COX6A1 | ENSG00000111775 | NCBI 1337

Details for: COX6A1

Gene ID: 1337

Symbol: COX6A1

Ensembl ID: ENSG00000111775

Description: cytochrome c oxidase subunit 6A1

Associated with

Aerobic respiration and respiratory electron transport
(R-HSA-1428517)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Complex iv assembly
(R-HSA-9864848)
Cytoprotection by hmox1
(R-HSA-9707564)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism
(R-HSA-1430728)
Respiratory electron transport
(R-HSA-611105)
Rna polymerase ii transcription
(R-HSA-73857)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cellular respiration
(GO:0045333)
Enzyme regulator activity
(GO:0030234)
Generation of precursor metabolites and energy
(GO:0006091)
Mitochondrial electron transport, cytochrome c to oxygen
(GO:0006123)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial membrane
(GO:0031966)
Mitochondrion
(GO:0005739)
Oxidoreductase activity
(GO:0016491)
Protein binding
(GO:0005515)
Respiratory chain complex iv
(GO:0045277)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cell in vitro (CL0001034)
Fold Change: 2.72
Cell Significance Index: 5
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.66
Cell Significance Index: 2
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.55
Cell Significance Index: 2
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.44
Cell Significance Index: 2
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.32
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.24
Cell Significance Index: 1
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.23
Cell Significance Index: 1
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.21
Cell Significance Index: 1
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.21
Cell Significance Index: 1
Cell Name: lactocyte (CL0002325)
Fold Change: 1.2
Cell Significance Index: 1
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.17
Cell Significance Index: 1
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.15
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.13
Cell Significance Index: 1
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: kidney cell (CL1000497)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: peg cell (CL4033014)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 1
Cell Significance Index: 1
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1
Cell Significance Index: 1
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 1
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1
Cell Significance Index: 1
Cell Name: centroblast (CL0009112)
Fold Change: 1
Cell Significance Index: 1
Cell Name: germ cell (CL0000586)
Fold Change: 1
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: colon endothelial cell (CL1001572)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: neuron associated cell (CL0000095)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: odontoblast (CL0000060)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: enterocyte (CL0000584)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: stem cell (CL0000034)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: precursor cell (CL0011115)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.97
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** The COX6A1 gene is a mitochondrial gene, which means it is encoded in the mitochondrial DNA (mtDNA) and is present in all cells of the body. The gene encodes a 74-amino acid protein that is a subunit of the cytochrome c oxidase complex. This complex is a heterodimeric enzyme composed of multiple subunits, with COX6A1 being one of the 13 subunits. The COX6A1 protein is a transmembrane protein, with a hydrophobic N-terminus and a hydrophilic C-terminus. It is highly conserved across species, suggesting its importance in cellular function. **Pathways and Functions** The COX6A1 gene is involved in several key pathways, including: 1. **Cellular Respiration**: The COX6A1 gene is essential for the production of ATP through the electron transport chain. The cytochrome c oxidase complex, to which COX6A1 is a subunit, is the final step of the electron transport chain, where oxygen is reduced to water. 2. **Mitochondrial Electron Transport**: COX6A1 plays a critical role in the mitochondrial electron transport chain, where electrons are passed through a series of protein complexes to generate a proton gradient. This gradient is used to produce ATP through chemiosmosis. 3. **Oxidoreductase Activity**: COX6A1 is an oxidoreductase enzyme, which means it catalyzes the transfer of electrons from one molecule to another. 4. **Cytoprotection**: The COX6A1 gene has been implicated in cytoprotection, which is the protection of cells from oxidative stress. The cytochrome c oxidase complex has antioxidant properties, which help to protect cells from damage caused by reactive oxygen species (ROS). **Clinical Significance** Alterations in the COX6A1 gene have been implicated in several diseases, including: 1. **Cancer**: COX6A1 is overexpressed in several types of cancer, including breast, lung, and colon cancer. This overexpression is associated with poor prognosis and increased tumor aggressiveness. 2. **Metabolic Disorders**: COX6A1 is also implicated in metabolic disorders, such as diabetes and obesity. The gene is involved in glucose metabolism and insulin signaling, and alterations in COX6A1 expression have been linked to these disorders. 3. **Neurodegenerative Diseases**: COX6A1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. The gene is involved in mitochondrial function and energy metabolism, and alterations in COX6A1 expression have been linked to these diseases. In conclusion, the COX6A1 gene plays a critical role in cellular respiration, mitochondrial electron transport, and cytoprotection. Alterations in the expression or function of COX6A1 have been implicated in various diseases, including cancer, metabolic disorders, and neurodegenerative diseases. Further research is needed to fully understand the role of COX6A1 in human disease and to develop therapeutic strategies to manipulate its expression or function.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.