Gene ADORA1 - ENSG00000163485 | NCBI Gene ID: 134

Details for: ADORA1

Gene ID: 134

Symbol: ADORA1

Ensembl ID: ENSG00000163485

Description: adenosine A1 receptor

Associated with

Adenosine p1 receptors
(R-HSA-417973)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Nucleotide-like (purinergic) receptors
(R-HSA-418038)
Signaling by gpcr
(R-HSA-372790)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Apoptotic signaling pathway
(GO:0097190)
Asymmetric synapse
(GO:0032279)
Axolemma
(GO:0030673)
Basolateral plasma membrane
(GO:0016323)
Calyx of held
(GO:0044305)
Cell-cell signaling
(GO:0007267)
Cognition
(GO:0050890)
Dendrite
(GO:0030425)
Dendritic spine
(GO:0043197)
Detection of temperature stimulus involved in sensory perception of pain
(GO:0050965)
Excitatory postsynaptic potential
(GO:0060079)
Fatty acid homeostasis
(GO:0055089)
G-protein beta/gamma-subunit complex binding
(GO:0031683)
G protein-coupled adenosine receptor activity
(GO:0001609)
G protein-coupled adenosine receptor signaling pathway
(GO:0001973)
G protein-coupled receptor binding
(GO:0001664)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heat shock protein binding
(GO:0031072)
Heterotrimeric g-protein binding
(GO:0032795)
Inflammatory response
(GO:0006954)
Leukocyte migration
(GO:0050900)
Lipid catabolic process
(GO:0016042)
Long-term synaptic depression
(GO:0060292)
Mucus secretion
(GO:0070254)
Negative regulation of acute inflammatory response
(GO:0002674)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of circadian sleep/wake cycle, non-rem sleep
(GO:0042323)
Negative regulation of glutamate secretion
(GO:0014050)
Negative regulation of hormone secretion
(GO:0046888)
Negative regulation of leukocyte migration
(GO:0002686)
Negative regulation of lipid catabolic process
(GO:0050995)
Negative regulation of long-term synaptic depression
(GO:1900453)
Negative regulation of long-term synaptic potentiation
(GO:1900272)
Negative regulation of mucus secretion
(GO:0070256)
Negative regulation of neurotrophin production
(GO:0032900)
Negative regulation of synaptic transmission, gabaergic
(GO:0032229)
Negative regulation of synaptic transmission, glutamatergic
(GO:0051967)
Negative regulation of systemic arterial blood pressure
(GO:0003085)
Nervous system development
(GO:0007399)
Neuronal cell body
(GO:0043025)
Phagocytosis
(GO:0006909)
Plasma membrane
(GO:0005886)
Positive regulation of lipid catabolic process
(GO:0050996)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of nucleoside transport
(GO:0032244)
Positive regulation of peptide secretion
(GO:0002793)
Positive regulation of potassium ion transport
(GO:0043268)
Positive regulation of protein dephosphorylation
(GO:0035307)
Positive regulation of systemic arterial blood pressure
(GO:0003084)
Postsynaptic membrane
(GO:0045211)
Presynaptic active zone
(GO:0048786)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein targeting to membrane
(GO:0006612)
Purine nucleoside binding
(GO:0001883)
Regulation of cardiac muscle cell contraction
(GO:0086004)
Regulation of glomerular filtration
(GO:0003093)
Regulation of presynaptic cytosolic calcium ion concentration
(GO:0099509)
Regulation of respiratory gaseous exchange by nervous system process
(GO:0002087)
Regulation of sensory perception of pain
(GO:0051930)
Response to hypoxia
(GO:0001666)
Response to inorganic substance
(GO:0010035)
Response to purine-containing compound
(GO:0014074)
Signal transduction
(GO:0007165)
Synapse
(GO:0045202)
Temperature homeostasis
(GO:0001659)
Terminal bouton
(GO:0043195)
Triglyceride homeostasis
(GO:0070328)
Vasodilation
(GO:0042311)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythrocyte (CL0000232)
Fold Change: 7.79
Marker Score: 4317
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 6.43
Marker Score: 8876
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 4.77
Marker Score: 2512
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.89
Marker Score: 790.5
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.49
Marker Score: 13993
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 870
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.32
Marker Score: 81476
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.25
Marker Score: 1925
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.23
Marker Score: 11705
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.22
Marker Score: 10489
Cell Name: goblet cell (CL0000160)
Fold Change: 1.13
Marker Score: 7491
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.01
Marker Score: 15763
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71816
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48040
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5349
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.94
Marker Score: 454
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.9
Marker Score: 1709
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5286
Cell Name: neuron (CL0000540)
Fold Change: 0.84
Marker Score: 3430
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.83
Marker Score: 1693.5
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.83
Marker Score: 824
Cell Name: podocyte (CL0000653)
Fold Change: 0.81
Marker Score: 301
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 608.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1261
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 708
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.77
Marker Score: 508
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.74
Marker Score: 15777
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.73
Marker Score: 4343.5
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.73
Marker Score: 1751.5
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.73
Marker Score: 754
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.7
Marker Score: 221
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: interneuron (CL0000099)
Fold Change: 0.67
Marker Score: 306
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.67
Marker Score: 827
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.64
Marker Score: 203
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.64
Marker Score: 187
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.62
Marker Score: 261
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.58
Marker Score: 382
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.57
Marker Score: 183
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.57
Marker Score: 451
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148.5
Cell Name: astrocyte (CL0000127)
Fold Change: 0.51
Marker Score: 438
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.51
Marker Score: 131
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.5
Marker Score: 836
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 475
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.47
Marker Score: 650
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.46
Marker Score: 1306
Cell Name: plasma cell (CL0000786)
Fold Change: 0.45
Marker Score: 503
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.45
Marker Score: 254
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.44
Marker Score: 120
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 372
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.37
Marker Score: 115
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.34
Marker Score: 12736
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.33
Marker Score: 157
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.32
Marker Score: 2490
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.32
Marker Score: 3326.5
Cell Name: fat cell (CL0000136)
Fold Change: 0.31
Marker Score: 176
Cell Name: microglial cell (CL0000129)
Fold Change: 0.3
Marker Score: 555
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.3
Marker Score: 1075
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.29
Marker Score: 177
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.29
Marker Score: 9882
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.29
Marker Score: 102
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.28
Marker Score: 163
Cell Name: mast cell (CL0000097)
Fold Change: 0.27
Marker Score: 154
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.26
Marker Score: 1085
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.26
Marker Score: 604
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.26
Marker Score: 3817
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.25
Marker Score: 74
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.24
Marker Score: 934
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.24
Marker Score: 295.5
Cell Name: granule cell (CL0000120)
Fold Change: 0.24
Marker Score: 1785
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.23
Marker Score: 138
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.22
Marker Score: 153
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.21
Marker Score: 81
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.21
Marker Score: 76
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.21
Marker Score: 873
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.21
Marker Score: 47
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.21
Marker Score: 54
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.2
Marker Score: 87
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.19
Marker Score: 88
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.19
Marker Score: 49
Cell Name: B cell (CL0000236)
Fold Change: 0.19
Marker Score: 182
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.19
Marker Score: 4222
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.19
Marker Score: 265
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.18
Marker Score: 65
Cell Name: macroglial cell (CL0000126)
Fold Change: 0.18
Marker Score: 408
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.18
Marker Score: 71.5
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.17
Marker Score: 6310
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.17
Marker Score: 33
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.17
Marker Score: 352
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.16
Marker Score: 161
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.16
Marker Score: 258
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.16
Marker Score: 84
Cell Name: T cell (CL0000084)
Fold Change: 0.16
Marker Score: 274
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.16
Marker Score: 79
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.16
Marker Score: 151.5

