Details for: COX10

Gene ID: 1352

Symbol: COX10

Ensembl ID: ENSG00000006695

Description: cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.8
    Marker Score: 3138
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.48
    Marker Score: 54736
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168450
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.41
    Marker Score: 5838
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.36
    Marker Score: 2093
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.27
    Marker Score: 10945
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.26
    Marker Score: 77412
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.24
    Marker Score: 11663
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.24
    Marker Score: 27704
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.24
    Marker Score: 5034
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.22
    Marker Score: 11599
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.18
    Marker Score: 622
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18304
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.14
    Marker Score: 43237
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.08
    Marker Score: 4171
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.07
    Marker Score: 11086
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.03
    Marker Score: 3659
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71752
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47977
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.99
    Marker Score: 19779
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.99
    Marker Score: 21104
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.97
    Marker Score: 947
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.96
    Marker Score: 739
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.95
    Marker Score: 14175
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.95
    Marker Score: 758
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.93
    Marker Score: 559
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2718
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.9
    Marker Score: 1291
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.89
    Marker Score: 987
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4967
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.85
    Marker Score: 6513
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1275
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.78
    Marker Score: 225
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.78
    Marker Score: 1708
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.77
    Marker Score: 969.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 588.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 303
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.72
    Marker Score: 228
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.71
    Marker Score: 712
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.71
    Marker Score: 1496
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.7
    Marker Score: 318
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7
    Marker Score: 4471
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2903
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.69
    Marker Score: 277
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 625
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.67
    Marker Score: 2880
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.67
    Marker Score: 324
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.66
    Marker Score: 446
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.66
    Marker Score: 1548
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.65
    Marker Score: 752
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 410
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.64
    Marker Score: 553
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.63
    Marker Score: 1285
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.63
    Marker Score: 313
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.61
    Marker Score: 870
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.6
    Marker Score: 647
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6
    Marker Score: 2348
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.57
    Marker Score: 214
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.57
    Marker Score: 2637
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.57
    Marker Score: 3421
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.57
    Marker Score: 1351
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.57
    Marker Score: 149
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.56
    Marker Score: 138
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.55
    Marker Score: 161
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.55
    Marker Score: 203
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.55
    Marker Score: 319
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.55
    Marker Score: 574
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.54
    Marker Score: 673
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 431
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.53
    Marker Score: 704
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.53
    Marker Score: 383
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.52
    Marker Score: 481
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.52
    Marker Score: 2501
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.52
    Marker Score: 2790
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.52
    Marker Score: 551
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.52
    Marker Score: 997
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.51
    Marker Score: 1379
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.51
    Marker Score: 286
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.51
    Marker Score: 541
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.5
    Marker Score: 250
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5
    Marker Score: 332
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.5
    Marker Score: 209
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.5
    Marker Score: 278
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.49
    Marker Score: 727
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.49
    Marker Score: 369
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.49
    Marker Score: 557
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.49
    Marker Score: 198
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.48
    Marker Score: 168
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 289
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.48
    Marker Score: 1497
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.47
    Marker Score: 5509
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.47
    Marker Score: 917

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Other Information

**Key characteristics:** - COX10 is a protein of the cytochrome c oxidase assembly factor family. - It is responsible for the assembly of cytochrome c oxidase in mitochondria. - It is expressed in a variety of cell types. - It is a highly conserved protein. **Pathways and functions:** - COX10 is involved in the assembly of cytochrome c oxidase in mitochondria. - Cytochrome c oxidase is an enzyme that is responsible for the electron transport chain, which is a series of electron carriers that allow for the production of ATP from glucose. - The assembly of cytochrome c oxidase is a complex process that requires the coordinated action of several proteins. COX10 is one of these proteins. **Clinical significance:** - Mutations in COX10 have been linked to a number of human diseases, including mitochondrial disorders, neurodegenerative diseases, and cancer. - These diseases are characterized by the accumulation of damaged mitochondria. - COX10 is a potential target for therapeutic intervention in these diseases.

Genular Protein ID: 4179774580

Symbol: COX10_HUMAN

Name: Protoheme IX farnesyltransferase, mitochondrial

UniProtKB Accession Codes:

Q12887 B2R6U5 B4DJ50 O15334 Q969F7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 15 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8078902

Title: Isolation of a human cDNA for heme A:farnesyltransferase by functional complementation of a yeast cox10 mutant.

PubMed ID: 8078902

DOI: 10.1073/pnas.91.18.8452

PubMed ID: 9177788

Title: Genomic structure and expression of the human heme A:farnesyltransferase (COX10) gene.

PubMed ID: 9177788

DOI: 10.1006/geno.1997.4711

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10767350

Title: A mutation in the human heme A:farnesyltransferase gene (COX10) causes cytochrome c oxidase deficiency.

PubMed ID: 10767350

DOI: 10.1093/hmg/9.8.1245

PubMed ID: 12928484

Title: Mutations in COX10 result in a defect in mitochondrial heme A biosynthesis and account for multiple, early-onset clinical phenotypes associated with isolated COX deficiency.

PubMed ID: 12928484

DOI: 10.1093/hmg/ddg284

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

PubMed ID: 26741492

Title: A comprehensive genomic analysis reveals the genetic landscape of mitochondrial respiratory chain complex deficiencies.

PubMed ID: 26741492

DOI: 10.1371/journal.pgen.1005679

Sequence Information:

  • Length: 443
  • Mass: 48910
  • Checksum: EC39E8D8966F4094
  • Sequence:
    • MAASPHTLSS RLLTGCVGGS VWYLERRTIQ DSPHKFLHLL RNVNKQWITF QHFSFLKRMY 
VTQLNRSHNQ QVRPKPEPVA SPFLEKTSSG QAKAEIYEMR PLSPPSLSLS RKPNEKELIE 
LEPDSVIEDS IDVGKETKEE KRWKEMKLQV YDLPGILARL SKIKLTALVV STTAAGFALA 
PGPFDWPCFL LTSVGTGLAS CAANSINQFF EVPFDSNMNR TKNRPLVRGQ ISPLLAVSFA 
TCCAVPGVAI LTLGVNPLTG ALGLFNIFLY TCCYTPLKRI SIANTWVGAV VGAIPPVMGW 
TAATGSLDAG AFLLGGILYS WQFPHFNALS WGLREDYSRG GYCMMSVTHP GLCRRVALRH 
CLALLVLSAA APVLDITTWT FPIMALPINA YISYLGFRFY VDADRRSSRR LFFCSLWHLP 
LLLLLMLTCK RPSGGGDAGP PPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.