Gene ADORA2B - ENSG00000170425 | NCBI Gene ID: 136

Details for: ADORA2B

Gene ID: 136

Symbol: ADORA2B

Ensembl ID: ENSG00000170425

Description: adenosine A2b receptor

Associated with

Adenosine p1 receptors
(R-HSA-417973)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Disease
(R-HSA-1643685)
G alpha (s) signalling events
(R-HSA-418555)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Infectious disease
(R-HSA-5663205)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism of proteins
(R-HSA-392499)
Nucleotide-like (purinergic) receptors
(R-HSA-418038)
Parasitic infection pathways
(R-HSA-9824443)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Surfactant metabolism
(R-HSA-5683826)
Activation of adenylate cyclase activity
(GO:0007190)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Cellular response to extracellular stimulus
(GO:0031668)
Cgmp-mediated signaling
(GO:0019934)
Glutamatergic synapse
(GO:0098978)
G protein-coupled adenosine receptor activity
(GO:0001609)
G protein-coupled adenosine receptor signaling pathway
(GO:0001973)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Mast cell degranulation
(GO:0043303)
Plasma membrane
(GO:0005886)
Positive regulation of cgmp-mediated signaling
(GO:0010753)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of chronic inflammatory response to non-antigenic stimulus
(GO:0002882)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of mast cell degranulation
(GO:0043306)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Presynapse
(GO:0098793)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein binding
(GO:0005515)
Relaxation of vascular associated smooth muscle
(GO:0060087)
Schaffer collateral - ca1 synapse
(GO:0098685)
Vasodilation
(GO:0042311)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 2.27
Marker Score: 19178
Cell Name: retinal cone cell (CL0000573)
Fold Change: 1.36
Marker Score: 3905
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.28
Marker Score: 2595
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 1.15
Marker Score: 1142
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.04
Marker Score: 22230
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71814
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48039
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 503
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 456
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.92
Marker Score: 6870
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5255
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 368
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2734
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 320
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5281
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.86
Marker Score: 290
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.8
Marker Score: 1653
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.8
Marker Score: 12443
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1255
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 585
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 391
Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 681
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.72
Marker Score: 1364
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.71
Marker Score: 341
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.7
Marker Score: 2211
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.69
Marker Score: 2889
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.61
Marker Score: 483
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6
Marker Score: 884
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.6
Marker Score: 295
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.52
Marker Score: 333
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.51
Marker Score: 1249
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.51
Marker Score: 163
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.5
Marker Score: 333
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.5
Marker Score: 298
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.45
Marker Score: 519
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.44
Marker Score: 290
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.44
Marker Score: 461.5
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.42
Marker Score: 106
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.42
Marker Score: 120
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.41
Marker Score: 168
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.4
Marker Score: 269
Cell Name: club cell (CL0000158)
Fold Change: 0.39
Marker Score: 461
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.38
Marker Score: 434
Cell Name: germ cell (CL0000586)
Fold Change: 0.37
Marker Score: 650
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.36
Marker Score: 169
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.36
Marker Score: 202
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.35
Marker Score: 1382
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.35
Marker Score: 2128
Cell Name: astrocyte (CL0000127)
Fold Change: 0.35
Marker Score: 302
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.34
Marker Score: 2979
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.34
Marker Score: 107
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.33
Marker Score: 1136
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.32
Marker Score: 226
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.31
Marker Score: 98.5
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.3
Marker Score: 381
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.3
Marker Score: 126
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.3
Marker Score: 116
Cell Name: malignant cell (CL0001064)
Fold Change: 0.3
Marker Score: 4008
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.3
Marker Score: 298.5
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.29
Marker Score: 143
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.29
Marker Score: 195
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.28
Marker Score: 231
Cell Name: secretory cell (CL0000151)
Fold Change: 0.27
Marker Score: 496
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.27
Marker Score: 270
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.27
Marker Score: 434
Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 0.27
Marker Score: 74
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.27
Marker Score: 80.5
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.27
Marker Score: 132
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.26
Marker Score: 276
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.26
Marker Score: 366
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.26
Marker Score: 191
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.26
Marker Score: 403
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.26
Marker Score: 69
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.26
Marker Score: 176
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.25
Marker Score: 243
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.25
Marker Score: 592
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.25
Marker Score: 110
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.24
Marker Score: 1464
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.24
Marker Score: 58
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.24
Marker Score: 1168
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.23
Marker Score: 139
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.23
Marker Score: 66
Cell Name: basal cell (CL0000646)
Fold Change: 0.23
Marker Score: 293
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 63
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.22
Marker Score: 165
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.22
Marker Score: 5574.5
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.22
Marker Score: 1861
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.22
Marker Score: 1407
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.21
Marker Score: 79
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.21
Marker Score: 63
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.21
Marker Score: 98
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.21
Marker Score: 72
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.21
Marker Score: 403.5
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.21
Marker Score: 1635
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.21
Marker Score: 60
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.21
Marker Score: 539

