Genular: Defining Cellular Identity and Function

Details for: Dvl2

Gene ID: 13543

Symbol: Dvl2

Ensembl ID: ENSMUSG00000020888

Description: dishevelled segment polarity protein 2

Associated with

Asymmetric localization of pcp proteins
(R-MMU-4608870)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Degradation of dvl
(R-MMU-4641258)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-MMU-4641262)
Membrane trafficking
(R-MMU-199991)
Pcp/ce pathway
(R-MMU-4086400)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Signaling by hippo
(R-MMU-2028269)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Vesicle-mediated transport
(R-MMU-5653656)
Wnt5a-dependent internalization of fzd4
(R-MMU-5099900)
Wnt mediated activation of dvl
(R-MMU-201688)
Aggresome
(GO:0016235)
Apical part of cell
(GO:0045177)
Canonical wnt signaling pathway
(GO:0060070)
Cell cortex
(GO:0005938)
Clathrin-coated vesicle
(GO:0030136)
Cochlea morphogenesis
(GO:0090103)
Convergent extension involved in neural plate elongation
(GO:0022007)
Convergent extension involved in organogenesis
(GO:0060029)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Frizzled binding
(GO:0005109)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Heart morphogenesis
(GO:0003007)
Identical protein binding
(GO:0042802)
Intracellular signal transduction
(GO:0035556)
Lateral plasma membrane
(GO:0016328)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Neural tube closure
(GO:0001843)
Non-canonical wnt signaling pathway
(GO:0035567)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Outflow tract morphogenesis
(GO:0003151)
Planar cell polarity pathway involved in neural tube closure
(GO:0090179)
Plasma membrane
(GO:0005886)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of protein tyrosine kinase activity
(GO:0061098)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase binding
(GO:0019901)
Protein localization
(GO:0008104)
Protein self-association
(GO:0043621)
Regulation of cell population proliferation
(GO:0042127)
Regulation of dna-templated transcription
(GO:0006355)
Segmentation
(GO:0035282)
Segment specification
(GO:0007379)
Small gtpase binding
(GO:0031267)
Wnt signaling pathway
(GO:0016055)
Wnt signaling pathway, planar cell polarity pathway
(GO:0060071)

Other Information

Proteins

Segment polarity protein dishevelled homolog DVL-2

Genular Protein ID: 1499316970

Symbol: DVL2_MOUSE

Name: Segment polarity protein dishevelled homolog DVL-2

UniProtKB Accession Codes:

Q60838 Q7TN14

Database IDs:

Citations:

PubMed ID: 8887313

Title: Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2.

PubMed ID: 8887313

DOI: 10.1016/s0925-4773(96)00549-7

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15262978

Title: The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.

PubMed ID: 15262978

DOI: 10.1074/jbc.m404598200

PubMed ID: 15456783

Title: Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.

PubMed ID: 15456783

DOI: 10.1074/jbc.m408675200

PubMed ID: 17199046

Title: Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling.

PubMed ID: 17199046

DOI: 10.1016/j.devcel.2006.10.015

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21189423

Title: Molecular basis of Wnt activation via the DIX-domain protein Ccd1.

PubMed ID: 21189423

DOI: 10.1074/jbc.m110.186742

PubMed ID: 23708998

Title: The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.

PubMed ID: 23708998

DOI: 10.1038/nature12296

PubMed ID: 25823377

Title: ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled.

PubMed ID: 25823377

DOI: 10.1038/ncomms7666

PubMed ID: 27214281

Title: The polycystin complex mediates Wnt/Ca(2+) signalling.

PubMed ID: 27214281

DOI: 10.1038/ncb3363

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

PubMed ID: 20947020

Title: Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.

PubMed ID: 20947020

DOI: 10.1016/j.str.2010.07.010

Sequence Information:

Length: 736
Mass: 78861
Checksum: 928A527143BBBBB0
Sequence:

MAGSSAGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP AGAKYFFKSM 
DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDTPQPEVA PPAHESRTEL VPPPPPLPPL 
PPERTSGIGD SRPPSFHPNV SSSHENLEPE TETESVVSLR RDRPRRRDSS EHGAGGHRPG 
GPSRLERHLA GYESSSTLMT SELESTSLGD SDEDDTMSRF SSSTEQSSAS RLLKRHRRRR 
KQRPPRMERT SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM 
KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT VAKCWDPSPQ 
AYFTLPRNEP IQPIDPAAWV SHSAALTGAF PAYPGSSSMS TITSGSSLPD GCEGRGLSVH 
MDMASVTKAM AAPESGLEVR DRMWLKITIP NAFLGSDVVD WLYHHVEGFP ERREARKYAS 
GLLKAGLIRH TVNKITFSEQ CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP 
GATPWPLLPT FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG 
AGRTGRPEER APESKSGSGS ESELSSRGGS LRRGGEPGGT GDGGPPPSRG STGAPPNLRA 
LPGLHPYGAP SGMALPYNPM MVVMMPPPPP PVSTAVQPPG APPVRDLGSV PPELTASRQS 
FHMAMGNPSE FFVDVM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dvl2

Associated with

Other Information

Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. PubMed ID: 8887313

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. PubMed ID: 15262978

Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. PubMed ID: 15456783

Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling. PubMed ID: 17199046

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Molecular basis of Wnt activation via the DIX-domain protein Ccd1. PubMed ID: 21189423

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. PubMed ID: 23708998

ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled. PubMed ID: 25823377

The polycystin complex mediates Wnt/Ca(2+) signalling. PubMed ID: 27214281

LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. PubMed ID: 31073040

Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. PubMed ID: 20947020