Details for: COX8A

Gene ID: 1351

Symbol: COX8A

Ensembl ID: ENSG00000176340

Description: cytochrome c oxidase subunit 8A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 622.5842
    Cell Significance Index: -96.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 411.6409
    Cell Significance Index: -104.4100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 305.6457
    Cell Significance Index: -125.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 266.8798
    Cell Significance Index: -126.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 242.3281
    Cell Significance Index: -124.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 188.2203
    Cell Significance Index: -126.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 96.9418
    Cell Significance Index: -119.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 33.1472
    Cell Significance Index: -101.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 31.9763
    Cell Significance Index: -126.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 31.2297
    Cell Significance Index: -83.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.8412
    Cell Significance Index: 254.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.8050
    Cell Significance Index: 88.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 4.6554
    Cell Significance Index: 124.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.2068
    Cell Significance Index: 123.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.7149
    Cell Significance Index: 669.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.4639
    Cell Significance Index: 408.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.4332
    Cell Significance Index: 31.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.3923
    Cell Significance Index: 158.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.3892
    Cell Significance Index: 416.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.1096
    Cell Significance Index: 1698.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.0233
    Cell Significance Index: 415.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.9646
    Cell Significance Index: 220.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.9522
    Cell Significance Index: 1305.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.8678
    Cell Significance Index: 78.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.7299
    Cell Significance Index: 63.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.7264
    Cell Significance Index: 192.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.5247
    Cell Significance Index: 118.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.5201
    Cell Significance Index: 28.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.2670
    Cell Significance Index: 224.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.1552
    Cell Significance Index: 278.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.9162
    Cell Significance Index: 40.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.8293
    Cell Significance Index: 48.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7203
    Cell Significance Index: 110.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.6100
    Cell Significance Index: 206.3900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5668
    Cell Significance Index: 12.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5660
    Cell Significance Index: 81.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4243
    Cell Significance Index: 64.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0199
    Cell Significance Index: 194.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.8582
    Cell Significance Index: 629.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8339
    Cell Significance Index: 24.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.6593
    Cell Significance Index: 52.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6375
    Cell Significance Index: 108.8500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4986
    Cell Significance Index: 5.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4184
    Cell Significance Index: 26.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4033
    Cell Significance Index: 11.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3892
    Cell Significance Index: 294.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2907
    Cell Significance Index: 10.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2144
    Cell Significance Index: 43.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0896
    Cell Significance Index: 1.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0824
    Cell Significance Index: 2.2000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0528
    Cell Significance Index: 0.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0466
    Cell Significance Index: 16.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0010
    Cell Significance Index: -0.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0188
    Cell Significance Index: -1.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0390
    Cell Significance Index: -1.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0634
    Cell Significance Index: -119.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0871
    Cell Significance Index: -160.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0911
    Cell Significance Index: -56.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1043
    Cell Significance Index: -160.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1182
    Cell Significance Index: -160.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1363
    Cell Significance Index: -76.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1806
    Cell Significance Index: -38.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1848
    Cell Significance Index: -117.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2393
    Cell Significance Index: -12.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2463
    Cell Significance Index: -3.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2544
    Cell Significance Index: -10.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2831
    Cell Significance Index: -128.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2859
    Cell Significance Index: -32.7500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3127
    Cell Significance Index: -2.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3495
