Details for: COX7C

Gene ID: 1350

Symbol: COX7C

Ensembl ID: ENSG00000127184

Description: cytochrome c oxidase subunit 7C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1008.2920
    Cell Significance Index: -156.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 569.4215
    Cell Significance Index: -144.4300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 486.6153
    Cell Significance Index: -200.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 449.8937
    Cell Significance Index: -182.7700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 412.3505
    Cell Significance Index: -194.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 386.8307
    Cell Significance Index: -198.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 291.6297
    Cell Significance Index: -195.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 192.2821
    Cell Significance Index: -183.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 147.3046
    Cell Significance Index: -181.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 52.5690
    Cell Significance Index: -140.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 50.1616
    Cell Significance Index: -197.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 48.4461
    Cell Significance Index: -148.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 28.4704
    Cell Significance Index: -62.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 7.5475
    Cell Significance Index: 198.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.8474
    Cell Significance Index: 319.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 6.8267
    Cell Significance Index: 157.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 6.5336
    Cell Significance Index: 343.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 6.4723
    Cell Significance Index: 1166.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 6.3243
    Cell Significance Index: 777.6400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.1509
    Cell Significance Index: 49.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.8918
    Cell Significance Index: 160.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.7805
    Cell Significance Index: 3156.8900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.7674
    Cell Significance Index: 53.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.6671
    Cell Significance Index: 778.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.6546
    Cell Significance Index: 265.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.6284
    Cell Significance Index: 96.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.5434
    Cell Significance Index: 535.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.5328
    Cell Significance Index: 320.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.5218
    Cell Significance Index: 51.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 4.3731
    Cell Significance Index: 1933.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.3434
    Cell Significance Index: 561.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.2938
    Cell Significance Index: 320.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.2018
    Cell Significance Index: 410.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.7008
    Cell Significance Index: 79.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 2.3020
    Cell Significance Index: 182.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2644
    Cell Significance Index: 146.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.1643
    Cell Significance Index: 62.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.1592
    Cell Significance Index: 368.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.0314
    Cell Significance Index: 70.5900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.8504
    Cell Significance Index: 11.3900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.7983
    Cell Significance Index: 19.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7429
    Cell Significance Index: 90.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7080
    Cell Significance Index: 77.4200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.6581
    Cell Significance Index: 21.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4403
    Cell Significance Index: 26.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.4242
    Cell Significance Index: 1044.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.3988
    Cell Significance Index: 1058.8100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1705
    Cell Significance Index: 20.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0160
    Cell Significance Index: 27.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7441
    Cell Significance Index: 147.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6854
    Cell Significance Index: 130.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6161
    Cell Significance Index: 556.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4973
    Cell Significance Index: 99.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1198
    Cell Significance Index: 42.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0514
    Cell Significance Index: 0.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0240
    Cell Significance Index: -45.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0570
    Cell Significance Index: -42.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0616
    Cell Significance Index: -6.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0938
    Cell Significance Index: -58.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0949
    Cell Significance Index: -175.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1219
    Cell Significance Index: -187.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1507
    Cell Significance Index: -5.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1567
    Cell Significance Index: -213.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2060
    Cell Significance Index: -130.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2128
    Cell Significance Index: -120.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2172
    Cell Significance Index: -21.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3160
    Cell Significance Index: -143.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3176
