Genular: Defining Cellular Identity and Function

Details for: Dhh

Gene ID: 13363

Symbol: Dhh

Ensembl ID: ENSMUSG00000023000

Description: desert hedgehog

Associated with

Activation of smo
(R-MMU-5635838)
Hedgehog 'on' state
(R-MMU-5632684)
Hedgehog ligand biogenesis
(R-MMU-5358346)
Ligand-receptor interactions
(R-MMU-5632681)
Release of hh-np from the secreting cell
(R-MMU-5362798)
Signaling by hedgehog
(R-MMU-5358351)
Signal transduction
(R-MMU-162582)
Calcium ion binding
(GO:0005509)
Cell-cell signaling
(GO:0007267)
Cell fate specification
(GO:0001708)
Endoplasmic reticulum
(GO:0005783)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Hydrolase activity
(GO:0016787)
Intein-mediated protein splicing
(GO:0016539)
Leydig cell differentiation
(GO:0033327)
Male gonad development
(GO:0008584)
Male sex determination
(GO:0030238)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Multicellular organism development
(GO:0007275)
Osteoblast differentiation
(GO:0001649)
Paracrine signaling
(GO:0038001)
Patched binding
(GO:0005113)
Peptidase activity
(GO:0008233)
Plasma membrane
(GO:0005886)
Positive regulation of smoothened signaling pathway
(GO:0045880)
Protein autoprocessing
(GO:0016540)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Regulation of gene expression
(GO:0010468)
Regulation of steroid biosynthetic process
(GO:0050810)
Schwann cell development
(GO:0014044)
Smoothened signaling pathway
(GO:0007224)
Spermatid development
(GO:0007286)
Spermatogenesis
(GO:0007283)
Transferase activity
(GO:0016740)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

HHG-3

Genular Protein ID: 2507100695

Symbol: DHH_MOUSE

Name: HHG-3

UniProtKB Accession Codes:

Q61488

Database IDs:

Citations:

PubMed ID: 7916661

Title: Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.

PubMed ID: 7916661

DOI: 10.1016/0092-8674(93)90627-3

PubMed ID: 7720571

Title: Products, genetic linkage and limb patterning activity of a murine hedgehog gene.

PubMed ID: 7720571

DOI: 10.1242/dev.120.11.3339

PubMed ID: 8805249

Title: Sertoli cell signaling by Desert hedgehog regulates the male germline.

PubMed ID: 8805249

DOI: 10.1016/s0960-9822(02)00480-3

PubMed ID: 9811851

Title: Characterization of two patched receptors for the vertebrate hedgehog protein family.

PubMed ID: 9811851

DOI: 10.1073/pnas.95.23.13630

PubMed ID: 10482238

Title: Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths.

PubMed ID: 10482238

DOI: 10.1016/s0896-6273(01)80030-1

PubMed ID: 11090455

Title: Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules.

PubMed ID: 11090455

DOI: 10.1095/biolreprod63.6.1825

PubMed ID: 32151560

Title: Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin.

PubMed ID: 32151560

DOI: 10.1016/j.ydbio.2020.03.003

PubMed ID: 33063110

Title: Full-length Dhh and N-terminal Shh act as competitive antagonists to regulate angiogenesis and vascular permeability.

PubMed ID: 33063110

DOI: 10.1093/cvr/cvaa285

Sequence Information:

Length: 396
Mass: 43542
Checksum: AFFEB051BE950FD8
Sequence:

MALPASLLPL CCLALLALSA QSCGPGRGPV GRRRYVRKQL VPLLYKQFVP SMPERTLGAS 
GPAEGRVTRG SERFRDLVPN YNPDIIFKDE ENSGADRLMT ERCKERVNAL AIAVMNMWPG 
VRLRVTEGWD EDGHHAQDSL HYEGRALDIT TSDRDRNKYG LLARLAVEAG FDWVYYESRN 
HIHVSVKADN SLAVRAGGCF PGNATVRLRS GERKGLRELH RGDWVLAADA AGRVVPTPVL 
LFLDRDLQRR ASFVAVETER PPRKLLLTPW HLVFAARGPA PAPGDFAPVF ARRLRAGDSV 
LAPGGDALQP ARVARVAREE AVGVFAPLTA HGTLLVNDVL ASCYAVLESH QWAHRAFAPL 
RLLHALGALL PGGAVQPTGM HWYSRLLYRL AEELMG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dhh

Associated with

Other Information

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. PubMed ID: 7916661

Products, genetic linkage and limb patterning activity of a murine hedgehog gene. PubMed ID: 7720571

Sertoli cell signaling by Desert hedgehog regulates the male germline. PubMed ID: 8805249

Characterization of two patched receptors for the vertebrate hedgehog protein family. PubMed ID: 9811851

Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. PubMed ID: 10482238

Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules. PubMed ID: 11090455

Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin. PubMed ID: 32151560

Full-length Dhh and N-terminal Shh act as competitive antagonists to regulate angiogenesis and vascular permeability. PubMed ID: 33063110