Genular: Defining Cellular Identity and Function

Details for: Drd4

Gene ID: 13491

Symbol: Drd4

Ensembl ID: ENSMUSG00000025496

Description: dopamine receptor D4

Associated with

Amine ligand-binding receptors
(R-MMU-375280)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
Dopamine receptors
(R-MMU-390651)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Signaling by gpcr
(R-MMU-372790)
Adenylate cyclase-inhibiting dopamine receptor signaling pathway
(GO:0007195)
Adenylate cyclase-inhibiting serotonin receptor signaling pathway
(GO:0007198)
Adult locomotory behavior
(GO:0008344)
Arachidonic acid secretion
(GO:0050482)
Associative learning
(GO:0008306)
Axon
(GO:0030424)
Axon terminus
(GO:0043679)
Behavioral fear response
(GO:0001662)
Behavioral response to cocaine
(GO:0048148)
Cell cortex
(GO:0005938)
Centrosome
(GO:0005813)
Chemical synaptic transmission
(GO:0007268)
Dendrite
(GO:0030425)
Dendritic spine
(GO:0043197)
Dopamine binding
(GO:0035240)
Dopamine neurotransmitter receptor activity
(GO:0004952)
Dopamine neurotransmitter receptor activity, coupled via gi/go
(GO:0001591)
Dopamine receptor signaling pathway
(GO:0007212)
Epinephrine binding
(GO:0051379)
Fear response
(GO:0042596)
Gaba-ergic synapse
(GO:0098982)
Glutamatergic synapse
(GO:0098978)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
G protein-coupled serotonin receptor activity
(GO:0004993)
Heterocyclic compound binding
(GO:1901363)
Identical protein binding
(GO:0042802)
Inhibitory postsynaptic potential
(GO:0060080)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of protein secretion
(GO:0050709)
Negative regulation of synaptic transmission
(GO:0050805)
Negative regulation of vascular associated smooth muscle cell migration
(GO:1904753)
Negative regulation of vascular associated smooth muscle cell proliferation
(GO:1904706)
Negative regulation of voltage-gated calcium channel activity
(GO:1901386)
Neuronal cell body
(GO:0043025)
Neurotransmitter receptor activity
(GO:0030594)
Norepinephrine binding
(GO:0051380)
Olfactory learning
(GO:0008355)
Plasma membrane
(GO:0005886)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of penile erection
(GO:0060406)
Positive regulation of sodium:proton antiporter activity
(GO:0032417)
Postsynaptic membrane
(GO:0045211)
Presynaptic membrane
(GO:0042734)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Regulation of calcium-mediated signaling
(GO:0050848)
Regulation of circadian rhythm
(GO:0042752)
Regulation of dopamine metabolic process
(GO:0042053)
Regulation of neurotransmitter secretion
(GO:0046928)
Regulation of postsynaptic membrane neurotransmitter receptor levels
(GO:0099072)
Regulation of postsynaptic neurotransmitter receptor internalization
(GO:0099149)
Response to amphetamine
(GO:0001975)
Response to histamine
(GO:0034776)
Rhythmic process
(GO:0048511)
Serotonin binding
(GO:0051378)
Sh3 domain binding
(GO:0017124)
Short-term memory
(GO:0007614)
Signal transduction
(GO:0007165)
Synaptic transmission, dopaminergic
(GO:0001963)
Terminal bouton
(GO:0043195)

Other Information

Proteins

D(4) dopamine receptor

Genular Protein ID: 908055553

Symbol: DRD4_MOUSE

Name: D(4) dopamine receptor

UniProtKB Accession Codes:

P51436 O35838 Q7TT80 Q8BXS4

Database IDs:

Citations:

PubMed ID: 7698326

Title: Molecular cloning and characterisation of the gene encoding the murine D4 dopamine receptor.

PubMed ID: 7698326

DOI: 10.1016/0014-5793(95)00168-9

PubMed ID: 8584230

Title: Genomic structure and tissue distribution of the mouse dopamine D4 receptor.

PubMed ID: 8584230

DOI: 10.1016/0304-3940(95)12021-u

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18303015

Title: BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase.

PubMed ID: 18303015

DOI: 10.1074/jbc.m708473200

PubMed ID: 24048828

Title: Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells.

PubMed ID: 24048828

DOI: 10.1523/jneurosci.2039-13.2013

Sequence Information:

Length: 387
Mass: 41487
Checksum: BEA306D5E8AA02E9
Sequence:

MGNSSATEDG GLLAGRGPES LGTGAGLGGA GAAALVGGVL LIGLVLAGNS LVCVSVASER 
TLQTPTNYFI VSLAAADLLL AVLVLPLFVY SEVQGGVWLL SPRLCDTLMA MDVMLCTASI 
FNLCAISVDR FVAVTVPLRY NQQGQCQLLL IAATWLLSAA VASPVVCGLN DVPGRDPAVC 
CLENRDYVVY SSVCSFFLPC PLMLLLYWAT FRGLRRWEAA RHTKLHSRAP RRPSGPGPPV 
SDPTQGPFFP DCPPPLPSLR TSPSDSSRPE SELSQRPCSP GCLLADAALP QPPEPSSRRR 
RGAKITGRER KAMRVLPVVV GAFLVCWTPF FVVHITRALC PACFVSPRLV SAVTWLGYVN 
SALNPIIYTI FNAEFRSVFR KTLRLRC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Drd4

Associated with

Other Information

Molecular cloning and characterisation of the gene encoding the murine D4 dopamine receptor. PubMed ID: 7698326

Genomic structure and tissue distribution of the mouse dopamine D4 receptor. PubMed ID: 8584230

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase. PubMed ID: 18303015