Details for: Dnmt3a
Associated with
Other Information
Genular Protein ID: 2983818514
Symbol: DNM3A_MOUSE
Name: DNA (cytosine-5)-methyltransferase 3A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9662389
Title: Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases.
PubMed ID: 9662389
DOI: 10.1038/890
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 12138111
Title: A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.
PubMed ID: 12138111
PubMed ID: 10555141
Title: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
PubMed ID: 10555141
PubMed ID: 11399089
Title: Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG correction sites.
PubMed ID: 11399089
PubMed ID: 11350943
Title: Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription.
PubMed ID: 11350943
PubMed ID: 11919202
Title: Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases.
PubMed ID: 11919202
PubMed ID: 12616525
Title: Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1.
PubMed ID: 12616525
DOI: 10.1002/jcb.10457
PubMed ID: 15456878
Title: The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin.
PubMed ID: 15456878
PubMed ID: 15215868
Title: Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.
PubMed ID: 15215868
DOI: 10.1038/nature02633
PubMed ID: 14752048
Title: Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription.
PubMed ID: 14752048
DOI: 10.1093/nar/gkh195
PubMed ID: 15671018
Title: Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L.
PubMed ID: 15671018
PubMed ID: 16567415
Title: Distinct DNA methylation activity of Dnmt3a and Dnmt3b towards naked and nucleosomal DNA.
PubMed ID: 16567415
DOI: 10.1093/jb/mvj044
PubMed ID: 16472822
Title: Mutational analysis of the catalytic domain of the murine Dnmt3a DNA-(cytosine C5)-methyltransferase.
PubMed ID: 16472822
PubMed ID: 16357870
Title: The Polycomb group protein EZH2 directly controls DNA methylation.
PubMed ID: 16357870
DOI: 10.1038/nature04431
PubMed ID: 17713477
Title: Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation.
PubMed ID: 17713477
DOI: 10.1038/nature06146
PubMed ID: 18823905
Title: Mouse Dnmt3a preferentially methylates linker DNA and is inhibited by histone H1.
PubMed ID: 18823905
PubMed ID: 19798101
Title: Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells.
PubMed ID: 19798101
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 20547484
Title: The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation.
PubMed ID: 20547484
PubMed ID: 21481189
Title: Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue.
PubMed ID: 21481189
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 30478443
Title: Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions.
PubMed ID: 30478443
PubMed ID: 32674113
Title: SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation.
PubMed ID: 32674113
Sequence Information:
- Length: 908
- Mass: 101672
- Checksum: 5F98D5A8092C84A5
- Sequence:
MPSSGPGDTS SSSLEREDDR KEGEEQEENR GKEERQEPSA TARKVGRPGR KRKHPPVESS DTPKDPAVTT KSQPMAQDSG PSDLLPNGDL EKRSEPQPEE GSPAAGQKGG APAEGEGTET PPEASRAVEN GCCVTKEGRG ASAGEGKEQK QTNIESMKME GSRGRLRGGL GWESSLRQRP MPRLTFQAGD PYYISKRKRD EWLARWKREA EKKAKVIAVM NAVEENQASG ESQKVEEASP PAVQQPTDPA SPTVATTPEP VGGDAGDKNA TKAADDEPEY EDGRGFGIGE LVWGKLRGFS WWPGRIVSWW MTGRSRAAEG TRWVMWFGDG KFSVVCVEKL MPLSSFCSAF HQATYNKQPM YRKAIYEVLQ VASSRAGKLF PACHDSDESD SGKAVEVQNK QMIEWALGGF QPSGPKGLEP PEEEKNPYKE VYTDMWVEPE AAAYAPPPPA KKPRKSTTEK PKVKEIIDER TRERLVYEVR QKCRNIEDIC ISCGSLNVTL EHPLFIGGMC QNCKNCFLEC AYQYDDDGYQ SYCTICCGGR EVLMCGNNNC CRCFCVECVD LLVGPGAAQA AIKEDPWNCY MCGHKGTYGL LRRREDWPSR LQMFFANNHD QEFDPPKVYP PVPAEKRKPI RVLSLFDGIA TGLLVLKDLG IQVDRYIASE VCEDSITVGM VRHQGKIMYV GDVRSVTQKH IQEWGPFDLV IGGSPCNDLS IVNPARKGLY EGTGRLFFEF YRLLHDARPK EGDDRPFFWL FENVVAMGVS DKRDISRFLE SNPVMIDAKE VSAAHRARYF WGNLPGMNRP LASTVNDKLE LQECLEHGRI AKFSKVRTIT TRSNSIKQGK DQHFPVFMNE KEDILWCTEM ERVFGFPVHY TDVSNMSRLA RQRLLGRSWS VPVIRHLFAP LKEYFACV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.