Details for: COX7A2

Gene ID: 1347

Symbol: COX7A2

Ensembl ID: ENSG00000112695

Description: cytochrome c oxidase subunit 7A2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 727.1197
    Cell Significance Index: -113.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 447.3604
    Cell Significance Index: -113.4700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 361.5023
    Cell Significance Index: -148.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 320.7082
    Cell Significance Index: -130.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 311.1056
    Cell Significance Index: -146.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 279.2071
    Cell Significance Index: -143.6200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 220.0225
    Cell Significance Index: -147.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 138.1629
    Cell Significance Index: -131.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 110.6690
    Cell Significance Index: -136.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 37.7846
    Cell Significance Index: -149.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.2044
    Cell Significance Index: -88.9500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 33.1960
    Cell Significance Index: -101.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.4503
    Cell Significance Index: -40.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 9.0879
    Cell Significance Index: 477.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.7925
    Cell Significance Index: 223.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.7365
    Cell Significance Index: 222.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.1495
    Cell Significance Index: 112.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.1370
    Cell Significance Index: 308.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.1282
    Cell Significance Index: 744.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.0389
    Cell Significance Index: 84.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.8313
    Cell Significance Index: 2092.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.8295
    Cell Significance Index: 35.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.7045
    Cell Significance Index: 455.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.4050
    Cell Significance Index: 439.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.3103
    Cell Significance Index: 327.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.2681
    Cell Significance Index: 95.9800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.2409
    Cell Significance Index: 19.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.1617
    Cell Significance Index: 83.1400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.0786
    Cell Significance Index: 24.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.0608
    Cell Significance Index: 420.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.0474
    Cell Significance Index: 70.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.9976
    Cell Significance Index: 1325.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.8463
    Cell Significance Index: 335.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.7199
    Cell Significance Index: 192.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.2191
    Cell Significance Index: 25.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.2149
    Cell Significance Index: 283.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0501
    Cell Significance Index: 132.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.8975
    Cell Significance Index: 35.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6968
    Cell Significance Index: 48.6400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.6473
    Cell Significance Index: 29.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5292
    Cell Significance Index: 53.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4284
    Cell Significance Index: 74.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.4169
    Cell Significance Index: 16.8900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4055
    Cell Significance Index: 15.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9777
    Cell Significance Index: 186.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.8784
    Cell Significance Index: 664.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6863
    Cell Significance Index: 43.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6782
    Cell Significance Index: 115.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.6343
    Cell Significance Index: 465.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6266
    Cell Significance Index: 16.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5773
    Cell Significance Index: 8.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3343
    Cell Significance Index: 54.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2926
    Cell Significance Index: 58.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1654
    Cell Significance Index: 32.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0974
    Cell Significance Index: 1.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0217
    Cell Significance Index: 7.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0304
    Cell Significance Index: -57.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0345
    Cell Significance Index: -25.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0456
    Cell Significance Index: -3.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0737
    Cell Significance Index: -7.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0755
    Cell Significance Index: -139.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0950
    Cell Significance Index: -146.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1108
    Cell Significance Index: -69.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1154
    Cell Significance Index: -156.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1585
    Cell Significance Index: -100.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1680
    Cell Significance Index: -94.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1723
    Cell Significance Index: -49.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2165
    Cell Significance Index: -45.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2169
    Cell Significance Index: -11.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2460
    Cell Significance Index: -111.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4720
    Cell Significance Index: -16.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5028
    Cell Significance Index: -16.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5917
    Cell Significance Index: -26.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6055
    Cell Significance Index: -69.3700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6161
    Cell Significance Index: -15.7400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.6422
    Cell Significance Index: -4.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6719
    Cell Significance Index: -41.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6988
    Cell Significance Index: -19.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7542
    Cell Significance Index: -109.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7917
    Cell Significance Index: -92.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8521
    Cell Significance Index: -97.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8526
    Cell Significance Index: -24.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9088
    Cell Significance Index: -19.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0591
    Cell Significance Index: -14.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.2689
    Cell Significance Index: -97.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.3322
    Cell Significance Index: -79.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.4138
    Cell Significance Index: -147.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.5837
    Cell Significance Index: -88.8700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -1.6991
    Cell Significance Index: -14.6000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.7573
    Cell Significance Index: -36.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.8758
    Cell Significance Index: -126.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.9236
    Cell Significance Index: -32.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.1017
    Cell Significance Index: -145.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.1633
    Cell Significance Index: -13.0700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.1840
    Cell Significance Index: -37.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.3599
    Cell Significance Index: -50.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.3830
    Cell Significance Index: -146.1000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.4465
    Cell Significance Index: -20.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.5416
    Cell Significance Index: -74.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.6330
    Cell Significance Index: -70.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** COX7A2 is a mitochondrial protein, specifically a subunit of cytochrome c oxidase (Complex IV). It is a small protein, consisting of 161 amino acids, and is encoded by a single gene in humans. The COX7A2 subunit is crucial for the assembly and function of the mitochondrial respiratory chain, which is responsible for generating energy for the cell through oxidative phosphorylation. The COX7A2 subunit is also involved in the regulation of oxidative phosphorylation, a process that is essential for maintaining cellular homeostasis. **Pathways and Functions:** COX7A2 plays a vital role in several cellular processes, including: 1. **Mitochondrial Electron Transport Chain**: COX7A2 is a key component of Complex IV, the final enzyme in the mitochondrial electron transport chain. This complex is responsible for transferring electrons from cytochrome c to oxygen, resulting in the production of ATP, the primary energy currency of the cell. 2. **Oxidative Phosphorylation**: COX7A2 is involved in the regulation of oxidative phosphorylation, a process that generates energy for the cell through the transfer of electrons across the mitochondrial membrane. 3. **Regulation of Oxidative Stress**: COX7A2 has been implicated in the regulation of oxidative stress, a condition characterized by an imbalance between the production of reactive oxygen species (ROS) and the cell's ability to detoxify them. 4. **Cellular Energy Metabolism**: COX7A2 is highly expressed in cells involved in energy metabolism, such as renal intercalated cells, thyroid follicular cells, and glycinergic neurons. **Clinical Significance:** Dysregulation of COX7A2 has been implicated in various diseases, including: 1. **Mitochondrial Diseases**: Mutations in the COX7A2 gene have been associated with mitochondrial diseases, such as Leber's hereditary optic neuropathy and Kearns-Sayre syndrome. 2. **Cancer**: Overexpression of COX7A2 has been observed in various types of cancer, including breast, lung, and colon cancer. 3. **Neurodegenerative Diseases**: COX7A2 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Metabolic Disorders**: Dysregulation of COX7A2 has been linked to metabolic disorders, such as obesity and type 2 diabetes. In conclusion, COX7A2 is a critical component of the mitochondrial respiratory chain, playing a vital role in energy metabolism, oxidative stress regulation, and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully elucidate the functions of COX7A2 and its role in human disease.

