Genular: Defining Cellular Identity and Function

Details for: Dvl1

Gene ID: 13542

Symbol: Dvl1

Ensembl ID: ENSMUSG00000029071

Description: dishevelled segment polarity protein 1

Associated with

Beta-catenin independent wnt signaling
(R-MMU-3858494)
Degradation of dvl
(R-MMU-4641258)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-MMU-4641262)
Pcp/ce pathway
(R-MMU-4086400)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Wnt mediated activation of dvl
(R-MMU-201688)
Axon
(GO:0030424)
Axon extension
(GO:0048675)
Axon guidance
(GO:0007411)
Axonogenesis
(GO:0007409)
Beta-catenin binding
(GO:0008013)
Canonical wnt signaling pathway
(GO:0060070)
Clathrin-coated vesicle
(GO:0030136)
Cochlea morphogenesis
(GO:0090103)
Collateral sprouting
(GO:0048668)
Convergent extension involved in neural plate elongation
(GO:0022007)
Convergent extension involved in organogenesis
(GO:0060029)
Cytoplasm
(GO:0005737)
Cytoplasmic microtubule organization
(GO:0031122)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Dendrite morphogenesis
(GO:0048813)
Dendritic spine
(GO:0043197)
Dendritic spine morphogenesis
(GO:0060997)
Enzyme binding
(GO:0019899)
Frizzled binding
(GO:0005109)
Glutamatergic synapse
(GO:0098978)
Growth cone
(GO:0030426)
Heart looping
(GO:0001947)
Identical protein binding
(GO:0042802)
Intracellular signal transduction
(GO:0035556)
Lateral plasma membrane
(GO:0016328)
Membrane
(GO:0016020)
Microtubule
(GO:0005874)
Microtubule cytoskeleton
(GO:0015630)
Multicellular organism development
(GO:0007275)
Negative regulation of protein phosphorylation
(GO:0001933)
Neuromuscular junction development
(GO:0007528)
Neuronal cell body
(GO:0043025)
Neuronal dense core vesicle
(GO:0098992)
Neuron projection
(GO:0043005)
Neurotransmitter secretion
(GO:0007269)
Outflow tract morphogenesis
(GO:0003151)
Planar cell polarity pathway involved in neural tube closure
(GO:0090179)
Plasma membrane
(GO:0005886)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of neuron projection arborization
(GO:0150012)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of protein phosphorylation
(GO:0001934)
Postsynapse organization
(GO:0099173)
Postsynaptic density
(GO:0014069)
Prepulse inhibition
(GO:0060134)
Presynapse
(GO:0098793)
Presynapse assembly
(GO:0099054)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein localization to microtubule
(GO:0035372)
Protein stabilization
(GO:0050821)
Receptor clustering
(GO:0043113)
Regulation of postsynapse organization
(GO:0099175)
Regulation of protein phosphorylation
(GO:0001932)
Regulation of synaptic vesicle exocytosis
(GO:2000300)
Schaffer collateral - ca1 synapse
(GO:0098685)
Skeletal muscle acetylcholine-gated channel clustering
(GO:0071340)
Small gtpase binding
(GO:0031267)
Social behavior
(GO:0035176)
Synapse
(GO:0045202)
Synapse organization
(GO:0050808)
Synaptic vesicle exocytosis
(GO:0016079)
Wnt signaling pathway
(GO:0016055)
Wnt signaling pathway, planar cell polarity pathway
(GO:0060071)
Wnt signalosome
(GO:1990909)

Other Information

Proteins

Segment polarity protein dishevelled homolog DVL-1

Genular Protein ID: 4425589

Symbol: DVL1_MOUSE

Name: Segment polarity protein dishevelled homolog DVL-1

UniProtKB Accession Codes:

P51141 Q3U2D3 Q60868

Database IDs:

Citations:

PubMed ID: 7958461

Title: Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled.

PubMed ID: 7958461

DOI: 10.1006/dbio.1994.1297

PubMed ID: 9132266

Title: Organization and promoter analysis of the mouse dishevelled-1 gene.

PubMed ID: 9132266

DOI: 10.1101/gr.5.2.116

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9298901

Title: Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1.

