Genular: Defining Cellular Identity and Function

Details for: Dkk1

Gene ID: 13380

Symbol: Dkk1

Ensembl ID: ENSMUSG00000024868

Description: dickkopf WNT signaling pathway inhibitor 1

Associated with

Negative regulation of tcf-dependent signaling by wnt ligand antagonists
(R-MMU-3772470)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Canonical wnt signaling pathway
(GO:0060070)
Cell morphogenesis
(GO:0000902)
Co-receptor binding
(GO:0039706)
Embryonic limb morphogenesis
(GO:0030326)
Endoderm development
(GO:0007492)
Endoderm formation
(GO:0001706)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Face morphogenesis
(GO:0060325)
Forebrain development
(GO:0030900)
Hair follicle development
(GO:0001942)
Head morphogenesis
(GO:0060323)
Heart induction
(GO:0003129)
Learning or memory
(GO:0007611)
Limb development
(GO:0060173)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Mesoderm formation
(GO:0001707)
Motor learning
(GO:0061743)
Multicellular organism development
(GO:0007275)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cardiac muscle cell differentiation
(GO:2000726)
Negative regulation of mesodermal cell fate specification
(GO:0042662)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of ossification
(GO:0030279)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of presynapse assembly
(GO:1905607)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of smad protein signal transduction
(GO:0060392)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of wnt-frizzled-lrp5/6 complex assembly
(GO:1904723)
Negative regulation of wnt signaling pathway
(GO:0030178)
Plasma membrane
(GO:0005886)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of midbrain dopaminergic neuron differentiation
(GO:1904958)
Protein binding
(GO:0005515)
Receptor antagonist activity
(GO:0048019)
Regulation of endodermal cell fate specification
(GO:0042663)
Regulation of receptor internalization
(GO:0002090)
Regulation of synapse organization
(GO:0050807)
Regulation of synaptic transmission, glutamatergic
(GO:0051966)
Regulation of wnt signaling pathway
(GO:0030111)
Response to retinoic acid
(GO:0032526)
Wnt signaling pathway
(GO:0016055)
Wnt signaling pathway involved in somitogenesis
(GO:0090244)

Other Information

Proteins

Dickkopf-related protein 1

Genular Protein ID: 2275179244

Symbol: DKK1_MOUSE

Name: Dickkopf-related protein 1

UniProtKB Accession Codes:

O54908 Q80UL5

Database IDs:

Citations:

PubMed ID: 9450748

Title: Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.

PubMed ID: 9450748

DOI: 10.1038/34848

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17143291

Title: Function and biological roles of the Dickkopf family of Wnt modulators.

PubMed ID: 17143291

DOI: 10.1038/sj.onc.1210054

PubMed ID: 18524778

Title: Structural insight into the mechanisms of Wnt signaling antagonism by Dkk.

PubMed ID: 18524778

DOI: 10.1074/jbc.m802375200

PubMed ID: 18505822

Title: Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density.

PubMed ID: 18505822

DOI: 10.1128/mcb.00222-08

PubMed ID: 26206087

Title: Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner.

PubMed ID: 26206087

DOI: 10.1038/cdd.2015.100

PubMed ID: 27550540

Title: Kremen1 regulates mechanosensory hair cell development in the mammalian cochlea and the zebrafish lateral line.

PubMed ID: 27550540

DOI: 10.1038/srep31668

Sequence Information:

Length: 272
Mass: 29298
Checksum: ADFAC3E7B8858A9E
Sequence:

MMVVCAAAAV RFLAVFTMMA LCSLPLLGAS ATLNSVLINS NAIKNLPPPL GGAGGQPGSA 
VSVAPGVLYE GGNKYQTLDN YQPYPCAEDE ECGSDEYCSS PSRGAAGVGG VQICLACRKR 
RKRCMRHAMC CPGNYCKNGI CMPSDHSHFP RGEIEESIIE NLGNDHNAAA GDGYPRRTTL 
TSKIYHTKGQ EGSVCLRSSD CAAGLCCARH FWSKICKPVL KEGQVCTKHK RKGSHGLEIF 
QRCYCGEGLA CRIQKDHHQA SNSSRLHTCQ RH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dkk1

Associated with

Other Information

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. PubMed ID: 9450748

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Function and biological roles of the Dickkopf family of Wnt modulators. PubMed ID: 17143291

Structural insight into the mechanisms of Wnt signaling antagonism by Dkk. PubMed ID: 18524778

Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. PubMed ID: 18505822

Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner. PubMed ID: 26206087

Kremen1 regulates mechanosensory hair cell development in the mammalian cochlea and the zebrafish lateral line. PubMed ID: 27550540