Details for: CPA3

Gene ID: 1359

Symbol: CPA3

Ensembl ID: ENSG00000163751

Description: carboxypeptidase A3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 23.4658
    Cell Significance Index: -3.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 12.8648
    Cell Significance Index: 452.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 6.8060
    Cell Significance Index: -2.7700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 6.7712
    Cell Significance Index: 43.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 5.8365
    Cell Significance Index: 357.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.0171
    Cell Significance Index: -3.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.1814
    Cell Significance Index: 58.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1334
    Cell Significance Index: 96.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 1.9318
    Cell Significance Index: -0.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5103
    Cell Significance Index: 32.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4586
    Cell Significance Index: 277.5800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2903
    Cell Significance Index: 31.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1865
    Cell Significance Index: 117.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9646
    Cell Significance Index: 870.9300
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.7610
    Cell Significance Index: 5.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5611
    Cell Significance Index: 11.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4872
    Cell Significance Index: 52.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4852
    Cell Significance Index: 78.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3488
    Cell Significance Index: 73.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.3391
    Cell Significance Index: 191.2400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.3241
    Cell Significance Index: 2.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2710
    Cell Significance Index: 18.7400
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.2465
    Cell Significance Index: 2.0800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.1850
    Cell Significance Index: 5.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.1371
    Cell Significance Index: 101.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0903
    Cell Significance Index: 5.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0664
    Cell Significance Index: 41.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0494
    Cell Significance Index: 1.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0316
    Cell Significance Index: 5.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0015
    Cell Significance Index: 0.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0003
    Cell Significance Index: 0.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0021
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0022
    Cell Significance Index: -1.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0024
    Cell Significance Index: -4.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0029
    Cell Significance Index: -0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0030
    Cell Significance Index: -4.6000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0032
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.8900
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.0043
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0059
    Cell Significance Index: -3.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0064
    Cell Significance Index: -1.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0080
    Cell Significance Index: -3.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0085
    Cell Significance Index: -0.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0121
    Cell Significance Index: -4.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0145
    Cell Significance Index: -2.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0154
    Cell Significance Index: -2.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0154
    Cell Significance Index: -3.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0168
    Cell Significance Index: -0.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0177
    Cell Significance Index: -0.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0183
    Cell Significance Index: -2.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0183
    Cell Significance Index: -0.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0206
    Cell Significance Index: -0.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0272
    Cell Significance Index: -2.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0279
    Cell Significance Index: -0.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0280
    Cell Significance Index: -3.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0294
    Cell Significance Index: -0.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0314
    Cell Significance Index: -4.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0330
    Cell Significance Index: -3.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0340
    Cell Significance Index: -1.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0370
    Cell Significance Index: -4.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0402
    Cell Significance Index: -2.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0447
    Cell Significance Index: -5.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0519
    Cell Significance Index: -0.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0530
    Cell Significance Index: -4.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0631
    Cell Significance Index: -1.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0677
    Cell Significance Index: -4.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0703
    Cell Significance Index: -4.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0761
    Cell Significance Index: -1.4900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0767
    Cell Significance Index: -1.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0776
    Cell Significance Index: -4.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0803
    Cell Significance Index: -5.1800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0839
    Cell Significance Index: -1.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0843
    Cell Significance Index: -4.7300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0848
    Cell Significance Index: -0.9300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0896
    Cell Significance Index: -1.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0997
    Cell Significance Index: -4.6500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1005
    Cell Significance Index: -1.4100
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1023
    Cell Significance Index: -1.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1053
    Cell Significance Index: -3.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1076
    Cell Significance Index: -2.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1084
    Cell Significance Index: -3.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1121
    Cell Significance Index: -5.2700
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.1127
    Cell Significance Index: -1.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1160
    Cell Significance Index: -3.8000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1168
    Cell Significance Index: -1.2700
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.1169
    Cell Significance Index: -1.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1199
    Cell Significance Index: -3.8200
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.1200
    Cell Significance Index: -1.2200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1214
    Cell Significance Index: -1.7400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1236
    Cell Significance Index: -1.8000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1253
    Cell Significance Index: -1.1900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1257
    Cell Significance Index: -1.0000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1283
    Cell Significance Index: -1.6600
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1359
    Cell Significance Index: -1.3100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1422
    Cell Significance Index: -1.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1423
    Cell Significance Index: -4.1900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1432
    Cell Significance Index: -0.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CPA3 is a member of the carboxypeptidase family, which is involved in the hydrolysis of peptides and proteins. The enzyme is characterized by its ability to cleave the C-terminal amino acid of various substrates, including peptides, proteins, and hormones. Notably, CPA3 is predominantly expressed in mast cells, but it is also detectable in other cell types such as early promyelocytes, enterocytes, and hematopoietic stem cells. This widespread expression suggests that CPA3 plays a multifaceted role in cellular processes beyond its primary function as a proteolytic enzyme. **Pathways and Functions:** CPA3 is implicated in various signaling pathways, including: 1. **Angiotensin maturation:** CPA3 is involved in the conversion of angiotensinogen to angiotensin I, a critical step in the renin-angiotensin-aldosterone system (RAAS). 2. **Proteolysis:** CPA3's proteolytic activity is essential for the degradation of various proteins, including hormones, growth factors, and cytokines. 3. **Metabolism of peptides and proteins:** CPA3 contributes to the breakdown of peptides and proteins, influencing cellular metabolism and homeostasis. 4. **Zinc ion binding:** CPA3's ability to bind zinc ions is crucial for its enzymatic activity and may also play a role in regulating cellular zinc homeostasis. **Clinical Significance:** The dysregulation of CPA3 has been implicated in various diseases, including: 1. **Mast cell disorders:** CPA3's overexpression in mast cells has been linked to mast cell activation and the development of allergic responses. 2. **Renal disease:** The RAAS pathway, in which CPA3 plays a critical role, is dysregulated in various renal diseases, including hypertension and kidney failure. 3. **Gastrointestinal disorders:** CPA3's expression in enterocytes and goblet cells suggests its involvement in gastrointestinal homeostasis and the pathogenesis of diseases such as inflammatory bowel disease. 4. **Cancer:** CPA3's expression in various cancer types, including leukemia and lymphoma, has been associated with tumor progression and metastasis. In conclusion, CPA3 is a multifaceted enzyme that plays a critical role in various cellular processes, including proteolysis, metabolism, and signaling pathways. Its dysregulation has been implicated in a range of diseases, highlighting the need for further research into the molecular mechanisms underlying CPA3's functions and its potential as a therapeutic target. As an immunologist, it is essential to continue exploring the intricacies of CPA3 and its role in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 798622465

