Genular: Defining Cellular Identity and Function

Details for: Dgat1

Gene ID: 13350

Symbol: Dgat1

Ensembl ID: ENSMUSG00000022555

Description: diacylglycerol O-acyltransferase 1

Associated with

Acyl chain remodeling of dag and tag
(R-MMU-1482883)
Glycerophospholipid biosynthesis
(R-MMU-1483206)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Neutrophil degranulation
(R-MMU-6798695)
Phospholipid metabolism
(R-MMU-1483257)
Triglyceride biosynthesis
(R-MMU-75109)
Triglyceride metabolism
(R-MMU-8979227)
2-acylglycerol o-acyltransferase activity
(GO:0003846)
Acyltransferase activity
(GO:0016746)
Diacylglycerol binding
(GO:0019992)
Diacylglycerol metabolic process
(GO:0046339)
Diacylglycerol o-acyltransferase activity
(GO:0004144)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Fatty acid binding
(GO:0005504)
Fatty acid homeostasis
(GO:0055089)
Glycerolipid metabolic process
(GO:0046486)
Identical protein binding
(GO:0042802)
Insulin secretion
(GO:0030073)
Intracellular membrane-bounded organelle
(GO:0043231)
Ketone body metabolic process
(GO:1902224)
Lipid metabolic process
(GO:0006629)
Lipid storage
(GO:0019915)
Long-chain fatty-acyl-coa metabolic process
(GO:0035336)
Membrane
(GO:0016020)
Monoacylglycerol biosynthetic process
(GO:0006640)
O-acyltransferase activity
(GO:0008374)
Positive regulation of fatty acid oxidation
(GO:0046321)
Positive regulation of hepatic stellate cell activation
(GO:2000491)
Positive regulation of triglyceride biosynthetic process
(GO:0010867)
Regulation of eating behavior
(GO:1903998)
Regulation of intestinal lipid absorption
(GO:1904729)
Regulation of vitamin a metabolic process
(GO:1901738)
Retinol o-fatty-acyltransferase activity
(GO:0050252)
Transferase activity
(GO:0016740)
Triglyceride biosynthetic process
(GO:0019432)
Very-low-density lipoprotein particle assembly
(GO:0034379)

Other Information

Proteins

Diglyceride acyltransferase

Genular Protein ID: 1998843635

Symbol: DGAT1_MOUSE

Name: Diglyceride acyltransferase

UniProtKB Accession Codes:

Q9Z2A7 Q9D7Q5

Database IDs:

Citations:

PubMed ID: 9789033

Title: Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis.

PubMed ID: 9789033

DOI: 10.1073/pnas.95.22.13018

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10802663

Title: Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat.

PubMed ID: 10802663

DOI: 10.1038/75651

PubMed ID: 11959864

Title: DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis.

PubMed ID: 11959864

DOI: 10.1074/jbc.m202013200

PubMed ID: 11956242

Title: Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.

PubMed ID: 11956242

DOI: 10.1172/jci14672

PubMed ID: 19028692

Title: Retinol esterification by DGAT1 is essential for retinoid homeostasis in murine skin.

PubMed ID: 19028692

DOI: 10.1074/jbc.m807503200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 15834126

Title: The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters.

PubMed ID: 15834126

DOI: 10.1194/jlr.m500036-jlr200

PubMed ID: 16106050

Title: A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters.

PubMed ID: 16106050

DOI: 10.1194/jlr.m500168-jlr200

PubMed ID: 20876538

Title: Acyl CoA:diacylglycerol acyltransferase-1 (DGAT1): topological orientation, identification of a putative active site histidine and the role of the N-terminus in dimer/tetramer formation.

PubMed ID: 20876538

DOI: 10.1074/jbc.m110.163691

PubMed ID: 22493088

Title: The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.

PubMed ID: 22493088

DOI: 10.1194/jlr.m020156

PubMed ID: 23066022

Title: Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases.

PubMed ID: 23066022

DOI: 10.1074/jbc.m112.400416

PubMed ID: 28420705

Title: Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases.

PubMed ID: 28420705

DOI: 10.1194/jlr.m073445

Sequence Information:

Length: 498
Mass: 56790
Checksum: E7B0DD6DDCF1EC2B
Sequence:

MGDRGGAGSS RRRRTGSRVS VQGGSGPKVE EDEVRDAAVS PDLGAGGDAP APAPAPAHTR 
DKDGRTSVGD GYWDLRCHRL QDSLFSSDSG FSNYRGILNW CVVMLILSNA RLFLENLIKY 
GILVDPIQVV SLFLKDPYSW PAPCVIIASN IFVVAAFQIE KRLAVGALTE QMGLLLHVVN 
LATIICFPAA VALLVESITP VGSVFALASY SIMFLKLYSY RDVNLWCRQR RVKAKAVSTG 
KKVSGAAAQQ AVSYPDNLTY RDLYYFIFAP TLCYELNFPR SPRIRKRFLL RRVLEMLFFT 
QLQVGLIQQW MVPTIQNSMK PFKDMDYSRI IERLLKLAVP NHLIWLIFFY WFFHSCLNAV 
AELLQFGDRE FYRDWWNAES VTYFWQNWNI PVHKWCIRHF YKPMLRHGSS KWVARTGVFL 
TSAFFHEYLV SVPLRMFRLW AFTAMMAQVP LAWIVGRFFQ GNYGNAAVWV TLIIGQPVAV 
LMYVHDYYVL NYDAPVGV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dgat1

Associated with

Other Information

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. PubMed ID: 9789033

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. PubMed ID: 10802663

DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis. PubMed ID: 11959864

Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. PubMed ID: 11956242

Retinol esterification by DGAT1 is essential for retinoid homeostasis in murine skin. PubMed ID: 19028692

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters. PubMed ID: 15834126

A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters. PubMed ID: 16106050

Acyl CoA:diacylglycerol acyltransferase-1 (DGAT1): topological orientation, identification of a putative active site histidine and the role of the N-terminus in dimer/tetramer formation. PubMed ID: 20876538

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2. PubMed ID: 22493088

Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases. PubMed ID: 23066022

Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases. PubMed ID: 28420705