Details for: CPA2

Gene ID: 1358

Symbol: CPA2

Ensembl ID: ENSG00000158516

Description: carboxypeptidase A2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 8.44
    Marker Score: 4759
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 8.2
    Marker Score: 5785
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.51
    Marker Score: 10087
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.57
    Marker Score: 5431
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.12
    Marker Score: 2137
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.64
    Marker Score: 2530.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.56
    Marker Score: 1618
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.13
    Marker Score: 254
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.1
    Marker Score: 697
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5337
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 639
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.78
    Marker Score: 351
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 695
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.76
    Marker Score: 438
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2974
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 178.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 414
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 390.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.59
    Marker Score: 1127
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 458
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.54
    Marker Score: 871
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.54
    Marker Score: 329
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.5
    Marker Score: 386.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 440
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.42
    Marker Score: 175
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.42
    Marker Score: 117
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4
    Marker Score: 6314
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.4
    Marker Score: 817
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.39
    Marker Score: 379
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.34
    Marker Score: 85
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 88
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.33
    Marker Score: 143
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.33
    Marker Score: 680
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 152
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.3
    Marker Score: 173
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.3
    Marker Score: 110.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3
    Marker Score: 125
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.25
    Marker Score: 156
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.24
    Marker Score: 124
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.23
    Marker Score: 162
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.23
    Marker Score: 139
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.23
    Marker Score: 154
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.23
    Marker Score: 119
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.22
    Marker Score: 77
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.22
    Marker Score: 47
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.21
    Marker Score: 256
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.21
    Marker Score: 153
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.19
    Marker Score: 57
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.18
    Marker Score: 93
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.17
    Marker Score: 45
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.17
    Marker Score: 1693
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.17
    Marker Score: 472
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.17
    Marker Score: 148
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.16
    Marker Score: 158
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.15
    Marker Score: 42
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 62
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.14
    Marker Score: 242
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.14
    Marker Score: 49
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.14
    Marker Score: 187
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.13
    Marker Score: 149
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.13
    Marker Score: 634
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.13
    Marker Score: 112
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.13
    Marker Score: 309
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.13
    Marker Score: 222.5
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.12
    Marker Score: 114
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.12
    Marker Score: 48
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.11
    Marker Score: 62
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.1
    Marker Score: 113
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.09
    Marker Score: 81
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.09
    Marker Score: 62
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.09
    Marker Score: 22

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Other Information

**Key characteristics:** * The CPA2 gene is located on chromosome 17q21.1. * It is a large gene with a size of approximately 10.6 kb. * The protein encoded by the CPA2 gene is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a member of the carboxypeptidase family of enzymes. * The CPA2 gene is expressed in high levels in epithelial cells of the exocrine pancreas, acinar cells, retinal cone cells, pancreatic acinar cells, blood vessel endothelial cells, enterocytes of the colon, pancreatic ductal cells, and cerebral cortex GABAergic interneurons. **Pathways and functions:** * The CPA2 gene is involved in a variety of cellular processes, including protein processing, proteolysis, and cell signaling. * It is responsible for the removal of pro-proteins from the cell and for the processing of secreted proteins. * It is also involved in the regulation of cell growth, differentiation, and apoptosis. * The CPA2 gene has been linked to a number of human diseases, including cancer and cardiovascular disease. **Clinical significance:** * The CPA2 gene is a potential target for cancer therapy. * Inhibition of CPA2 has been shown to inhibit cancer cell growth in vitro and in vivo. * Therefore, CPA2 is a promising target for the development of new cancer drugs.

Genular Protein ID: 2912044296

Symbol: CBPA2_HUMAN

Name: Carboxypeptidase A2

UniProtKB Accession Codes:

P48052 A4D1M4 C9JIK1 Q53XS1 Q96A12 Q96QN3 Q9UCF1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7896805

Title: The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model.

PubMed ID: 7896805

DOI: 10.1074/jbc.270.12.6651

PubMed ID: 8806703

Title: Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2.

PubMed ID: 8806703

DOI: 10.1006/abbi.1996.0310

PubMed ID: 2920728

Title: Purification and properties of five different forms of human procarboxypeptidases.

PubMed ID: 2920728

DOI: 10.1111/j.1432-1033.1989.tb14590.x

PubMed ID: 8318831

Title: Separation of human pancreatic carboxypeptidase A isoenzymes by high performance liquid chromatography.

PubMed ID: 8318831

DOI: 10.1002/bmc.1130070308

PubMed ID: 9384570

Title: The three-dimensional structure of human procarboxypeptidase A2. Deciphering the basis of the inhibition, activation and intrinsic activity of the zymogen.

PubMed ID: 9384570

DOI: 10.1093/emboj/16.23.6906

PubMed ID: 9450539

Title: Characterisation and preliminary X-ray diffraction analysis of human pancreatic procarboxypeptidase A2.

PubMed ID: 9450539

DOI: 10.1016/s0014-5793(97)01476-2

PubMed ID: 10742178

Title: Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2.

PubMed ID: 10742178

DOI: 10.1038/74092

PubMed ID: 12948494

Title: A large scale test of computational protein design: folding and stability of nine completely redesigned globular proteins.

PubMed ID: 12948494

DOI: 10.1016/s0022-2836(03)00888-x

PubMed ID: 12538893

Title: NMR solution structure of the activation domain of human procarboxypeptidase A2.

PubMed ID: 12538893

DOI: 10.1110/ps.0227303

Sequence Information:

  • Length: 419
  • Mass: 47030
  • Checksum: 00269F2AE50CA38D
  • Sequence:
    • MAMRLILFFG ALFGHIYCLE TFVGDQVLEI VPSNEEQIKN LLQLEAQEHL QLDFWKSPTT 
PGETAHVRVP FVNVQAVKVF LESQGIAYSI MIEDVQVLLD KENEEMLFNR RRERSGNFNF 
GAYHTLEEIS QEMDNLVAEH PGLVSKVNIG SSFENRPMNV LKFSTGGDKP AIWLDAGIHA 
REWVTQATAL WTANKIVSDY GKDPSITSIL DALDIFLLPV TNPDGYVFSQ TKNRMWRKTR 
SKVSGSLCVG VDPNRNWDAG FGGPGASSNP CSDSYHGPSA NSEVEVKSIV DFIKSHGKVK 
AFITLHSYSQ LLMFPYGYKC TKLDDFDELS EVAQKAAQSL RSLHGTKYKV GPICSVIYQA 
SGGSIDWSYD YGIKYSFAFE LRDTGRYGFL LPARQILPTA EETWLGLKAI MEHVRDHPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.