Details for: ADORA2A

Gene ID: 135

Symbol: ADORA2A

Ensembl ID: ENSG00000128271

Description: adenosine A2a receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 6.32
    Marker Score: 11206
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.29
    Marker Score: 4739.5
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.26
    Marker Score: 2436
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.95
    Marker Score: 688.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.72
    Marker Score: 3255
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1166
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.31
    Marker Score: 1303
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 485
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4805
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 500
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 1.08
    Marker Score: 1323
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.03
    Marker Score: 451
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48040
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.95
    Marker Score: 298
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5338
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.91
    Marker Score: 2150
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.89
    Marker Score: 593.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.85
    Marker Score: 752
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.79
    Marker Score: 306.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 589
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.76
    Marker Score: 454
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.73
    Marker Score: 11496
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.73
    Marker Score: 838
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 460
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.61
    Marker Score: 221
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.61
    Marker Score: 471
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.6
    Marker Score: 1215
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.6
    Marker Score: 285
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.58
    Marker Score: 242
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.58
    Marker Score: 187
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.57
    Marker Score: 986
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.55
    Marker Score: 454
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 285
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.45
    Marker Score: 260
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 251
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 113
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.41
    Marker Score: 1024
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.4
    Marker Score: 404
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.4
    Marker Score: 288
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.39
    Marker Score: 517
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.39
    Marker Score: 694
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.39
    Marker Score: 428
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.38
    Marker Score: 1063
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.36
    Marker Score: 338
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.35
    Marker Score: 121
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.34
    Marker Score: 490
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.33
    Marker Score: 364
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.32
    Marker Score: 562
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.32
    Marker Score: 285
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.31
    Marker Score: 154
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.31
    Marker Score: 915
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.3
    Marker Score: 183
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.3
    Marker Score: 457
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.29
    Marker Score: 406.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.29
    Marker Score: 318
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.28
    Marker Score: 695
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.28
    Marker Score: 1822
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.27
    Marker Score: 197
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.26
    Marker Score: 583
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.25
    Marker Score: 141
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.24
    Marker Score: 140
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.24
    Marker Score: 14722
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.23
    Marker Score: 382
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.23
    Marker Score: 220
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.23
    Marker Score: 2190
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.23
    Marker Score: 207
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.23
    Marker Score: 413
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.22
    Marker Score: 50
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.21
    Marker Score: 303
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.21
    Marker Score: 63
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.21
    Marker Score: 1951
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.21
    Marker Score: 142
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.2
    Marker Score: 203
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.2
    Marker Score: 1735
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.2
    Marker Score: 152
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2
    Marker Score: 10460.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.2
    Marker Score: 848
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.2
    Marker Score: 121

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Other Information

**Key characteristics:** - Type: G protein-coupled receptor - Ensembl ID: ENSG00000128271 - Protein sequence length: 1006 amino acids - Subcellular localization: Extracellular - Functional class: Class a/1 (rhodopsin-like receptors) **Pathways and functions:** - Activation of trka receptors - Adenosine p1 receptors - Calmodulin binding - Class a/1 (rhodopsin-like receptors) - G alpha (s) signalling events - Gpcr downstream signalling - Gpcr ligand binding - G protein-coupled adenosine receptor activity - Lipid binding - Metabolism of proteins **Clinical significance:** - ADORA2A has been implicated in a variety of human diseases, including asthma, cancer, and inflammation. - Mutations in the ADORA2A gene have been linked to the development of these diseases. - ADORA2A is a potential target for the development of new therapies for these diseases. **Additional notes:** - The ADORA2A gene is highly expressed in the luminal epithelial cell of the mammary gland, suggesting a role in breast development and milk production. - It is also expressed in immune cells, including CD4-positive and alpha-beta T cells, suggesting a role in immune surveillance. - Expression of ADORA2A is also observed in cardiac endothelial cells, suggesting a potential role in cardiovascular health.

Genular Protein ID: 4080930424

Symbol: AA2AR_HUMAN

Name: Adenosine receptor A2a

UniProtKB Accession Codes:

P29274 B2R7E0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 20 DrugCentral 1 EMBL 11 EMDB 3 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 69 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 81 PDBsum 74 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1331670

Title: Molecular characterization of a human brain adenosine A2 receptor.

