COX8A | ENSG00000176340 | NCBI 1351

Details for: COX8A

Gene ID: 1351

Symbol: COX8A

Ensembl ID: ENSG00000176340

Description: cytochrome c oxidase subunit 8A

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cytoprotection by hmox1
(R-HSA-9707564)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism
(R-HSA-1430728)
Respiratory electron transport
(R-HSA-611105)
Respiratory electron transport, atp synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
(R-HSA-163200)
Rna polymerase ii transcription
(R-HSA-73857)
The citric acid (tca) cycle and respiratory electron transport
(R-HSA-1428517)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cellular respiration
(GO:0045333)
Cytochrome-c oxidase activity
(GO:0004129)
Generation of precursor metabolites and energy
(GO:0006091)
Mitochondrial electron transport, cytochrome c to oxygen
(GO:0006123)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial membrane
(GO:0031966)
Mitochondrial respiratory chain complex iv
(GO:0005751)
Mitochondrion
(GO:0005739)
Protein binding
(GO:0005515)
Proton transmembrane transport
(GO:1902600)
Respiratory chain complex iv
(GO:0045277)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 5.04
Marker Score: 3,560
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.9
Marker Score: 10,453
Cell Name: elicited macrophage (CL0000861)
Fold Change: 3.88
Marker Score: 23,575
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.87
Marker Score: 18,995
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 3.78
Marker Score: 2,019
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.76
Marker Score: 3,922
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.75
Marker Score: 209,853
Cell Name: secretory cell (CL0000151)
Fold Change: 3.72
Marker Score: 6,792
Cell Name: mature T cell (CL0002419)
Fold Change: 3.68
Marker Score: 36,431
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.64
Marker Score: 2,851
Cell Name: blood cell (CL0000081)
Fold Change: 3.59
Marker Score: 41,778
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.42
Marker Score: 21,846
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.42
Marker Score: 25,483
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.42
Marker Score: 4,125
Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.4
Marker Score: 3,403
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 3.35
Marker Score: 5,560
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.3
Marker Score: 11,703
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.27
Marker Score: 3,089
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 3.27
Marker Score: 10,259
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.26
Marker Score: 7,968
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.26
Marker Score: 8,994
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 3.21
Marker Score: 4,949
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.21
Marker Score: 25,065
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.21
Marker Score: 1,056
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.19
Marker Score: 3,235
Cell Name: mesodermal cell (CL0000222)
Fold Change: 3.18
Marker Score: 41,926
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 3.17
Marker Score: 1,093
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.17
Marker Score: 20,650
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 3.16
Marker Score: 1,312
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.11
Marker Score: 2,209
Cell Name: malignant cell (CL0001064)
Fold Change: 3.1
Marker Score: 41,661
Cell Name: enterocyte (CL0000584)
Fold Change: 3.06
Marker Score: 14,683
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.06
Marker Score: 4,863
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.03
Marker Score: 5,903
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.03
Marker Score: 3,235
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.03
Marker Score: 104,815
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.02
Marker Score: 2,380
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 3
Marker Score: 2,877
Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.96
Marker Score: 2,641
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.96
Marker Score: 3,385
Cell Name: serous secreting cell (CL0000313)
Fold Change: 2.94
Marker Score: 1,172
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.92
Marker Score: 4,131
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 2.91
Marker Score: 25,323
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.87
Marker Score: 11,058
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.86
Marker Score: 6,497
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.85
Marker Score: 3,021
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.84
Marker Score: 1,472
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.84
Marker Score: 24,452
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.81
Marker Score: 6,395
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.8
Marker Score: 4,494
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.79
Marker Score: 71,356
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.79
Marker Score: 3,944
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.78
Marker Score: 14,631
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.78
Marker Score: 665
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.78
Marker Score: 94,663
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.78
Marker Score: 5,640
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.76
Marker Score: 4,533
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.75
Marker Score: 8,694
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.75
Marker Score: 17,611
Cell Name: endocrine cell (CL0000163)
Fold Change: 2.74
Marker Score: 1,418
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.74
Marker Score: 6,442
Cell Name: supporting cell (CL0000630)
Fold Change: 2.72
Marker Score: 5,115
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 2.71
Marker Score: 1,398
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.7
Marker Score: 6,636
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 2.69
Marker Score: 1,798
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.69
Marker Score: 17,472
Cell Name: chondrocyte (CL0000138)
Fold Change: 2.68
Marker Score: 1,207
Cell Name: PP cell (CL0000696)
Fold Change: 2.67
Marker Score: 601
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.66
Marker Score: 6,429
Cell Name: papillary tips cell (CL1000597)
Fold Change: 2.64
Marker Score: 533
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 2.64
Marker Score: 7,691
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.63
Marker Score: 2,546
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.63
Marker Score: 7,800
Cell Name: Unknown (CL0000548)
Fold Change: 2.63
Marker Score: 1,914
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.62
Marker Score: 4,038
Cell Name: basal cell (CL0000646)
Fold Change: 2.62
Marker Score: 3,381
Cell Name: skin fibroblast (CL0002620)
Fold Change: 2.61
Marker Score: 678
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.61
Marker Score: 1,529
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 2.6
Marker Score: 2,887
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 2.6
Marker Score: 967
Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.59
Marker Score: 2,034
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.59
Marker Score: 4,619
Cell Name: centroblast (CL0009112)
Fold Change: 2.58
Marker Score: 1,271
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 2.57
Marker Score: 1,168
Cell Name: exhausted T cell (CL0011025)
Fold Change: 2.57
Marker Score: 1,477
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.57
Marker Score: 1,321
Cell Name: radial glial cell (CL0000681)
Fold Change: 2.56
Marker Score: 945
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 2.56
Marker Score: 2,176
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.56
Marker Score: 2,876
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.56
Marker Score: 1,608
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.55
Marker Score: 10,955
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.55
Marker Score: 15,145
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 2.55
Marker Score: 884
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 2.55
Marker Score: 1,926
Cell Name: acinar cell (CL0000622)
Fold Change: 2.55
Marker Score: 1,799
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.55
Marker Score: 2,239
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.55
Marker Score: 7,152
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.54
Marker Score: 805
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.54
Marker Score: 2,136
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 2.53
Marker Score: 667

