Details for: ADORA1

Gene ID: 134

Symbol: ADORA1

Ensembl ID: ENSG00000163485

Description: adenosine A1 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.1041
    Cell Significance Index: -12.2300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 11.6065
    Cell Significance Index: 198.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9158
    Cell Significance Index: 183.7000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7363
    Cell Significance Index: 16.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5627
    Cell Significance Index: 24.8900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.5367
    Cell Significance Index: 7.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5004
    Cell Significance Index: 18.9500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.4663
    Cell Significance Index: 6.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4636
    Cell Significance Index: 13.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3229
    Cell Significance Index: 21.7100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.1505
    Cell Significance Index: 1.6600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1198
    Cell Significance Index: 1.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0887
    Cell Significance Index: 61.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0818
    Cell Significance Index: 29.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0734
    Cell Significance Index: 5.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0610
    Cell Significance Index: 38.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0336
    Cell Significance Index: 4.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0305
    Cell Significance Index: 1.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0185
    Cell Significance Index: 3.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0099
    Cell Significance Index: 1.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0031
    Cell Significance Index: -4.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0050
    Cell Significance Index: -9.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0158
    Cell Significance Index: -11.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0160
    Cell Significance Index: -12.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0177
    Cell Significance Index: -9.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0182
    Cell Significance Index: -13.4500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0222
    Cell Significance Index: -0.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0249
    Cell Significance Index: -14.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0251
    Cell Significance Index: -11.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0278
    Cell Significance Index: -12.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0313
    Cell Significance Index: -1.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0324
    Cell Significance Index: -0.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0364
    Cell Significance Index: -10.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0427
    Cell Significance Index: -6.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0495
    Cell Significance Index: -8.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0607
    Cell Significance Index: -10.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0663
    Cell Significance Index: -13.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0802
    Cell Significance Index: -11.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0930
    Cell Significance Index: -11.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1055
    Cell Significance Index: -3.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1086
    Cell Significance Index: -11.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1145
    Cell Significance Index: -7.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1179
    Cell Significance Index: -3.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1227
    Cell Significance Index: -14.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1231
    Cell Significance Index: -3.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1247
    Cell Significance Index: -12.9800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1524
    Cell Significance Index: -1.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1657
    Cell Significance Index: -4.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1675
    Cell Significance Index: -12.4800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1800
    Cell Significance Index: -1.9300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1862
    Cell Significance Index: -2.3500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1930
    Cell Significance Index: -1.4900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2015
    Cell Significance Index: -2.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2018
    Cell Significance Index: -12.7200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2070
    Cell Significance Index: -2.4200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2076
    Cell Significance Index: -3.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2087
    Cell Significance Index: -7.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2114
    Cell Significance Index: -11.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2149
    Cell Significance Index: -12.0600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2212
    Cell Significance Index: -2.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2229
    Cell Significance Index: -11.6100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2300
    Cell Significance Index: -2.1800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2360
    Cell Significance Index: -3.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2648
    Cell Significance Index: -6.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2720
    Cell Significance Index: -14.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2737
    Cell Significance Index: -7.6500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2750
    Cell Significance Index: -4.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3119
    Cell Significance Index: -10.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3350
    Cell Significance Index: -8.8100
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.3377
    Cell Significance Index: -3.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3381
    Cell Significance Index: -12.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3660
    Cell Significance Index: -10.7800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3699
    Cell Significance Index: -7.9900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3753
    Cell Significance Index: -4.6600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3810
    Cell Significance Index: -4.3600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3867
    Cell Significance Index: -12.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3870
    Cell Significance Index: -7.7700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4112
    Cell Significance Index: -8.7900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4123
    Cell Significance Index: -5.3400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4131
    Cell Significance Index: -10.0800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4148
    Cell Significance Index: -5.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4193
    Cell Significance Index: -12.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4195
    Cell Significance Index: -10.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4422
    Cell Significance Index: -9.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4423
    Cell Significance Index: -12.6800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.4479
    Cell Significance Index: -5.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4523
    Cell Significance Index: -12.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4653
    Cell Significance Index: -11.8600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4696
    Cell Significance Index: -9.8000
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.4701
    Cell Significance Index: -4.7500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4799
    Cell Significance Index: -7.7000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4801
    Cell Significance Index: -19.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4855
    Cell Significance Index: -13.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4913
    Cell Significance Index: -9.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4986
    Cell Significance Index: -11.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5045
    Cell Significance Index: -13.4700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5055
    Cell Significance Index: -9.9500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5097
    Cell Significance Index: -12.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G-protein coupled receptor:** The A1 receptor is a G-protein coupled receptor (GPCR) that belongs to the class A/1 (rhodopsin-like receptors) family. 2. **Adenosine specificity:** The A1 receptor is specifically activated by adenosine, a purine nucleoside, and exhibits a high affinity for this ligand. 3. **Antagonist sensitivity:** The A1 receptor is sensitive to antagonists, such as 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), which can block its activity. 4. **Expression pattern:** The A1 receptor is widely expressed in the nervous system, immune system, and other tissues, including erythrocytes, double negative thymocytes, and hematopoietic stem cells. **Pathways and Functions:** 1. **Adenosine signaling pathway:** The A1 receptor is part of the adenosine signaling pathway, which regulates various physiological processes, including cardiovascular function, immune response, and neurotransmission. 2. **Inflammatory response:** The A1 receptor is involved in the regulation of the inflammatory response, and its dysregulation has been implicated in several inflammatory diseases. 3. **Apoptotic signaling pathway:** The A1 receptor is also involved in the regulation of the apoptotic signaling pathway, and its dysregulation has been implicated in several neurodegenerative disorders. 4. **Neurotransmission:** The A1 receptor is involved in the regulation of neurotransmission, particularly in the regulation of excitatory and inhibitory neurotransmission. 5. **Cardiovascular function:** The A1 receptor is involved in the regulation of cardiovascular function, including blood pressure regulation and cardiac muscle contraction. **Clinical Significance:** 1. **Cardiovascular disease:** The A1 receptor has been implicated in the pathogenesis of cardiovascular disease, including hypertension, heart failure, and atherosclerosis. 2. **Neurodegenerative disorders:** The A1 receptor has been implicated in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer:** The A1 receptor has been implicated in the regulation of cancer cell proliferation and survival, and its dysregulation has been implicated in several types of cancer. 4. **Inflammatory diseases:** The A1 receptor has been implicated in the pathogenesis of inflammatory diseases, including rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. In conclusion, the adenosine A1 receptor gene (ADORA1) plays a crucial role in various physiological and pathological processes, and its dysregulation has been implicated in several diseases. Further research is needed to fully understand the mechanisms of A1 receptor signaling and its clinical significance.

