Details for: CP

Gene ID: 1356

Symbol: CP

Ensembl ID: ENSG00000047457

Description: ceruloplasmin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 117.3292
    Cell Significance Index: -18.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.1880
    Cell Significance Index: -18.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.4393
    Cell Significance Index: -15.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.3863
    Cell Significance Index: -14.6900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 15.0858
    Cell Significance Index: 254.1200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 6.1840
    Cell Significance Index: 104.0100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 5.8561
    Cell Significance Index: 36.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.0150
    Cell Significance Index: 2738.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2600
    Cell Significance Index: -16.8100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 4.2064
    Cell Significance Index: 43.3900
  • Cell Name: chorionic trophoblast cell (CL0011101)
    Fold Change: 4.1651
    Cell Significance Index: 12.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 3.7735
    Cell Significance Index: 2396.5500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 3.4851
    Cell Significance Index: 20.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4433
    Cell Significance Index: 286.4300
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 1.2953
    Cell Significance Index: 9.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1345
    Cell Significance Index: 26.2100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.0508
    Cell Significance Index: 15.5100
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 1.0123
    Cell Significance Index: 6.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8820
    Cell Significance Index: 28.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.8727
    Cell Significance Index: 1343.4200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.7852
    Cell Significance Index: 5.3200
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.5631
    Cell Significance Index: 4.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3815
    Cell Significance Index: 703.4900
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.3530
    Cell Significance Index: 2.5400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.3016
    Cell Significance Index: 2.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2534
    Cell Significance Index: 344.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2459
    Cell Significance Index: 13.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2275
    Cell Significance Index: 11.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2071
    Cell Significance Index: 26.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2019
    Cell Significance Index: 3.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1782
    Cell Significance Index: 33.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1532
    Cell Significance Index: 7.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1277
    Cell Significance Index: 6.4500
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.0961
    Cell Significance Index: 0.7700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0867
    Cell Significance Index: 0.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0762
    Cell Significance Index: 1.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0530
    Cell Significance Index: 99.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0393
    Cell Significance Index: 7.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0371
    Cell Significance Index: 6.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0361
    Cell Significance Index: 4.4400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0292
    Cell Significance Index: 0.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0125
    Cell Significance Index: 0.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0069
    Cell Significance Index: 0.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0052
    Cell Significance Index: 2.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0003
    Cell Significance Index: 0.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0021
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0037
    Cell Significance Index: -2.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0041
    Cell Significance Index: -0.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0054
    Cell Significance Index: -4.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0078
    Cell Significance Index: -5.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0091
    Cell Significance Index: -8.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0139
    Cell Significance Index: -7.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0156
    Cell Significance Index: -5.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0172
    Cell Significance Index: -4.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0182
    Cell Significance Index: -3.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0230
    Cell Significance Index: -16.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0287
    Cell Significance Index: -12.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0303
    Cell Significance Index: -4.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0323
    Cell Significance Index: -3.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0458
    Cell Significance Index: -9.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0481
    Cell Significance Index: -7.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0517
    Cell Significance Index: -5.2900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0634
    Cell Significance Index: -0.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0670
    Cell Significance Index: -4.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0711
    Cell Significance Index: -2.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0818
    Cell Significance Index: -10.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0848
    Cell Significance Index: -9.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0884
    Cell Significance Index: -6.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0947
    Cell Significance Index: -9.3700
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.1044
    Cell Significance Index: -1.0300
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.1077
    Cell Significance Index: -0.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1129
    Cell Significance Index: -6.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1170
    Cell Significance Index: -13.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1208
    Cell Significance Index: -12.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1241
    Cell Significance Index: -3.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1273
    Cell Significance Index: -14.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1383
    Cell Significance Index: -8.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1412
    Cell Significance Index: -3.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1493
    Cell Significance Index: -3.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1520
    Cell Significance Index: -17.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1708
    Cell Significance Index: -4.2700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1733
    Cell Significance Index: -2.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1756
    Cell Significance Index: -9.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1818
    Cell Significance Index: -8.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2071
    Cell Significance Index: -14.6500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2100
    Cell Significance Index: -3.1700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2163
    Cell Significance Index: -1.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2202
    Cell Significance Index: -10.3500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.2237
    Cell Significance Index: -2.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2327
    Cell Significance Index: -15.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2372
    Cell Significance Index: -18.2000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2763
    Cell Significance Index: -8.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2780
    Cell Significance Index: -7.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2830
    Cell Significance Index: -18.2600
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.3059
    Cell Significance Index: -2.4200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3170
    Cell Significance Index: -12.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3277
    Cell Significance Index: -12.0300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.3618
    Cell Significance Index: -3.5400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3632
    Cell Significance Index: -5.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3904
    Cell Significance Index: -17.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Copper-binding protein**: Ceruloplasmin is a copper-binding protein, which means it contains copper ions that are essential for its enzymatic activity. 2. **Ferroxidase activity**: Ceruloplasmin has ferroxidase activity, which allows it to oxidize ferrous iron (Fe2+) to ferric iron (Fe3+), making it available for utilization by the body. 3. **Oxidative stress defense**: Ceruloplasmin plays a key role in defending against oxidative stress by reducing hydrogen peroxide (H2O2) to water and oxygen. 4. **Copper ion transport**: Ceruloplasmin is involved in the transport of copper ions across cell membranes, which is essential for maintaining copper homeostasis in the body. 5. **Iron regulation**: Ceruloplasmin helps regulate iron levels in the body by oxidizing iron and making it available for utilization by the body. **Pathways and Functions** 1. **Cellular oxidant detoxification**: Ceruloplasmin plays a crucial role in cellular oxidant detoxification by reducing hydrogen peroxide and other reactive oxygen species (ROS). 2. **Copper ion homeostasis**: Ceruloplasmin is involved in maintaining copper ion homeostasis in the body by regulating copper transport and storage. 3. **Iron ion homeostasis**: Ceruloplasmin helps regulate iron ion homeostasis in the body by oxidizing iron and making it available for utilization by the body. 4. **Regulation of IGF transport**: Ceruloplasmin is involved in the regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor binding proteins (IGFBPs). 5. **Metabolism of proteins**: Ceruloplasmin is involved in the metabolism of proteins, including the oxidation of cysteine residues and the formation of disulfide bonds. **Clinical Significance** 1. **Aceruloplasminemia**: Mutations in the CP gene can lead to aceruloplasminemia, a rare genetic disorder characterized by copper accumulation in the body and various systemic symptoms, including liver and kidney disease, neurological symptoms, and psychiatric symptoms. 2. **Hemochromatosis 4**: Mutations in the CP gene can also lead to hemochromatosis 4 (HFE4), a rare genetic disorder characterized by iron overload and various systemic symptoms, including liver and kidney disease. 3. **Copper metabolism disorders**: Ceruloplasmin is involved in copper metabolism, and mutations in the CP gene can lead to copper metabolism disorders, including Wilson's disease and Menkes disease. 4. **Oxidative stress disorders**: Ceruloplasmin plays a crucial role in oxidative stress defense, and mutations in the CP gene can lead to oxidative stress disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, ceruloplasmin is a crucial enzyme that plays a key role in maintaining copper homeostasis and iron regulation in the body. Mutations in the CP gene can lead to various genetic disorders, including aceruloplasminemia, hemochromatosis 4, and copper metabolism disorders. Understanding the role of ceruloplasmin in physiological processes and disease will be essential for the development of new therapeutic strategies for these disorders.

