Details for: Dlx2

Gene ID: 13392

Symbol: Dlx2

Ensembl ID: ENSMUSG00000023391

Description: distal-less homeobox 2

Associated with

  • Branching morphogenesis of a nerve
    (GO:0048755)
  • Cartilage development
    (GO:0051216)
  • Cell differentiation
    (GO:0030154)
  • Cerebral cortex gabaergic interneuron differentiation
    (GO:0021892)
  • Cerebral cortex gabaergic interneuron fate commitment
    (GO:0021893)
  • Chromatin binding
    (GO:0003682)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryo development
    (GO:0009790)
  • Embryonic cranial skeleton morphogenesis
    (GO:0048701)
  • Embryonic skeletal system development
    (GO:0048706)
  • Forebrain neuron differentiation
    (GO:0021879)
  • Gabaergic neuron differentiation
    (GO:0097154)
  • Hippocampus development
    (GO:0021766)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of notch signaling pathway
    (GO:0045746)
  • Negative regulation of oligodendrocyte differentiation
    (GO:0048715)
  • Negative regulation of photoreceptor cell differentiation
    (GO:0046533)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuroblast differentiation
    (GO:0014016)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleus
    (GO:0005634)
  • Odontogenesis of dentin-containing tooth
    (GO:0042475)
  • Olfactory bulb development
    (GO:0021772)
  • Oligodendrocyte differentiation
    (GO:0048709)
  • Positive regulation of amacrine cell differentiation
    (GO:1902871)
  • Positive regulation of cell differentiation
    (GO:0045597)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Proximal/distal pattern formation
    (GO:0009954)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Single-stranded rna binding
    (GO:0003727)
  • Subpallium development
    (GO:0021544)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Other Information

Genular Protein ID: 2939230429

Symbol: DLX2_MOUSE

Name: Homeobox protein DLX-2

UniProtKB Accession Codes:

P40764

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 1678612

Title: Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain.

PubMed ID: 1678612

DOI: 10.1016/0896-6273(91)90260-7

PubMed ID: 1632970

Title: A partial cDNA sequence of the Dlx-2 cDNA.

PubMed ID: 1632970

DOI: 10.1016/0896-6273(92)90233-4

PubMed ID: 8812481

Title: Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus.

PubMed ID: 8812481

DOI: 10.1006/geno.1996.0387

PubMed ID: 1687503

Title: Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain.

PubMed ID: 1687503

PubMed ID: 8098616

Title: The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos.

PubMed ID: 8098616

DOI: 10.1016/0925-4773(93)90071-5

PubMed ID: 7893603

Title: Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development.

PubMed ID: 7893603

DOI: 10.1016/0925-4773(94)90060-4

PubMed ID: 21875655

Title: Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina.

PubMed ID: 21875655

DOI: 10.1016/j.neuroscience.2011.08.015

PubMed ID: 23371388

Title: Msx1 homeodomain protein represses the alphaGSU and GnRH receptor genes during gonadotrope development.

PubMed ID: 23371388

DOI: 10.1210/me.2012-1289

Sequence Information:

  • Length: 332
  • Mass: 34746
  • Checksum: FEC8483D1CAA71EA
  • Sequence:
    • MTGVFDSLVA DMHSTQITAS STYHQHQQPP SGAGAGPGGN SNSSSSNSSL HKPQESPTLP 
VSTATDSSYY TNQQHPAGGG GGGASPYAHM GSYQYHASGL NNVSYSAKSS YDLGYTAAYT 
SYAPYGTSSS PVNNEPDKED LEPEIRIVNG KPKKVRKPRT IYSSFQLAAL QRRFQKTQYL 
ALPERAELAA SLGLTQTQVK IWFQNRRSKF KKMWKSGEIP TEQHPGASAS PPCASPPVSA 
PASWDFGAPQ RMAGGGPGSG GGGAGSSGSS PSSAASAFLG NYPWYHQASG SASHLQATAP 
LLHPSQTPQA HHHHHHHHHA GGGAPVSAGT IF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.