Details for: COX6A2

Gene ID: 1339

Symbol: COX6A2

Ensembl ID: ENSG00000156885

Description: cytochrome c oxidase subunit 6A2

Associated with

  • Enzyme regulator activity
    (GO:0030234)
  • Generation of precursor metabolites and energy
    (GO:0006091)
  • Mitochondrial electron transport, cytochrome c to oxygen
    (GO:0006123)
  • Mitochondrial respiratory chain complex iv
    (GO:0005751)
  • Oxidoreductase activity
    (GO:0016491)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.3
    Marker Score: 757
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 2.28
    Marker Score: 944
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.11
    Marker Score: 47075
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 2.06
    Marker Score: 1569.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.73
    Marker Score: 1194.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1171
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.51
    Marker Score: 1501
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169071
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.45
    Marker Score: 4018
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.31
    Marker Score: 4673
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7689
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 704
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.02
    Marker Score: 421
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1
    Marker Score: 503
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.95
    Marker Score: 436
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.93
    Marker Score: 1435
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.93
    Marker Score: 12315
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.88
    Marker Score: 940
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 659.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.8
    Marker Score: 4785
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1288
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.77
    Marker Score: 12005.5
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.76
    Marker Score: 228.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1183
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.71
    Marker Score: 1471
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 388
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.62
    Marker Score: 398
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 479
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.53
    Marker Score: 665
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.5
    Marker Score: 448
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 199
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.47
    Marker Score: 154
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.46
    Marker Score: 199
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.46
    Marker Score: 1004
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.44
    Marker Score: 495
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.4
    Marker Score: 392
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.38
    Marker Score: 360
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 217
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.35
    Marker Score: 111
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.34
    Marker Score: 142.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.33
    Marker Score: 328
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.32
    Marker Score: 315.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.3
    Marker Score: 170
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.26
    Marker Score: 180
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.26
    Marker Score: 925
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.25
    Marker Score: 122
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.25
    Marker Score: 138
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.23
    Marker Score: 163
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.22
    Marker Score: 147
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.22
    Marker Score: 71
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.22
    Marker Score: 123
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.19
    Marker Score: 177
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.18
    Marker Score: 372
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.17
    Marker Score: 90
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.16
    Marker Score: 376.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.16
    Marker Score: 167
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.15
    Marker Score: 110
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.15
    Marker Score: 193
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 132
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.13
    Marker Score: 52
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.12
    Marker Score: 224
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.12
    Marker Score: 147
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.11
    Marker Score: 100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.11
    Marker Score: 215.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.11
    Marker Score: 38.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.11
    Marker Score: 185
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.11
    Marker Score: 38
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.11
    Marker Score: 116
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.11
    Marker Score: 170
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.11
    Marker Score: 208
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.1
    Marker Score: 68
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.1
    Marker Score: 22

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Other Information

**Key characteristics:** - Gene name: COX6A2 - Ensembl ID: ENSG00000156885 - Protein name: Cytochrome c oxidase subunit 6A2 - Protein function: Component of the mitochondrial electron transport chain - Expression: Significantly expressed in fetal cardiomyocyte, endothelial cell of artery, regular ventricular cardiac myocyte, cell of skeletal muscle, conventional dendritic cell, colon goblet cell, enterocyte of epithelium of large intestine, mural cell, decidual natural killer cell **Pathways and functions:** - Enzyme regulator activity: COX6A2 is an enzyme that is involved in the regulation of the mitochondrial electron transport chain. - Generation of precursor metabolites and energy: COX6A2 is involved in the generation of precursor metabolites and energy in the mitochondria. - Mitochondrial electron transport: COX6A2 is a component of the mitochondrial electron transport chain, where it transfers electrons from cytochrome c to oxygen. - Cytochrome c to oxygen: COX6A2 is responsible for the transfer of electrons from cytochrome c to oxygen, which is necessary for the production of ATP through oxidative phosphorylation. **Clinical significance:** - Mutations in the COX6A2 gene have been linked to several human diseases, including mitochondrial diseases, cardiovascular diseases, and cancer. - Understanding the role of COX6A2 in the mitochondria is important for the development of new therapeutic strategies for these diseases.

Genular Protein ID: 3451808827

Symbol: CX6A2_HUMAN

Name: Cytochrome c oxidase subunit 6A2, mitochondrial

UniProtKB Accession Codes:

Q02221 O00761 Q6GTW6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 3 Ensembl 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 1327966

Title: Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase.

PubMed ID: 1327966

DOI: 10.1016/0378-1119(92)90288-z

PubMed ID: 9177785

Title: Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle.

PubMed ID: 9177785

DOI: 10.1006/geno.1997.4687

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 31155743

Title: COX6A2 variants cause a muscle-specific cytochrome c oxidase deficiency.

PubMed ID: 31155743

DOI: 10.1002/ana.25517

Sequence Information:

  • Length: 97
  • Mass: 10815
  • Checksum: 843AD80319891F1B
  • Sequence:
    • MALPLRPLTR GLASAAKGGH GGAGARTWRL LTFVLALPSV ALCTFNSYLH SGHRPRPEFR 
PYQHLRIRTK PYPWGDGNHT LFHNSHVNPL PTGYEHP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.