Genular Protein ID: 1840105270

Symbol: CERU_HUMAN

Name: Ferroxidase ceruloplasmin

UniProtKB Accession Codes:

P00450 Q14063 Q2PP18 Q9UKS4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 6 CORUM 1 CPTAC 4 CTD 1 CarbonylDB 1 ChEBI 65 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 16 EC 4 EMBL 11 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 4 PDBsum 4 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 Rhea 10 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2873574

Title: Complete cDNA sequence of human preceruloplasmin.

PubMed ID: 2873574

DOI: 10.1073/pnas.83.14.5086

PubMed ID: 7702601

Title: Fine structure of the human ceruloplasmin gene.

PubMed ID: 7702601

DOI: 10.1006/bbrc.1995.1437

PubMed ID: 3755405

Title: Isolation of a human ceruloplasmin cDNA clone that includes the N-terminal leader sequence.

PubMed ID: 3755405

DOI: 10.1016/0014-5793(86)80739-6

PubMed ID: 3486416

Title: Characterization, mapping, and expression of the human ceruloplasmin gene.

PubMed ID: 3486416

DOI: 10.1073/pnas.83.10.3257

PubMed ID: 6582496

Title: Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule.

PubMed ID: 6582496

DOI: 10.1073/pnas.81.2.390

PubMed ID: 6571985

Title: Internal triplication in the structure of human ceruloplasmin.

PubMed ID: 6571985

DOI: 10.1073/pnas.80.1.115

PubMed ID: 6940148

Title: Complete amino acid sequence of a 50,000-dalton fragment of human ceruloplasmin.