PubMed ID: 1331670

DOI: 10.1016/0169-328x(92)90152-2

PubMed ID: 8670304

Title: Characterization and chromosomal localization of the human A2a adenosine receptor gene: ADORA2A.

PubMed ID: 8670304

DOI: 10.1006/bbrc.1996.0916

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17689978

Title: The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor.

PubMed ID: 17689978

DOI: 10.1016/j.mcn.2007.05.007

PubMed ID: 20836733

Title: The dopamine D(4) receptor, the ultimate disordered protein.

PubMed ID: 20836733

DOI: 10.3109/10799893.2010.513842

PubMed ID: 7775460

Title: Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor.

PubMed ID: 7775460

DOI: 10.1074/jbc.270.23.13987

PubMed ID: 16339847

Title: The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor.

PubMed ID: 16339847

DOI: 10.1124/mol.105.015818

PubMed ID: 18832607

Title: The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.

PubMed ID: 18832607

DOI: 10.1126/science.1164772

PubMed ID: 21593763

Title: Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation.

PubMed ID: 21593763

DOI: 10.1038/nature10136

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 412
  • Mass: 44707
  • Checksum: 9438E9D64A6BE61B
  • Sequence:
    • MPIMGSSVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFVVSLAA ADIAVGVLAI 
PFAITISTGF CAACHGCLFI ACFVLVLTQS SIFSLLAIAI DRYIAIRIPL RYNGLVTGTR 
AKGIIAICWV LSFAIGLTPM LGWNNCGQPK EGKNHSQGCG EGQVACLFED VVPMNYMVYF 
NFFACVLVPL LLMLGVYLRI FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG 
LFALCWLPLH IINCFTFFCP DCSHAPLWLM YLAIVLSHTN SVVNPFIYAY RIREFRQTFR 
KIIRSHVLRQ QEPFKAAGTS ARVLAAHGSD GEQVSLRLNG HPPGVWANGS APHPERRPNG 
YALGLVSGGS AQESQGNTGL PDVELLSHEL KGVCPEPPGL DDPLAQDGAG VS

Genular Protein ID: 2512058737

Symbol: A8K1F6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K1F6

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 Pfam 1 RefSeq 2 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 412
  • Mass: 44647
  • Checksum: 94255F04DDE1C75E
  • Sequence:
    • MPIMGSSVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFVVSLAA ADIAVGVLAI 
PFAITISTGF CAACHGCLFI ACFVLVLTQS SIFSLLAIAI DRYIAIRIPL RYNGLVTGTR 
AKGIIAICWV LSFAIGLTPM LGWNNCGQPK EGKNHSQGCG EGQVACLFED VVPMNYMVYF 
NFFACVLVPL LLMLGVYLRI FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG 
LFALCWLPLH IINCFTSFCP DCSHAPLWLM YLAIVLSHTN SVVNPFIYAY RIREFRQTFR 
KIIRSHVLRQ QEPFKAAGTS ARVLAAHGSD GEQVSLRLNG HPPGVWANGS APHPERRPNG 
YALGLVSGGS AQESQGNTGL PDVELLSHEL KGVCPEPPGL DDPLAQDGAG VS

Genular Protein ID: 3403555348

Symbol: B3KVQ4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KVQ4

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 PANTHER 2 PRINTS 3 PROSITE 3 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 412
  • Mass: 44721
  • Checksum: 712F5F0900CEACB2
  • Sequence:
    • MPIMGSSVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFLVSLAA ADIAVGVLAI 
PFAITISTGF CAACHGCLFI ACFVLVLTQS SIFSLLAIAI DRYIAIRIPL RYNGLVTGTR 
AKGIIAICWV LSFAIGLTPM LGWNNCGQPK EGKNHSQGCG EGQVACLFED VVPMNYMVYF 
NFFACVLVPL LLMLGVYLRI FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG 
LFALCWLPLH IINCFTFFCP DCSHAPLWLM YLAIVLSHTN SVVNPFIYAY RIREFRQTFR 
KIIRSHVLRQ QEPFKAAGTS ARVLAAHGSD GEQVSLRLNG HPPGVWANGS APHPERRPNG 
YALGLVSGGS AQESQGNTGL PDVELLSHEL KGVCPEPPGL DDPLAQDGAG VS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.