Details for: COX15

Gene ID: 1355

Symbol: COX15

Ensembl ID: ENSG00000014919

Description: cytochrome c oxidase assembly homolog COX15

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71735
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47959
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.95
    Marker Score: 9790
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.94
    Marker Score: 1458
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.91
    Marker Score: 7854
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.91
    Marker Score: 8678.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2713
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14168
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5150
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9
    Marker Score: 55292
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.89
    Marker Score: 602
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.85
    Marker Score: 295
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.84
    Marker Score: 1052
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.8
    Marker Score: 7505.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.79
    Marker Score: 29230
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.76
    Marker Score: 2944
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 580
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 299
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.73
    Marker Score: 1076
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.72
    Marker Score: 15329
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7
    Marker Score: 2759
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2925
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.69
    Marker Score: 13644
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.68
    Marker Score: 1200
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 614
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.66
    Marker Score: 9862
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.66
    Marker Score: 1785
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.64
    Marker Score: 321
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.64
    Marker Score: 691
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.62
    Marker Score: 1424
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.62
    Marker Score: 1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.62
    Marker Score: 657
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.62
    Marker Score: 4760
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.62
    Marker Score: 23494
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.61
    Marker Score: 406
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.6
    Marker Score: 139
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.6
    Marker Score: 453
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.6
    Marker Score: 1419
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.6
    Marker Score: 251
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.59
    Marker Score: 1483.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.59
    Marker Score: 591
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.59
    Marker Score: 623
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.58
    Marker Score: 1218
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.58
    Marker Score: 1376
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.57
    Marker Score: 134
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.57
    Marker Score: 816.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.56
    Marker Score: 603
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.56
    Marker Score: 1648
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.55
    Marker Score: 366
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.55
    Marker Score: 1481
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.55
    Marker Score: 19021
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.55
    Marker Score: 366
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.54
    Marker Score: 563
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.54
    Marker Score: 1330
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.54
    Marker Score: 393
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.54
    Marker Score: 314
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.54
    Marker Score: 367
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 428
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.53
    Marker Score: 362
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.53
    Marker Score: 9352
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.52
    Marker Score: 1107
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 334
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.52
    Marker Score: 142.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.52
    Marker Score: 864
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.52
    Marker Score: 1789
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.52
    Marker Score: 1176
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.52
    Marker Score: 5212.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.52
    Marker Score: 328
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1051
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.52
    Marker Score: 4445.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.51
    Marker Score: 3258
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.51
    Marker Score: 281
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.51
    Marker Score: 2438
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.51
    Marker Score: 372
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.51
    Marker Score: 12975
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.51
    Marker Score: 861
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.49
    Marker Score: 97
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.49
    Marker Score: 2973
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.49
    Marker Score: 2041.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.49
    Marker Score: 497
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.49
    Marker Score: 171
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 470
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.49
    Marker Score: 1802
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.49
    Marker Score: 1724
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.48
    Marker Score: 329
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.48
    Marker Score: 428
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.48
    Marker Score: 297
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 197
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.47
    Marker Score: 95
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.47
    Marker Score: 905

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Other Information

**Key characteristics:** * The COX15 gene is located on chromosome 15q21.1. * It is a large gene, encoding for a protein of 1,473 amino acids. * The protein is a member of the cytochrome c oxidase assembly protein family. * It is significantly expressed in various brain regions, including the cerebral cortex, forebrain, and colon. **Pathways and functions:** * The COX15 gene is involved in the assembly of cytochrome c oxidase. * It interacts with other proteins to form the complete enzyme complex. * Cytochrome c oxidase is essential for the electron transport chain, which is responsible for generating ATP in the mitochondria. * Cytochrome c oxidase is also involved in the biosynthesis of heme, a protein that is essential for the enzyme complex. **Clinical significance:** * Mutations in the COX15 gene have been linked to several human diseases, including Leigh's syndrome and mitochondrial complex I deficiency. * These diseases are caused by mutations in genes that are involved in the assembly or function of cytochrome c oxidase. * Understanding the role of COX15 in cytochrome c oxidase assembly may lead to the development of new therapies for these diseases. **Additional notes:** * The COX15 gene is also involved in the regulation of apoptosis. * It is a key regulator of mitochondrial respiration. * Mutations in the COX15 gene have been linked to the development of cancer.

Genular Protein ID: 1897245697

Symbol: COX15_HUMAN

Name: Cytochrome c oxidase assembly protein COX15 homolog

UniProtKB Accession Codes:

Q7KZN9 A8K6I9 O60556 O75878 Q5TD00 Q5TD01 Q7Z3Q3 Q9NTN0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 2 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9878253

Title: Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain.

PubMed ID: 9878253

DOI: 10.1006/geno.1998.5580

PubMed ID: 12474143

Title: Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy.

PubMed ID: 12474143

DOI: 10.1086/345489

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15235026

Title: Functional and genetic studies demonstrate that mutation in the COX15 gene can cause Leigh syndrome.

PubMed ID: 15235026

DOI: 10.1136/jmg.2003.017426

PubMed ID: 15863660

Title: Novel mutations in COX15 in a long surviving Leigh syndrome patient with cytochrome c oxidase deficiency.

PubMed ID: 15863660

DOI: 10.1136/jmg.2004.029926

PubMed ID: 21412973

Title: Infantile cardioencephalopathy due to a COX15 gene defect: report and review.

PubMed ID: 21412973

DOI: 10.1002/ajmg.a.33881

Sequence Information:

  • Length: 410
  • Mass: 46030
  • Checksum: 98E9FD9D1D28EFC0
  • Sequence:
    • MQRLLFPPLR ALKGRQYLPL LAPRAAPRAQ CDCIRRPLRP GQYSTISEVA LQSGRGTVSL 
PSKAAERVVG RWLLVCSGTV AGAVILGGVT RLTESGLSMV DWHLIKEMKP PTSQEEWEAE 
FQRYQQFPEF KILNHDMTLT EFKFIWYMEY SHRMWGRLVG LVYILPAAYF WRKGWLSRGM 
KGRVLALCGL VCFQGLLGWY MVKSGLEEKS DSHDIPRVSQ YRLAAHLGSA LVLYCASLWT 
SLSLLLPPHK LPETHQLLQL RRFAHGTAGL VFLTALSGAF VAGLDAGLVY NSFPKMGESW 
IPEDLFTFSP ILRNVFENPT MVQFDHRILG ITSVTAITVL YFLSRRIPLP RRTKMAAVTL 
LALAYTQVGL GISTLLMYVP TPLAATHQSG SLALLTGALW LMNELRRVPK

Genular Protein ID: 3249979197

Symbol: B4DQM2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DQM2

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 231
  • Mass: 25434
  • Checksum: 58217136B120E68B
  • Sequence:
    • MKGRVLALCG LVCFQGLLGW YMVKSGLEEK SDSHDIPRVS QYRLAAHLGS ALVLYCASLW 
TSLSLLLPPH KLPETHQLLQ LRRFAHGTAG LVFLTALSGA FVAGLDAGLV YNSFPKMGES 
WIPEDLFTFS PILRNVFENP TMVQFDHRIL GITSVTAITV LYFLSRRIPL PRRTKMAAVT 
LLALAYTQVG LGISTLLMYV PTPLAATHQS GSLALLTGAL WLMNELRRVP K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.