PubMed ID: 6940148

DOI: 10.1073/pnas.78.2.790

PubMed ID: 6987229

Title: Primary structure of a histidine-rich proteolytic fragment of human ceruloplasmin. I. Amino acid sequence of the cyanogen bromide peptides.

PubMed ID: 6987229

DOI: 10.1016/s0021-9258(19)85822-2

PubMed ID: 6987230

Title: Primary structure of a histidine-rich proteolytic fragment of human ceruloplasmin. II. Amino acid sequence of the tryptic peptides.

PubMed ID: 6987230

DOI: 10.1016/s0021-9258(19)85823-4

PubMed ID: 2355023

Title: Human ceruloplasmin. Tissue-specific expression of transcripts produced by alternative splicing.

PubMed ID: 2355023

DOI: 10.1016/s0021-9258(18)87015-6

PubMed ID: 5912351

Title: The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum.

PubMed ID: 5912351

DOI: 10.1016/s0021-9258(18)96527-0

PubMed ID: 4643313

Title: A method for obtaining linear reciprocal plots with caeruloplasmin and its application in a study of the kinetic parameters of caeruloplasmin substrates.

PubMed ID: 4643313

DOI: 10.1042/bj1290273

PubMed ID: 10508415

Title: Ceruloplasmin has a distinct active site for the catalyzing glutathione-dependent reduction of alkyl hydroperoxide.

PubMed ID: 10508415

DOI: 10.1021/bi990444b

PubMed ID: 10481051

Title: Glutathione peroxidase-like activity of caeruloplasmin as an important lung antioxidant.

PubMed ID: 10481051

DOI: 10.1016/s0014-5793(99)01142-4

PubMed ID: 12055353

Title: Ceruloplasmin metabolism and function.

PubMed ID: 12055353

DOI: 10.1146/annurev.nutr.22.012502.114457

PubMed ID: 14623105

Title: Cuprous oxidase activity of yeast Fet3p and human ceruloplasmin: implication for function.

PubMed ID: 14623105

DOI: 10.1016/s0014-5793(03)01218-3

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16906150

Title: Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis.

PubMed ID: 16906150

DOI: 10.1038/nchembio813

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 29183916

Title: Ceruloplasmin replacement therapy ameliorates neurological symptoms in a preclinical model of aceruloplasminemia.

PubMed ID: 29183916

DOI: 10.15252/emmm.201708361

PubMed ID: 17242517

Title: Ceruloplasmin revisited: structural and functional roles of various metal cation-binding sites.

PubMed ID: 17242517

DOI: 10.1107/s090744490604947x

PubMed ID: 23843990

Title: Ceruloplasmin: macromolecular assemblies with iron-containing acute phase proteins.

PubMed ID: 23843990

DOI: 10.1371/journal.pone.0067145

PubMed ID: 7708681

Title: Aceruloplasminemia: molecular characterization of this disorder of iron metabolism.

PubMed ID: 7708681

DOI: 10.1073/pnas.92.7.2539

PubMed ID: 15557511

Title: Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease.

PubMed ID: 15557511

DOI: 10.1212/01.wnl.0000144276.29988.c3

PubMed ID: 16150804

Title: Functional relevance of ceruloplasmin mutations in Parkinson's disease.

PubMed ID: 16150804

DOI: 10.1096/fj.04-3486fje

Sequence Information:

