Details for: COX7B

Gene ID: 1349

Symbol: COX7B

Ensembl ID: ENSG00000131174

Description: cytochrome c oxidase subunit 7B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 451.0585
    Cell Significance Index: -70.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 324.5502
    Cell Significance Index: -82.3200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 285.3518
    Cell Significance Index: -117.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 242.9030
    Cell Significance Index: -114.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 217.3663
    Cell Significance Index: -111.8100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 171.4847
    Cell Significance Index: -115.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 105.6462
    Cell Significance Index: -100.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 76.4504
    Cell Significance Index: -94.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 36.3737
    Cell Significance Index: -97.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 30.8844
    Cell Significance Index: -94.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.7252
    Cell Significance Index: -109.4100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.5985
    Cell Significance Index: -31.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.1425
    Cell Significance Index: 118.8100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.0984
    Cell Significance Index: 75.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.8894
    Cell Significance Index: 701.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.5804
    Cell Significance Index: 440.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.5605
    Cell Significance Index: 186.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.4782
    Cell Significance Index: 32.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.3704
    Cell Significance Index: 238.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.3555
    Cell Significance Index: 156.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.1107
    Cell Significance Index: 84.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.1103
    Cell Significance Index: 146.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.0707
    Cell Significance Index: 1676.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.9667
    Cell Significance Index: 1311.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.4177
    Cell Significance Index: 180.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4045
    Cell Significance Index: 330.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.2200
    Cell Significance Index: 219.6100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.0622
    Cell Significance Index: 16.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.0461
    Cell Significance Index: 264.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.9595
    Cell Significance Index: 231.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.8691
    Cell Significance Index: 120.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.6557
    Cell Significance Index: 18.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6263
    Cell Significance Index: 84.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5446
    Cell Significance Index: 40.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4983
    Cell Significance Index: 89.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.4529
    Cell Significance Index: 115.0700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1179
    Cell Significance Index: 16.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1093
    Cell Significance Index: 31.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1005
    Cell Significance Index: 23.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0819
    Cell Significance Index: 138.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.9422
    Cell Significance Index: 690.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8653
    Cell Significance Index: 140.7300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.7157
    Cell Significance Index: 6.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5611
    Cell Significance Index: 16.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5141
    Cell Significance Index: 97.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5028
    Cell Significance Index: 31.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4903
    Cell Significance Index: 14.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4235
    Cell Significance Index: 320.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4065
    Cell Significance Index: 69.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1929
    Cell Significance Index: 38.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0920
    Cell Significance Index: 4.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0654
    Cell Significance Index: 12.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0596
    Cell Significance Index: 21.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0498
    Cell Significance Index: 1.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0303
    Cell Significance Index: 57.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0055
    Cell Significance Index: -4.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0391
    Cell Significance Index: -72.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0421
    Cell Significance Index: -26.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0593
    Cell Significance Index: -6.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0633
    Cell Significance Index: -97.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0931
    Cell Significance Index: -126.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1063
    Cell Significance Index: -67.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1266
    Cell Significance Index: -71.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1476
    Cell Significance Index: -66.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1667
    Cell Significance Index: -35.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3004
    Cell Significance Index: -10.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3292
    Cell Significance Index: -38.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3321
    Cell Significance Index: -38.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3331
    Cell Significance Index: -25.5600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3449
    Cell Significance Index: -3.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3893
    Cell Significance Index: -10.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4014
    Cell Significance Index: -115.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4934
    Cell Significance Index: -7.2900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5013
    Cell Significance Index: -57.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5071
    Cell Significance Index: -31.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5080
    Cell Significance Index: -16.2700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.5250
    Cell Significance Index: -10.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5274
    Cell Significance Index: -76.6700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5492
    Cell Significance Index: -9.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6402
    Cell Significance Index: -16.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6813
    Cell Significance Index: -14.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8515
    Cell Significance Index: -14.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.8699
    Cell Significance Index: -39.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0252
    Cell Significance Index: -106.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1654
    Cell Significance Index: -24.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.3420
    Cell Significance Index: -18.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.3424
    Cell Significance Index: -92.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.3487
    Cell Significance Index: -47.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.3775
    Cell Significance Index: -77.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4256
    Cell Significance Index: -95.8600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.5372
    Cell Significance Index: -9.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.5905
    Cell Significance Index: -18.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.6846
    Cell Significance Index: -42.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7043
    Cell Significance Index: -104.4900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.8230
    Cell Significance Index: -44.4800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.8691
    Cell Significance Index: -15.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.9449
    Cell Significance Index: -52.0300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.0834
    Cell Significance Index: -35.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.1084
    Cell Significance Index: -62.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.1259
    Cell Significance Index: -78.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** COX7B is a subunit of the mitochondrial cytochrome c oxidase complex, which is responsible for the transfer of electrons from cytochrome c to oxygen. This complex is a critical component of the electron transport chain, playing a central role in the generation of ATP during cellular respiration. COX7B is a mitochondrial protein, with its expression being primarily restricted to cells with high energy demands, such as skeletal muscle, cardiac muscle, and immune cells. **Pathways and Functions:** COX7B is involved in several key pathways, including: 1. **Cellular Respiration:** COX7B is a critical component of the electron transport chain, facilitating the transfer of electrons from cytochrome c to oxygen and contributing to the generation of ATP. 2. **Immune Response:** COX7B is significantly expressed in various immune cells, including professional antigen-presenting cells and CD8-positive T cells, suggesting its role in regulating immune responses. 3. **Mitochondrial Biogenesis:** COX7B has been implicated in the regulation of mitochondrial biogenesis, with its expression being influenced by factors that regulate mitochondrial DNA replication and transcription. 4. **Stress Response:** COX7B has been shown to play a role in the regulation of stress responses, including the response to chemical stress and heat shock. **Clinical Significance:** The clinical significance of COX7B is multifaceted, with its dysregulation being implicated in various diseases, including: 1. **Mitochondrial Diseases:** Mutations in the COX7B gene have been associated with mitochondrial diseases, including Leigh syndrome and MERRF syndrome. 2. **Cancer:** COX7B has been implicated in the regulation of cancer cell metabolism, with its expression being elevated in various types of cancer. 3. **Inflammatory Disorders:** COX7B has been shown to play a role in the regulation of inflammatory responses, with its expression being elevated in various inflammatory disorders, including rheumatoid arthritis and multiple sclerosis. 4. **Neurodegenerative Disorders:** COX7B has been implicated in the regulation of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, COX7B is a critical component of the mitochondrial respiratory chain, playing a vital role in cellular respiration, energy production, and the regulation of various cellular processes. Its dysregulation has been implicated in various diseases, including mitochondrial diseases, cancer, inflammatory disorders, and neurodegenerative disorders. Further research is needed to fully elucidate the role of COX7B in human health and disease.

