Details for: CPB1

Gene ID: 1360

Symbol: CPB1

Ensembl ID: ENSG00000153002

Description: carboxypeptidase B1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 5.1
    Marker Score: 2874
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 4.3
    Marker Score: 3032
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.57
    Marker Score: 5431
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.29
    Marker Score: 3530
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.82
    Marker Score: 473
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.78
    Marker Score: 1848
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.74
    Marker Score: 391
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.66
    Marker Score: 1146
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5
    Marker Score: 1498
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 854
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.24
    Marker Score: 783.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4814
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.82
    Marker Score: 1667
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.81
    Marker Score: 1529
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.71
    Marker Score: 1478.5
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.71
    Marker Score: 468
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.7
    Marker Score: 437
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.65
    Marker Score: 636
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.63
    Marker Score: 571
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.57
    Marker Score: 2476
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.52
    Marker Score: 305
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.5
    Marker Score: 159
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.5
    Marker Score: 200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 296
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.49
    Marker Score: 3235
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 442
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.44
    Marker Score: 230
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.43
    Marker Score: 194
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.43
    Marker Score: 106
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.43
    Marker Score: 7642
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.39
    Marker Score: 6101
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.37
    Marker Score: 876
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.37
    Marker Score: 159
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.35
    Marker Score: 246
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.34
    Marker Score: 111
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.32
    Marker Score: 129
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.32
    Marker Score: 165
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.31
    Marker Score: 114
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.3
    Marker Score: 96
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.28
    Marker Score: 116
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.25
    Marker Score: 80
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.24
    Marker Score: 110
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.23
    Marker Score: 62
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 129
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.22
    Marker Score: 55
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.22
    Marker Score: 96
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.21
    Marker Score: 201
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 126
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.21
    Marker Score: 382
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.2
    Marker Score: 82
  • Cell Name: enucleate erythrocyte (CL0000595)
    Fold Change: 0.2
    Marker Score: 79
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2
    Marker Score: 67
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.19
    Marker Score: 165
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.19
    Marker Score: 59
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.18
    Marker Score: 50
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.18
    Marker Score: 102
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.16
    Marker Score: 123
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.16
    Marker Score: 374
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.15
    Marker Score: 73
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.15
    Marker Score: 167
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.15
    Marker Score: 54
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.15
    Marker Score: 172
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.15
    Marker Score: 51
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.14
    Marker Score: 128
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.14
    Marker Score: 135
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.14
    Marker Score: 139
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.14
    Marker Score: 47
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.12
    Marker Score: 1285
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.12
    Marker Score: 470
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.12
    Marker Score: 149

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

## Summary CPB1, also known as CD13, is a transmembrane protein that is expressed in various cell types and plays a crucial role in the regulation of blood pressure and inflammation. It is a carboxypeptidase, which catalyzes the hydrolysis of various substrates, including angiotensinogen, to angiotensins. This process is essential for the regulation of blood pressure and is also involved in inflammation and tissue remodeling. ## Key characteristics * CBP1 is a type of metallocarboxypeptidase, which is a group of enzymes that catalyze the hydrolysis of peptide bonds using a metal ion as a cofactor. * It is expressed in high levels in the epithelial cell of the exocrine pancreas, acinar cell, pancreatic acinar cell, mesenchymal stem cell, skin fibroblast, and PP cell. * It is also expressed in low levels in the colon goblet cell, enterocyte of the epithelium of the large intestine. ## Pathways and functions * CBP1 is involved in the regulation of blood pressure by catalyzing the hydrolysis of angiotensinogen to angiotensins. * Angiotensin is a hormone that is produced by the kidneys in response to increased blood pressure. It acts on blood vessels, causing them to relax and increasing blood flow. * CBP1 is also involved in inflammation and tissue remodeling. It is expressed in high levels in the epithelial cell of the exocrine pancreas, acinar cell, and pancreatic ductal cell, which are all involved in the production and secretion of digestive enzymes. * CBP1 is also involved in the metabolism of proteins. It is expressed in the cytoplasm of cells, where it is involved in the proteolytic degradation of proteins. ## Clinical significance CPB1 gene is known to be a tumor suppressor gene. Mutations in the CBP1 gene have been linked to the development of several types of cancer, including lung cancer, breast cancer, and colon cancer. In these cancers, CBP1 is often overexpressed, which leads to the uncontrolled growth and proliferation of cancer cells. CPB1 gene is a promising target for cancer therapy. Inhibition of CBP1 has been shown to be effective in inhibiting cancer growth and metastasis. This makes CBP1 a potential therapeutic target for the treatment of cancer.

Genular Protein ID: 2682065944

Symbol: CBPB1_HUMAN

Name: Carboxypeptidase B

UniProtKB Accession Codes:

P15086 O60834 Q53XJ0 Q96BQ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 EC 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1370825

Title: Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B.

PubMed ID: 1370825

DOI: 10.1016/s0021-9258(18)45919-4

PubMed ID: 9524066

Title: Comparative analysis of the sequences and three-dimensional models of human procarboxypeptidases A1, A2 and B.

PubMed ID: 9524066

DOI: 10.1515/bchm.1998.379.2.149

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2920728

Title: Purification and properties of five different forms of human procarboxypeptidases.

PubMed ID: 2920728

DOI: 10.1111/j.1432-1033.1989.tb14590.x

PubMed ID: 20600119

Title: Structure-function analysis of the short splicing variant carboxypeptidase encoded by Drosophila melanogaster silver.

PubMed ID: 20600119

DOI: 10.1016/j.jmb.2010.06.035

PubMed ID: 12162965

Title: Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI).

PubMed ID: 12162965

DOI: 10.1016/s0022-2836(02)00648-4

Sequence Information:

  • Length: 417
  • Mass: 47368
  • Checksum: EBBB98B27F5D5AF9
  • Sequence:
    • MLALLVLVTV ALASAHHGGE HFEGEKVFRV NVEDENHINI IRELASTTQI DFWKPDSVTQ 
IKPHSTVDFR VKAEDTVTVE NVLKQNELQY KVLISNLRNV VEAQFDSRVR ATGHSYEKYN 
KWETIEAWTQ QVATENPALI SRSVIGTTFE GRAIYLLKVG KAGQNKPAIF MDCGFHAREW 
ISPAFCQWFV REAVRTYGRE IQVTELLDKL DFYVLPVLNI DGYIYTWTKS RFWRKTRSTH 
TGSSCIGTDP NRNFDAGWCE IGASRNPCDE TYCGPAAESE KETKALADFI RNKLSSIKAY 
LTIHSYSQMM IYPYSYAYKL GENNAELNAL AKATVKELAS LHGTKYTYGP GATTIYPAAG 
GSDDWAYDQG IRYSFTFELR DTGRYGFLLP ESQIRATCEE TFLAIKYVAS YVLEHLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.