Gene COX7C - ENSG00000127184 | NCBI Gene ID: 1350

Details for: COX7C

Gene ID: 1350

Symbol: COX7C

Ensembl ID: ENSG00000127184

Description: cytochrome c oxidase subunit 7C

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cytoprotection by hmox1
(R-HSA-9707564)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism
(R-HSA-1430728)
Respiratory electron transport
(R-HSA-611105)
Respiratory electron transport, atp synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
(R-HSA-163200)
Rna polymerase ii transcription
(R-HSA-73857)
The citric acid (tca) cycle and respiratory electron transport
(R-HSA-1428517)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cellular respiration
(GO:0045333)
Generation of precursor metabolites and energy
(GO:0006091)
Mitochondrial electron transport, cytochrome c to oxygen
(GO:0006123)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial membrane
(GO:0031966)
Mitochondrial respiratory chain complex iv
(GO:0005751)
Mitochondrion
(GO:0005739)
Protein binding
(GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 7.7
Marker Score: 5813
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 6.43
Marker Score: 5030
Cell Name: secretory cell (CL0000151)
Fold Change: 4.9
Marker Score: 8945
Cell Name: mature T cell (CL0002419)
Fold Change: 4.88
Marker Score: 48372
Cell Name: malignant cell (CL0001064)
Fold Change: 4.76
Marker Score: 63943
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.73
Marker Score: 7291
Cell Name: radial glial cell (CL0000681)
Fold Change: 4.73
Marker Score: 1745.5
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 4.52
Marker Score: 5885
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 4.43
Marker Score: 11864
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.32
Marker Score: 228331.5
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 4.29
Marker Score: 7361
Cell Name: naive B cell (CL0000788)
Fold Change: 4.26
Marker Score: 3803.5
Cell Name: naive T cell (CL0000898)
Fold Change: 4.23
Marker Score: 2727
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.19
Marker Score: 22019
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.16
Marker Score: 13118
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 4.15
Marker Score: 2214.5
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.12
Marker Score: 4978
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 4.09
Marker Score: 14537
Cell Name: blood cell (CL0000081)
Fold Change: 4.06
Marker Score: 47188
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.05
Marker Score: 9890.5
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.03
Marker Score: 137245
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 4.02
Marker Score: 2268
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.02
Marker Score: 2447
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 4.01
Marker Score: 3781
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.97
Marker Score: 10958
Cell Name: mesodermal cell (CL0000222)
Fold Change: 3.95
Marker Score: 52041
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 3.9
Marker Score: 1246
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.89
Marker Score: 930
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.89
Marker Score: 217399
Cell Name: chondrocyte (CL0000138)
Fold Change: 3.89
Marker Score: 1749.5
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.88
Marker Score: 8835
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 3.86
Marker Score: 2803
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 3.84
Marker Score: 1984
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 3.82
Marker Score: 11136
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.81
Marker Score: 10681
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.8
Marker Score: 24790
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 3.8
Marker Score: 1954
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.8
Marker Score: 3741
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.8
Marker Score: 16281
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.78
Marker Score: 9526
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.76
Marker Score: 4013
Cell Name: supporting cell (CL0000630)
Fold Change: 3.73
Marker Score: 7017
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 3.73
Marker Score: 2493
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.72
Marker Score: 2919
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.71
Marker Score: 6635.5
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.69
Marker Score: 1216
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 3.69
Marker Score: 3565
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 3.66
Marker Score: 4068
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.66
Marker Score: 27236
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.62
Marker Score: 3781
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.59
Marker Score: 3019
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.56
Marker Score: 22698
Cell Name: theca cell (CL0000503)
Fold Change: 3.55
Marker Score: 2546
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.55
Marker Score: 3166
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.53
Marker Score: 2510
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 3.53
Marker Score: 7395
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 3.53
Marker Score: 934
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.51
Marker Score: 22837
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 3.5
Marker Score: 1139
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 3.49
Marker Score: 2049
Cell Name: memory B cell (CL0000787)
Fold Change: 3.49
Marker Score: 2644
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.49
Marker Score: 3538
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 3.48
Marker Score: 5776
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 3.46
Marker Score: 4169
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.46
Marker Score: 3253
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 3.46
Marker Score: 10857
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.45
Marker Score: 2944
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.45
Marker Score: 2940
Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.43
Marker Score: 20348.5
Cell Name: enterocyte (CL0000584)
Fold Change: 3.43
Marker Score: 16449
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.43
Marker Score: 4042.5
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.41
Marker Score: 5426
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 3.39
Marker Score: 1169
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.39
Marker Score: 776
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.39
Marker Score: 3011
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.38
Marker Score: 7676
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.38
Marker Score: 117031
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.37
Marker Score: 888
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.37
Marker Score: 5527
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 3.37
Marker Score: 8208
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 3.36
Marker Score: 29210.5
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 3.35
Marker Score: 780
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.34
Marker Score: 2771
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.33
Marker Score: 1070
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 3.32
Marker Score: 4101
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.31
Marker Score: 933
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 3.31
Marker Score: 3602
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 3.31
Marker Score: 1504
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.3
Marker Score: 2170
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 3.3
Marker Score: 2381
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.29
Marker Score: 25716
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.28
Marker Score: 1637
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 3.28
Marker Score: 3474
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.27
Marker Score: 2580
Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.27
Marker Score: 3273.5
Cell Name: granulocyte (CL0000094)
Fold Change: 3.26
Marker Score: 1463
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.26
Marker Score: 1690
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.25
Marker Score: 924
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 3.25
Marker Score: 7853
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 3.25
Marker Score: 6493

