Details for: CPA1

Gene ID: 1357

Symbol: CPA1

Ensembl ID: ENSG00000091704

Description: carboxypeptidase A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 25.2670
    Cell Significance Index: 2884.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 16.4353
    Cell Significance Index: 2806.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2028
    Cell Significance Index: 29.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.1972
    Cell Significance Index: 137.1600
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.2576
    Cell Significance Index: 1.7600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.2438
    Cell Significance Index: 3.1300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1765
    Cell Significance Index: 1.5000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1652
    Cell Significance Index: 2.6500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1569
    Cell Significance Index: 2.2300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.0449
    Cell Significance Index: 0.5700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0376
    Cell Significance Index: 0.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0253
    Cell Significance Index: 0.6700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0180
    Cell Significance Index: 0.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0094
    Cell Significance Index: 0.1600
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.0082
    Cell Significance Index: 0.0500
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: 0.0061
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0039
    Cell Significance Index: 0.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0030
    Cell Significance Index: 0.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0025
    Cell Significance Index: 1.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0001
    Cell Significance Index: -0.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0002
    Cell Significance Index: -0.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0003
    Cell Significance Index: -0.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0033
    Cell Significance Index: -2.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0048
    Cell Significance Index: -3.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0055
    Cell Significance Index: -10.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0059
    Cell Significance Index: -0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0066
    Cell Significance Index: -10.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0075
    Cell Significance Index: -10.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0088
    Cell Significance Index: -3.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0090
    Cell Significance Index: -4.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0093
    Cell Significance Index: -0.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0098
    Cell Significance Index: -0.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0105
    Cell Significance Index: -0.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0110
    Cell Significance Index: -0.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0126
    Cell Significance Index: -5.7400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0129
    Cell Significance Index: -0.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0135
    Cell Significance Index: -2.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0135
    Cell Significance Index: -0.6800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0146
    Cell Significance Index: -0.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0149
    Cell Significance Index: -2.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0156
    Cell Significance Index: -3.1300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0156
    Cell Significance Index: -0.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0172
    Cell Significance Index: -2.5000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0184
    Cell Significance Index: -0.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0190
    Cell Significance Index: -2.3400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0201
    Cell Significance Index: -0.2100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0225
    Cell Significance Index: -0.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0234
    Cell Significance Index: -0.4900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0255
    Cell Significance Index: -0.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0270
    Cell Significance Index: -3.1500
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0275
    Cell Significance Index: -0.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0288
    Cell Significance Index: -1.0000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0288
    Cell Significance Index: -0.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0297
    Cell Significance Index: -0.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0305
    Cell Significance Index: -3.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0307
    Cell Significance Index: -2.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0342
    Cell Significance Index: -4.6900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0377
    Cell Significance Index: -0.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0380
    Cell Significance Index: -3.9600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0391
    Cell Significance Index: -0.4500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0440
    Cell Significance Index: -0.5300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0447
    Cell Significance Index: -0.5000
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0458
    Cell Significance Index: -0.4500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0470
    Cell Significance Index: -0.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0486
    Cell Significance Index: -3.2700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0486
    Cell Significance Index: -0.5500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0491
    Cell Significance Index: -0.4700
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0492
    Cell Significance Index: -0.5500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0495
    Cell Significance Index: -0.5500
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0505
    Cell Significance Index: -0.4900
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0507
    Cell Significance Index: -0.5300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0515
    Cell Significance Index: -0.5500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0522
    Cell Significance Index: -0.5400
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.0540
    Cell Significance Index: -0.4900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0541
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0541
    Cell Significance Index: -0.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0545
    Cell Significance Index: -0.7800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0557
    Cell Significance Index: -0.3700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0571
    Cell Significance Index: -0.4400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0574
    Cell Significance Index: -0.3900
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0588
    Cell Significance Index: -0.6800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0594
    Cell Significance Index: -0.7800
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0594
    Cell Significance Index: -0.6200
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0599
    Cell Significance Index: -0.6200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0605
    Cell Significance Index: -0.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0606
    Cell Significance Index: -1.0200
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: -0.0614
    Cell Significance Index: -0.4600
  • Cell Name: smooth muscle cell of the pulmonary artery (CL0002591)
    Fold Change: -0.0624
    Cell Significance Index: -0.5300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0625
    Cell Significance Index: -0.6000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0633
    Cell Significance Index: -1.0800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0638
    Cell Significance Index: -0.7400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0668
    Cell Significance Index: -0.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0686
    Cell Significance Index: -2.0200
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0694
    Cell Significance Index: -0.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0700
    Cell Significance Index: -3.9300
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.0705
    Cell Significance Index: -0.5600
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0723
    Cell Significance Index: -0.6100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0734
    Cell Significance Index: -1.2100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0742
    Cell Significance Index: -0.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CPA1 is a metalloprotease enzyme, specifically a carboxypeptidase, which is characterized by its ability to cleave peptides at the carboxy-terminal end. This enzyme is predominantly expressed in the exocrine pancreas, particularly in epithelial cells, acinar cells, and pancreatic ductal cells. CPA1 is also found in various immune cells, including T cells and pancreatic stellate cells, suggesting its involvement in immune regulation. **Pathways and Functions:** CPA1 is involved in several biological pathways, including: 1. **Proteolysis**: CPA1 participates in the proteolytic cleavage of proteins, which is essential for protein digestion and modification. 2. **Leukotriene metabolic process**: CPA1 has been implicated in the regulation of leukotriene metabolism, a process involved in inflammatory responses. 3. **Metallocarboxypeptidase activity**: CPA1 exhibits metallocarboxypeptidase activity, which is essential for the cleavage of peptides. 4. **Protein binding**: CPA1 interacts with various proteins, including proteins involved in immune regulation. 5. **Response to cadmium ion**: CPA1 is responsive to cadmium ions, which can modulate its activity. **Clinical Significance:** CPA1 plays a crucial role in pancreatic secretion and immune regulation. Dysregulation of CPA1 has been implicated in various diseases, including: 1. **Pancreatitis**: CPA1 has been shown to be involved in the pathogenesis of pancreatitis, a disease characterized by inflammation of the pancreas. 2. **Diabetes**: CPA1 has been implicated in the regulation of glucose metabolism, which is essential for the development of diabetes. 3. **Cancer**: CPA1 has been shown to be overexpressed in various cancers, including pancreatic cancer, suggesting its potential role in tumorigenesis. 4. **Immune disorders**: CPA1 has been implicated in the regulation of immune responses, which is essential for the development of autoimmune diseases. In conclusion, CPA1 is a multifunctional enzyme that plays a crucial role in pancreatic secretion and immune regulation. Further research is necessary to fully elucidate the mechanisms by which CPA1 modulates these processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 476644469

