Details for: ADORA2B

Gene ID: 136

Symbol: ADORA2B

Ensembl ID: ENSG00000170425

Description: adenosine A2b receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 43.0743
    Cell Significance Index: -6.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.0799
    Cell Significance Index: -6.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.4665
    Cell Significance Index: -6.7400
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.0598
    Cell Significance Index: 9.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.5515
    Cell Significance Index: -6.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8898
    Cell Significance Index: 98.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.5718
    Cell Significance Index: -3.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3663
    Cell Significance Index: 260.0200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3054
    Cell Significance Index: 19.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0459
    Cell Significance Index: 14.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9016
    Cell Significance Index: 40.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8493
    Cell Significance Index: 84.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6364
    Cell Significance Index: 574.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6313
    Cell Significance Index: 73.5700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.6098
    Cell Significance Index: 6.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5945
    Cell Significance Index: 64.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4604
    Cell Significance Index: 74.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4521
    Cell Significance Index: 12.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4136
    Cell Significance Index: 23.2100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.3757
    Cell Significance Index: 2.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2951
    Cell Significance Index: 7.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2534
    Cell Significance Index: 17.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2224
    Cell Significance Index: 98.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2179
    Cell Significance Index: 28.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1628
    Cell Significance Index: 4.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0982
    Cell Significance Index: 3.1500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0973
    Cell Significance Index: 1.3600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0815
    Cell Significance Index: 1.4100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0791
    Cell Significance Index: 1.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0707
    Cell Significance Index: 14.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0576
    Cell Significance Index: 7.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0519
    Cell Significance Index: 0.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0466
    Cell Significance Index: 8.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0465
    Cell Significance Index: 0.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0208
    Cell Significance Index: 0.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0164
    Cell Significance Index: 0.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0151
    Cell Significance Index: 0.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0132
    Cell Significance Index: 2.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0080
    Cell Significance Index: 5.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0068
    Cell Significance Index: 0.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0058
    Cell Significance Index: 2.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0034
    Cell Significance Index: 1.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0023
    Cell Significance Index: 0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0021
    Cell Significance Index: 3.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0003
    Cell Significance Index: -0.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0021
    Cell Significance Index: -2.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0060
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0100
    Cell Significance Index: -7.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0124
    Cell Significance Index: -5.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0125
    Cell Significance Index: -7.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0136
    Cell Significance Index: -8.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0155
    Cell Significance Index: -4.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0195
    Cell Significance Index: -1.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0198
    Cell Significance Index: -0.5400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0216
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0257
    Cell Significance Index: -2.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0265
    Cell Significance Index: -4.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0277
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0344
    Cell Significance Index: -7.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0360
    Cell Significance Index: -1.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0388
    Cell Significance Index: -3.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0415
    Cell Significance Index: -5.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0512
    Cell Significance Index: -6.5600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0518
    Cell Significance Index: -0.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0564
    Cell Significance Index: -6.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0588
    Cell Significance Index: -6.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0589
    Cell Significance Index: -3.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0704
    Cell Significance Index: -4.3300
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0721
    Cell Significance Index: -0.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0748
    Cell Significance Index: -5.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0794
    Cell Significance Index: -6.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0796
    Cell Significance Index: -1.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0923
    Cell Significance Index: -5.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1029
    Cell Significance Index: -6.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1043
    Cell Significance Index: -2.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1101
    Cell Significance Index: -5.7800
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1129
    Cell Significance Index: -0.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1164
    Cell Significance Index: -5.1500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1207
    Cell Significance Index: -1.9200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1302
    Cell Significance Index: -1.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1347
    Cell Significance Index: -5.1000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1350
    Cell Significance Index: -2.6700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1358
    Cell Significance Index: -4.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1456
    Cell Significance Index: -5.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1474
    Cell Significance Index: -4.7000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1515
    Cell Significance Index: -2.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1533
    Cell Significance Index: -7.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1561
    Cell Significance Index: -5.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1595
    Cell Significance Index: -4.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1688
    Cell Significance Index: -7.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1806
    Cell Significance Index: -4.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1811
    Cell Significance Index: -7.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1819
    Cell Significance Index: -6.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1831
    Cell Significance Index: -5.2500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1852
    Cell Significance Index: -4.6200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1866
    Cell Significance Index: -2.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1984
    Cell Significance Index: -5.1000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1988
    Cell Significance Index: -2.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ADORA2B is a member of the G protein-coupled receptor family, which is characterized by its ability to bind adenosine ligands and activate downstream signaling pathways. The receptor is composed of seven transmembrane domains and has a high degree of homology with other adenosine receptors. ADORA2B is specifically activated by the endogenous ligand adenosine, which is involved in various physiological processes, including immune regulation, inflammation, and neurotransmission. **Pathways and Functions** ADORA2B is involved in several signaling pathways, including: 1. **Activation of adenylate cyclase activity**: ADORA2B activation leads to the stimulation of adenylate cyclase, an enzyme that converts ATP to cyclic AMP (cAMP), a secondary messenger molecule that regulates various cellular processes. 2. **Adenosine p1 receptors**: ADORA2B is part of the adenosine p1 receptor family, which is involved in regulating immune responses, inflammation, and neurotransmission. 3. **Adenylate cyclase-activating g protein-coupled receptor signaling pathway**: ADORA2B activates the adenylate cyclase-activating g protein-coupled receptor signaling pathway, which regulates various cellular processes, including immune responses and neurotransmission. 4. **Anti-inflammatory cytokines production**: ADORA2B activation leads to the production of anti-inflammatory cytokines, which regulate immune responses and inflammation. 5. **Leishmania parasite growth and survival**: ADORA2B is involved in the regulation of Leishmania parasite growth and survival, highlighting its potential as a therapeutic target for treating parasitic diseases. **Clinical Significance** ADORA2B dysregulation has been implicated in various diseases, including: 1. **Cancer**: ADORA2B overexpression has been observed in certain types of cancer, including breast and lung cancer, suggesting its potential role as a tumor suppressor. 2. **Inflammatory disorders**: ADORA2B dysregulation has been implicated in inflammatory disorders, such as rheumatoid arthritis and asthma, highlighting its potential as a therapeutic target for treating these diseases. 3. **Infectious diseases**: ADORA2B is involved in the regulation of Leishmania parasite growth and survival, suggesting its potential as a therapeutic target for treating parasitic diseases. 4. **Neurological disorders**: ADORA2B dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, highlighting its potential role in modulating neurotransmission and immune responses. In conclusion, ADORA2B is a complex receptor involved in various physiological and pathological processes. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target for treating these conditions. Further research is needed to fully understand the mechanisms of ADORA2B and its role in regulating immune responses, inflammation, and neurotransmission.

