Genular: Defining Cellular Identity and Function

Details for: Dld

Gene ID: 13382

Symbol: Dld

Ensembl ID: ENSMUSG00000020664

Description: dihydrolipoamide dehydrogenase

Associated with

Branched-chain amino acid catabolism
(R-MMU-70895)
Citric acid cycle (tca cycle)
(R-MMU-71403)
Glycine degradation
(R-MMU-6783984)
Glyoxylate metabolism and glycine degradation
(R-MMU-389661)
Lysine catabolism
(R-MMU-71064)
Metabolism
(R-MMU-1430728)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Metabolism of proteins
(R-MMU-392499)
Mitochondrial protein degradation
(R-MMU-9837999)
Pyruvate metabolism
(R-MMU-70268)
Pyruvate metabolism and citric acid (tca) cycle
(R-MMU-71406)
Regulation of pyruvate dehydrogenase (pdh) complex
(R-MMU-204174)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by retinoic acid
(R-MMU-5362517)
Signal transduction
(R-MMU-162582)
The citric acid (tca) cycle and respiratory electron transport
(R-MMU-1428517)
2-oxoglutarate metabolic process
(GO:0006103)
Acetyl-coa biosynthetic process from pyruvate
(GO:0006086)
Acetyltransferase complex
(GO:1902493)
Acrosomal matrix
(GO:0043159)
Branched-chain amino acid catabolic process
(GO:0009083)
Cell projection
(GO:0042995)
Cilium
(GO:0005929)
Cytoplasmic vesicle
(GO:0031410)
Dihydrolipoamide metabolic process
(GO:0051068)
Dihydrolipoyl dehydrogenase activity
(GO:0004148)
Dihydrolipoyl dehydrogenase complex
(GO:0045240)
Flavin adenine dinucleotide binding
(GO:0050660)
Gastrulation
(GO:0007369)
Histone succinylation
(GO:0106077)
Lipoamide binding
(GO:0043544)
Lipoate metabolic process
(GO:0009106)
Mitochondrial alpha-ketoglutarate dehydrogenase complex
(GO:0005947)
Mitochondrial electron transport, nadh to ubiquinone
(GO:0006120)
Mitochondrial matrix
(GO:0005759)
Mitochondrial pyruvate dehydrogenase complex
(GO:0005967)
Mitochondrion
(GO:0005739)
Motile cilium
(GO:0031514)
Myelin sheath
(GO:0043209)
Nad binding
(GO:0051287)
Nucleus
(GO:0005634)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on a sulfur group of donors, nad(p) as acceptor
(GO:0016668)
Oxoglutarate dehydrogenase complex
(GO:0045252)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Pyruvate dehydrogenase (nad+) activity
(GO:0034604)
Pyruvate dehydrogenase complex
(GO:0045254)
Regulation of membrane potential
(GO:0042391)
Sperm capacitation
(GO:0048240)

Other Information

Proteins

Dihydrolipoyl dehydrogenase, mitochondrial

Genular Protein ID: 1431340099

Symbol: DLDH_MOUSE

Name: Dihydrolipoyl dehydrogenase, mitochondrial

UniProtKB Accession Codes:

O08749 Q3TG55 Q3U5W5 Q3UWP7 Q99LD3

Database IDs:

Citations:

PubMed ID: 9169128

Title: Characterization of the mouse dihydrolipoamide dehydrogenase (Dld) gene: genomic structure, promoter sequence, and chromosomal localization.

PubMed ID: 9169128

DOI: 10.1006/geno.1997.4670

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15888450

Title: Novelty of the pyruvate metabolic enzyme dihydrolipoamide dehydrogenase in spermatozoa: correlation of its localization, tyrosine phosphorylation, and activity during sperm capacitation.

PubMed ID: 15888450

DOI: 10.1074/jbc.m500310200

PubMed ID: 17404228

Title: Cryptic proteolytic activity of dihydrolipoamide dehydrogenase.

PubMed ID: 17404228

DOI: 10.1073/pnas.0610618104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

PubMed ID: 36854377

Title: MRPS36 provides a structural link in the eukaryotic 2-oxoglutarate dehydrogenase complex.

PubMed ID: 36854377

DOI: 10.1098/rsob.220363

Sequence Information:

Length: 509
Mass: 54272
Checksum: 2C381852BAAD0441
Sequence:

MQSWSRVYRS LAKKGHFNRI SHGLQGVSSV PLRTYADQPI EADVTVIGSG PGGYVAAIKS 
AQLGFKTVCI EKNETLGGTC LNVGCIPSKA LLNNSHYYHM AHGKDFASRG IEIPEVRLNL 
EKMMEQKHSA VKALTGGIAH LFKQNKVVHV NGFGKITGKN QVTATKADGS TQVIDTKNIL 
VATGSEVTPF PGITIDEDTI VSSTGALSLK KVPEKLVVIG AGVIGVELGS VWQRLGADVT 
AVEFLGHVGG IGIDMEISKN FQRILQRQGF KFKLNTKVTG ATKKSDGKID VSVEAASGGK 
AEVITCDVLL VCIGRRPFTQ NLGLEELGIE LDPKGRIPVN NRFQTKIPNI YAIGDVVAGP 
MLAHKAEDEG IICVEGMAGG AVHIDYNCVP SVIYTHPEVA WVGKSEEQLK EEGIEFKIGK 
FPFAANSRAK TNADTDGMVK ILGHKSTDRV LGAHILGPGA GEMVNEAALA LEYGASCEDI 
ARVCHAHPTL SEAFREANLA AAFGKPINF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dld

Associated with

Other Information

Characterization of the mouse dihydrolipoamide dehydrogenase (Dld) gene: genomic structure, promoter sequence, and chromosomal localization. PubMed ID: 9169128

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Novelty of the pyruvate metabolic enzyme dihydrolipoamide dehydrogenase in spermatozoa: correlation of its localization, tyrosine phosphorylation, and activity during sperm capacitation. PubMed ID: 15888450

Cryptic proteolytic activity of dihydrolipoamide dehydrogenase. PubMed ID: 17404228

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753

MRPS36 provides a structural link in the eukaryotic 2-oxoglutarate dehydrogenase complex. PubMed ID: 36854377