Genular Protein ID: 630303780

Symbol: AA1R_HUMAN

Name: Adenosine receptor A1

UniProtKB Accession Codes:

P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 19 DrugCentral 1 EMBL 14 Ensembl 4 ExpressionAtlas 1 GO 69 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1530647

Title: Cloning and functional characterization of a human A1 adenosine receptor.

PubMed ID: 1530647

DOI: 10.1016/0006-291x(92)91285-x

PubMed ID: 1339301

Title: Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA.

PubMed ID: 1339301

DOI: 10.1016/0169-328x(92)90248-a

PubMed ID: 8300646

Title: Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing.

PubMed ID: 8300646

DOI: 10.1016/s0021-9258(17)42054-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 27134041

Title: Mutation in ADORA1 identified as likely cause of early-onset parkinsonism and cognitive dysfunction.

PubMed ID: 27134041

DOI: 10.1002/mds.26627

Sequence Information:

  • Length: 326
  • Mass: 36512
  • Checksum: 1B555893BCDEC9A6
  • Sequence:
    • MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA 
LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKMVVT 
PRRAAVAIAG CWILSFVVGL TPMFGWNNLS AVERAWAANG SMGEPVIKCE FEKVISMEYM 
VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL 
FLFALSWLPL HILNCITLFC PSCHKPSILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL 
KIWNDHFRCQ PAPPIDEDLP EERPDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.