Genular: Defining Cellular Identity and Function

Details for: Twist2

Gene ID: 13345

Symbol: Twist2

Ensembl ID: ENSMUSG00000007805

Description: twist basic helix-loop-helix transcription factor 2

Associated with

Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Chromatin binding
(GO:0003682)
Cornea development in camera-type eye
(GO:0061303)
Cytoplasm
(GO:0005737)
Developmental process
(GO:0032502)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Embryonic cranial skeleton morphogenesis
(GO:0048701)
Face morphogenesis
(GO:0060325)
Keratinocyte proliferation
(GO:0043616)
Macrophage cytokine production
(GO:0010934)
Multicellular organism development
(GO:0007275)
Myeloid cell differentiation
(GO:0030099)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of dna binding
(GO:0043392)
Negative regulation of macrophage cytokine production
(GO:0010936)
Negative regulation of molecular function
(GO:0044092)
Negative regulation of myeloid cell differentiation
(GO:0045638)
Negative regulation of osteoblast differentiation
(GO:0045668)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of keratinocyte proliferation
(GO:0010838)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein domain specific binding
(GO:0019904)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Transcription factor binding
(GO:0008134)
Transcription regulator complex
(GO:0005667)
Tumor necrosis factor production
(GO:0032640)

Other Information

Proteins

Twist-related protein 2
A5D6P6_MOUSE

Genular Protein ID: 3704231470

Symbol: TWST2_MOUSE

Name: Twist-related protein 2

UniProtKB Accession Codes:

Q9D030

Database IDs:

Citations:

PubMed ID: 7589808

Title: Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis.

PubMed ID: 7589808

DOI: 10.1006/dbio.1995.0023

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 11809751

Title: Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation.

PubMed ID: 11809751

DOI: 10.1074/jbc.m110228200

PubMed ID: 12553906

Title: Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity.

PubMed ID: 12553906

DOI: 10.1016/s0092-8674(03)00002-3

Sequence Information:

Length: 160
Mass: 18140
Checksum: 6394750916940C12
Sequence:

MEEGSSSPVS PVDSLGTSEE ELERQPKRFG RKRRYSKKSS EDGSPTPGKR GKKGSPSAQS 
FEELQSQRIL ANVRERQRTQ SLNEAFAALR KIIPTLPSDK LSKIQTLKLA ARYIDFLYQV 
LQSDEMDNKM TSCSYVAHER LSYAYSVWRM EGAWSMSASH

Genular Protein ID: 3020242626

Symbol: A5D6P6_MOUSE

Name: N/A

UniProtKB Accession Codes:

A5D6P6

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 160
Mass: 18124
Checksum: 8F44750916940C0A
Sequence:

MEEGSSSPVS PVDSLGTSEE ELERQPKRFG RKRRYSKKSS EDGSPTPGKR GKKGSPSAQS 
FEELQSQRIL ANVRERQRTQ SLNEAFAALR KIIPTLPSDK LSKIQTLKLA ARYIDFLYQV 
LQSDEMDNKM TSCSYVAHER LSYAFSVWRM EGAWSMSASH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Twist2

Associated with

Other Information

Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis. PubMed ID: 7589808

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation. PubMed ID: 11809751

Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. PubMed ID: 12553906

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334