  • Length: 1065
  • Mass: 122219
  • Checksum: 2F2F76BB47D30F58
  • Sequence:
    • MKILILGIFL FLCSTPAWAK EKHYYIGIIE TTWDYASDHG EKKLISVDTE HSNIYLQNGP 
DRIGRLYKKA LYLQYTDETF RTTIEKPVWL GFLGPIIKAE TGDKVYVHLK NLASRPYTFH 
SHGITYYKEH EGAIYPDNTT DFQRADDKVY PGEQYTYMLL ATEEQSPGEG DGNCVTRIYH 
SHIDAPKDIA SGLIGPLIIC KKDSLDKEKE KHIDREFVVM FSVVDENFSW YLEDNIKTYC 
SEPEKVDKDN EDFQESNRMY SVNGYTFGSL PGLSMCAEDR VKWYLFGMGN EVDVHAAFFH 
GQALTNKNYR IDTINLFPAT LFDAYMVAQN PGEWMLSCQN LNHLKAGLQA FFQVQECNKS 
SSKDNIRGKH VRHYYIAAEE IIWNYAPSGI DIFTKENLTA PGSDSAVFFE QGTTRIGGSY 
KKLVYREYTD ASFTNRKERG PEEEHLGILG PVIWAEVGDT IRVTFHNKGA YPLSIEPIGV 
RFNKNNEGTY YSPNYNPQSR SVPPSASHVA PTETFTYEWT VPKEVGPTNA DPVCLAKMYY 
SAVEPTKDIF TGLIGPMKIC KKGSLHANGR QKDVDKEFYL FPTVFDENES LLLEDNIRMF 
TTAPDQVDKE DEDFQESNKM HSMNGFMYGN QPGLTMCKGD SVVWYLFSAG NEADVHGIYF 
SGNTYLWRGE RRDTANLFPQ TSLTLHMWPD TEGTFNVECL TTDHYTGGMK QKYTVNQCRR 
QSEDSTFYLG ERTYYIAAVE VEWDYSPQRE WEKELHHLQE QNVSNAFLDK GEFYIGSKYK 
KVVYRQYTDS TFRVPVERKA EEEHLGILGP QLHADVGDKV KIIFKNMATR PYSIHAHGVQ 
TESSTVTPTL PGETLTYVWK IPERSGAGTE DSACIPWAYY STVDQVKDLY SGLIGPLIVC 
RRPYLKVFNP RRKLEFALLF LVFDENESWY LDDNIKTYSD HPEKVNKDDE EFIESNKMHA 
INGRMFGNLQ GLTMHVGDEV NWYLMGMGNE IDLHTVHFHG HSFQYKHRGV YSSDVFDIFP 
GTYQTLEMFP RTPGIWLLHC HVTDHIHAGM ETTYTVLQNE DTKSG

Genular Protein ID: 786062727

Symbol: A5PL27_HUMAN

Name: N/A

UniProtKB Accession Codes:

A5PL27

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 6 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 GO 5 Gene3D 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 6 PharmGKB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1065
  • Mass: 122205
  • Checksum: 2F2F1294E2D30F58
  • Sequence:
    • MKILILGIFL FLCSTPAWAK EKHYYIGIIE TTWDYASDHG EKKLISVDTE HSNIYLQNGP 
DRIGRLYKKA LYLQYTDETF RTTIEKPVWL GFLGPIIKAE TGDKVYVHLK NLASRPYTFH 
SHGITYYKEH EGAIYPDNTT DFQRADDKVY PGEQYTYMLL ATEEQSPGEG DGNCVTRIYH 
SHIDAPKDIA SGLIGPLIIC KKDSLDKEKE KHIDREFVVM FSVVDENFSW YLEDNIKTYC 
SEPEKVDKDN EDFQESNRMY SVNGYTFGSL PGLSMCAEDR VKWYLFGMGN EVDVHAAFFH 
GQALTNKNYR IDTINLFPAT LFDAYMVAQN PGEWMLSCQN LNHLKAGLQA FFQVQECNKS 
SSKDNIRGKH VRHYYIAAEE IIWNYAPSGI DIFTKENLTA PGSDSAVFFE QGTTRIGGSY 
KKLVYREYTD ASFTNRKERG PEEEHLGILG PVIWAEVGDT IRVTFHNKGA YPLSIEPIGV 
RFNKNNEGTY YSPNYNPQSR SVPPSASHVA PTETFTYEWT VPKEVGPTNA DPVCLAKMYY 
SAVDPTKDIF TGLIGPMKIC KKGSLHANGR QKDVDKEFYL FPTVFDENES LLLEDNIRMF 
TTAPDQVDKE DEDFQESNKM HSMNGFMYGN QPGLTMCKGD SVVWYLFSAG NEADVHGIYF 
SGNTYLWRGE RRDTANLFPQ TSLTLHMWPD TEGTFNVECL TTDHYTGGMK QKYTVNQCRR 
QSEDSTFYLG ERTYYIAAVE VEWDYSPQRE WEKELHHLQE QNVSNAFLDK GEFYIGSKYK 
KVVYRQYTDS TFRVPVERKA EEEHLGILGP QLHADVGDKV KIIFKNMATR PYSIHAHGVQ 
TESSTVTPTL PGETLTYVWK IPERSGAGTE DSACIPWAYY STVDQVKDLY SGLIGPLIVC 
RRPYLKVFNP RRKLEFALLF LVFDENESWY LDDNIKTYSD HPEKVNKDDE EFIESNKMHA 
INGRMFGNLQ GLTMHVGDEV NWYLMGMGNE IDLHTVHFHG HSFQYKHRGV YSSDVFDIFP 
GTYQTLEMFP RTPGIWLLHC HVTDHIHAGM ETTYTVLQNE DTKSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.