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** COX8A is a mitochondrial protein that is part of the cytochrome c oxidase complex, a crucial enzyme in the mitochondrial respiratory chain. It is characterized by its ability to bind to the mitochondrial inner membrane and participate in the transfer of electrons from cytochrome c to oxygen. COX8A is highly conserved across species, suggesting its evolutionary importance. The gene is expressed in various cell types, including immune cells, epithelial cells, and hematopoietic progenitor cells, indicating its role in maintaining cellular homeostasis. **Pathways and Functions:** COX8A is involved in several key pathways, including: 1. **Cellular Respiration**: COX8A plays a critical role in the mitochondrial respiratory chain, facilitating the transfer of electrons from cytochrome c to oxygen, which is essential for ATP synthesis. 2. **Stress Response**: COX8A is upregulated in response to cellular stress, including oxidative stress, heat shock, and hypoxia. This suggests its role in maintaining cellular homeostasis under stressful conditions. 3. **Cytoprotection**: COX8A has been shown to exert cytoprotective effects, protecting cells from oxidative damage and apoptosis. 4. **Energy Production**: COX8A is essential for the generation of ATP, which is critical for cellular function. **Clinical Significance:** Dysregulation of COX8A has been implicated in various diseases, including: 1. **Cancer**: Overexpression of COX8A has been observed in various cancers, including breast, lung, and colon cancer. This suggests its role in tumorigenesis and cancer progression. 2. **Neurodegenerative Diseases**: COX8A has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where it plays a role in energy metabolism and oxidative stress. 3. **Infectious Diseases**: COX8A has been shown to play a role in the regulation of immune responses, including the activation of macrophages and the production of cytokines. 4. **Metabolic Disorders**: COX8A has been implicated in metabolic disorders, including diabetes and obesity, where it plays a role in energy metabolism and glucose homeostasis. In conclusion, COX8A is a critical gene that plays a pivotal role in cellular respiration, stress response, and energy production. Its dysregulation has been implicated in various diseases, highlighting its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the role of COX8A in human disease and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cytochrome c oxidase subunit 8A, mitochondrial

Genular Protein ID: 828621175

Symbol: COX8A_HUMAN

Name: Cytochrome c oxidase subunit 8A, mitochondrial

UniProtKB Accession Codes:

P10176 P15955

Database IDs:

Citations:

PubMed ID: 2543673

Title: A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non-muscle tissues.

PubMed ID: 2543673

DOI: 10.1016/s0021-9258(18)81662-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2847943

Title: Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence.

PubMed ID: 2847943

DOI: 10.1016/0014-5793(88)80353-3

PubMed ID: 26685157

Title: Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy.

PubMed ID: 26685157

DOI: 10.1093/brain/awv357

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 30030519

Title: Structure of the intact 14-subunit human cytochrome c oxidase.

PubMed ID: 30030519

DOI: 10.1038/s41422-018-0071-1

Sequence Information:

Length: 69
Mass: 7579
Checksum: E1736E52AD0F76E2
Sequence:

MSVLTPLLLR GLTGSARRLP VPRAKIHSLP PEGKLGIMEL AVGLTSCFVT FLLPAGWILS 
HLETYRRPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: COX8A

Associated with

Cells (max top 100)

Other Information

A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non-muscle tissues. PubMed ID: 2543673

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence. PubMed ID: 2847943

Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy. PubMed ID: 26685157

Architecture of human mitochondrial respiratory megacomplex I2III2IV2. PubMed ID: 28844695