Symbol: CBPA1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P15085 A4D1M1 Q53XU0 Q9BS67 Q9UCF2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 14 EC 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1417781

Title: cDNA cloning and sequence analysis of human pancreatic procarboxypeptidase A1.

PubMed ID: 1417781

DOI: 10.1042/bj2870299

PubMed ID: 8806703

Title: Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2.

PubMed ID: 8806703

DOI: 10.1006/abbi.1996.0310

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2307232

Title: Further studies on the human pancreatic binary complexes involving procarboxypeptidase A.

PubMed ID: 2307232

DOI: 10.1016/0014-5793(90)80665-6

PubMed ID: 2920728

Title: Purification and properties of five different forms of human procarboxypeptidases.

PubMed ID: 2920728

DOI: 10.1111/j.1432-1033.1989.tb14590.x

PubMed ID: 8318831

Title: Separation of human pancreatic carboxypeptidase A isoenzymes by high performance liquid chromatography.

PubMed ID: 8318831

DOI: 10.1002/bmc.1130070308

PubMed ID: 1969228

Title: Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter.

PubMed ID: 1969228

PubMed ID: 23746805

Title: A noncanonical mechanism of carboxypeptidase inhibition revealed by the crystal structure of the Tri-Kunitz SmCI in complex with human CPA4.

PubMed ID: 23746805

DOI: 10.1016/j.str.2013.04.021

PubMed ID: 20385563

Title: Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing.

PubMed ID: 20385563

DOI: 10.1074/jbc.m109.060350

PubMed ID: 18566513

Title: Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid).

PubMed ID: 18566513

DOI: 10.1107/s0907444908013474

PubMed ID: 19179285

Title: Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite.

PubMed ID: 19179285

DOI: 10.1073/pnas.0812623106

Sequence Information:

  • Length: 419
  • Mass: 47140
  • Checksum: 439FAFFFAEE958B1
  • Sequence:
    • MRGLLVLSVL LGAVFGKEDF VGHQVLRISV ADEAQVQKVK ELEDLEHLQL DFWRGPAHPG 
SPIDVRVPFP SIQAVKIFLE SHGISYETMI EDVQSLLDEE QEQMFAFRSR ARSTDTFNYA 
TYHTLEEIYD FLDLLVAENP HLVSKIQIGN TYEGRPIYVL KFSTGGSKRP AIWIDTGIHS 
REWVTQASGV WFAKKITQDY GQDAAFTAIL DTLDIFLEIV TNPDGFAFTH STNRMWRKTR 
SHTAGSLCIG VDPNRNWDAG FGLSGASSNP CSETYHGKFA NSEVEVKSIV DFVKDHGNIK 
AFISIHSYSQ LLMYPYGYKT EPVPDQDELD QLSKAAVTAL ASLYGTKFNY GSIIKAIYQA 
SGSTIDWTYS QGIKYSFTFE LRDTGRYGFL LPASQIIPTA KETWLALLTI MEHTLNHPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.