Genular Protein ID: 3497148990

Symbol: COX7B_HUMAN

Name: Cytochrome c oxidase subunit 7B, mitochondrial

UniProtKB Accession Codes:

P24311 B2R4M3 Q6ICR1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8382530

Title: Isolation of a cDNA specifying subunit VIIb of human cytochrome c oxidase.

PubMed ID: 8382530

DOI: 10.1016/0167-4781(93)90301-s

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1309697

Title: Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.

PubMed ID: 1309697

DOI: 10.1111/j.1432-1033.1992.tb19847.x

PubMed ID: 23122588

Title: Mutations in COX7B cause microphthalmia with linear skin lesions, an unconventional mitochondrial disease.

PubMed ID: 23122588

DOI: 10.1016/j.ajhg.2012.09.016

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 30030519

Title: Structure of the intact 14-subunit human cytochrome c oxidase.

PubMed ID: 30030519

DOI: 10.1038/s41422-018-0071-1

Sequence Information:

  • Length: 80
  • Mass: 9161
  • Checksum: 1EE75BD1AA253E59
  • Sequence:
    • MFPLVKSALN RLQVRSIQQT MARQSHQKRT PDFHDKYGNA VLASGATFCI VTWTYVATQV 
GIEWNLSPVG RVTPKEWRNQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.