    Cell Significance Index: -66.8900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3263
    Cell Significance Index: -4.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4373
    Cell Significance Index: -26.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4429
    Cell Significance Index: -127.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.4528
    Cell Significance Index: -73.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6474
    Cell Significance Index: -40.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8017
    Cell Significance Index: -91.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.8367
    Cell Significance Index: -57.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8580
    Cell Significance Index: -24.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8796
    Cell Significance Index: -22.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.0777
    Cell Significance Index: -156.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.0897
    Cell Significance Index: -126.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.0923
    Cell Significance Index: -65.5800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.1951
    Cell Significance Index: -136.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1955
    Cell Significance Index: -25.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2420
    Cell Significance Index: -39.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.2563
    Cell Significance Index: -35.1100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.4496
    Cell Significance Index: -24.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.6051
    Cell Significance Index: -123.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.7681
    Cell Significance Index: -30.3000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.8168
    Cell Significance Index: -37.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.8519
    Cell Significance Index: -192.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.9243
    Cell Significance Index: -26.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.0961
    Cell Significance Index: -117.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.2782
    Cell Significance Index: -56.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.4134
    Cell Significance Index: -162.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -2.5746
    Cell Significance Index: -134.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.7527
    Cell Significance Index: -168.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.4667
    Cell Significance Index: -102.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -3.6061
    Cell Significance Index: -76.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.8384
    Cell Significance Index: -169.7800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -3.8387
    Cell Significance Index: -45.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -3.9229
    Cell Significance Index: -104.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** COX7C is a mitochondrial gene that encodes a subunit of cytochrome c oxidase, a key enzyme in the mitochondrial electron transport chain. This complex is responsible for the transfer of electrons from cytochrome c to oxygen, generating a proton gradient that drives ATP synthesis by chemiosmotic coupling. COX7C is a highly conserved gene across species, with high expression levels in cells with high energy demands. The gene is also highly regulated by transcription factors, including TP53, which plays a crucial role in maintaining cellular homeostasis and preventing cancer. **Pathways and Functions** COX7C is involved in various cellular processes, including: 1. **Cellular Respiration**: COX7C is a critical component of the mitochondrial electron transport chain, responsible for generating ATP through oxidative phosphorylation. 2. **Mitochondrial Function**: COX7C is essential for maintaining mitochondrial structure and function, regulating the production of reactive oxygen species (ROS) and preventing mitochondrial dysfunction. 3. **Stress Response**: COX7C is highly expressed in response to cellular stress, including hypoxia, oxidative stress, and heat shock. 4. **Gene Regulation**: COX7C is regulated by transcription factors, including TP53, which plays a crucial role in maintaining cellular homeostasis and preventing cancer. **Clinical Significance** Dysregulation of COX7C has been implicated in various diseases, including: 1. **Cancer**: Overexpression of COX7C has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative Disorders**: Mutations in COX7C have been linked to neurodegenerative disorders, including Parkinson's disease and Alzheimer's disease. 3. **Metabolic Disorders**: COX7C dysfunction has been implicated in metabolic disorders, including diabetes and obesity. 4. **Mitochondrial Diseases**: Mutations in COX7C can lead to mitochondrial diseases, including Kearns-Sayre syndrome and MELAS syndrome. In conclusion, COX7C is a critical gene involved in mitochondrial function, cellular respiration, and gene regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying COX7C function and its role in human disease.

Genular Protein ID: 1301367267

Symbol: COX7C_HUMAN

Name: Cytochrome c oxidase subunit 7C, mitochondrial

UniProtKB Accession Codes:

P15954 Q6NR81

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2155413

Title: Sequence of a cDNA specifying subunit VIIc of human cytochrome c oxidase.

PubMed ID: 2155413

DOI: 10.1093/nar/18.3.684

PubMed ID: 10072584

Title: Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping.

PubMed ID: 10072584

DOI: 10.1159/000015185

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1309697

Title: Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.

PubMed ID: 1309697

DOI: 10.1111/j.1432-1033.1992.tb19847.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31536960

Title: Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

PubMed ID: 31536960

DOI: 10.1016/j.isci.2019.08.057

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 30030519

Title: Structure of the intact 14-subunit human cytochrome c oxidase.

PubMed ID: 30030519

DOI: 10.1038/s41422-018-0071-1

Sequence Information:

  • Length: 63
  • Mass: 7246
  • Checksum: A7DF0F4BAF39FB28
  • Sequence:
    • MLGQSIRRFT TSVVRRSHYE EGPGKNLPFS VENKWSLLAK MCLYFGSAFA TPFLVVRHQL 
LKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.