Details for: COX15

Gene ID: 1355

Symbol: COX15

Ensembl ID: ENSG00000014919

Description: cytochrome c oxidase assembly homolog COX15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 112.6039
    Cell Significance Index: -17.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 66.5896
    Cell Significance Index: -16.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.9790
    Cell Significance Index: -18.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.2516
    Cell Significance Index: -15.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.4020
    Cell Significance Index: -18.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.5065
    Cell Significance Index: -17.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8960
    Cell Significance Index: -19.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.8512
    Cell Significance Index: -6.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.9781
    Cell Significance Index: 230.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5912
    Cell Significance Index: 157.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0688
    Cell Significance Index: 116.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9839
    Cell Significance Index: 26.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8509
    Cell Significance Index: 138.4000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7991
    Cell Significance Index: 12.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7361
    Cell Significance Index: 664.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5914
    Cell Significance Index: 30.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5884
    Cell Significance Index: 15.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5859
    Cell Significance Index: 117.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5374
    Cell Significance Index: 106.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5173
    Cell Significance Index: 93.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4137
    Cell Significance Index: 50.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3870
    Cell Significance Index: 26.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3680
    Cell Significance Index: 132.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3513
    Cell Significance Index: 7.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3470
    Cell Significance Index: 3.2000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2906
    Cell Significance Index: 4.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2883
    Cell Significance Index: 39.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2874
    Cell Significance Index: 156.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2829
    Cell Significance Index: 17.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2778
    Cell Significance Index: 52.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2742
    Cell Significance Index: 32.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2559
    Cell Significance Index: 16.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2347
    Cell Significance Index: 4.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2279
    Cell Significance Index: 17.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2182
    Cell Significance Index: 3.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1951
    Cell Significance Index: 86.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1793
    Cell Significance Index: 5.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1758
    Cell Significance Index: 7.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1755
    Cell Significance Index: 12.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1688
    Cell Significance Index: 7.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1467
    Cell Significance Index: 8.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1109
    Cell Significance Index: 7.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0898
    Cell Significance Index: 3.9700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0880
    Cell Significance Index: 1.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0824
    Cell Significance Index: 3.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0727
    Cell Significance Index: 1.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0724
    Cell Significance Index: 2.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0548
    Cell Significance Index: 7.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0451
    Cell Significance Index: 0.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0315
    Cell Significance Index: 1.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0256
    Cell Significance Index: 0.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0144
    Cell Significance Index: 0.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0017
    Cell Significance Index: 0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0012
    Cell Significance Index: 0.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0023
    Cell Significance Index: -0.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0034
    Cell Significance Index: -0.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0084
    Cell Significance Index: -0.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0090
    Cell Significance Index: -1.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0100
    Cell Significance Index: -18.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0114
    Cell Significance Index: -20.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0120
    Cell Significance Index: -9.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0141
    Cell Significance Index: -21.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0158
    Cell Significance Index: -21.4900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0193
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0201
    Cell Significance Index: -14.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0261
    Cell Significance Index: -16.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0267
    Cell Significance Index: -15.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0277
    Cell Significance Index: -2.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0330
    Cell Significance Index: -20.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0409
    Cell Significance Index: -18.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0411
    Cell Significance Index: -0.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0460
    Cell Significance Index: -1.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0470
    Cell Significance Index: -13.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0635
    Cell Significance Index: -1.3900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0650
    Cell Significance Index: -0.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0759
    Cell Significance Index: -5.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0936
    Cell Significance Index: -2.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0955
    Cell Significance Index: -20.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0984
    Cell Significance Index: -11.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1073
    Cell Significance Index: -3.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1135
    Cell Significance Index: -5.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1186
    Cell Significance Index: -17.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1303
    Cell Significance Index: -2.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1319
    Cell Significance Index: -1.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1388
    Cell Significance Index: -7.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1388
    Cell Significance Index: -3.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1510
    Cell Significance Index: -1.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1572
    Cell Significance Index: -12.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1584
    Cell Significance Index: -1.6400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1829
    Cell Significance Index: -2.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1860
    Cell Significance Index: -19.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1995
    Cell Significance Index: -10.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2126
    Cell Significance Index: -4.4500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2282
    Cell Significance Index: -3.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2447
    Cell Significance Index: -15.0000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2500
    Cell Significance Index: -1.6300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2832
    Cell Significance Index: -4.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2835
    Cell Significance Index: -19.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2855
    Cell Significance Index: -6.0600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3052
    Cell Significance Index: -5.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **COX15 is a mitochondrial protein**: COX15 is primarily located in the mitochondrial inner membrane, where it is involved in the assembly of cytochrome c oxidase, a key complex in the mitochondrial electron transport chain. 2. **Heme biosynthesis**: COX15 is also implicated in the biosynthesis of heme, a crucial component of various proteins, including hemoglobin, myoglobin, and cytochromes. 3. **Cytochrome c oxidase assembly**: COX15 is essential for the assembly of cytochrome c oxidase, a complex that plays a critical role in the regulation of cellular respiration. 4. **Expression in various tissues**: COX15 is significantly expressed in the cerebral cortex, forebrain, intestinal crypt stem cells, and dopaminergic neurons, among other tissues. **Pathways and Functions:** 1. **Cellular respiration**: COX15 is involved in the regulation of cellular respiration through its role in the assembly of cytochrome c oxidase, a key complex in the mitochondrial electron transport chain. 2. **Heme biosynthesis**: COX15 is also implicated in the biosynthesis of heme, a crucial component of various proteins. 3. **Mitochondrial electron transport**: COX15 is involved in the mitochondrial electron transport chain, where it plays a critical role in the regulation of cellular respiration. 4. **Protein binding**: COX15 interacts with various proteins, including cytochrome c oxidase subunits, to regulate cellular respiration and heme biosynthesis. **Clinical Significance:** 1. **Neurological disorders**: Mutations in the COX15 gene have been associated with neurological disorders, such as Parkinson's disease and Huntington's disease, highlighting the gene's importance in the regulation of cellular respiration and heme biosynthesis. 2. **Heme-related disorders**: COX15 mutations have also been linked to heme-related disorders, such as sideroblastic anemia, emphasizing the gene's role in heme biosynthesis. 3. **Cancer**: COX15 has been implicated in cancer development, where its dysregulation can contribute to the progression of various cancers. 4. **Metabolic disorders**: COX15 is also involved in the regulation of metabolic disorders, such as diabetes, where its dysregulation can contribute to impaired glucose metabolism. In conclusion, COX15 plays a crucial role in the regulation of cellular respiration and heme biosynthesis, and its dysregulation has been implicated in various diseases, including neurological disorders, heme-related disorders, cancer, and metabolic disorders. Further research is necessary to fully elucidate the mechanisms by which COX15 regulates cellular respiration and heme biosynthesis, and to explore its therapeutic potential in the treatment of these diseases.

