Details for: COX6C

Gene ID: 1345

Symbol: COX6C

Ensembl ID: ENSG00000164919

Description: cytochrome c oxidase subunit 6C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 853.8031
    Cell Significance Index: -132.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 505.5129
    Cell Significance Index: -128.2200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 407.4304
    Cell Significance Index: -167.8400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 360.0675
    Cell Significance Index: -146.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 347.8969
    Cell Significance Index: -164.2500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 314.3461
    Cell Significance Index: -161.7000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 245.3123
    Cell Significance Index: -164.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 154.8165
    Cell Significance Index: -147.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 125.7547
    Cell Significance Index: -155.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 41.8571
    Cell Significance Index: -165.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 40.7748
    Cell Significance Index: -109.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 40.1438
    Cell Significance Index: -123.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 6.5721
    Cell Significance Index: 345.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.5766
    Cell Significance Index: 765.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.9353
    Cell Significance Index: 367.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.4325
    Cell Significance Index: 799.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.2580
    Cell Significance Index: 523.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.9127
    Cell Significance Index: 2136.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.7868
    Cell Significance Index: 446.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.7775
    Cell Significance Index: 79.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.6777
    Cell Significance Index: 1626.0200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.5910
    Cell Significance Index: 22.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.4755
    Cell Significance Index: 80.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.4706
    Cell Significance Index: 163.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.3392
    Cell Significance Index: 90.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.3223
    Cell Significance Index: 234.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.8848
    Cell Significance Index: 26.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.7970
    Cell Significance Index: 130.4100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.7622
    Cell Significance Index: 31.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.6933
    Cell Significance Index: 79.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.5887
    Cell Significance Index: 68.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.5806
    Cell Significance Index: 116.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.2774
    Cell Significance Index: 294.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.2203
    Cell Significance Index: 284.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0741
    Cell Significance Index: 133.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.0006
    Cell Significance Index: 197.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4415
    Cell Significance Index: 38.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0524
    Cell Significance Index: 200.2900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.0195
    Cell Significance Index: 8.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0187
    Cell Significance Index: 35.4000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9315
    Cell Significance Index: 11.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7894
    Cell Significance Index: 134.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7807
    Cell Significance Index: 156.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7537
    Cell Significance Index: 39.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.6136
    Cell Significance Index: 464.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.6052
    Cell Significance Index: 443.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5204
    Cell Significance Index: 84.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4717
    Cell Significance Index: 8.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4352
    Cell Significance Index: 86.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2681
    Cell Significance Index: 96.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2356
    Cell Significance Index: 8.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1363
    Cell Significance Index: 8.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.1028
    Cell Significance Index: 8.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0827
    Cell Significance Index: 2.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0669
    Cell Significance Index: 1.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0438
    Cell Significance Index: 0.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0293
    Cell Significance Index: -55.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0311
    Cell Significance Index: -19.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0438
    Cell Significance Index: -32.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0856
    Cell Significance Index: -8.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0904
    Cell Significance Index: -166.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1137
    Cell Significance Index: -175.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1373
    Cell Significance Index: -186.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1685
    Cell Significance Index: -107.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1755
    Cell Significance Index: -9.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1788
    Cell Significance Index: -100.8300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2410
    Cell Significance Index: -2.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2545
    Cell Significance Index: -115.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2855
    Cell Significance Index: -60.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3434
    Cell Significance Index: -21.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3737
    Cell Significance Index: -5.6000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3771
    Cell Significance Index: -3.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4389
    Cell Significance Index: -50.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4718
    Cell Significance Index: -15.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4800
    Cell Significance Index: -138.1200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.6722
    Cell Significance Index: -10.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7817
    Cell Significance Index: -19.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.8461
    Cell Significance Index: -122.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8948
    Cell Significance Index: -104.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9767
    Cell Significance Index: -21.1600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0033
    Cell Significance Index: -114.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1587
    Cell Significance Index: -88.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.3143
    Cell Significance Index: -36.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.5177
    Cell Significance Index: -104.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.5653
    Cell Significance Index: -162.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.6575
    Cell Significance Index: -93.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.6843
    Cell Significance Index: -22.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.6930
    Cell Significance Index: -101.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.7707
    Cell Significance Index: -37.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.8486
    Cell Significance Index: -124.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.2176
    Cell Significance Index: -59.3200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.6596
    Cell Significance Index: -22.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.6626
    Cell Significance Index: -163.2500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.6693
    Cell Significance Index: -31.8200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.8436
    Cell Significance Index: -49.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.0301
    Cell Significance Index: -89.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -3.0371
    Cell Significance Index: -31.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.1824
    Cell Significance Index: -140.7700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.2358
    Cell Significance Index: -19.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -3.3668
    Cell Significance Index: -97.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** COX6C is a mitochondrial protein that belongs to the cytochrome c oxidase family. It is a small subunit of the cytochrome c oxidase complex, which is the terminal enzyme of the mitochondrial electron transport chain. The COX6C gene encodes a 51-amino acid protein that is highly conserved across species, suggesting its essential role in maintaining cellular function. The protein is localized to the inner mitochondrial membrane, where it interacts with other subunits to facilitate electron transfer and ATP production. **Pathways and Functions** COX6C is involved in several critical cellular processes, including: 1. **Cellular Respiration**: COX6C plays a key role in the electron transport chain, where it helps to generate ATP through the transfer of electrons from cytochrome c to oxygen. 2. **Cytoprotection**: COX6C is involved in the regulation of mitochondrial function and has been implicated in the protection of cells against oxidative stress and damage. 3. **Metabolism**: COX6C is essential for the production of ATP, which is necessary for various cellular processes, including energy-dependent transport and biosynthesis. 4. **Regulation of Gene Expression**: COX6C has been shown to interact with transcription factors, such as TP53, to regulate the expression of genes involved in metabolism and energy production. **Clinical Significance** Dysregulation of COX6C has been implicated in various diseases, including: 1. **Mitochondrial Disorders**: Mutations in the COX6C gene have been associated with mitochondrial disorders, such as Leigh syndrome, which is characterized by progressive neurological deterioration and death. 2. **Cancer**: Overexpression of COX6C has been observed in certain types of cancer, including lung and breast cancer, suggesting its potential role in tumor progression and metastasis. 3. **Cardiovascular Disease**: COX6C has been implicated in the development of cardiovascular disease, including atherosclerosis and heart failure, due to its role in energy production and oxidative stress regulation. 4. **Neurodegenerative Diseases**: COX6C has been shown to play a role in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, due to its involvement in energy production and oxidative stress regulation. In conclusion, COX6C is a critical component of the mitochondrial respiratory chain, playing a pivotal role in cellular respiration, cytoprotection, and metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and overall health.

Genular Protein ID: 3397587353

Symbol: COX6C_HUMAN

Name: Cytochrome c oxidase subunit 6C

UniProtKB Accession Codes:

P09669 B2R4D7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 7 Ensembl 10 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2849755

Title: Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc.

PubMed ID: 2849755

DOI: 10.1093/nar/16.22.10916

PubMed ID: 10072584

Title: Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping.

PubMed ID: 10072584

DOI: 10.1159/000015185

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 30030519

Title: Structure of the intact 14-subunit human cytochrome c oxidase.

PubMed ID: 30030519

DOI: 10.1038/s41422-018-0071-1

Sequence Information:

  • Length: 75
  • Mass: 8781
  • Checksum: D09FEE0C0AA7A798
  • Sequence:
    • MAPEVLPKPR MRGLLARRLR NHMAVAFVLS LGVAALYKFR VADQRKKAYA DFYRNYDVMK 
DFEEMRKAGI FQSVK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.