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**Key characteristics:** * ADORA2B is a single-pass transmembrane protein with a molecular weight of approximately 140 kDa. * It belongs to the A2a/A2b family of adenosine receptors and is a member of the G protein-coupled receptor (GPCR) superfamily. * ADORA2B is expressed in high levels in the retina, where it is involved in the regulation of inflammation and vision. * It is also expressed in immune cells, where it modulates inflammatory responses. **Pathways and functions:** * ADORA2B is a key regulator of inflammatory responses through its interaction with G proteins. * It is a downstream target for a variety of cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-6 (IL-6). * Activation of ADORA2B by its ligand, adenosine, leads to the inhibition of these pro-inflammatory cytokines, promoting anti-inflammatory responses. * In the context of leishmaniasis, ADORA2B is highly expressed in immune cells, including macrophages, dendritic cells, and neutrophils. * Activation of ADORA2B by its ligand leads to the production of anti-inflammatory cytokines, including IL-10, which promotes immune tolerance and suppresses inflammation. **Clinical significance:** * ADORA2B is a potential therapeutic target for inflammatory diseases, particularly those characterized by chronic inflammation, such as rheumatoid arthritis, asthma, and inflammatory bowel disease. * Inhibition of ADORA2B signaling has been shown to reduce inflammation and promote disease resolution. * Therefore, targeting ADORA2B is a promising approach for the treatment of inflammatory diseases. **Additional notes:** * ADORA2B is also involved in the regulation of epithelial cell migration and wound healing. * It is a potential therapeutic target for cancer, as it is expressed on cancer cells and promotes tumor growth and metastasis. * Further research is needed to fully understand the role of ADORA2B in inflammatory diseases and to develop effective therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Adenosine receptor A2b

Genular Protein ID: 4217169827

Symbol: AA2BR_HUMAN

Name: Adenosine receptor A2b

UniProtKB Accession Codes:

P29275

Database IDs:

Citations:

PubMed ID: 1325798

Title: Molecular cloning and expression of an adenosine A2b receptor from human brain.

PubMed ID: 1325798

DOI: 10.1016/s0006-291x(05)81462-7

PubMed ID: 7558011

Title: Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene.

PubMed ID: 7558011

DOI: 10.1006/geno.1995.1061

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 332
Mass: 36333
Checksum: 38AD088E2439C7FA
Sequence:

MLLETQDALY VALELVIAAL SVAGNVLVCA AVGTANTLQT PTNYFLVSLA AADVAVGLFA 
IPFAITISLG FCTDFYGCLF LACFVLVLTQ SSIFSLLAVA VDRYLAICVP LRYKSLVTGT 
RARGVIAVLW VLAFGIGLTP FLGWNSKDSA TNNCTEPWDG TTNESCCLVK CLFENVVPMS 
YMVYFNFFGC VLPPLLIMLV IYIKIFLVAC RQLQRTELMD HSRTTLQREI HAAKSLAMIV 
GIFALCWLPV HAVNCVTLFQ PAQGKNKPKW AMNMAILLSH ANSVVNPIVY AYRNRDFRYT 
FHKIISRYLL CQADVKSGNG QAGVQPALGV GL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.