Symbol: CBPA3_HUMAN

Name: Mast cell carboxypeptidase A

UniProtKB Accession Codes:

P15088 Q96E94

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 Ensembl 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2594780

Title: Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases.

PubMed ID: 2594780

DOI: 10.1073/pnas.86.23.9480

PubMed ID: 1729276

Title: Cloning and characterization of the novel gene for mast cell carboxypeptidase A.

PubMed ID: 1729276

DOI: 10.1172/jci115571

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1629626

Title: Human skin mast cell carboxypeptidase: functional characterization, cDNA cloning, and genealogy.

PubMed ID: 1629626

DOI: 10.1111/1523-1747.ep12616776

PubMed ID: 2708524

Title: Human mast cell carboxypeptidase. Purification and characterization.

PubMed ID: 2708524

DOI: 10.1172/jci114061

Sequence Information:

  • Length: 417
  • Mass: 48670
  • Checksum: ACB9038758117F9A
  • Sequence:
    • MRLILPVGLI ATTLAIAPVR FDREKVFRVK PQDEKQADII KDLAKTNELD FWYPGATHHV 
AANMMVDFRV SEKESQAIQS ALDQNKMHYE ILIHDLQEEI EKQFDVKEDI PGRHSYAKYN 
NWEKIVAWTE KMMDKYPEMV SRIKIGSTVE DNPLYVLKIG EKNERRKAIF TDCGIHAREW 
VSPAFCQWFV YQATKTYGRN KIMTKLLDRM NFYILPVFNV DGYIWSWTKN RMWRKNRSKN 
QNSKCIGTDL NRNFNASWNS IPNTNDPCAD NYRGSAPESE KETKAVTNFI RSHLNEIKVY 
ITFHSYSQML LFPYGYTSKL PPNHEDLAKV AKIGTDVLST RYETRYIYGP IESTIYPISG 
SSLDWAYDLG IKHTFAFELR DKGKFGFLLP ESRIKPTCRE TMLAVKFIAK YILKHTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.