Details for: COX7B
Gene ID: 1349
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: COX7B
Ensembl ID: ENSG00000131174
Description: cytochrome c oxidase subunit 7B
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 91.05rCSI 78.84%PRS 6.59
-
CSI 89.16rCSI 85.82%PRS 6.15
-
CSI 88.78rCSI 69.84%PRS 7.06
-
CSI 88.57rCSI 78.62%PRS 5.94
-
CSI 85.81rCSI 82.74%PRS 3.48
-
CSI 85.76rCSI 91.12%PRS 10.64
-
CSI 84.37rCSI 68.22%PRS 5.83
-
CSI 84.17rCSI 74.02%PRS 4.28
-
CSI 81.59rCSI 68.39%PRS 7.11
-
CSI 78.22rCSI 91.87%PRS 7.11
-
CSI 76.55rCSI 80.19%PRS 5.52
-
CSI 75.34rCSI 78.74%PRS 6.24
-
CSI 70.5rCSI 63.66%PRS 5.24
-
CSI 64.85rCSI 69.51%PRS 5.47
-
CSI 64.59rCSI 56.73%PRS 6.66
-
CSI 63.64rCSI 52.76%PRS 5.66
-
CSI 63.31rCSI 59.82%PRS 6.21
-
CSI 61.9rCSI 61.78%PRS 5.1
-
CSI 59.96rCSI 39.86%PRS 7.07
-
CSI 59.95rCSI 55.04%PRS 6.81
-
CSI 57.63rCSI 60.38%PRS 6.33
-
CSI 56.97rCSI 65.21%PRS 12.33
-
CSI 56.06rCSI 90.4%PRS 9.63
-
CSI 55.18rCSI 75.18%PRS 5.34
-
CSI 54.57rCSI 78.71%PRS 8.28
-
CSI 54.38rCSI 77.94%PRS 8.19
-
CSI 53.92rCSI 56.26%PRS 6.08
-
CSI 51.54rCSI 88.3%PRS 7.96
-
CSI 48.97rCSI 37.73%PRS 5.37
-
CSI 48.35rCSI 66.07%PRS 6.56
-
CSI 47.67rCSI 55.12%PRS 4.33
-
CSI 47.22rCSI 72.22%PRS 9.72
-
CSI 45.98rCSI 57.7%PRS 7.55
-
CSI 45.62rCSI 67.81%PRS 7.55
-
CSI 45.54rCSI 62.26%PRS 10.35
-
CSI 44.02rCSI 36.45%PRS 5.94
-
CSI 43.8rCSI 67.31%PRS 8.59
-
CSI 42.77rCSI 39.46%PRS 6.02
-
CSI 42.38rCSI 61.08%PRS 9.63
-
CSI 42.14rCSI 65.11%PRS 5.57
-
CSI 41.08rCSI 66.12%PRS 4.55
-
CSI 39.42rCSI 32.91%PRS 19.16
-
CSI 39.24rCSI 51.41%PRS 8.34
-
CSI 39.14rCSI 46.98%PRS 5.9
-
CSI 38.32rCSI 37.69%PRS 6.45
-
CSI 38.26rCSI 49.07%PRS 6.85
-
CSI 38.23rCSI 55.94%PRS 6.29
-
CSI 37.59rCSI 80.01%PRS 9.63
-
CSI 37.49rCSI 72.92%PRS 6.06
-
CSI 37.16rCSI 37.87%PRS 8.57
-
CSI 37.08rCSI 88.14%PRS 8.95
-
CSI 36.85rCSI 42.73%PRS 8.85
-
CSI 36.16rCSI 28.71%PRS 10.49
-
CSI 35.71rCSI 56.72%PRS 7.72
-
CSI 35.36rCSI 50.46%PRS 6.72
-
CSI 34.87rCSI 42.11%PRS 7.01
-
CSI 34.77rCSI 42.32%PRS 7.51
-
CSI 34.13rCSI 50.05%PRS 7.8
-
CSI 34rCSI 26.87%PRS 4.1
-
CSI 33.29rCSI 41.19%PRS 5.2
-
CSI 32.93rCSI 72.91%PRS 5.54
-
CSI 32.86rCSI 25.48%PRS 5.67
-
CSI 32.73rCSI 22.05%PRS 7.16
-
CSI 32.14rCSI 49.09%PRS 5.95
-
CSI 32.1rCSI 39.92%PRS 6.31
-
CSI 31.89rCSI 22.26%PRS 6.24
-
CSI 31.68rCSI 67.37%PRS 11.22
-
CSI 31.39rCSI 64.46%PRS 14.41
-
CSI 30.82rCSI 47.1%PRS 6.84
-
CSI 30.8rCSI 55.96%PRS 9.07
-
