Details for: COX7A1

Gene ID: 1346

Symbol: COX7A1

Ensembl ID: ENSG00000161281

Description: cytochrome c oxidase subunit 7A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 137.2399
    Cell Significance Index: -34.8100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 100.5710
    Cell Significance Index: -41.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 66.9529
    Cell Significance Index: -31.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.1896
    Cell Significance Index: -26.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.6988
    Cell Significance Index: -27.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7353
    Cell Significance Index: -34.4700
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 3.7430
    Cell Significance Index: 13.9500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.9343
    Cell Significance Index: 24.2700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.7530
    Cell Significance Index: 21.2200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.7171
    Cell Significance Index: 48.0200
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 2.5568
    Cell Significance Index: 9.7900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.5531
    Cell Significance Index: 41.2000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.5300
    Cell Significance Index: 61.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.9877
    Cell Significance Index: 104.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.6267
    Cell Significance Index: 18.4800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.4466
    Cell Significance Index: 8.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3483
    Cell Significance Index: 38.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3437
    Cell Significance Index: 172.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2185
    Cell Significance Index: 56.8100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.2165
    Cell Significance Index: 12.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1742
    Cell Significance Index: 161.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7543
    Cell Significance Index: 39.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7397
    Cell Significance Index: 46.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.4965
    Cell Significance Index: 7.3300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.4397
    Cell Significance Index: 2.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4341
    Cell Significance Index: 33.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.2622
    Cell Significance Index: 20.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2247
    Cell Significance Index: 38.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2093
    Cell Significance Index: 153.4600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1702
    Cell Significance Index: 1.4300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1416
    Cell Significance Index: 2.1900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1183
    Cell Significance Index: 1.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1031
    Cell Significance Index: 20.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0655
    Cell Significance Index: 29.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0645
    Cell Significance Index: 8.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0527
    Cell Significance Index: 39.0200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0429
    Cell Significance Index: 0.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0294
    Cell Significance Index: 1.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0277
    Cell Significance Index: 9.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0134
    Cell Significance Index: -25.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0228
    Cell Significance Index: -12.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0244
    Cell Significance Index: -15.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0250
    Cell Significance Index: -15.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0255
    Cell Significance Index: -47.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0293
    Cell Significance Index: -12.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0309
    Cell Significance Index: -47.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0349
    Cell Significance Index: -47.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0431
    Cell Significance Index: -32.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0507
    Cell Significance Index: -27.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0546
    Cell Significance Index: -15.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0731
    Cell Significance Index: -15.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0759
    Cell Significance Index: -1.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0954
    Cell Significance Index: -17.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1231
    Cell Significance Index: -17.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1327
    Cell Significance Index: -1.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1577
    Cell Significance Index: -18.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1647
    Cell Significance Index: -32.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1790
    Cell Significance Index: -18.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1947
    Cell Significance Index: -23.9500
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: -0.2059
    Cell Significance Index: -0.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2370
    Cell Significance Index: -16.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2389
    Cell Significance Index: -6.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2572
    Cell Significance Index: -13.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2709
    Cell Significance Index: -30.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2727
    Cell Significance Index: -32.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2772
    Cell Significance Index: -20.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2955
    Cell Significance Index: -34.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3044
    Cell Significance Index: -31.7000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3623
    Cell Significance Index: -4.6400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4032
    Cell Significance Index: -16.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4207
    Cell Significance Index: -8.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4488
    Cell Significance Index: -12.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4567
    Cell Significance Index: -9.5600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4641
    Cell Significance Index: -9.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4743
    Cell Significance Index: -31.8900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.4870
    Cell Significance Index: -4.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4907
    Cell Significance Index: -31.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5008
    Cell Significance Index: -30.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5228
    Cell Significance Index: -32.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6026
    Cell Significance Index: -26.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6362
    Cell Significance Index: -17.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6556
    Cell Significance Index: -36.7900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.6656
    Cell Significance Index: -4.7800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6869
    Cell Significance Index: -9.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7252
    Cell Significance Index: -25.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7365
    Cell Significance Index: -4.4500
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.7454
    Cell Significance Index: -5.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7491
    Cell Significance Index: -38.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7686
    Cell Significance Index: -24.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7799
    Cell Significance Index: -27.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8359
    Cell Significance Index: -24.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8390
    Cell Significance Index: -37.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8552
    Cell Significance Index: -28.0000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.8569
    Cell Significance Index: -9.6800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8592
    Cell Significance Index: -31.5400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.9001
    Cell Significance Index: -9.7900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.9194
    Cell Significance Index: -11.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9521
    Cell Significance Index: -25.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9903
    Cell Significance Index: -37.5000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.0554
    Cell Significance Index: -26.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** COX7A1 is a mitochondrial protein that belongs to the cytochrome c oxidase family. It is composed of 167 amino acids and is highly conserved across species. The protein is localized to the intermembrane space of mitochondria and is involved in the transfer of electrons from cytochrome c to oxygen, resulting in the production of water and ATP. COX7A1 is also known to interact with other proteins, including cytochrome c oxidase subunit 1 (COX1), cytochrome c oxidase subunit 2 (COX2), and cytochrome c oxidase subunit 3 (COX3), to form the mitochondrial respiratory chain complex IV. **Pathways and Functions:** COX7A1 is integral to several key pathways, including: 1. **Mitochondrial Electron Transport Chain:** COX7A1 plays a critical role in the electron transport chain, facilitating the transfer of electrons from cytochrome c to oxygen, resulting in the production of ATP. 2. **Generation of Precursor Metabolites and Energy:** COX7A1 is involved in the generation of precursor metabolites, such as NADH and FADH2, which are essential for energy production in cells. 3. **Mitochondrial Respirasome Assembly:** COX7A1 is required for the assembly of the mitochondrial respirasome, a complex of proteins that facilitates the electron transport chain. 4. **Proton Transmembrane Transport:** COX7A1 is involved in the transport of protons across the mitochondrial inner membrane, facilitating the production of ATP. **Clinical Significance:** Dysregulation of COX7A1 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders:** Mutations in COX7A1 have been associated with neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease. 2. **Metabolic Disorders:** COX7A1 dysfunction has been linked to metabolic disorders, such as mitochondrial myopathies and Kearns-Sayre syndrome. 3. **Cardiovascular Diseases:** COX7A1 has been implicated in cardiovascular diseases, including heart failure and arrhythmias. 4. **Cancer:** COX7A1 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer. In conclusion, COX7A1 is a critical component of the mitochondrial respiratory chain complex IV, playing a vital role in energy production and precursor metabolite generation. Dysregulation of COX7A1 has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis. Further research is necessary to fully understand the mechanisms underlying COX7A1 dysfunction and to develop effective therapeutic strategies for the treatment of related diseases.

