Genular: Defining Cellular Identity and Function

Details for: Dlx5

Gene ID: 13395

Symbol: Dlx5

Ensembl ID: ENSMUSG00000029755

Description: distal-less homeobox 5

Associated with

Anatomical structure formation involved in morphogenesis
(GO:0048646)
Axon guidance
(GO:0007411)
Axonogenesis
(GO:0007409)
Bmp signaling pathway
(GO:0030509)
Bone morphogenesis
(GO:0060349)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Ear development
(GO:0043583)
Embryo development
(GO:0009790)
Embryonic limb morphogenesis
(GO:0030326)
Endochondral ossification
(GO:0001958)
Epithelial cell differentiation
(GO:0030855)
Face morphogenesis
(GO:0060325)
Head development
(GO:0060322)
Hmg box domain binding
(GO:0071837)
Inner ear morphogenesis
(GO:0042472)
Interneuron axon guidance
(GO:0097376)
Multicellular organism development
(GO:0007275)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Olfactory bulb interneuron differentiation
(GO:0021889)
Olfactory pit development
(GO:0060166)
Ossification
(GO:0001503)
Osteoblast differentiation
(GO:0001649)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Roof of mouth development
(GO:0060021)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription cis-regulatory region binding
(GO:0000976)

Other Information

Proteins

Homeobox protein DLX-5

Genular Protein ID: 894819426

Symbol: DLX5_MOUSE

Name: Homeobox protein DLX-5

UniProtKB Accession Codes:

P70396 O54876 O54877 O54878 Q9JJ45

Database IDs:

Citations:

PubMed ID: 8855272

Title: The evolution of the vertebrate Dlx gene family.

PubMed ID: 8855272

DOI: 10.1073/pnas.93.20.10858

PubMed ID: 10075846

Title: A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction.

PubMed ID: 10075846

DOI: 10.1006/dbio.1998.9197

PubMed ID: 9415433

Title: Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation.

PubMed ID: 9415433

DOI: 10.1002/(sici)1097-0177(199712)210:4<498::aid-aja12>3.0.co;2-3

PubMed ID: 9763476

Title: An early phase of embryonic Dlx5 expression defines the rostral boundary of the neural plate.

PubMed ID: 9763476

DOI: 10.1523/jneurosci.18-20-08322.1998

PubMed ID: 15383550

Title: Bone morphogenetic protein-2-induced alkaline phosphatase expression is stimulated by Dlx5 and repressed by Msx2.

PubMed ID: 15383550

DOI: 10.1074/jbc.m404145200

PubMed ID: 18056716

Title: BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38.

PubMed ID: 18056716

DOI: 10.1074/jbc.m704724200

PubMed ID: 19393622

Title: Calmodulin-dependent kinase II regulates Dlx5 during osteoblast differentiation.

PubMed ID: 19393622

DOI: 10.1016/j.bbrc.2009.04.082

PubMed ID: 19956613

Title: Dlx5 Is a cell autonomous regulator of chondrocyte hypertrophy in mice and functionally substitutes for Dlx6 during endochondral ossification.

PubMed ID: 19956613

DOI: 10.1371/journal.pone.0008097

Sequence Information:

Length: 289
Mass: 31396
Checksum: C53555610E9F8777
Sequence:

MTGVFDRRVP SIRSGDFQAP FPTSAAMHHP SQESPTLPES SATDSDYYSP AGAAPHGYCS 
PTSASYGKAL NPYQYQYHGV NGSAAGYPAK AYADYGYASP YHQYGGAYNR VPSATSQPEK 
EVAEPEVRMV NGKPKKVRKP RTIYSSFQLA ALQRRFQKTQ YLALPERAEL AASLGLTQTQ 
VKIWFQNKRS KIKKIMKNGE MPPEHSPSSS DPMACNSPQS PAVWEPQGSS RSLSHHPHAH 
PPTSNQSPAS SYLENSASWY PSAASSINSH LPPPGSLQHP LALASGTLY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dlx5

Associated with

Other Information

The evolution of the vertebrate Dlx gene family. PubMed ID: 8855272

A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction. PubMed ID: 10075846

Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation. PubMed ID: 9415433

An early phase of embryonic Dlx5 expression defines the rostral boundary of the neural plate. PubMed ID: 9763476

Bone morphogenetic protein-2-induced alkaline phosphatase expression is stimulated by Dlx5 and repressed by Msx2. PubMed ID: 15383550

BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38. PubMed ID: 18056716

Calmodulin-dependent kinase II regulates Dlx5 during osteoblast differentiation. PubMed ID: 19393622

Dlx5 Is a cell autonomous regulator of chondrocyte hypertrophy in mice and functionally substitutes for Dlx6 during endochondral ossification. PubMed ID: 19956613