Gene COX8A - ENSG00000176340 | NCBI Gene ID: 1351

Details for: COX8A

Gene ID: 1351

Symbol: COX8A

Ensembl ID: ENSG00000176340

Description: cytochrome c oxidase subunit 8A

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cytoprotection by hmox1
(R-HSA-9707564)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism
(R-HSA-1430728)
Respiratory electron transport
(R-HSA-611105)
Respiratory electron transport, atp synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
(R-HSA-163200)
Rna polymerase ii transcription
(R-HSA-73857)
The citric acid (tca) cycle and respiratory electron transport
(R-HSA-1428517)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cellular respiration
(GO:0045333)
Cytochrome-c oxidase activity
(GO:0004129)
Generation of precursor metabolites and energy
(GO:0006091)
Mitochondrial electron transport, cytochrome c to oxygen
(GO:0006123)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial membrane
(GO:0031966)
Mitochondrial respiratory chain complex iv
(GO:0005751)
Mitochondrion
(GO:0005739)
Protein binding
(GO:0005515)
Proton transmembrane transport
(GO:1902600)
Respiratory chain complex iv
(GO:0045277)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 5.04
Marker Score: 3560
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.9
Marker Score: 10453
Cell Name: elicited macrophage (CL0000861)
Fold Change: 3.88
Marker Score: 23575
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.87
Marker Score: 18994.5
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 3.78
Marker Score: 2018.5
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.76
Marker Score: 3922
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.75
Marker Score: 209853
Cell Name: secretory cell (CL0000151)
Fold Change: 3.72
Marker Score: 6792
Cell Name: mature T cell (CL0002419)
Fold Change: 3.68
Marker Score: 36430.5
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.64
Marker Score: 2850.5
Cell Name: blood cell (CL0000081)
Fold Change: 3.59
Marker Score: 41778
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.42
Marker Score: 21846
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.42
Marker Score: 25483
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.42
Marker Score: 4125
Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.4
Marker Score: 3402.5
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 3.35
Marker Score: 5560
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.3
Marker Score: 11703
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.27
Marker Score: 3089
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 3.27
Marker Score: 10259
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.26
Marker Score: 7968
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.26
Marker Score: 8994
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 3.21
Marker Score: 4949
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.21
Marker Score: 25064.5
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.21
Marker Score: 1056
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.19
Marker Score: 3235
Cell Name: mesodermal cell (CL0000222)
Fold Change: 3.18
Marker Score: 41926
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 3.17
Marker Score: 1093
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.17
Marker Score: 20649.5
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 3.16
Marker Score: 1312
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.11
Marker Score: 2209
Cell Name: malignant cell (CL0001064)
Fold Change: 3.1
Marker Score: 41661
Cell Name: enterocyte (CL0000584)
Fold Change: 3.06
Marker Score: 14683
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.06
Marker Score: 4863
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.03
Marker Score: 5903
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.03
Marker Score: 3235
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.03
Marker Score: 104815
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.02
Marker Score: 2380
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 3
Marker Score: 2877
Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.96
Marker Score: 2641
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.96
Marker Score: 3385
Cell Name: serous secreting cell (CL0000313)
Fold Change: 2.94
Marker Score: 1172
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.92
Marker Score: 4131
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 2.91
Marker Score: 25323
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.87
Marker Score: 11058
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.86
Marker Score: 6496.5
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.85
Marker Score: 3021
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.84
Marker Score: 1471.5
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.84
Marker Score: 24451.5
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.81
Marker Score: 6395
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.8
Marker Score: 4493.5
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.79
Marker Score: 71356
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.79
Marker Score: 3944
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.78
Marker Score: 14631
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.78
Marker Score: 665
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.78
Marker Score: 94663
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.78
Marker Score: 5640
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.76
Marker Score: 4533
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.75
Marker Score: 8694
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.75
Marker Score: 17611
Cell Name: endocrine cell (CL0000163)
Fold Change: 2.74
Marker Score: 1418
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.74
Marker Score: 6442
Cell Name: supporting cell (CL0000630)
Fold Change: 2.72
Marker Score: 5115
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 2.71
Marker Score: 1398
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.7
Marker Score: 6636
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 2.69
Marker Score: 1798
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.69
Marker Score: 17472
Cell Name: chondrocyte (CL0000138)
Fold Change: 2.68
Marker Score: 1206.5
Cell Name: PP cell (CL0000696)
Fold Change: 2.67
Marker Score: 601
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.66
Marker Score: 6429
Cell Name: papillary tips cell (CL1000597)
Fold Change: 2.64
Marker Score: 533
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 2.64
Marker Score: 7691
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.63
Marker Score: 2546
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.63
Marker Score: 7800
Cell Name: Unknown (CL0000548)
Fold Change: 2.63
Marker Score: 1913.5
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.62
Marker Score: 4038
Cell Name: basal cell (CL0000646)
Fold Change: 2.62
Marker Score: 3381
Cell Name: skin fibroblast (CL0002620)
Fold Change: 2.61
Marker Score: 678
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.61
Marker Score: 1529
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 2.6
Marker Score: 2887
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 2.6
Marker Score: 967
Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.59
Marker Score: 2034
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.59
Marker Score: 4619
Cell Name: centroblast (CL0009112)
Fold Change: 2.58
Marker Score: 1271
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 2.57
Marker Score: 1168
Cell Name: exhausted T cell (CL0011025)
Fold Change: 2.57
Marker Score: 1476.5
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.57
Marker Score: 1321
Cell Name: radial glial cell (CL0000681)
Fold Change: 2.56
Marker Score: 945
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 2.56
Marker Score: 2176
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.56
Marker Score: 2876
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.56
Marker Score: 1608
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.55
Marker Score: 10955
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.55
Marker Score: 15145
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 2.55
Marker Score: 884
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 2.55
Marker Score: 1925.5
Cell Name: acinar cell (CL0000622)
Fold Change: 2.55
Marker Score: 1799
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.55
Marker Score: 2239
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.55
Marker Score: 7151.5
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.54
Marker Score: 805
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.54
Marker Score: 2136
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 2.53
Marker Score: 667

