Details for: CPB1

Gene ID: 1360

Symbol: CPB1

Ensembl ID: ENSG00000153002

Description: carboxypeptidase B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 32.9808
    Cell Significance Index: -5.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 20.3435
    Cell Significance Index: -5.1600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 18.3243
    Cell Significance Index: 2091.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 15.8520
    Cell Significance Index: 2706.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.1729
    Cell Significance Index: -5.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.7723
    Cell Significance Index: 74.2900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.6192
    Cell Significance Index: 43.1600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.0987
    Cell Significance Index: 14.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8842
    Cell Significance Index: 85.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3811
    Cell Significance Index: 262.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.3203
    Cell Significance Index: -5.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9023
    Cell Significance Index: 89.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8201
    Cell Significance Index: 740.5100
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 0.6788
    Cell Significance Index: 6.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5912
    Cell Significance Index: 18.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5714
    Cell Significance Index: 12.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4847
    Cell Significance Index: 78.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4632
    Cell Significance Index: 50.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3519
    Cell Significance Index: 8.5300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.3419
    Cell Significance Index: 3.7400
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.3158
    Cell Significance Index: 3.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2926
    Cell Significance Index: 11.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2653
    Cell Significance Index: 15.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2637
    Cell Significance Index: 18.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1727
    Cell Significance Index: 3.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1214
    Cell Significance Index: 5.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1102
    Cell Significance Index: 12.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1037
    Cell Significance Index: 7.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0326
    Cell Significance Index: 3.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0217
    Cell Significance Index: 29.5700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0188
    Cell Significance Index: 0.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0143
    Cell Significance Index: 0.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0078
    Cell Significance Index: 4.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0034
    Cell Significance Index: 0.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0025
    Cell Significance Index: 0.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0019
    Cell Significance Index: 1.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0000
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0004
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0007
    Cell Significance Index: -0.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0049
    Cell Significance Index: -0.1400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0052
    Cell Significance Index: -0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0056
    Cell Significance Index: -1.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0077
    Cell Significance Index: -2.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0078
    Cell Significance Index: -5.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0083
    Cell Significance Index: -0.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0090
    Cell Significance Index: -1.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0104
    Cell Significance Index: -6.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0109
    Cell Significance Index: -3.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0153
    Cell Significance Index: -6.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0226
    Cell Significance Index: -0.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0291
    Cell Significance Index: -5.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0346
    Cell Significance Index: -0.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0395
    Cell Significance Index: -4.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0410
    Cell Significance Index: -5.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0414
    Cell Significance Index: -6.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0448
    Cell Significance Index: -1.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0454
    Cell Significance Index: -5.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0468
    Cell Significance Index: -0.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0475
    Cell Significance Index: -5.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0492
    Cell Significance Index: -5.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0606
    Cell Significance Index: -3.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0617
    Cell Significance Index: -2.9000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0651
    Cell Significance Index: -2.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0667
    Cell Significance Index: -1.8700
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0683
    Cell Significance Index: -0.8600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0686
    Cell Significance Index: -2.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0692
    Cell Significance Index: -4.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0692
    Cell Significance Index: -1.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0759
    Cell Significance Index: -1.3000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0763
    Cell Significance Index: -1.0700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0849
    Cell Significance Index: -0.9100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0873
    Cell Significance Index: -1.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0885
    Cell Significance Index: -1.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0897
    Cell Significance Index: -6.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1040
    Cell Significance Index: -6.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1078
    Cell Significance Index: -6.0500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1177
    Cell Significance Index: -0.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1182
    Cell Significance Index: -4.1400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1219
    Cell Significance Index: -1.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1319
    Cell Significance Index: -4.3200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1319
    Cell Significance Index: -1.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1372
    Cell Significance Index: -4.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1386
    Cell Significance Index: -6.4600
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1420
    Cell Significance Index: -2.0200
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1425
    Cell Significance Index: -1.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1509
    Cell Significance Index: -7.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1574
    Cell Significance Index: -4.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1601
    Cell Significance Index: -1.7400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1682
    Cell Significance Index: -2.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1703
    Cell Significance Index: -4.8600
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1734
    Cell Significance Index: -1.7600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1749
    Cell Significance Index: -6.4200
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.1786
    Cell Significance Index: -1.0700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1793
    Cell Significance Index: -4.4700
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1794
    Cell Significance Index: -1.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1839
    Cell Significance Index: -4.9100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1856
    Cell Significance Index: -4.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CPB1 is a metalloprotease enzyme that belongs to the carboxypeptidase family. It is a homodimeric enzyme, consisting of two identical subunits, each containing a zinc ion cofactor. The enzyme has a broad substrate specificity, allowing it to hydrolyze a wide range of peptides and proteins. CPB1 is primarily expressed in various cell types, including epithelial cells of the exocrine pancreas, acinar cells, and mesenchymal stem cells. Its expression is also observed in skin fibroblasts, pancreatic ductal cells, and cells of the large intestine. **Pathways and Functions:** CPB1 is involved in several critical pathways, including: 1. **Metabolism of Angiotensinogen to Angiotensins:** CPB1 plays a key role in the conversion of angiotensinogen to angiotensin I, a crucial step in the renin-angiotensin system. This process regulates blood pressure, fluid balance, and electrolyte homeostasis. 2. **Metabolism of Proteins:** CPB1 is involved in the degradation of various proteins, including peptides and proteins involved in cell growth, differentiation, and survival. 3. **Zinc Ion Binding:** The zinc ion cofactor in CPB1 is essential for its enzymatic activity and plays a crucial role in the regulation of zinc ion binding in other biological processes. 4. **Carboxypeptidase Activity:** CPB1 exhibits carboxypeptidase activity, which involves the hydrolysis of peptides and proteins at the carboxy-terminal end. **Clinical Significance:** CPB1 has significant implications in various diseases and disorders, including: 1. **Hypertension:** Dysregulation of the renin-angiotensin system, led by CPB1, can contribute to the development of hypertension. 2. **Diabetes:** CPB1 has been implicated in the regulation of protein degradation and metabolism, which can impact glucose homeostasis and insulin sensitivity. 3. **Cancer:** CPB1's role in protein degradation and metabolism can influence tumor growth, progression, and metastasis. 4. **Neurological Disorders:** CPB1's involvement in protein degradation and metabolism can contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CPB1 is a multifaceted enzyme that plays a critical role in various biological processes, including angiotensinogen metabolism, protein processing, and zinc ion binding. Its dysregulation can contribute to various diseases and disorders, highlighting the importance of further research into the molecular mechanisms underlying CPB1's functions.