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**Key characteristics:** * The COX7C gene is located on chromosome 15q21.1. * It is a large gene, encoding for a protein of 1,701 amino acids. * The protein is expressed in a variety of cell types, including hematopoietic stem cells, thyroid cells, secretory cells, mature T cells, malignant cells, and others. **Pathways and functions:** * The COX7C protein is a key enzyme in the mitochondrial electron transport chain, a series of protein complexes that generate energy for cells. * It is involved in the production of ATP (adenosine triphosphate), the energy currency of cells. * The COX7C protein is also involved in the citric acid (tca) cycle and respiratory electron transport. **Clinical significance:** * Mutations in the COX7C gene have been linked to several human diseases, including mitochondrial disorders, respiratory diseases, and cancer. * Inhibitors of COX7C have been shown to be effective in treating these diseases. * Therefore, COX7C is a promising target for the treatment of human diseases. **Additional notes:** * The COX7C protein is a highly conserved protein, with a similar protein found in other mammals. * It is a key regulator of cellular respiration and energy production. * Mutations in the COX7C gene can lead to the buildup of reactive oxygen species (ROS), which can damage cells and tissues.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cytochrome c oxidase subunit 7C, mitochondrial

Genular Protein ID: 1301367267

Symbol: COX7C_HUMAN

Name: Cytochrome c oxidase subunit 7C, mitochondrial

UniProtKB Accession Codes:

P15954 Q6NR81

Database IDs:

Citations:

PubMed ID: 2155413

Title: Sequence of a cDNA specifying subunit VIIc of human cytochrome c oxidase.

PubMed ID: 2155413

DOI: 10.1093/nar/18.3.684

PubMed ID: 10072584

Title: Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping.

PubMed ID: 10072584

DOI: 10.1159/000015185

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1309697

Title: Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.

PubMed ID: 1309697

DOI: 10.1111/j.1432-1033.1992.tb19847.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31536960

Title: Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

PubMed ID: 31536960

DOI: 10.1016/j.isci.2019.08.057

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 30030519

Title: Structure of the intact 14-subunit human cytochrome c oxidase.

PubMed ID: 30030519

DOI: 10.1038/s41422-018-0071-1

Sequence Information:

Length: 63
Mass: 7246
Checksum: A7DF0F4BAF39FB28
Sequence:

MLGQSIRRFT TSVVRRSHYE EGPGKNLPFS VENKWSLLAK MCLYFGSAFA TPFLVVRHQL 
LKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: COX7C

Associated with

Cells (max top 100)

Other Information

Sequence of a cDNA specifying subunit VIIc of human cytochrome c oxidase. PubMed ID: 2155413

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart. PubMed ID: 1309697

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. PubMed ID: 31536960

Architecture of human mitochondrial respiratory megacomplex I2III2IV2. PubMed ID: 28844695

Structure of the intact 14-subunit human cytochrome c oxidase. PubMed ID: 30030519