Details for: Drd3

Gene ID: 13490

Symbol: Drd3

Ensembl ID: ENSMUSG00000022705

Description: dopamine receptor D3

Associated with

  • Amine ligand-binding receptors
    (R-MMU-375280)
  • Class a/1 (rhodopsin-like receptors)
    (R-MMU-373076)
  • Dopamine receptors
    (R-MMU-390651)
  • G alpha (i) signalling events
    (R-MMU-418594)
  • Gpcr downstream signalling
    (R-MMU-388396)
  • Gpcr ligand binding
    (R-MMU-500792)
  • Signaling by gpcr
    (R-MMU-372790)
  • Acid secretion
    (GO:0046717)
  • Adenylate cyclase-activating adrenergic receptor signaling pathway
    (GO:0071880)
  • Adenylate cyclase-activating dopamine receptor signaling pathway
    (GO:0007191)
  • Adenylate cyclase-inhibiting dopamine receptor signaling pathway
    (GO:0007195)
  • Apical part of cell
    (GO:0045177)
  • Arachidonic acid secretion
    (GO:0050482)
  • Autophagy
    (GO:0006914)
  • Behavioral response to cocaine
    (GO:0048148)
  • Cell projection
    (GO:0042995)
  • Circadian regulation of gene expression
    (GO:0032922)
  • D1 dopamine receptor binding
    (GO:0031748)
  • Dopamine neurotransmitter receptor activity
    (GO:0004952)
  • Dopamine neurotransmitter receptor activity, coupled via gi/go
    (GO:0001591)
  • Dopamine receptor signaling pathway
    (GO:0007212)
  • Dopaminergic synapse
    (GO:0098691)
  • Endocytic vesicle
    (GO:0030139)
  • Gaba-ergic synapse
    (GO:0098982)
  • Glutamatergic synapse
    (GO:0098978)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor internalization
    (GO:0002031)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Intracellular calcium ion homeostasis
    (GO:0006874)
  • Locomotory behavior
    (GO:0007626)
  • Membrane
    (GO:0016020)
  • Musculoskeletal movement, spinal reflex action
    (GO:0050883)
  • Negative regulation of adenylate cyclase activity
    (GO:0007194)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of blood pressure
    (GO:0045776)
  • Negative regulation of cytosolic calcium ion concentration
    (GO:0051481)
  • Negative regulation of dopamine receptor signaling pathway
    (GO:0060160)
  • Negative regulation of oligodendrocyte differentiation
    (GO:0048715)
  • Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051898)
  • Negative regulation of protein secretion
    (GO:0050709)
  • Negative regulation of synaptic transmission, glutamatergic
    (GO:0051967)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of voltage-gated calcium channel activity
    (GO:1901386)
  • Oligodendrocyte differentiation
    (GO:0048709)
  • Phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0043491)
  • Phospholipase c-activating dopamine receptor signaling pathway
    (GO:0060158)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cytokinesis
    (GO:0032467)
  • Positive regulation of dopamine receptor signaling pathway
    (GO:0060161)
  • Positive regulation of mitotic nuclear division
    (GO:0045840)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Postsynaptic density membrane
    (GO:0098839)
  • Prepulse inhibition
    (GO:0060134)
  • Protein binding
    (GO:0005515)
  • Protein domain specific binding
    (GO:0019904)
  • Regulation of blood volume by renin-angiotensin
    (GO:0002016)
  • Regulation of circadian sleep/wake cycle, sleep
    (GO:0045187)
  • Regulation of dopamine secretion
    (GO:0014059)
  • Regulation of lipid metabolic process
    (GO:0019216)
  • Regulation of locomotion involved in locomotory behavior
    (GO:0090325)
  • Regulation of multicellular organism growth
    (GO:0040014)
  • Regulation of neurotransmitter uptake
    (GO:0051580)
  • Regulation of postsynaptic neurotransmitter receptor internalization
    (GO:0099149)
  • Regulation of potassium ion transport
    (GO:0043266)
  • Response to amphetamine
    (GO:0001975)
  • Response to cocaine
    (GO:0042220)
  • Response to ethanol
    (GO:0045471)
  • Response to histamine
    (GO:0034776)
  • Response to morphine
    (GO:0043278)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Signal transduction
    (GO:0007165)
  • Visual learning
    (GO:0008542)

Other Information

Genular Protein ID: 2287638840

Symbol: DRD3_MOUSE

Name: D(3) dopamine receptor

UniProtKB Accession Codes:

P30728

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 DNASU 1 DrugCentral 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 62 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 8449953

Title: A novel short isoform of the D3 dopamine receptor generated by alternative splicing in the third cytoplasmic loop.

PubMed ID: 8449953

DOI: 10.1016/s0021-9258(18)53401-3

PubMed ID: 7598803

Title: Molecular cloning and characterization of the mouse dopamine D3 receptor gene: an additional intron and an mRNA variant.

PubMed ID: 7598803

DOI: 10.1089/dna.1995.14.485

Sequence Information:

  • Length: 446
  • Mass: 49669
  • Checksum: B391C2D493B58242
  • Sequence:
    • MAPLSQISSH INSTCGAENS TGVNRARPHA YYALSYCALI LAIIFGNGLV CAAVLRERAL 
QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR ICCDVFVTLD VMMCTASILN 
LCAISIDRYT AVVMPVHYQH GTGQSSCRRV ALMITAVWVL AFAVSCPLLF GFNTTGDPSI 
CSISNPDFVI YSSVVSFYVP FGVTVLVYAR IYMVLRQRRR KRILTRQNSQ CISIRPGFPQ 
QSSCLRLHPI RQFSIRARFL SDATGQMEHI EDKPYPQKCQ DPLLSHLQPL SPGQTHGELK 
RYYSICQDTA LRHPNFEGGG GMSQVERTRN SLSPTMAPKL SLEVRKLSNG RLSTSLKLGP 
LQPRGVPLRE KKATQMVVIV LGAFIVCWLP FFLTHVLNTH CQACHVSPEL YRATTWLGYV 
NSALNPVIYT TFNIEFRKAF LKILSC

Genular Protein ID: 3382544473

Symbol: A0A2R8VHF0_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A2R8VHF0

Database IDs:

AGR 1 ARBA 13 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneTree 1 InterPro 4 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 478
  • Mass: 53103
  • Checksum: 20C0D099506FE89F
  • Sequence:
    • MASGTEALNT TVSRHQKKFS GNILESNSSV WAMAPLSQIS SHINSTCGAE NSTGVNRARP 
HAYYALSYCA LILAIIFGNG LVCAAVLRER ALQTTTNYLV VSLAVADLLV ATLVMPWVVY 
LEVTGGVWNF SRICCDVFVT LDVMMCTASI LNLCAISIDR YTAVVMPVHY QHGTGQSSCR 
RVALMITAVW VLAFAVSCPL LFGFNTTGDP SICSISNPDF VIYSSVVSFY VPFGVTVLVY 
ARIYMVLRQR RRKRILTRQN SQCISIRPGF PQQSSCLRLH PIRQFSIRAR FLSDATGQME 
HIEDKPYPQK CQDPLLSHLQ PLSPGQTHGE LKRYYSICQD TALRHPNFEG GGGMSQVERT 
RNSLSPTMAP KLSLEVRKLS NGRLSTSLKL GPLQPRGVPL REKKATQMVV IVLGAFIVCW 
LPFFLTHVLN THCQACHVSP ELYRATTWLG YVNSALNPVI YTTFNIEFRK AFLKILSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.