Genular Protein ID: 2682065944

Symbol: CBPB1_HUMAN

Name: Carboxypeptidase B

UniProtKB Accession Codes:

P15086 O60834 Q53XJ0 Q96BQ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 EC 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1370825

Title: Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B.

PubMed ID: 1370825

DOI: 10.1016/s0021-9258(18)45919-4

PubMed ID: 9524066

Title: Comparative analysis of the sequences and three-dimensional models of human procarboxypeptidases A1, A2 and B.

PubMed ID: 9524066

DOI: 10.1515/bchm.1998.379.2.149

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2920728

Title: Purification and properties of five different forms of human procarboxypeptidases.

PubMed ID: 2920728

DOI: 10.1111/j.1432-1033.1989.tb14590.x

PubMed ID: 20600119

Title: Structure-function analysis of the short splicing variant carboxypeptidase encoded by Drosophila melanogaster silver.

PubMed ID: 20600119

DOI: 10.1016/j.jmb.2010.06.035

PubMed ID: 12162965

Title: Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI).

PubMed ID: 12162965

DOI: 10.1016/s0022-2836(02)00648-4

Sequence Information:

  • Length: 417
  • Mass: 47368
  • Checksum: EBBB98B27F5D5AF9
  • Sequence:
    • MLALLVLVTV ALASAHHGGE HFEGEKVFRV NVEDENHINI IRELASTTQI DFWKPDSVTQ 
IKPHSTVDFR VKAEDTVTVE NVLKQNELQY KVLISNLRNV VEAQFDSRVR ATGHSYEKYN 
KWETIEAWTQ QVATENPALI SRSVIGTTFE GRAIYLLKVG KAGQNKPAIF MDCGFHAREW 
ISPAFCQWFV REAVRTYGRE IQVTELLDKL DFYVLPVLNI DGYIYTWTKS RFWRKTRSTH 
TGSSCIGTDP NRNFDAGWCE IGASRNPCDE TYCGPAAESE KETKALADFI RNKLSSIKAY 
LTIHSYSQMM IYPYSYAYKL GENNAELNAL AKATVKELAS LHGTKYTYGP GATTIYPAAG 
GSDDWAYDQG IRYSFTFELR DTGRYGFLLP ESQIRATCEE TFLAIKYVAS YVLEHLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.