Details for: CPA3

Gene ID: 1359

Symbol: CPA3

Ensembl ID: ENSG00000163751

Description: carboxypeptidase A3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basophil (CL0000767)
    Fold Change: 3.83
    Marker Score: 1820
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 3.51
    Marker Score: 2812.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1991
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.66
    Marker Score: 416
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.63
    Marker Score: 1230
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1166.5
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.52
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251808
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5346
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.94
    Marker Score: 1773
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.92
    Marker Score: 531
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.9
    Marker Score: 373
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.84
    Marker Score: 385
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11786
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.74
    Marker Score: 1499
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 451
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.65
    Marker Score: 229
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6
    Marker Score: 358.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.59
    Marker Score: 264
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.53
    Marker Score: 141
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.51
    Marker Score: 214
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.47
    Marker Score: 343
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 273
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.45
    Marker Score: 222
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.42
    Marker Score: 219
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 179
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.41
    Marker Score: 304
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.4
    Marker Score: 254.5
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.4
    Marker Score: 111
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.39
    Marker Score: 185
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.37
    Marker Score: 153
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.33
    Marker Score: 185
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 143
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.32
    Marker Score: 102
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.3
    Marker Score: 149
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.29
    Marker Score: 161
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.29
    Marker Score: 884
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.26
    Marker Score: 163
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.26
    Marker Score: 85
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.25
    Marker Score: 87
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.25
    Marker Score: 521
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.23
    Marker Score: 138
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.22
    Marker Score: 161
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.21
    Marker Score: 63
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.19
    Marker Score: 84
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.18
    Marker Score: 121
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.16
    Marker Score: 210
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.16
    Marker Score: 85
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.16
    Marker Score: 163
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.15
    Marker Score: 169
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 134
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.15
    Marker Score: 144.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.15
    Marker Score: 201
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.13
    Marker Score: 100.5
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.13
    Marker Score: 136
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.12
    Marker Score: 259
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.12
    Marker Score: 118
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.12
    Marker Score: 120.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 184
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.1
    Marker Score: 134
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 111
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.1
    Marker Score: 62
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.09
    Marker Score: 103
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.09
    Marker Score: 85
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.09
    Marker Score: 94
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.09
    Marker Score: 218
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.09
    Marker Score: 46
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.09
    Marker Score: 92.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.09
    Marker Score: 101

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Other Information

**Key characteristics:** * The protein is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in the cytoplasm of cells. * It is a member of the carboxypeptidase family of enzymes. * It is responsible for the proteolytic cleavage of proangiotensinogen to angiotensin I, which is a potent vasoconstrictor. * It is also involved in the regulation of blood pressure and fluid balance. **Pathways and functions:** * The CPA3 gene is involved in the production of angiotensinogen, a peptide hormone that regulates blood pressure. * Angiotensinogen is produced in the liver and then secreted into the bloodstream. * It is converted to angiotensin I by angiotensin-converting enzyme (ACE), which is expressed in the lungs, kidney, and liver. * Angiotensin I is a potent vasoconstrictor, which means that it causes blood vessels to narrow. * Angiotensin I is released into the plasma and binds to angiotensin receptors on blood vessel walls, which causes the blood vessels to constrict. * This leads to a decrease in blood pressure. **Clinical significance:** * Mutations in the CPA3 gene have been linked to the development of hypertension and other cardiovascular diseases. * In one study, mutations in the CPA3 gene were found in 10% of patients with hypertension. * These mutations were associated with a higher risk of cardiovascular events, such as heart disease and stroke. * Therefore, CPA3 is a promising target for the treatment of hypertension.

Genular Protein ID: 798622465

Symbol: CBPA3_HUMAN

Name: Mast cell carboxypeptidase A

UniProtKB Accession Codes:

P15088 Q96E94

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 Ensembl 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2594780

Title: Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases.

PubMed ID: 2594780

DOI: 10.1073/pnas.86.23.9480

PubMed ID: 1729276

Title: Cloning and characterization of the novel gene for mast cell carboxypeptidase A.

PubMed ID: 1729276

DOI: 10.1172/jci115571

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1629626

Title: Human skin mast cell carboxypeptidase: functional characterization, cDNA cloning, and genealogy.

PubMed ID: 1629626

DOI: 10.1111/1523-1747.ep12616776

PubMed ID: 2708524

Title: Human mast cell carboxypeptidase. Purification and characterization.

PubMed ID: 2708524

DOI: 10.1172/jci114061

Sequence Information:

  • Length: 417
  • Mass: 48670
  • Checksum: ACB9038758117F9A
  • Sequence:
    • MRLILPVGLI ATTLAIAPVR FDREKVFRVK PQDEKQADII KDLAKTNELD FWYPGATHHV 
AANMMVDFRV SEKESQAIQS ALDQNKMHYE ILIHDLQEEI EKQFDVKEDI PGRHSYAKYN 
NWEKIVAWTE KMMDKYPEMV SRIKIGSTVE DNPLYVLKIG EKNERRKAIF TDCGIHAREW 
VSPAFCQWFV YQATKTYGRN KIMTKLLDRM NFYILPVFNV DGYIWSWTKN RMWRKNRSKN 
QNSKCIGTDL NRNFNASWNS IPNTNDPCAD NYRGSAPESE KETKAVTNFI RSHLNEIKVY 
ITFHSYSQML LFPYGYTSKL PPNHEDLAKV AKIGTDVLST RYETRYIYGP IESTIYPISG 
SSLDWAYDLG IKHTFAFELR DKGKFGFLLP ESRIKPTCRE TMLAVKFIAK YILKHTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.