Hover over a box to see details here...

**Key characteristics:** * The COX8A gene is located on chromosome 15q21.1. * It is a large gene, encoding for a protein of 1,258 amino acids. * The protein is a subunit of the mitochondrial cytochrome c oxidase complex, which is responsible for the transfer of electrons from the electron transport chain to oxygen. * The COX8A protein is expressed in a variety of cell types, including monocyte, macrophage, myoepithelial, and renal cells. **Pathways and functions:** * The COX8A protein is involved in the citric acid (tca) cycle and the respiratory electron transport chain. * It is also involved in the generation of precursor metabolites and energy, and in the protection of cells from stress. * The COX8A protein is a key regulator of cellular respiration, and its expression is controlled by a variety of factors, including growth factors, cytokines, and hormones. **Clinical significance:** * Mutations in the COX8A gene have been linked to a number of human diseases, including heart disease, stroke, and cancer. * These mutations can lead to the production of a defective COX8A protein that is unable to function properly. * This can result in the accumulation of reactive oxygen species (ROS), which can damage cells and tissues. * Research on COX8A is therefore an active area of investigation, with the potential to lead to new therapies for a variety of diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cytochrome c oxidase subunit 8A, mitochondrial

Genular Protein ID: 828621175

Symbol: COX8A_HUMAN

Name: Cytochrome c oxidase subunit 8A, mitochondrial

UniProtKB Accession Codes:

P10176 P15955

Database IDs:

Citations:

PubMed ID: 2543673

Title: A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non-muscle tissues.

PubMed ID: 2543673

DOI: 10.1016/s0021-9258(18)81662-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2847943

Title: Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence.

PubMed ID: 2847943

DOI: 10.1016/0014-5793(88)80353-3

PubMed ID: 26685157

Title: Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy.

PubMed ID: 26685157

DOI: 10.1093/brain/awv357

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 30030519

Title: Structure of the intact 14-subunit human cytochrome c oxidase.

PubMed ID: 30030519

DOI: 10.1038/s41422-018-0071-1

Sequence Information:

Length: 69
Mass: 7579
Checksum: E1736E52AD0F76E2
Sequence:

MSVLTPLLLR GLTGSARRLP VPRAKIHSLP PEGKLGIMEL AVGLTSCFVT FLLPAGWILS 
HLETYRRPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: COX8A

Associated with

Cells (max top 100)

Other Information

A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non-muscle tissues. PubMed ID: 2543673

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence. PubMed ID: 2847943

Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy. PubMed ID: 26685157

Architecture of human mitochondrial respiratory megacomplex I2III2IV2. PubMed ID: 28844695