Details for: COX11

Gene ID: 1353

Symbol: COX11

Ensembl ID: ENSG00000166260

Description: cytochrome c oxidase copper chaperone COX11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 185.0266
    Cell Significance Index: -28.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 105.6602
    Cell Significance Index: -26.8000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 87.8267
    Cell Significance Index: -36.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.1891
    Cell Significance Index: -33.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.0203
    Cell Significance Index: -28.0400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.7825
    Cell Significance Index: -31.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.6729
    Cell Significance Index: -28.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.1299
    Cell Significance Index: -33.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.8139
    Cell Significance Index: -26.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7860
    Cell Significance Index: -34.6700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.7878
    Cell Significance Index: -23.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.5451
    Cell Significance Index: 245.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.3166
    Cell Significance Index: 139.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.0173
    Cell Significance Index: 235.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.8874
    Cell Significance Index: 118.9600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.5691
    Cell Significance Index: 13.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2149
    Cell Significance Index: 243.7000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.1962
    Cell Significance Index: 14.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9721
    Cell Significance Index: 26.4600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.9523
    Cell Significance Index: 7.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9407
    Cell Significance Index: 49.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7655
    Cell Significance Index: 105.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7404
    Cell Significance Index: 16.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7340
    Cell Significance Index: 145.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6977
    Cell Significance Index: 113.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5787
    Cell Significance Index: 316.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5780
    Cell Significance Index: 207.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5515
    Cell Significance Index: 243.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5471
    Cell Significance Index: 19.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5353
    Cell Significance Index: 68.6200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5248
    Cell Significance Index: 4.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5242
    Cell Significance Index: 61.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4987
    Cell Significance Index: 61.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4533
    Cell Significance Index: 32.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4241
    Cell Significance Index: 76.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3309
    Cell Significance Index: 15.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3146
    Cell Significance Index: 9.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2928
    Cell Significance Index: 12.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2785
    Cell Significance Index: 5.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2718
    Cell Significance Index: 12.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2376
    Cell Significance Index: 7.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2256
    Cell Significance Index: 11.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2208
    Cell Significance Index: 8.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1716
    Cell Significance Index: 11.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1664
    Cell Significance Index: 21.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1534
    Cell Significance Index: 9.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1477
    Cell Significance Index: 8.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1395
    Cell Significance Index: 23.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1378
    Cell Significance Index: 1.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1167
    Cell Significance Index: 105.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1106
    Cell Significance Index: 21.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0944
    Cell Significance Index: 2.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0867
    Cell Significance Index: 2.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0547
    Cell Significance Index: 3.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0462
    Cell Significance Index: 85.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0433
    Cell Significance Index: 66.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0412
    Cell Significance Index: 3.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0372
    Cell Significance Index: 27.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0351
    Cell Significance Index: 0.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0297
    Cell Significance Index: 40.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0244
    Cell Significance Index: 1.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0226
    Cell Significance Index: 0.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0176
    Cell Significance Index: 33.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0174
    Cell Significance Index: 0.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0153
    Cell Significance Index: 1.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0151
    Cell Significance Index: 10.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0019
    Cell Significance Index: 0.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0008
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0008
    Cell Significance Index: -0.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0032
    Cell Significance Index: -2.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0045
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0116
    Cell Significance Index: -7.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0116
    Cell Significance Index: -8.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0304
    Cell Significance Index: -13.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0405
    Cell Significance Index: -22.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0488
    Cell Significance Index: -4.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0686
    Cell Significance Index: -14.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0852
    Cell Significance Index: -9.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0877
    Cell Significance Index: -25.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1006
    Cell Significance Index: -2.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1336
    Cell Significance Index: -19.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1382
    Cell Significance Index: -3.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1801
    Cell Significance Index: -14.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2118
    Cell Significance Index: -3.6300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2201
    Cell Significance Index: -2.5000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2266
    Cell Significance Index: -2.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2486
    Cell Significance Index: -28.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3132
    Cell Significance Index: -32.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3740
    Cell Significance Index: -22.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3991
    Cell Significance Index: -11.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4678
    Cell Significance Index: -11.2200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4710
    Cell Significance Index: -5.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4777
    Cell Significance Index: -12.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4906
    Cell Significance Index: -14.0000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5127
    Cell Significance Index: -9.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5272
    Cell Significance Index: -12.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5384
    Cell Significance Index: -11.7900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5492
    Cell Significance Index: -5.6900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5568
    Cell Significance Index: -17.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5825
    Cell Significance Index: -8.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** COX11 is a small protein (12 kDa) that belongs to the CCH1 family of copper chaperones. It is specifically localized to the mitochondrial intermembrane space and is required for the assembly of COX complexes in mitochondria. COX11 is unique in its ability to bind copper ions and facilitate their incorporation into COX, which is essential for the enzyme's activity. The protein is highly conserved across species, suggesting its critical importance in mitochondrial function. **Pathways and Functions:** COX11 is involved in several key pathways, including: 1. **Electron Transport Chain (ETC):** COX11 plays a crucial role in the assembly and function of COX complexes, which are essential components of the ETC. The ETC is responsible for generating ATP through the transfer of electrons from NADH and FADH2 to oxygen. 2. **ATP Biosynthesis:** COX11 is required for the production of ATP through the chemiosmotic coupling mechanism. This process involves the generation of a proton gradient across the mitochondrial inner membrane, which drives the production of ATP. 3. **Mitochondrial Inner Membrane:** COX11 is localized to the mitochondrial inner membrane and is required for the assembly of COX complexes, which are embedded in this membrane. 4. **Intracellular Monoatomic Cation Homeostasis:** COX11 is involved in the regulation of copper ion homeostasis in cells, which is critical for maintaining cellular function. **Clinical Significance:** Dysregulation of COX11 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders:** Mutations in COX11 have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Metabolic Disorders:** COX11 has been implicated in metabolic disorders, such as diabetes and obesity. 3. **Cancer:** COX11 has been shown to be overexpressed in certain types of cancer, suggesting its potential role in tumorigenesis. In conclusion, COX11 is a critical protein that plays a pivotal role in mitochondrial function and disease. Its dysregulation has been implicated in various diseases, highlighting the importance of its study and potential therapeutic targeting. Further research is needed to fully elucidate the mechanisms by which COX11 regulates mitochondrial function and to explore its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 1170855491

