Details for: COX7A2

Gene ID: 1347

Symbol: COX7A2

Ensembl ID: ENSG00000112695

Description: cytochrome c oxidase subunit 7A2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 5.07
    Marker Score: 2704
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.69
    Marker Score: 3670
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.38
    Marker Score: 8002
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.35
    Marker Score: 3283
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.09
    Marker Score: 4936
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.04
    Marker Score: 6226.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.95
    Marker Score: 39076
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.94
    Marker Score: 1453
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.83
    Marker Score: 9366
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.81
    Marker Score: 3595
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.79
    Marker Score: 10159.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.64
    Marker Score: 4743
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.57
    Marker Score: 1608
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.53
    Marker Score: 22520
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.51
    Marker Score: 9702
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.49
    Marker Score: 6553
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.49
    Marker Score: 40528
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.47
    Marker Score: 45736
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.44
    Marker Score: 22448
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.42
    Marker Score: 3566
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.42
    Marker Score: 25441
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.42
    Marker Score: 1178
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.41
    Marker Score: 115949
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.39
    Marker Score: 2414
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.38
    Marker Score: 3011
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.36
    Marker Score: 10561
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.34
    Marker Score: 2846
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.32
    Marker Score: 9479
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.31
    Marker Score: 5494
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.27
    Marker Score: 3491
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.26
    Marker Score: 182562
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.25
    Marker Score: 28216.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.24
    Marker Score: 2554
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.23
    Marker Score: 5140
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.22
    Marker Score: 111662
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.21
    Marker Score: 15410.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.21
    Marker Score: 3077
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.2
    Marker Score: 24984.5
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.2
    Marker Score: 1023
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.17
    Marker Score: 16656
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.14
    Marker Score: 5602
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.13
    Marker Score: 1622
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.13
    Marker Score: 747
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.12
    Marker Score: 12024
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.11
    Marker Score: 6330
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.09
    Marker Score: 7012
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.08
    Marker Score: 9727
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.05
    Marker Score: 7690
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.04
    Marker Score: 1570
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.04
    Marker Score: 1848
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.03
    Marker Score: 3078
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.03
    Marker Score: 40710
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.02
    Marker Score: 4280
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.01
    Marker Score: 2690
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.01
    Marker Score: 159222
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.01
    Marker Score: 3633
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3
    Marker Score: 10668.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3
    Marker Score: 2525
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.99
    Marker Score: 1928
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.99
    Marker Score: 1753
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.98
    Marker Score: 2882
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.98
    Marker Score: 1190
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.98
    Marker Score: 8685
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.97
    Marker Score: 3578
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.97
    Marker Score: 2329
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.96
    Marker Score: 1950
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.95
    Marker Score: 972
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.95
    Marker Score: 3372
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.95
    Marker Score: 4734
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.92
    Marker Score: 6661
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.92
    Marker Score: 5825
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.91
    Marker Score: 3399.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.91
    Marker Score: 25055
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.9
    Marker Score: 12445
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.89
    Marker Score: 1814.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.88
    Marker Score: 1368
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 2.88
    Marker Score: 786
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.87
    Marker Score: 8050
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.87
    Marker Score: 2868
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.86
    Marker Score: 4145
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.86
    Marker Score: 3036.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.86
    Marker Score: 7266
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.85
    Marker Score: 3681
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.85
    Marker Score: 755
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.84
    Marker Score: 2418
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.83
    Marker Score: 3077
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.83
    Marker Score: 2051
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.82
    Marker Score: 1284
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.81
    Marker Score: 3028
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.79
    Marker Score: 1396
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2.79
    Marker Score: 735
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.78
    Marker Score: 5424
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.78
    Marker Score: 2739
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.78
    Marker Score: 71126
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.77
    Marker Score: 3105.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.76
    Marker Score: 1734
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.76
    Marker Score: 2087
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.75
    Marker Score: 17586
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.74
    Marker Score: 17852
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.74
    Marker Score: 1626

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Other Information

**Key characteristics:** * The COX7A2 gene is located on chromosome 15q26.1. * It is a large gene with an estimated length of 13.6 kb. * The protein encoded by COX7A2 is a glycoprotein with a molecular weight of approximately 150 kDa. * It is a subunit of the mitochondrial cytochrome c oxidase complex. **Pathways and functions:** * The COX7A2 protein is involved in cellular respiration, a set of metabolic reactions that break down glucose to produce energy (ATP) and reduce oxygen to water. * The enzyme is located in the mitochondrial matrix, where it is found in association with other mitochondrial proteins. * It is involved in the electron transport chain, a series of protein complexes that pass electrons from one molecule to another, driving the synthesis of ATP. * The COX7A2 protein also plays a role in mitochondrial membrane function, where it is involved in the regulation of ion flow and the maintenance of mitochondrial membrane integrity. **Clinical significance:** * Mutations in the COX7A2 gene have been linked to several human diseases, including mitochondrial disorders and certain types of cancer. * In some cases, mutations in COX7A2 can be the cause of Leigh syndrome, a fatal mitochondrial disorder characterized by progressive neurological decline and death. * Studies of the COX7A2 gene and its role in cellular respiration are important for understanding the mechanisms of mitochondrial function and for developing therapeutic strategies for mitochondrial disorders.

Genular Protein ID: 333285929

Symbol: CX7A2_HUMAN

Name: Cytochrome c oxidase subunit 7A2, mitochondrial

UniProtKB Accession Codes:

P14406 B2R5E1 Q3MIH5 Q5TF59 Q6FGI2

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 UniPathway 1 UniProtKB 3 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2550906

Title: Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase.

PubMed ID: 2550906

DOI: 10.1093/nar/17.17.7107

PubMed ID: 11004498

Title: Isolation and sequence of the human cytochrome c oxidase subunit VIIaL gene.

PubMed ID: 11004498

DOI: 10.1016/s0167-4781(00)00087-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1309697

Title: Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.

PubMed ID: 1309697

DOI: 10.1111/j.1432-1033.1992.tb19847.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22356826

Title: Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.

PubMed ID: 22356826

DOI: 10.1186/gb-2012-13-2-r12

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 30030519

Title: Structure of the intact 14-subunit human cytochrome c oxidase.

PubMed ID: 30030519

DOI: 10.1038/s41422-018-0071-1

Sequence Information:

  • Length: 83
  • Mass: 9396
  • Checksum: 490F45059CAF971F
  • Sequence:
    • MLRNLLALRQ IGQRTISTAS RRHFKNKVPE KQKLFQEDDE IPLYLKGGVA DALLYRATMI 
LTVGGTAYAI YELAVASFPK KQE

Genular Protein ID: 786604685

Symbol: H0UI06_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0UI06

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 3 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 115
  • Mass: 12844
  • Checksum: EC24A88F4E104C34
  • Sequence:
    • MHTQDSEVVP VPAWPFSLVV FSCGGCWSVT AKMLRNLLAL RQIGQRTIST ASRRHFKNKV 
PEKQKLFQED DEIPLYLKGG VADALLYRAT MILTVGGTAY AIYELAVASF PKKQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.