Details for: COX6B1

Gene ID: 1340

Symbol: COX6B1

Ensembl ID: ENSG00000126267

Description: cytochrome c oxidase subunit 6B1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.97
    Marker Score: 3751
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.42
    Marker Score: 2359.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.09
    Marker Score: 40495
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.05
    Marker Score: 10845
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.96
    Marker Score: 221407
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.87
    Marker Score: 7073
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.82
    Marker Score: 51282.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.8
    Marker Score: 44125
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.72
    Marker Score: 5729
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.64
    Marker Score: 23254
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.58
    Marker Score: 2803
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.57
    Marker Score: 12676
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.51
    Marker Score: 9702
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.49
    Marker Score: 46016
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.45
    Marker Score: 8699
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.45
    Marker Score: 3597
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.43
    Marker Score: 10767
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.42
    Marker Score: 1124
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.38
    Marker Score: 8257.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.38
    Marker Score: 5598
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.32
    Marker Score: 2964
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.32
    Marker Score: 2967
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.3
    Marker Score: 10418
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.3
    Marker Score: 24546
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.29
    Marker Score: 4283
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.28
    Marker Score: 2194
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.27
    Marker Score: 1987
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.25
    Marker Score: 17083
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.23
    Marker Score: 3099
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.23
    Marker Score: 25200
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.21
    Marker Score: 3677
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.21
    Marker Score: 111323
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.2
    Marker Score: 169166
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.2
    Marker Score: 3243
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.19
    Marker Score: 5704
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.19
    Marker Score: 20801
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.19
    Marker Score: 761
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.18
    Marker Score: 15244
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.17
    Marker Score: 5439
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.16
    Marker Score: 1166
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.16
    Marker Score: 2982
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.16
    Marker Score: 7201
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.16
    Marker Score: 3811
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.14
    Marker Score: 2477
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.13
    Marker Score: 6104
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.12
    Marker Score: 5864
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.11
    Marker Score: 7496
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.09
    Marker Score: 7012
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.08
    Marker Score: 3268.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.07
    Marker Score: 2182
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.06
    Marker Score: 3060
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.06
    Marker Score: 4330
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.05
    Marker Score: 13093
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.05
    Marker Score: 8908
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.05
    Marker Score: 4849
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.04
    Marker Score: 2387
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.03
    Marker Score: 1365
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.03
    Marker Score: 26319
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.03
    Marker Score: 1209
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.02
    Marker Score: 1559
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.02
    Marker Score: 1040
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.99
    Marker Score: 3193
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.99
    Marker Score: 4230
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.97
    Marker Score: 2875
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.96
    Marker Score: 1477
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.95
    Marker Score: 3280
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.95
    Marker Score: 11372
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.94
    Marker Score: 25339
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.92
    Marker Score: 19000
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.92
    Marker Score: 2562
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.91
    Marker Score: 1436
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.91
    Marker Score: 2476
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.9
    Marker Score: 769
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.9
    Marker Score: 1500
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.89
    Marker Score: 1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.89
    Marker Score: 98354
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.89
    Marker Score: 2186.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.88
    Marker Score: 1690
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.88
    Marker Score: 1854
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.87
    Marker Score: 4618
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.87
    Marker Score: 8508
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.86
    Marker Score: 3337
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.85
    Marker Score: 7994
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.85
    Marker Score: 2058
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.85
    Marker Score: 3095
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.84
    Marker Score: 3352
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.84
    Marker Score: 1291
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.84
    Marker Score: 908
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2.83
    Marker Score: 746
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.83
    Marker Score: 4639.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.83
    Marker Score: 18084
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.83
    Marker Score: 1771
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.82
    Marker Score: 4921
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.82
    Marker Score: 72129
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.81
    Marker Score: 2335
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.81
    Marker Score: 8017
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.79
    Marker Score: 3603
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.79
    Marker Score: 1323
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.79
    Marker Score: 5666
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.79
    Marker Score: 2366

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Other Information

**Key characteristics:** * The COX6B1 gene is located on chromosome 17p13.3. * It is a large gene with a length of approximately 2.8 megabase pairs. * The protein encoded by COX6B1 is a transmembrane protein that is found in the mitochondrial inner membrane. * It is a key enzyme in the citric acid (tca) cycle, which is a metabolic pathway that generates energy for cells. * It is also involved in the respiratory electron transport chain, which is a series of electron carriers that generate energy for cells. **Pathways and functions:** * The COX6B1 gene is involved in cellular respiration, the citric acid (tca) cycle, and the respiratory electron transport chain. * It is also involved in the regulation of metabolic genes by the tumor suppressor protein TP53. * Mutations in the COX6B1 gene have been linked to several human diseases, including cancer and heart disease. **Clinical significance:** * Targeting COX6B1 has been explored as a therapeutic strategy for cancer and other diseases that are characterized by oxidative stress and mitochondrial dysfunction. * Inhibitors of COX6B1 have been shown to inhibit tumor growth and metastasis. * Clinical trials of COX6B1 inhibitors are currently underway.

Genular Protein ID: 3802753109

Symbol: CX6B1_HUMAN

Name: Cytochrome c oxidase subunit 6B1

UniProtKB Accession Codes:

P14854 B2R5C9 Q6IBL4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 10 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2537962

Title: Nucleotide sequence of cDNA encoding subunit VIb of human cytochrome c oxidase.

PubMed ID: 2537962

DOI: 10.1093/nar/17.4.1766

PubMed ID: 2172092

Title: Isolation of cDNAs encoding subunit VIb of cytochrome c oxidase and steady-state levels of coxVIb mRNA in different tissues.

PubMed ID: 2172092

DOI: 10.1016/0378-1119(90)90237-l

PubMed ID: 1651883

Title: Human cytochrome c oxidase subunit VIb: characterization and mapping of a multigene family.

PubMed ID: 1651883

DOI: 10.1016/0378-1119(91)90082-m

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1647217

Title: Nucleotide sequence of the last exon of the gene for human cytochrome c oxidase subunit VIb and its flanking regions.

PubMed ID: 1647217

DOI: 10.1016/0167-4781(91)90027-j

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 30030519

Title: Structure of the intact 14-subunit human cytochrome c oxidase.

PubMed ID: 30030519

DOI: 10.1038/s41422-018-0071-1

PubMed ID: 18499082

Title: Severe infantile encephalomyopathy caused by a mutation in COX6B1, a nucleus-encoded subunit of cytochrome c oxidase.

PubMed ID: 18499082

DOI: 10.1016/j.ajhg.2008.05.002

PubMed ID: 24781756

Title: Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy.

PubMed ID: 24781756

DOI: 10.1038/ejhg.2014.85

Sequence Information:

  • Length: 86
  • Mass: 10192
  • Checksum: 15C8B056491FB248
  • Sequence:
    • MAEDMETKIK NYKTAPFDSR FPNQNQTRNC WQNYLDFHRC QKAMTAKGGD ISVCEWYQRV 
YQSLCPTSWV TDWDEQRAEG TFPGKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.