Symbol: COX11_HUMAN

Name: Cytochrome c oxidase assembly protein COX11, mitochondrial

UniProtKB Accession Codes:

Q9Y6N1 D3DTY5 I3L220 Q6FHB7 Q9BRX0 Q9UME8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9878253

Title: Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain.

PubMed ID: 9878253

DOI: 10.1006/geno.1998.5580

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 15229189

Title: Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase.

PubMed ID: 15229189

DOI: 10.1093/hmg/ddh197

PubMed ID: 15840172

Title: Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis.

PubMed ID: 15840172

DOI: 10.1186/1744-8069-1-15

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 34400285

Title: RANBP2 mutation causing autosomal dominant acute necrotizing encephalopathy attenuates its interaction with COX11.

PubMed ID: 34400285

DOI: 10.1016/j.neulet.2021.136173

PubMed ID: 36030551

Title: Biallelic pathogenic variants in COX11 are associated with an infantile-onset mitochondrial encephalopathy.

PubMed ID: 36030551

DOI: 10.1002/humu.24453

Sequence Information:

  • Length: 276
  • Mass: 31430
  • Checksum: 1F2BD22E1E7DD52D
  • Sequence:
    • MGGLWRPGWR CVPFCGWRWI HPGSPTRAAE RVEPFLRPEW SGTGGAERGL RWLGTWKRCS 
LRARHPALQP PRRPKSSNPF TRAQEEERRR QNKTTLTYVA AVAVGMLGAS YAAVPLYRLY 
CQTTGLGGSA VAGHASDKIE NMVPVKDRII KISFNADVHA SLQWNFRPQQ TEIYVVPGET 
ALAFYRAKNP TDKPVIGIST YNIVPFEAGQ YFNKIQCFCF EEQRLNPQEE VDMPVFFYID 
PEFAEDPRMI KVDLITLSYT FFEAKEGHKL PVPGYN

Genular Protein ID: 1045021594

Symbol: B4DI26_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DI26

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 230
  • Mass: 25978
  • Checksum: B0EEBC7FE01BDA8E
  • Sequence:
    • MGGLWRPGWR CVPFCGWRWI HPGSPTRAAE RVEPFLRPEW SGTGGAERGL RWLGTWKRCS 
LRARHPALQP PRRPKSSNPF TRAQEEERRR QNKTTLTYVA AVAVGMLGAS YAAVPLYRLY 
CQTTGLGGSA VAGHASDKIE NMVPVKDRII KISFNADVHA SLQWNFRPQQ TEIYVVPGET 
ALAFYRAKNP TDKPVIGIST YNIVPFEAGQ YFNKIQVHQS VNFTEYDKDT

Genular Protein ID: 2659855836

Symbol: B4DEY8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DEY8

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 HAMAP 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 3 SUPFAM 1

Sequence Information:

  • Length: 171
  • Mass: 19371
  • Checksum: 8FDF72C3F69B6050
  • Sequence:
    • MLGASYAAVP LYRLYCQTTG LGGSAVAGHA SDKIENMVPV KDRIIKISFN ADVHASLQWN 
FRPQQTEIYV VPGETALAFY RAKNPTDKPV IGISTYNIVP FEAGQYFNKI QCFCFEEQRL 
NPQEEVDMPV FFYIDPEFAE DPRMIKVDLI TLSYTFFEAK EGHKLPVPGY N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.