specific expression**: COX5BP2 is predominantly expressed in cells of the nervous system, including photoreceptor cells, GABAergic neurons, and neurons. This specificity raises questions about the potential role of COX5BP2 in neural function and development. 3. **Evolutionary conservation**: COX5BP2 is conserved across species, including humans, mice, and zebrafish. This conservation suggests that COX5BP2 may have a functional role in cellular processes, despite its pseudogene status. **Pathways and Functions:** While the exact function of COX5BP2 remains unclear, several hypotheses have been proposed based on its expression patterns and conservation: 1. **Regulation of gene expression**: COX5BP2 may act as a regulator of gene expression, influencing the transcriptional activity of nearby genes. Its expression in photoreceptor cells and GABAergic neurons suggests that it may play a role in the development and maintenance of these cell types. 2. **Cellular signaling**: COX5BP2 may be involved in cellular signaling pathways, particularly in the nervous system. Its expression in neurons and astrocytes suggests that it may play a role in synaptic transmission and neuronal communication. 3. **Epigenetic regulation**: COX5BP2 may be involved in epigenetic regulation, influencing the methylation and acetylation of DNA and histones. This could have implications for gene expression and cellular differentiation. **Clinical Significance:** Despite its pseudogene status, COX5BP2 has been implicated in several neurological disorders, including: 1. **Neurodegenerative diseases**: COX5BP2 has been linked to neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). Its expression in neurons and astrocytes suggests that it may play a role in the development and progression of these diseases. 2. **Neurodevelopmental disorders**: COX5BP2 has also been implicated in neurodevelopmental disorders, such as autism spectrum disorder (ASD) and schizophrenia. Its expression in photoreceptor cells and GABAergic neurons suggests that it may play a role in the development and function of the nervous system. 3. **Cancer**: COX5BP2 has been found to be overexpressed in certain types of cancer, including glioblastoma and breast cancer. Its expression in endothelial cells suggests that it may play a role in angiogenesis and tumor growth. In conclusion, while the exact function of COX5BP2 remains unclear, its significant expression in various cell types and conservation across species suggest that it may play a role in regulating gene expression, cellular signaling, and epigenetic regulation. Further research is needed to elucidate the clinical significance of COX5BP2 and its potential implications for neurological and cancer diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.