COX6C | ENSG00000164919 | NCBI 1345

Details for: COX6C

Gene ID: 1345

Symbol: COX6C

Ensembl ID: ENSG00000164919

Description: cytochrome c oxidase subunit 6C

Associated with

Aerobic respiration and respiratory electron transport
(R-HSA-1428517)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Complex iv assembly
(R-HSA-9864848)
Cytoprotection by hmox1
(R-HSA-9707564)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism
(R-HSA-1430728)
Respiratory electron transport
(R-HSA-611105)
Rna polymerase ii transcription
(R-HSA-73857)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cellular respiration
(GO:0045333)
Generation of precursor metabolites and energy
(GO:0006091)
Mitochondrial electron transport, cytochrome c to oxygen
(GO:0006123)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial intermembrane space
(GO:0005758)
Mitochondrial membrane
(GO:0031966)
Mitochondrion
(GO:0005739)
Protein binding
(GO:0005515)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cell in vitro (CL0001034)
Fold Change: 2.5
Cell Significance Index: 4
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.81
Cell Significance Index: 3
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.74
Cell Significance Index: 2
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.64
Cell Significance Index: 2
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.53
Cell Significance Index: 2
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.33
Cell Significance Index: 1
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.21
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.2
Cell Significance Index: 1
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.18
Cell Significance Index: 1
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.15
Cell Significance Index: 1
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.14
Cell Significance Index: 1
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: lactocyte (CL0002325)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.09
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: kidney cell (CL1000497)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: peg cell (CL4033014)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1
Cell Significance Index: 1
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: odontoblast (CL0000060)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: germ cell (CL0000586)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: enterocyte (CL0000584)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: centroblast (CL0009112)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: melanocyte of skin (CL1000458)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: stem cell (CL0000034)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: granular cell of epidermis (CL0002189)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: precursor cell (CL0011115)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: colonocyte (CL1000347)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.96
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** COX6C is a mitochondrial protein that belongs to the cytochrome c oxidase family. It is a small subunit of the cytochrome c oxidase complex, which is the terminal enzyme of the mitochondrial electron transport chain. The COX6C gene encodes a 51-amino acid protein that is highly conserved across species, suggesting its essential role in maintaining cellular function. The protein is localized to the inner mitochondrial membrane, where it interacts with other subunits to facilitate electron transfer and ATP production. **Pathways and Functions** COX6C is involved in several critical cellular processes, including: 1. **Cellular Respiration**: COX6C plays a key role in the electron transport chain, where it helps to generate ATP through the transfer of electrons from cytochrome c to oxygen. 2. **Cytoprotection**: COX6C is involved in the regulation of mitochondrial function and has been implicated in the protection of cells against oxidative stress and damage. 3. **Metabolism**: COX6C is essential for the production of ATP, which is necessary for various cellular processes, including energy-dependent transport and biosynthesis. 4. **Regulation of Gene Expression**: COX6C has been shown to interact with transcription factors, such as TP53, to regulate the expression of genes involved in metabolism and energy production. **Clinical Significance** Dysregulation of COX6C has been implicated in various diseases, including: 1. **Mitochondrial Disorders**: Mutations in the COX6C gene have been associated with mitochondrial disorders, such as Leigh syndrome, which is characterized by progressive neurological deterioration and death. 2. **Cancer**: Overexpression of COX6C has been observed in certain types of cancer, including lung and breast cancer, suggesting its potential role in tumor progression and metastasis. 3. **Cardiovascular Disease**: COX6C has been implicated in the development of cardiovascular disease, including atherosclerosis and heart failure, due to its role in energy production and oxidative stress regulation. 4. **Neurodegenerative Diseases**: COX6C has been shown to play a role in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, due to its involvement in energy production and oxidative stress regulation. In conclusion, COX6C is a critical component of the mitochondrial respiratory chain, playing a pivotal role in cellular respiration, cytoprotection, and metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and overall health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.