Genular Protein ID: 333285929

Symbol: CX7A2_HUMAN

Name: Cytochrome c oxidase subunit 7A2, mitochondrial

UniProtKB Accession Codes:

P14406 B2R5E1 Q3MIH5 Q5TF59 Q6FGI2

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 UniPathway 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2550906

Title: Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase.

PubMed ID: 2550906

DOI: 10.1093/nar/17.17.7107

PubMed ID: 11004498

Title: Isolation and sequence of the human cytochrome c oxidase subunit VIIaL gene.

PubMed ID: 11004498

DOI: 10.1016/s0167-4781(00)00087-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1309697

Title: Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.

PubMed ID: 1309697

DOI: 10.1111/j.1432-1033.1992.tb19847.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22356826

Title: Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.

PubMed ID: 22356826

DOI: 10.1186/gb-2012-13-2-r12

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 30030519

Title: Structure of the intact 14-subunit human cytochrome c oxidase.

PubMed ID: 30030519

DOI: 10.1038/s41422-018-0071-1

Sequence Information:

  • Length: 83
  • Mass: 9396
  • Checksum: 490F45059CAF971F
  • Sequence:
    • MLRNLLALRQ IGQRTISTAS RRHFKNKVPE KQKLFQEDDE IPLYLKGGVA DALLYRATMI 
LTVGGTAYAI YELAVASFPK KQE

Genular Protein ID: 786604685

Symbol: H0UI06_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0UI06

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 Ensembl 3 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 115
  • Mass: 12844
  • Checksum: EC24A88F4E104C34
  • Sequence:
    • MHTQDSEVVP VPAWPFSLVV FSCGGCWSVT AKMLRNLLAL RQIGQRTIST ASRRHFKNKV 
PEKQKLFQED DEIPLYLKGG VADALLYRAT MILTVGGTAY AIYELAVASF PKKQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.