    Cell Significance Index: -100.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3628
    Cell Significance Index: -59.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4073
    Cell Significance Index: -8.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5394
    Cell Significance Index: -18.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5522
    Cell Significance Index: -64.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5887
    Cell Significance Index: -67.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5934
    Cell Significance Index: -15.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.6229
    Cell Significance Index: -123.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6958
    Cell Significance Index: -15.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.7720
    Cell Significance Index: -53.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.8611
    Cell Significance Index: -125.1700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0144
    Cell Significance Index: -17.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0300
    Cell Significance Index: -27.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.1286
    Cell Significance Index: -31.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1462
    Cell Significance Index: -70.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.2235
    Cell Significance Index: -73.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2353
    Cell Significance Index: -128.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.4139
    Cell Significance Index: -108.5000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.4637
    Cell Significance Index: -18.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.5143
    Cell Significance Index: -84.9700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -1.8806
    Cell Significance Index: -16.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.0581
    Cell Significance Index: -126.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.0984
    Cell Significance Index: -28.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.3093
    Cell Significance Index: -68.0200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.4947
    Cell Significance Index: -20.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.8952
    Cell Significance Index: -128.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.9238
    Cell Significance Index: -107.3300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -3.1191
    Cell Significance Index: -65.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -3.2784
    Cell Significance Index: -114.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -3.4118
    Cell Significance Index: -129.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -3.4249
    Cell Significance Index: -112.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** COX8A is a mitochondrial protein that is part of the cytochrome c oxidase complex, a crucial enzyme in the mitochondrial respiratory chain. It is characterized by its ability to bind to the mitochondrial inner membrane and participate in the transfer of electrons from cytochrome c to oxygen. COX8A is highly conserved across species, suggesting its evolutionary importance. The gene is expressed in various cell types, including immune cells, epithelial cells, and hematopoietic progenitor cells, indicating its role in maintaining cellular homeostasis. **Pathways and Functions:** COX8A is involved in several key pathways, including: 1. **Cellular Respiration**: COX8A plays a critical role in the mitochondrial respiratory chain, facilitating the transfer of electrons from cytochrome c to oxygen, which is essential for ATP synthesis. 2. **Stress Response**: COX8A is upregulated in response to cellular stress, including oxidative stress, heat shock, and hypoxia. This suggests its role in maintaining cellular homeostasis under stressful conditions. 3. **Cytoprotection**: COX8A has been shown to exert cytoprotective effects, protecting cells from oxidative damage and apoptosis. 4. **Energy Production**: COX8A is essential for the generation of ATP, which is critical for cellular function. **Clinical Significance:** Dysregulation of COX8A has been implicated in various diseases, including: 1. **Cancer**: Overexpression of COX8A has been observed in various cancers, including breast, lung, and colon cancer. This suggests its role in tumorigenesis and cancer progression. 2. **Neurodegenerative Diseases**: COX8A has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where it plays a role in energy metabolism and oxidative stress. 3. **Infectious Diseases**: COX8A has been shown to play a role in the regulation of immune responses, including the activation of macrophages and the production of cytokines. 4. **Metabolic Disorders**: COX8A has been implicated in metabolic disorders, including diabetes and obesity, where it plays a role in energy metabolism and glucose homeostasis. In conclusion, COX8A is a critical gene that plays a pivotal role in cellular respiration, stress response, and energy production. Its dysregulation has been implicated in various diseases, highlighting its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the role of COX8A in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 828621175

Symbol: COX8A_HUMAN

Name: Cytochrome c oxidase subunit 8A, mitochondrial

UniProtKB Accession Codes:

P10176 P15955

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 2 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2543673

Title: A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non-muscle tissues.

PubMed ID: 2543673

DOI: 10.1016/s0021-9258(18)81662-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2847943

Title: Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence.

PubMed ID: 2847943

DOI: 10.1016/0014-5793(88)80353-3

PubMed ID: 26685157

Title: Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy.

PubMed ID: 26685157

DOI: 10.1093/brain/awv357

PubMed ID: 38297121

Title: Stress response silencing by an E3 ligase mutated in neurodegeneration.

PubMed ID: 38297121

DOI: 10.1038/s41586-023-06985-7

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 30030519

Title: Structure of the intact 14-subunit human cytochrome c oxidase.

PubMed ID: 30030519

DOI: 10.1038/s41422-018-0071-1

Sequence Information:

  • Length: 69
  • Mass: 7579
  • Checksum: E1736E52AD0F76E2
  • Sequence:
    • MSVLTPLLLR GLTGSARRLP VPRAKIHSLP PEGKLGIMEL AVGLTSCFVT FLLPAGWILS 
HLETYRRPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.