Details for: Dll1
Associated with
Other Information
Genular Protein ID: 2924868677
Symbol: DLL1_MOUSE
Name: Drosophila Delta homolog 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7671806
Title: Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta.
PubMed ID: 7671806
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 19468303
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21572390
Title: MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development.
PubMed ID: 21572390
PubMed ID: 12794186
Title: The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase.
PubMed ID: 12794186
PubMed ID: 10958687
Title: Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2.
PubMed ID: 10958687
PubMed ID: 15146182
Title: Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo.
PubMed ID: 15146182
DOI: 10.1038/ni1075
PubMed ID: 15788413
Title: The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface.
PubMed ID: 15788413
PubMed ID: 15908431
Title: MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface.
PubMed ID: 15908431
PubMed ID: 16495313
Title: Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear.
PubMed ID: 16495313
DOI: 10.1242/dev.02284
PubMed ID: 17003037
Title: Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.
PubMed ID: 17003037
PubMed ID: 17194759
Title: Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.
PubMed ID: 17194759
PubMed ID: 18997111
Title: Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon.
PubMed ID: 18997111
DOI: 10.1242/dev.024570
PubMed ID: 17960184
Title: Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis.
PubMed ID: 17960184
PubMed ID: 18676613
Title: The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity.
PubMed ID: 18676613
PubMed ID: 19723503
Title: Neuralized-2: Expression in human and rodents and interaction with Delta-like ligands.
PubMed ID: 19723503
PubMed ID: 19144989
Title: DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries.
PubMed ID: 19144989
PubMed ID: 19389377
Title: Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity.
PubMed ID: 19389377
PubMed ID: 19217325
Title: Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches.
PubMed ID: 19217325
PubMed ID: 19562077
Title: Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.
PubMed ID: 19562077
PubMed ID: 20081190
Title: Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression.
PubMed ID: 20081190
DOI: 10.1242/dev.036806
PubMed ID: 21985982
Title: Delta-like 1-Lysine613 regulates notch signaling.
PubMed ID: 21985982
PubMed ID: 21238454
Title: Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells.
PubMed ID: 21238454
PubMed ID: 21915337
Title: Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system.
PubMed ID: 21915337
PubMed ID: 22282195
Title: Extrinsic Notch ligand Delta-like 1 regulates tip cell selection and vascular branching morphogenesis.
PubMed ID: 22282195
PubMed ID: 22096075
Title: Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism.
PubMed ID: 22096075
DOI: 10.1242/dev.071761
PubMed ID: 22015720
Title: Cdx regulates Dll1 in multiple lineages.
PubMed ID: 22015720
PubMed ID: 22940113
Title: Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on Notch signals.
PubMed ID: 22940113
PubMed ID: 22529374
Title: Mind bomb 1 is required for pancreatic beta-cell formation.
PubMed ID: 22529374
PubMed ID: 23806616
Title: The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development.
PubMed ID: 23806616
PubMed ID: 23699523
Title: Dynamic interactions between intermediate neurogenic progenitors and radial glia in embryonic mouse neocortex: potential role in Dll1-Notch signaling.
PubMed ID: 23699523
PubMed ID: 23688253
Title: Delta-like 1 regulates Bergmann glial monolayer formation during cerebellar development.
PubMed ID: 23688253
PubMed ID: 23695674
Title: Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis.
PubMed ID: 23695674
DOI: 10.1038/ncomms2895
PubMed ID: 24715457
Title: Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates.
PubMed ID: 24715457
DOI: 10.1242/dev.102988
PubMed ID: 25220152
Title: Divergent and conserved roles of Dll1 signaling in development of craniofacial and trunk muscle.
PubMed ID: 25220152
PubMed ID: 24449764
Title: S/T phosphorylation of DLL1 is required for full ligand activity in vitro but dispensable for DLL1 function in vivo during embryonic patterning and marginal zone B cell development.
PubMed ID: 24449764
DOI: 10.1128/mcb.00965-13
PubMed ID: 26114479
Title: Context-dependent functional divergence of the Notch ligands DLL1 and DLL4 in vivo.
PubMed ID: 26114479
Sequence Information:
- Length: 722
- Mass: 78449
- Checksum: 9D570B9DC7EEC75E
- Sequence:
MGRRSALALA VVSALLCQVW SSGVFELKLQ EFVNKKGLLG NRNCCRGGSG PPCACRTFFR VCLKHYQASV SPEPPCTYGS AVTPVLGVDS FSLPDGAGID PAFSNPIRFP FGFTWPGTFS LIIEALHTDS PDDLATENPE RLISRLTTQR HLTVGEEWSQ DLHSSGRTDL RYSYRFVCDE HYYGEGCSVF CRPRDDAFGH FTCGDRGEKM CDPGWKGQYC TDPICLPGCD DQHGYCDKPG ECKCRVGWQG RYCDECIRYP GCLHGTCQQP WQCNCQEGWG GLFCNQDLNY CTHHKPCRNG ATCTNTGQGS YTCSCRPGYT GANCELEVDE CAPSPCKNGA SCTDLEDSFS CTCPPGFYGK VCELSAMTCA DGPCFNGGRC SDNPDGGYTC HCPLGFSGFN CEKKMDLCGS SPCSNGAKCV DLGNSYLCRC QAGFSGRYCE DNVDDCASSP CANGGTCRDS VNDFSCTCPP GYTGKNCSAP VSRCEHAPCH NGATCHQRGQ RYMCECAQGY GGPNCQFLLP EPPPGPMVVD LSERHMESQG GPFPWVAVCA GVVLVLLLLL GCAAVVVCVR LKLQKHQPPP EPCGGETETM NNLANCQREK DVSVSIIGAT QIKNTNKKAD FHGDHGAEKS SFKVRYPTVD YNLVRDLKGD EATVRDTHSK RDTKCQSQSS AGEEKIAPTL RGGEIPDRKR PESVYSTSKD TKYQSVYVLS AEKDECVIAT EV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.