CSI 30.25rCSI 49.82%PRS 7.01
-
CSI 29.78rCSI 80.27%PRS 7.66
-
CSI 29.75rCSI 64.96%PRS 12.14
-
CSI 29.28rCSI 55.89%PRS 14.45
-
CSI 27.87rCSI 28.87%PRS 6.98
-
CSI 27.78rCSI 55.38%PRS 10.16
-
CSI 27.75rCSI 42.39%PRS 10.45
-
CSI 27.58rCSI 79.85%PRS 6.75
-
CSI 26.05rCSI 18.11%PRS 6.96
-
CSI 25.82rCSI 72.36%PRS 9.26
-
CSI 24.78rCSI 56.49%PRS 6.2
-
CSI 24.54rCSI 32.79%PRS 11.38
-
CSI 24.12rCSI 17.87%PRS 5.47
-
CSI 23.83rCSI 52.46%PRS 9.16
-
CSI 23.41rCSI 34.29%PRS 7.02
-
CSI 22.73rCSI 59.83%PRS 11.61
-
CSI 22.23rCSI 39.65%PRS 10.33
-
CSI 21.58rCSI 34.58%PRS 19.7
-
CSI 20.92rCSI 59.73%PRS 10.56
-
CSI 20.85rCSI 39.37%PRS 7.38
-
CSI 20.74rCSI 15.59%PRS 6.11
-
CSI 20.38rCSI 68.88%PRS 10.18
-
CSI 20.28rCSI 71.16%PRS 10.86
-
CSI 20.17rCSI 37.86%PRS 11.77
-
CSI 19.57rCSI 77.91%PRS 10.59
-
CSI 19.22rCSI 46.94%PRS 6.07
-
CSI 18.99rCSI 60.95%PRS 8.92
-
CSI 18.84rCSI 23.21%PRS 20.19
-
CSI 18.75rCSI 82.3%PRS 11.25
-
CSI 18.71rCSI 25.01%PRS 6.49
-
CSI -17.7rCSI -75.4%PRS 10.3%
-
CSI -11.3rCSI -13.5%PRS 10.4%
-
CSI -10.2rCSI -22.8%PRS 3.7%
-
CSI -9.1rCSI -39.9%PRS 6.0%
-
CSI -9.0rCSI -42.2%PRS 15.5%
-
CSI -8.0rCSI -5.8%PRS 8.1%
-
CSI -7.1rCSI -6.4%PRS 9.3%
-
CSI -6.6rCSI -17.2%PRS 6.6%
-
CSI -5.9rCSI -22.0%PRS 5.1%
-
CSI -5.7rCSI -16.4%PRS 8.6%
-
CSI -4.9rCSI -4.8%PRS 9.5%
-
CSI -4.6rCSI -13.2%PRS 7.8%
-
CSI -4.0rCSI -25.8%PRS 25.2%
-
CSI -4.0rCSI -15.0%PRS 11.4%
-
CSI -3.9rCSI -16.1%PRS 6.7%
-
CSI -3.9rCSI -7.5%PRS 9.6%
-
CSI -3.4rCSI -5.9%PRS 4.5%
-
CSI -3.4rCSI -13.5%PRS 22.3%
-
CSI -3.3rCSI -55.1%PRS 29.5%
-
CSI -3.1rCSI -2.1%PRS 8.6%
-
CSI -2.8rCSI -7.3%PRS 7.1%
-
CSI -2.5rCSI -9.7%PRS 6.4%
-
CSI -2.2rCSI -41.8%PRS 46.0%
-
CSI -2.1rCSI -8.6%PRS 6.2%
-
CSI -2.0rCSI -5.0%PRS 19.7%
-
CSI -1.9rCSI -2.3%PRS 3.2%
-
CSI -1.7rCSI -3.1%PRS 5.5%
-
CSI -1.5rCSI -30.8%PRS 5.5%
-
CSI -1.1rCSI -3.0%PRS 6.4%
-
CSI -1.0rCSI -3.7%PRS 28.0%
-
CSI -1.0rCSI -1.5%PRS 6.0%
-
CSI -0.9rCSI -1.5%PRS 3.9%
-
CSI -0.9rCSI -17.9%PRS 6.0%
-
CSI -0.9rCSI -3.1%PRS 3.2%
-
CSI -0.6rCSI -1.2%PRS 9.6%
-
CSI -0.4rCSI -2.4%PRS 21.3%
-
CSI -0.3rCSI -0.8%PRS 4.1%
-
CSI -0.2rCSI -0.2%PRS 6.0%
-
CSI -0.2rCSI -3.2%PRS 37.0%
-
CSI -0.2rCSI -0.3%PRS 7.6%
-
CSI -0.2rCSI -0.4%PRS 5.2%
-
CSI -0.1rCSI -0.2%PRS 6.9%
-
CSI 0.1rCSI 0.6%PRS 4.9%
-
CSI 0.1rCSI 0.3%PRS 3.7%
-
CSI 0.1rCSI 2.4%PRS 32.4%
-
CSI 0.1rCSI 0.2%PRS 4.5%
-
CSI 0.2rCSI 0.6%PRS 41.3%
-
CSI 0.2rCSI 5.5%PRS 31.9%
-
CSI 0.2rCSI 0.7%PRS 4.4%
-
