Details for: CPB2

Gene ID: 1361

Symbol: CPB2

Ensembl ID: ENSG00000080618

Description: carboxypeptidase B2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 5.61
    Marker Score: 16,368
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 4.92
    Marker Score: 14,589
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 4.18
    Marker Score: 4,145
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.87
    Marker Score: 11,118
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.55
    Marker Score: 30,058
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.75
    Marker Score: 7,855
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.69
    Marker Score: 8,813
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.28
    Marker Score: 12,267
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.95
    Marker Score: 12,568
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.92
    Marker Score: 8,290
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.61
    Marker Score: 10,485
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170,241
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.22
    Marker Score: 834
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.16
    Marker Score: 1,246
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,691
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.01
    Marker Score: 380
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.01
    Marker Score: 2,556
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,042
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.88
    Marker Score: 1,414
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.87
    Marker Score: 2,078
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.85
    Marker Score: 1,603
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.84
    Marker Score: 1,715
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.69
    Marker Score: 298
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.68
    Marker Score: 254
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 493
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.61
    Marker Score: 9,504
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.6
    Marker Score: 602
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.58
    Marker Score: 179
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.52
    Marker Score: 1,076
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.52
    Marker Score: 8,309
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 301
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.48
    Marker Score: 216
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.41
    Marker Score: 404
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.41
    Marker Score: 1,269
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.39
    Marker Score: 107
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.39
    Marker Score: 2,333
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.38
    Marker Score: 178
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.38
    Marker Score: 473
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.37
    Marker Score: 118
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.37
    Marker Score: 1,487
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.36
    Marker Score: 150
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.34
    Marker Score: 101
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.33
    Marker Score: 293
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.32
    Marker Score: 379
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.31
    Marker Score: 86
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.28
    Marker Score: 453
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.28
    Marker Score: 91
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.28
    Marker Score: 175
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.28
    Marker Score: 167
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.28
    Marker Score: 147
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.28
    Marker Score: 133
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.27
    Marker Score: 238
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.27
    Marker Score: 122
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.25
    Marker Score: 75
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.24
    Marker Score: 2,053
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.23
    Marker Score: 349
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.21
    Marker Score: 888
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 94
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.21
    Marker Score: 272
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.19
    Marker Score: 1,828
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.19
    Marker Score: 42
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.19
    Marker Score: 77
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.17
    Marker Score: 81
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.17
    Marker Score: 10,294
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.16
    Marker Score: 111
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.15
    Marker Score: 54
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.15
    Marker Score: 5,582
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.15
    Marker Score: 60
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.15
    Marker Score: 618
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.15
    Marker Score: 1,384
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.15
    Marker Score: 5,508
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.14
    Marker Score: 94
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.14
    Marker Score: 134
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.14
    Marker Score: 1,423
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.13
    Marker Score: 65
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.13
    Marker Score: 47
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.13
    Marker Score: 231
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.13
    Marker Score: 153
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.12
    Marker Score: 119
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.12
    Marker Score: 636
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.12
    Marker Score: 62
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.12
    Marker Score: 454
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.12
    Marker Score: 272

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** CPB2 is a zinc-dependent metallo-carboxypeptidase enzyme that cleaves peptides at the carboxy-terminal end, releasing amino acids. 2. **Tissue Distribution:** CPB2 is highly expressed in the liver, pancreas, retina, and other tissues, suggesting its involvement in multiple cellular processes. 3. **Cellular Localization:** CPB2 is found in various cell types, including hepatocytes, pancreatic cells, retinal bipolar neurons, and bipolar cells. **Pathways and Functions:** 1. **Blood Coagulation:** CPB2 participates in the regulation of fibrinolysis, a critical process that prevents excessive clot formation. By cleaving fibrinogen, CPB2 helps maintain the balance between coagulation and fibrinolysis. 2. **Glucose Metabolism:** CPB2 is involved in the regulation of glucose-stimulated insulin secretion from pancreatic beta cells. By cleaving glucagon-like peptide-1 (GLP-1), CPB2 modulates glucose metabolism and insulin sensitivity. 3. **Protein Degradation:** CPB2 is a key enzyme in the proteolytic processing of various proteins, including angiotensinogen, which is converted to angiotensin I and II, playing a crucial role in blood pressure regulation. 4. **Regulation of Complement Cascade:** CPB2 negatively regulates the complement cascade, a critical immune response that prevents excessive tissue damage. **Clinical Significance:** 1. **Hypertension:** Alterations in CPB2 expression or activity may contribute to the development of hypertension, as dysregulation of angiotensinogen processing can lead to increased blood pressure. 2. **Diabetes:** CPB2's role in glucose metabolism and insulin secretion makes it a potential target for the treatment of diabetes. 3. **Liver Disease:** CPB2's involvement in liver regeneration and hepatocyte proliferation suggests its potential as a biomarker or therapeutic target for liver diseases, such as cirrhosis. 4. **Retinal Disorders:** CPB2's expression in retinal cells implies its potential role in retinal diseases, such as age-related macular degeneration. In conclusion, CPB2 is a multifunctional enzyme that plays critical roles in various physiological processes, including blood coagulation, glucose metabolism, and protein degradation. Further research is needed to fully elucidate the mechanisms by which CPB2 regulates these processes and to explore its potential therapeutic applications in human disease.