Genular Protein ID: 4217169827

Symbol: AA2BR_HUMAN

Name: Adenosine receptor A2b

UniProtKB Accession Codes:

P29275

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EMBL 4 EMDB 4 Ensembl 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1325798

Title: Molecular cloning and expression of an adenosine A2b receptor from human brain.

PubMed ID: 1325798

DOI: 10.1016/s0006-291x(05)81462-7

PubMed ID: 7558011

Title: Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene.

PubMed ID: 7558011

DOI: 10.1006/geno.1995.1061

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 332
  • Mass: 36333
  • Checksum: 38AD088E2439C7FA
  • Sequence:
    • MLLETQDALY VALELVIAAL SVAGNVLVCA AVGTANTLQT PTNYFLVSLA AADVAVGLFA 
IPFAITISLG FCTDFYGCLF LACFVLVLTQ SSIFSLLAVA VDRYLAICVP LRYKSLVTGT 
RARGVIAVLW VLAFGIGLTP FLGWNSKDSA TNNCTEPWDG TTNESCCLVK CLFENVVPMS 
YMVYFNFFGC VLPPLLIMLV IYIKIFLVAC RQLQRTELMD HSRTTLQREI HAAKSLAMIV 
GIFALCWLPV HAVNCVTLFQ PAQGKNKPKW AMNMAILLSH ANSVVNPIVY AYRNRDFRYT 
FHKIISRYLL CQADVKSGNG QAGVQPALGV GL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.