Details for: COX7A1

Gene ID: 1346

Symbol: COX7A1

Ensembl ID: ENSG00000161281

Description: cytochrome c oxidase subunit 7A1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 3.26
    Marker Score: 4686
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.95
    Marker Score: 2099
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.65
    Marker Score: 2831.5
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.59
    Marker Score: 853
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.45
    Marker Score: 4603
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.39
    Marker Score: 8858
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.38
    Marker Score: 3952
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.25
    Marker Score: 9700
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.22
    Marker Score: 628
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.19
    Marker Score: 5859
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.17
    Marker Score: 3142
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.1
    Marker Score: 1120.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.06
    Marker Score: 1960
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.04
    Marker Score: 5341
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.04
    Marker Score: 4068
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.99
    Marker Score: 1658
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.94
    Marker Score: 4919
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.93
    Marker Score: 21776
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.93
    Marker Score: 2647.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9
    Marker Score: 4332
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.85
    Marker Score: 2413
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.8
    Marker Score: 419
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.78
    Marker Score: 1170
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.75
    Marker Score: 1855
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.73
    Marker Score: 38675.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.73
    Marker Score: 506
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.69
    Marker Score: 3433
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.69
    Marker Score: 57368
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.65
    Marker Score: 1418
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.64
    Marker Score: 378
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.57
    Marker Score: 1901
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.57
    Marker Score: 352
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.54
    Marker Score: 975
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.54
    Marker Score: 1549
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.48
    Marker Score: 1396
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.46
    Marker Score: 1799
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.44
    Marker Score: 841
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.44
    Marker Score: 2435
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.43
    Marker Score: 596
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.39
    Marker Score: 1184
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.38
    Marker Score: 2257
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.33
    Marker Score: 2055
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.33
    Marker Score: 532
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.31
    Marker Score: 1852
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.3
    Marker Score: 285
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.3
    Marker Score: 1257
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.29
    Marker Score: 1278
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.28
    Marker Score: 327
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.26
    Marker Score: 1131
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.25
    Marker Score: 443
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.25
    Marker Score: 517
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.24
    Marker Score: 297
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.23
    Marker Score: 3515
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.23
    Marker Score: 1320
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.2
    Marker Score: 300
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.2
    Marker Score: 736
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.19
    Marker Score: 300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.18
    Marker Score: 1067
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.13
    Marker Score: 485
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.12
    Marker Score: 523
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.11
    Marker Score: 2442.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.11
    Marker Score: 273
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.1
    Marker Score: 1038
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.1
    Marker Score: 1597
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.07
    Marker Score: 415
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.06
    Marker Score: 1114
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.05
    Marker Score: 267
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.04
    Marker Score: 221
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251752
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.03
    Marker Score: 272
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.03
    Marker Score: 3667
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.01
    Marker Score: 1028
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.01
    Marker Score: 367
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1
    Marker Score: 283
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71772
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47996.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.99
    Marker Score: 1876
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.99
    Marker Score: 261.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.98
    Marker Score: 1147
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.96
    Marker Score: 400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14917
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.95
    Marker Score: 543
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.95
    Marker Score: 494
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.94
    Marker Score: 6128
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.94
    Marker Score: 8210
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.93
    Marker Score: 829
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.92
    Marker Score: 1603
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.92
    Marker Score: 273
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.9
    Marker Score: 255.5
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.9
    Marker Score: 407
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.88
    Marker Score: 11718
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.87
    Marker Score: 668
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5264
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.86
    Marker Score: 297
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4883
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.85
    Marker Score: 533
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.85
    Marker Score: 4161

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Other Information

**Key characteristics:** * The COX7A1 gene is located on chromosome 15q26.1. * It is a large gene with a length of approximately 13.5 kb. * The protein encoded by the COX7A1 gene is a transmembrane protein with a molecular weight of approximately 170 kDa. * It is a member of the cytochrome c oxidase family of proteins. **Pathways and functions:** * The COX7A1 protein is localized to the mitochondrial outer membrane. * It is involved in the electron transport chain, which is a series of protein complexes that pass electrons from one to another. * The electron transport chain is responsible for the production of ATP from the hydrolysis of glucose. * Cytochrome c oxidase activity is regulated by a number of factors, including the levels of ATP and oxygen. * When the levels of ATP and oxygen are high, the electron transport chain is inhibited, which leads to a decrease in cytochrome c oxidase activity. * This inhibition prevents the production of ATP, which can lead to cellular fatigue and death. **Clinical significance:** * Mutations in the COX7A1 gene have been linked to a number of human diseases, including mitochondrial disorders and metabolic syndrome. * These diseases are characterized by a decrease in cytochrome c oxidase activity, which can lead to a decrease in ATP production and cell death. * Targeting the COX7A1 gene has been investigated as a potential treatment for these diseases. * However, clinical trials of COX7A1 inhibitors have not been successful to date. **Additional information:** * The COX7A1 gene is also known as SLC24A1. * It is a highly conserved gene, with a similar gene found in other vertebrates. * The COX7A1 protein is a key regulator of mitochondrial respiration. * It is a target for therapeutic intervention in mitochondrial disorders.

Genular Protein ID: 353941854

Symbol: CX7A1_HUMAN

Name: Cytochrome c oxidase subunit 7A1, mitochondrial

UniProtKB Accession Codes:

P24310

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1327965

Title: Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase.

PubMed ID: 1327965

DOI: 10.1016/0378-1119(92)90287-y

PubMed ID: 9344674

Title: Genomic sequence and organization of the human gene for cytochrome c oxidase subunit (COX7A1) VIIa-M.

PubMed ID: 9344674

DOI: 10.1006/geno.1997.4937

PubMed ID: 11997101

Title: Genomic organization and promoter regulation of human cytochrome c oxidase subunit VII heart/muscle isoform (COX7AH).

PubMed ID: 11997101

DOI: 10.1016/s0167-4781(02)00228-2

PubMed ID: 10335655

Title: Molecular evolution of the COX7A gene family in primates.

PubMed ID: 10335655

DOI: 10.1093/oxfordjournals.molbev.a026144

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1309697

Title: Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.

PubMed ID: 1309697

DOI: 10.1111/j.1432-1033.1992.tb19847.x

Sequence Information:

  • Length: 79
  • Mass: 9118
  • Checksum: AFE9C00C53CE35C2
  • Sequence:
    • MQALRVSQAL IRSFSSTARN RFQNRVREKQ KLFQEDNDIP LYLKGGIVDN ILYRVTMTLC 
LGGTVYSLYS LGWASFPRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.