Genular Protein ID: 353941854

Symbol: CX7A1_HUMAN

Name: Cytochrome c oxidase subunit 7A1, mitochondrial

UniProtKB Accession Codes:

P24310

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1327965

Title: Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase.

PubMed ID: 1327965

DOI: 10.1016/0378-1119(92)90287-y

PubMed ID: 9344674

Title: Genomic sequence and organization of the human gene for cytochrome c oxidase subunit (COX7A1) VIIa-M.

PubMed ID: 9344674

DOI: 10.1006/geno.1997.4937

PubMed ID: 11997101

Title: Genomic organization and promoter regulation of human cytochrome c oxidase subunit VII heart/muscle isoform (COX7AH).

PubMed ID: 11997101

DOI: 10.1016/s0167-4781(02)00228-2

PubMed ID: 10335655

Title: Molecular evolution of the COX7A gene family in primates.

PubMed ID: 10335655

DOI: 10.1093/oxfordjournals.molbev.a026144

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1309697

Title: Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.

PubMed ID: 1309697

DOI: 10.1111/j.1432-1033.1992.tb19847.x

Sequence Information:

  • Length: 79
  • Mass: 9118
  • Checksum: AFE9C00C53CE35C2
  • Sequence:
    • MQALRVSQAL IRSFSSTARN RFQNRVREKQ KLFQEDNDIP LYLKGGIVDN ILYRVTMTLC 
LGGTVYSLYS LGWASFPRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.