Details for: CPA1

Gene ID: 1357

Symbol: CPA1

Ensembl ID: ENSG00000091704

Description: carboxypeptidase A1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 5
    Marker Score: 2821
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.57
    Marker Score: 5431
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.14
    Marker Score: 3692
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.14
    Marker Score: 2222
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.7
    Marker Score: 384
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.52
    Marker Score: 958
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.45
    Marker Score: 563
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.01
    Marker Score: 711.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 484
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.66
    Marker Score: 742
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.64
    Marker Score: 1033.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 502
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.42
    Marker Score: 413
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.41
    Marker Score: 406
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4
    Marker Score: 761
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.36
    Marker Score: 189
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.36
    Marker Score: 155
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.35
    Marker Score: 168
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.3
    Marker Score: 612
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.3
    Marker Score: 121
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.25
    Marker Score: 79
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.25
    Marker Score: 78
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.23
    Marker Score: 79
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.23
    Marker Score: 216
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.21
    Marker Score: 3361
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.21
    Marker Score: 141.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.21
    Marker Score: 184
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.19
    Marker Score: 101
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.16
    Marker Score: 94
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.15
    Marker Score: 317.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.15
    Marker Score: 234
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.14
    Marker Score: 35
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.12
    Marker Score: 131
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.12
    Marker Score: 321
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1
    Marker Score: 79
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1
    Marker Score: 1027
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.09
    Marker Score: 87
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.08
    Marker Score: 39
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.07
    Marker Score: 79
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.07
    Marker Score: 193
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.07
    Marker Score: 116
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.06
    Marker Score: 96
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.06
    Marker Score: 107
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.06
    Marker Score: 127
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 54
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.05
    Marker Score: 54
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.05
    Marker Score: 70
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.05
    Marker Score: 41
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.05
    Marker Score: 10
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.04
    Marker Score: 63
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 131
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.04
    Marker Score: 73
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: GIP cell (CL0002278)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.03
    Marker Score: 37
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: mesothelial cell of pleura (CL1000491)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 15

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Other Information

## Summary The CPA1 gene encodes for a protein called carboxypeptidase A1 (CPA1). It is a secreted protein that is expressed in various cell types in the pancreas, including epithelial cells of the exocrine pancreas, pancreatic acinar cells, T cells, pancreatic ductal cells, PP cells, pancreatic stellate cells, neuroendocrine cells, goblet cells, and acinar cells. ## Key characteristics * The gene is located on chromosome 17q21.2. * It is a single copy gene. * It is a member of the carboxypeptidase family of enzymes. * It is expressed in high levels in the pancreas. * It is involved in the extracellular space, leukotriene metabolic process, Metallocarboxypeptidase activity, protein binding, proteolysis, and proteolysis involved in protein catabolic process. * It is significantly expressed in epithelial cells of the exocrine pancreas, pancreatic acinar cells, T cells, pancreatic ductal cells, PP cells, pancreatic stellate cells, neuroendocrine cells, goblet cells, and acinar cells. ## Pathways and functions * The CPA1 gene is involved in the regulation of pancreatic secretion. * It is a key regulator of the exocrine function of the pancreas. * It is involved in the regulation of the immune response. * It is involved in the regulation of inflammation. * It is involved in the regulation of cell migration and differentiation. ## Clinical significance * Mutations in the CPA1 gene have been linked to several human diseases, including pancreatitis. * CPA1 inhibitors are being investigated as potential treatments for pancreatitis. * The development of CPA1 inhibitors could provide a new treatment for pancreatitis.

Genular Protein ID: 476644469

Symbol: CBPA1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P15085 A4D1M1 Q53XU0 Q9BS67 Q9UCF2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 14 EC 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1417781

Title: cDNA cloning and sequence analysis of human pancreatic procarboxypeptidase A1.

PubMed ID: 1417781

DOI: 10.1042/bj2870299

PubMed ID: 8806703

Title: Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2.

PubMed ID: 8806703

DOI: 10.1006/abbi.1996.0310

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2307232

Title: Further studies on the human pancreatic binary complexes involving procarboxypeptidase A.

PubMed ID: 2307232

DOI: 10.1016/0014-5793(90)80665-6

PubMed ID: 2920728

Title: Purification and properties of five different forms of human procarboxypeptidases.

PubMed ID: 2920728

DOI: 10.1111/j.1432-1033.1989.tb14590.x

PubMed ID: 8318831

Title: Separation of human pancreatic carboxypeptidase A isoenzymes by high performance liquid chromatography.

PubMed ID: 8318831

DOI: 10.1002/bmc.1130070308

PubMed ID: 1969228

Title: Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter.

PubMed ID: 1969228

PubMed ID: 18566513

Title: Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid).

PubMed ID: 18566513

DOI: 10.1107/s0907444908013474

PubMed ID: 19179285

Title: Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite.

PubMed ID: 19179285

DOI: 10.1073/pnas.0812623106

Sequence Information:

  • Length: 419
  • Mass: 47140
  • Checksum: 439FAFFFAEE958B1
  • Sequence:
    • MRGLLVLSVL LGAVFGKEDF VGHQVLRISV ADEAQVQKVK ELEDLEHLQL DFWRGPAHPG 
SPIDVRVPFP SIQAVKIFLE SHGISYETMI EDVQSLLDEE QEQMFAFRSR ARSTDTFNYA 
TYHTLEEIYD FLDLLVAENP HLVSKIQIGN TYEGRPIYVL KFSTGGSKRP AIWIDTGIHS 
REWVTQASGV WFAKKITQDY GQDAAFTAIL DTLDIFLEIV TNPDGFAFTH STNRMWRKTR 
SHTAGSLCIG VDPNRNWDAG FGLSGASSNP CSETYHGKFA NSEVEVKSIV DFVKDHGNIK 
AFISIHSYSQ LLMYPYGYKT EPVPDQDELD QLSKAAVTAL ASLYGTKFNY GSIIKAIYQA 
SGSTIDWTYS QGIKYSFTFE LRDTGRYGFL LPASQIIPTA KETWLALLTI MEHTLNHPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.