Genular Protein ID: 1897245697

Symbol: COX15_HUMAN

Name: Heme A synthase COX15

UniProtKB Accession Codes:

Q7KZN9 A8K6I9 O60556 O75878 Q5TD00 Q5TD01 Q7Z3Q3 Q9NTN0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 14 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 10 Ensembl 2 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9878253

Title: Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain.

PubMed ID: 9878253

DOI: 10.1006/geno.1998.5580

PubMed ID: 12474143

Title: Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy.

PubMed ID: 12474143

DOI: 10.1086/345489

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15235026

Title: Functional and genetic studies demonstrate that mutation in the COX15 gene can cause Leigh syndrome.

PubMed ID: 15235026

DOI: 10.1136/jmg.2003.017426

PubMed ID: 15863660

Title: Novel mutations in COX15 in a long surviving Leigh syndrome patient with cytochrome c oxidase deficiency.

PubMed ID: 15863660

DOI: 10.1136/jmg.2004.029926

PubMed ID: 21412973

Title: Infantile cardioencephalopathy due to a COX15 gene defect: report and review.

PubMed ID: 21412973

DOI: 10.1002/ajmg.a.33881

Sequence Information:

  • Length: 410
  • Mass: 46030
  • Checksum: 98E9FD9D1D28EFC0
  • Sequence:
    • MQRLLFPPLR ALKGRQYLPL LAPRAAPRAQ CDCIRRPLRP GQYSTISEVA LQSGRGTVSL 
PSKAAERVVG RWLLVCSGTV AGAVILGGVT RLTESGLSMV DWHLIKEMKP PTSQEEWEAE 
FQRYQQFPEF KILNHDMTLT EFKFIWYMEY SHRMWGRLVG LVYILPAAYF WRKGWLSRGM 
KGRVLALCGL VCFQGLLGWY MVKSGLEEKS DSHDIPRVSQ YRLAAHLGSA LVLYCASLWT 
SLSLLLPPHK LPETHQLLQL RRFAHGTAGL VFLTALSGAF VAGLDAGLVY NSFPKMGESW 
IPEDLFTFSP ILRNVFENPT MVQFDHRILG ITSVTAITVL YFLSRRIPLP RRTKMAAVTL 
LALAYTQVGL GISTLLMYVP TPLAATHQSG SLALLTGALW LMNELRRVPK

Genular Protein ID: 3249979197

Symbol: B4DQM2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DQM2

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 6 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 4 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 2 SAM 1

Sequence Information:

  • Length: 231
  • Mass: 25434
  • Checksum: 58217136B120E68B
  • Sequence:
    • MKGRVLALCG LVCFQGLLGW YMVKSGLEEK SDSHDIPRVS QYRLAAHLGS ALVLYCASLW 
TSLSLLLPPH KLPETHQLLQ LRRFAHGTAG LVFLTALSGA FVAGLDAGLV YNSFPKMGES 
WIPEDLFTFS PILRNVFENP TMVQFDHRIL GITSVTAITV LYFLSRRIPL PRRTKMAAVT 
LLALAYTQVG LGISTLLMYV PTPLAATHQS GSLALLTGAL WLMNELRRVP K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.