PubMed ID: 9298901

DOI: 10.1016/s0092-8674(00)80354-2

PubMed ID: 12165471

Title: Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.

PubMed ID: 12165471

DOI: 10.1016/s0896-6273(02)00783-3

PubMed ID: 12941796

Title: BP75, bromodomain-containing M(r) 75,000 protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta.

PubMed ID: 12941796

PubMed ID: 15454084

Title: Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.

PubMed ID: 15454084

DOI: 10.1016/j.cell.2004.09.019

PubMed ID: 15353129

Title: Characterization of function of three domains in dishevelled-1: DEP domain is responsible for membrane translocation of dishevelled-1.

PubMed ID: 15353129

DOI: 10.1038/sj.cr.7290232

PubMed ID: 15456783

Title: Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.

PubMed ID: 15456783

DOI: 10.1074/jbc.m408675200

PubMed ID: 16604061

Title: The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled.

PubMed ID: 16604061

DOI: 10.1038/ncb1405

PubMed ID: 20227366

Title: Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.

PubMed ID: 20227366

DOI: 10.1016/j.molcel.2010.01.035

PubMed ID: 27214281

Title: The polycystin complex mediates Wnt/Ca(2+) signalling.

PubMed ID: 27214281

DOI: 10.1038/ncb3363

PubMed ID: 11101902

Title: Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway.

PubMed ID: 11101902

DOI: 10.1038/82047

PubMed ID: 14636582

Title: Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled.

PubMed ID: 14636582

DOI: 10.1016/s1097-2765(03)00427-1

PubMed ID: 19637179

Title: Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled.

PubMed ID: 19637179

DOI: 10.1002/anie.200902981

PubMed ID: 21189423

Title: Molecular basis of Wnt activation via the DIX-domain protein Ccd1.

PubMed ID: 21189423

DOI: 10.1074/jbc.m110.186742

Sequence Information:

Length: 695
Mass: 75359
Checksum: FA21ACAC48FF71E0
Sequence:

MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK SMDQDFGVVK 
EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT DLPPPLERTG GIGDSRPPSF 
HPNVASSRDG MDNETGTESM VSHRRERARR RNRDEAARTN GHPRGDRRRD LGLPPDSAST 
VLSSELESSS FIDSDEEDNT SRLSSSTEQS TSSRLVRKHK CRRRKQRLRQ TDRASSFSSI 
TDSTMSLNII TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM 
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTIP RADPVRPIDP 
AAWLSHTAAL TGALPRYGTS PCSSAITRTS SSSLTSSVPG APQLEEAPLT VKSDMSAIVR 
VMQLPDSGLE IRDRMWLKIT IANAVIGADV VDWLYTHVEG FKERREARKY ASSMLKHGFL 
RHTVNKITFS EQCYYVFGDL CSNLASLNLN SGSSGASDQD TLAPLPHPSV PWPLGQGYPY 
QYPGPPPCFP PAYQDPGFSC GSGSAGSQQS EGSKSSGSTR SSHRTPGREE RRATGAGGSG 
SESDHTVPSG SGSTGWWERP VSQLSRGSSP RSQASAVAPG LPPLHPLTKA YAVVGGPPGG 
PPVRELAAVP PELTGSRQSF QKAMGNPCEF FVDIM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dvl1

Associated with

Other Information

Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. PubMed ID: 7958461

Organization and promoter analysis of the mouse dishevelled-1 gene. PubMed ID: 9132266

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1. PubMed ID: 9298901

Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1. PubMed ID: 12165471

BP75, bromodomain-containing M(r) 75,000 protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta. PubMed ID: 12941796

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. PubMed ID: 15454084

Characterization of function of three domains in dishevelled-1: DEP domain is responsible for membrane translocation of dishevelled-1. PubMed ID: 15353129

Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. PubMed ID: 15456783

The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled. PubMed ID: 16604061

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. PubMed ID: 20227366

The polycystin complex mediates Wnt/Ca(2+) signalling. PubMed ID: 27214281

Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. PubMed ID: 11101902

Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. PubMed ID: 14636582

Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled. PubMed ID: 19637179

Molecular basis of Wnt activation via the DIX-domain protein Ccd1. PubMed ID: 21189423