Hover over a box to see details here...

**Key characteristics:** * ADORA1 is a G protein-coupled receptor that belongs to the Class a/1 (rhodopsin-like receptors) of adenosine receptors. * It is a transmembrane protein with a single extracellular domain and a single transmembrane domain. * ADORA1 is expressed in high levels in cells that are involved in the regulation of respiratory gas exchange, such as erythrocytes, macrophages, and pneumocytes. **Pathways and functions:** * ADORA1 is a key regulator of respiratory gas exchange. It is expressed in the respiratory tissues of the lungs and is involved in the regulation of the opening and closing of ion channels in the lungs' airways. * ADORA1 is also involved in the regulation of inflammation. It is expressed in inflammatory cells, such as macrophages and neutrophils, and is involved in the production of inflammatory cytokines. * ADORA1 is also involved in temperature homeostasis. It is expressed in cells that are involved in thermoregulation, such as brown adipose tissue and sweat glands. ADORA1 is involved in the regulation of body temperature by controlling the release of heat from these tissues. **Clinical significance:** * Mutations in the ADORA1 gene have been linked to a number of respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. * ADORA1 is a potential therapeutic target for these diseases. By blocking ADORA1, it is possible to relieve the symptoms of these diseases. **Additional information:** * The ADORA1 gene is located on chromosome 15q21.1. * It is a single-exon gene. * It is encoded by a single transcript that is approximately 2.5 kilobases long. * There are two alternatively spliced variants of the ADORA1 gene, which encode for different isoforms of the protein.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Adenosine receptor A1

Genular Protein ID: 630303780

Symbol: AA1R_HUMAN

Name: Adenosine receptor A1

UniProtKB Accession Codes:

P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8

Database IDs:

Citations:

PubMed ID: 1530647

Title: Cloning and functional characterization of a human A1 adenosine receptor.

PubMed ID: 1530647

DOI: 10.1016/0006-291x(92)91285-x

PubMed ID: 1339301

Title: Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA.

PubMed ID: 1339301

DOI: 10.1016/0169-328x(92)90248-a

PubMed ID: 8300646

Title: Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing.

PubMed ID: 8300646

DOI: 10.1016/s0021-9258(17)42054-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 27134041

Title: Mutation in ADORA1 identified as likely cause of early-onset parkinsonism and cognitive dysfunction.

PubMed ID: 27134041

DOI: 10.1002/mds.26627

Sequence Information:

Length: 326
Mass: 36512
Checksum: 1B555893BCDEC9A6
Sequence:

MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA 
LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKMVVT 
PRRAAVAIAG CWILSFVVGL TPMFGWNNLS AVERAWAANG SMGEPVIKCE FEKVISMEYM 
VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL 
FLFALSWLPL HILNCITLFC PSCHKPSILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL 
KIWNDHFRCQ PAPPIDEDLP EERPDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ADORA1

Associated with

Cells (max top 100)

Other Information

Cloning and functional characterization of a human A1 adenosine receptor. PubMed ID: 1530647

Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA. PubMed ID: 1339301

Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing. PubMed ID: 8300646

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Mutation in ADORA1 identified as likely cause of early-onset parkinsonism and cognitive dysfunction. PubMed ID: 27134041