Genular: Defining Cellular Identity and Function

Details for: Ect2

Gene ID: 13605

Symbol: Ect2

Ensembl ID: ENSMUSG00000027699

Description: ect2 oncogene

Associated with

Cdc42 gtpase cycle
(R-MMU-9013148)
Cell death signalling via nrage, nrif and nade
(R-MMU-204998)
Death receptor signaling
(R-MMU-73887)
G alpha (12/13) signalling events
(R-MMU-416482)
Gpcr downstream signalling
(R-MMU-388396)
Nrage signals death through jnk
(R-MMU-193648)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
Rac1 gtpase cycle
(R-MMU-9013149)
Rhoa gtpase cycle
(R-MMU-8980692)
Rhob gtpase cycle
(R-MMU-9013026)
Rho gtpase cycle
(R-MMU-9012999)
Signaling by gpcr
(R-MMU-372790)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Activation of gtpase activity
(GO:0090630)
Activation of protein kinase activity
(GO:0032147)
Anchoring junction
(GO:0070161)
Bicellular tight junction
(GO:0005923)
Bicellular tight junction assembly
(GO:0070830)
Cell-cell junction
(GO:0005911)
Cell cortex
(GO:0005938)
Cell cycle
(GO:0007049)
Cell differentiation
(GO:0030154)
Cell division
(GO:0051301)
Cell morphogenesis
(GO:0000902)
Cellular response to calcium ion
(GO:0071277)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to ionizing radiation
(GO:0071479)
Centralspindlin complex
(GO:0097149)
Cleavage furrow
(GO:0032154)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Gtpase activator activity
(GO:0005096)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Intracellular signal transduction
(GO:0035556)
Midbody
(GO:0030496)
Mitotic cytokinesis
(GO:0000281)
Mitotic spindle
(GO:0072686)
Nervous system development
(GO:0007399)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cytokinesis
(GO:0032467)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of protein import into nucleus
(GO:0042307)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein homooligomerization
(GO:0051260)
Protein transport
(GO:0015031)
Regulation of attachment of spindle microtubules to kinetochore
(GO:0051988)
Regulation of cytokinesis, actomyosin contractile ring assembly
(GO:2000431)
Regulation of protein kinase activity
(GO:0045859)
Small gtpase binding
(GO:0031267)

Other Information

Proteins

Protein ECT2

Genular Protein ID: 708557004

Symbol: ECT2_MOUSE

Name: Protein ECT2

UniProtKB Accession Codes:

Q07139 Q3TZP2 Q5DTR8 Q80VE4 Q8CIH2 Q8K2A0 Q8R3E2

Database IDs:

Citations:

PubMed ID: 8464478

Title: Oncogene ect2 is related to regulators of small GTP-binding proteins.

PubMed ID: 8464478

DOI: 10.1038/362462a0

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17904126

Title: Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver.

PubMed ID: 17904126

DOI: 10.1016/j.febslet.2007.09.024

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21350944

Title: Ect2, an ortholog of Drosophila's pebble, negatively regulates neurite outgrowth in neuroblastoma x glioma hybrid NG108-15 cells.

PubMed ID: 21350944

DOI: 10.1007/s10571-011-9668-3

Sequence Information:

Length: 913
Mass: 103131
Checksum: 2F0CC71DBF9D8280
Sequence:

MADDSVLPSP SEITSLADSS VFDSKVAEMS KENLCLASTS NVDEEMPQVE ARVIMVQDAG 
KQEELLKALK TIKIMEVPVI KIKESCPGKS EEKLIKSIIN MEMKVPCVKM DSMEEFESLD 
SPEFENIFVV TDFQNSVFND LYKADCRIVG PPVILNCAQR GEPLPFSCRP LYCTSMLNLV 
LCFTGFRKKE ELVKLVTLVH HMGGVIRKEC NSKVTHLVAN CTQGEKFRVA VSLGTPIMKP 
EWIYKAWERR NEQCFCAAVD DFRNEFKVPP FQDCILSFLG FSDEEKHSME EMTEMQGGSY 
LPVGDERCTH LIVEENTVKD LPFEPSKKLF VVKQEWFWGS IQMDARAGET MYLYEKANTP 
ELKKSVSLLS LSTPNSNRKR RRLKETLAQL SRETDLSPFP PRKRPSAEHS LSIGSLLDIS 
NTPESSIHYG ETPKSCAKSS RSSTPVPPKQ SARWQVAKEL YQTESNYVNI LATIIQLFQV 
PLEEEGQRGG PILAPEEIKT IFGSIPDIFD VHMKIKDDLE DLIANWDESR SIGDIFLKYA 
KDLVKTYPPF VNFFEMSKEM IIKCEKQKPR FHAFLKINQA KPECGRQSLV ELLIRPVQRL 
PSVALLLNDL KKHTADENPD KSTLEKAIGS LKEVMTHINE DKRKTEAQKQ IFDVVYEVDG 
CPANLLSSHR SLVQRVETVS LGEHPCDRGE QVTLFLFNDC LEIARKRHKV IGTFRSPHDR 
TRPPASLKHI HLMPLSQIKK VLDIRETEDC HNAFALLVRP PTEQANVLLS FQMTSEELPK 
ESWLKMLCRH VANTICKADA ENLMYVADPE SFEVNTKDMD STLSRASRAI KKTSKKVTRA 
FSFSKTPKRA LRMALSSSHS SEGRSPPSSG KLAVSRLSST SSLAGIPSPS LVSLPSFFER 
RSHTLSRSTT HLI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ect2

Associated with

Other Information

Oncogene ect2 is related to regulators of small GTP-binding proteins. PubMed ID: 8464478

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver. PubMed ID: 17904126

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Ect2, an ortholog of Drosophila's pebble, negatively regulates neurite outgrowth in neuroblastoma x glioma hybrid NG108-15 cells. PubMed ID: 21350944