Details for: COX7B

Gene ID: 1349

Symbol: COX7B

Ensembl ID: ENSG00000131174

Description: cytochrome c oxidase subunit 7B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 6.07
    Marker Score: 4062
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 4.88
    Marker Score: 2521
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.57
    Marker Score: 3222
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.32
    Marker Score: 3381
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.04
    Marker Score: 53764
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.01
    Marker Score: 2431.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.92
    Marker Score: 10518
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.87
    Marker Score: 1134
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.69
    Marker Score: 1532
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.68
    Marker Score: 3122
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.67
    Marker Score: 15257
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.59
    Marker Score: 200943
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.55
    Marker Score: 3170
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.48
    Marker Score: 8766
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.46
    Marker Score: 5323.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.41
    Marker Score: 5652
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.38
    Marker Score: 1112
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.34
    Marker Score: 11857
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.29
    Marker Score: 3429
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.28
    Marker Score: 2472
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.25
    Marker Score: 25340
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.21
    Marker Score: 10076.5
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.18
    Marker Score: 1695
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.17
    Marker Score: 3382
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.15
    Marker Score: 15137
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.09
    Marker Score: 30610
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.02
    Marker Score: 104451
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.01
    Marker Score: 3633
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.99
    Marker Score: 7305
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.99
    Marker Score: 4754
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.99
    Marker Score: 8251
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.98
    Marker Score: 34620
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.95
    Marker Score: 3128.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.93
    Marker Score: 2312
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.91
    Marker Score: 4120
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.91
    Marker Score: 18967
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.91
    Marker Score: 98945
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.9
    Marker Score: 2779
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.88
    Marker Score: 3292
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.87
    Marker Score: 21382
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.86
    Marker Score: 18221
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.85
    Marker Score: 6502
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.85
    Marker Score: 2690
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.85
    Marker Score: 2027
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.83
    Marker Score: 24366
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.82
    Marker Score: 5499
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.79
    Marker Score: 1486
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.78
    Marker Score: 2824
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.78
    Marker Score: 4470
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.75
    Marker Score: 1535
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.73
    Marker Score: 7789
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.73
    Marker Score: 5124
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.73
    Marker Score: 14325
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.72
    Marker Score: 2427
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.72
    Marker Score: 23626.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.7
    Marker Score: 3818
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.69
    Marker Score: 35433
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.69
    Marker Score: 68784
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.67
    Marker Score: 985
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.66
    Marker Score: 10273
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.66
    Marker Score: 2656
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.63
    Marker Score: 5351
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.62
    Marker Score: 3418
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.62
    Marker Score: 138398
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.62
    Marker Score: 2718
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.61
    Marker Score: 1715
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.6
    Marker Score: 8198
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.59
    Marker Score: 3998
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.57
    Marker Score: 1157
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.54
    Marker Score: 10965
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.52
    Marker Score: 3501
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.51
    Marker Score: 5697
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.51
    Marker Score: 1425
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.51
    Marker Score: 4371
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.49
    Marker Score: 28018
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.49
    Marker Score: 2988.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.47
    Marker Score: 10103
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.47
    Marker Score: 589
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.46
    Marker Score: 1273
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.45
    Marker Score: 7136
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.44
    Marker Score: 1620
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.43
    Marker Score: 1252
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.43
    Marker Score: 5712
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.43
    Marker Score: 5067
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.42
    Marker Score: 1333.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.41
    Marker Score: 1513.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.4
    Marker Score: 2671
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.4
    Marker Score: 693
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.39
    Marker Score: 974
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 2.38
    Marker Score: 651
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.38
    Marker Score: 765
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.38
    Marker Score: 820
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.38
    Marker Score: 1127
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.38
    Marker Score: 1230
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.37
    Marker Score: 895
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.36
    Marker Score: 2525
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.36
    Marker Score: 888
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.34
    Marker Score: 833
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.34
    Marker Score: 2203
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.33
    Marker Score: 562

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Other Information

**Key characteristics** * Gene name: COX7B * Ensembl ID: ENSG00000131174 * Protein: Cytochrome c oxidase subunit 7B * Protein function: Produces ATP through the citric acid cycle and respiratory electron transport pathways **Pathways and functions** * **Citric acid cycle:** The COX7B gene is involved in the citric acid cycle, a series of chemical reactions that break down glucose to produce energy in the form of ATP. * **Respiratory electron transport:** The COX7B gene is also involved in the respiratory electron transport pathway, a series of electron transfer reactions that produce ATP and carbon dioxide from the breakdown of glucose. **Clinical significance** Mutations in the COX7B gene have been linked to several human diseases, including hypertrophic cardiomyopathy, a condition characterized by heart failure. In this condition, the COX7B protein is mutated, leading to the accumulation of a toxic protein called cytochrome c in the mitochondria of cells. This can damage the heart muscle and lead to heart failure. **Other important facts** * The COX7B gene is highly expressed in skeletal muscle satellite cells, professional antigen presenting cells, CD14-low, CD16-positive monocytes, thyroid follicular cells, cardiac muscle cells, myeloid dendritic cells, kidney loop of Henle thick ascending limb epithelial cells, tracheobronchial smooth muscle cells, and ventricular cardiac muscle cells. * The COX7B protein is a key regulator of mitochondrial respiration. * Mutations in the COX7B gene can lead to the development of heart failure and other diseases.

Genular Protein ID: 3497148990

Symbol: COX7B_HUMAN

Name: Cytochrome c oxidase subunit 7B, mitochondrial

UniProtKB Accession Codes:

P24311 B2R4M3 Q6ICR1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8382530

Title: Isolation of a cDNA specifying subunit VIIb of human cytochrome c oxidase.

PubMed ID: 8382530

DOI: 10.1016/0167-4781(93)90301-s

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1309697

Title: Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.

PubMed ID: 1309697

DOI: 10.1111/j.1432-1033.1992.tb19847.x

PubMed ID: 23122588

Title: Mutations in COX7B cause microphthalmia with linear skin lesions, an unconventional mitochondrial disease.

PubMed ID: 23122588

DOI: 10.1016/j.ajhg.2012.09.016

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 30030519

Title: Structure of the intact 14-subunit human cytochrome c oxidase.

PubMed ID: 30030519

DOI: 10.1038/s41422-018-0071-1

Sequence Information:

  • Length: 80
  • Mass: 9161
  • Checksum: 1EE75BD1AA253E59
  • Sequence:
    • MFPLVKSALN RLQVRSIQQT MARQSHQKRT PDFHDKYGNA VLASGATFCI VTWTYVATQV 
GIEWNLSPVG RVTPKEWRNQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.