CSI 0.3rCSI 0.4%PRS 3.7%
-
CSI 0.3rCSI 1.8%PRS 10.4%
-
CSI 0.3rCSI 1.8%PRS 20.9%
-
CSI 0.3rCSI 4.0%PRS 32.1%
-
CSI 0.3rCSI 0.5%PRS 4.8%
-
CSI 0.5rCSI 2.2%PRS 7.8%
-
CSI 0.5rCSI 8.3%PRS 16.0%
-
CSI 0.5rCSI 10.5%PRS 36.0%
-
CSI 0.5rCSI 2.6%PRS 28.6%
-
CSI 0.5rCSI 1.2%PRS 7.9%
-
CSI 0.6rCSI 14.4%PRS 49.2%
-
CSI 0.6rCSI 1.6%PRS 3.4%
-
CSI 0.7rCSI 6.7%PRS 49.0%
-
CSI 0.7rCSI 5.2%PRS 52.4%
-
CSI 0.7rCSI 1.0%PRS 6.5%
-
CSI 0.8rCSI 4.2%PRS 13.5%
-
CSI 0.8rCSI 0.8%PRS 12.8%
-
CSI 0.9rCSI 5.8%PRS 42.3%
-
CSI 0.9rCSI 0.7%PRS 11.0%
-
CSI 0.9rCSI 2.3%PRS 10.0%
-
CSI 0.9rCSI 4.9%PRS 20.8%
-
CSI 1.0rCSI 7.7%PRS 47.1%
-
CSI 1.0rCSI 2.6%PRS 8.5%
-
CSI 1.1rCSI 1.5%PRS 8.7%
-
CSI 1.1rCSI 1.6%PRS 5.9%
-
CSI 1.1rCSI 1.9%PRS 3.5%
-
CSI 1.2rCSI 12.9%PRS 63.9%
-
CSI 1.3rCSI 6.2%PRS 9.3%
-
CSI 1.4rCSI 15.8%PRS 25.3%
-
CSI 1.4rCSI 1.6%PRS 9.2%
-
CSI 1.4rCSI 8.1%PRS 9.1%
-
CSI 1.5rCSI 3.2%PRS 33.7%
-
CSI 1.6rCSI 2.2%PRS 31.7%
-
CSI 1.6rCSI 1.7%PRS 11.3%
-
CSI 1.6rCSI 2.6%PRS 5.3%
-
CSI 1.8rCSI 20.1%PRS 10.9%
-
CSI 1.8rCSI 15.0%PRS 6.3%
-
CSI 1.9rCSI 36.1%PRS 21.3%
-
CSI 2.0rCSI 4.2%PRS 6.6%
-
CSI 2.1rCSI 2.8%PRS 14.9%
-
CSI 2.1rCSI 2.5%PRS 8.7%
-
CSI 2.1rCSI 16.8%PRS 26.9%
-
CSI 2.2rCSI 11.7%PRS 21.0%
-
CSI 2.2rCSI 16.9%PRS 31.2%
-
CSI 2.2rCSI 10.2%PRS 26.3%
-
CSI 2.3rCSI 30.0%PRS 44.6%
-
CSI 2.4rCSI 50.0%PRS 46.2%
-
CSI 2.4rCSI 22.1%PRS 22.2%
-
CSI 2.4rCSI 5.8%PRS 39.4%
-
CSI 2.4rCSI 6.7%PRS 26.7%
-
CSI 2.5rCSI 5.2%PRS 13.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 3497148990
Symbol: COX7B_HUMAN
Name: Cytochrome c oxidase subunit 7B, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8382530
Title: Isolation of a cDNA specifying subunit VIIb of human cytochrome c oxidase.
PubMed ID: 8382530
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1309697
Title: Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.
PubMed ID: 1309697
PubMed ID: 23122588
Title: Mutations in COX7B cause microphthalmia with linear skin lesions, an unconventional mitochondrial disease.
PubMed ID: 23122588
PubMed ID: 28844695
Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.
PubMed ID: 28844695
PubMed ID: 30030519
Title: Structure of the intact 14-subunit human cytochrome c oxidase.
PubMed ID: 30030519
Sequence Information:
- Length: 80
- Mass: 9161
- Checksum: 1EE75BD1AA253E59
- Sequence:
MFPLVKSALN RLQVRSIQQT MARQSHQKRT PDFHDKYGNA VLASGATFCI VTWTYVATQV GIEWNLSPVG RVTPKEWRNQ