Genular Protein ID: 3577744548

Symbol: CBPB2_HUMAN

Name: Carboxypeptidase B2

UniProtKB Accession Codes:

Q96IY4 A8K464 Q15114 Q5T9K1 Q5T9K2 Q9P2Y6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1939207

Title: Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma.

PubMed ID: 1939207

DOI: 10.1016/s0021-9258(18)54713-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10574983

Title: Characterization of plasmin-mediated activation of plasma procarboxypeptidase B. Modulation by glycosaminoglycans.

PubMed ID: 10574983

DOI: 10.1074/jbc.274.49.35046

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16445295

Title: Post-translational modifications of human thrombin-activatable fibrinolysis inhibitor (TAFI): evidence for a large shift in the isoelectric point and reduced solubility upon activation.

PubMed ID: 16445295

DOI: 10.1021/bi051956v

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 18559974

Title: Crystal structures of TAFI elucidate the inactivation mechanism of activated TAFI: a novel mechanism for enzyme autoregulation.

PubMed ID: 18559974

DOI: 10.1182/blood-2008-03-146001

PubMed ID: 20088943

Title: Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor.

PubMed ID: 20088943

DOI: 10.1111/j.1538-7836.2010.03740.x

Sequence Information:

  • Length: 423
  • Mass: 48424
  • Checksum: B4D20E03ECDD55EF
  • Sequence:
    • MKLCSLAVLV PIVLFCEQHV FAFQSGQVLA ALPRTSRQVQ VLQNLTTTYE IVLWQPVTAD 
LIVKKKQVHF FVNASDVDNV KAHLNVSGIP CSVLLADVED LIQQQISNDT VSPRASASYY 
EQYHSLNEIY SWIEFITERH PDMLTKIHIG SSFEKYPLYV LKVSGKEQAA KNAIWIDCGI 
HAREWISPAF CLWFIGHITQ FYGIIGQYTN LLRLVDFYVM PVVNVDGYDY SWKKNRMWRK 
NRSFYANNHC IGTDLNRNFA SKHWCEEGAS SSSCSETYCG LYPESEPEVK AVASFLRRNI 
NQIKAYISMH SYSQHIVFPY SYTRSKSKDH EELSLVASEA VRAIEKISKN TRYTHGHGSE 
TLYLAPGGGD DWIYDLGIKY SFTIELRDTG TYGFLLPERY IKPTCREAFA AVSKIAWHVI 
RNV

Genular Protein ID: 3068085381

Symbol: A0A087WSY5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WSY5

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MEROPS 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

Sequence Information:

  • Length: 386
  • Mass: 44022
  • Checksum: 76EAAED94C8E8F40
  • Sequence:
    • MKLCSLAVLV PIVLFCEQHV FAFQSGQVLA ALPRTSRQVQ VLQNLTTTYE IVLWQPVTAD 
LIVKKKQVHF FVNASDVDNV KAHLNVSGIP CSVLLADVED LIQQQISNDT VSPRASASYY 
EQYHSLNEIY SWIEFITERH PDMLTKIHIG SSFEKYPLYV LKVSGKEQAA KNAIWIDCGI 
HAREWISPAF CLWFIGHNRM WRKNRSFYAN NHCIGTDLNR NFASKHWCEE GASSSSCSET 
YCGLYPESEP EVKAVASFLR RNINQIKAYI SMHSYSQHIV FPYSYTRSKS KDHEELSLVA 
SEAVRAIEKI SKNTRYTHGH GSETLYLAPG GGDDWIYDLG IKYSFTIELR DTGTYGFLLP 
ERYIKPTCRE AFAAVSKIAW HVIRNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.