Details for: CPB2

Gene ID: 1361

Symbol: CPB2

Ensembl ID: ENSG00000080618

Description: carboxypeptidase B2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 5.61
    Marker Score: 16368
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 4.92
    Marker Score: 14589
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 4.18
    Marker Score: 4145
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.87
    Marker Score: 11118
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.55
    Marker Score: 30057.5
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.75
    Marker Score: 7855
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.69
    Marker Score: 8813
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.28
    Marker Score: 12266.5
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.95
    Marker Score: 12567.5
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.92
    Marker Score: 8289.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.61
    Marker Score: 10485
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170241
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.22
    Marker Score: 834
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.16
    Marker Score: 1246
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7691
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.01
    Marker Score: 380
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.01
    Marker Score: 2556
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48042
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.88
    Marker Score: 1414
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.87
    Marker Score: 2078
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.85
    Marker Score: 1603
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.84
    Marker Score: 1715
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.69
    Marker Score: 298
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.68
    Marker Score: 254
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 493
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.61
    Marker Score: 9504
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.6
    Marker Score: 602
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.58
    Marker Score: 179
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.52
    Marker Score: 1076
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.52
    Marker Score: 8308.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 301
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.48
    Marker Score: 216
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.41
    Marker Score: 404
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.41
    Marker Score: 1269
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.39
    Marker Score: 107
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.39
    Marker Score: 2333
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.38
    Marker Score: 178
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.38
    Marker Score: 473
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.37
    Marker Score: 118
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.37
    Marker Score: 1487
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.36
    Marker Score: 150
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.34
    Marker Score: 101
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.33
    Marker Score: 293
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.32
    Marker Score: 379
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.31
    Marker Score: 86
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.28
    Marker Score: 453
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.28
    Marker Score: 91
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.28
    Marker Score: 175
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.28
    Marker Score: 167
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.28
    Marker Score: 147
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.28
    Marker Score: 133
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.27
    Marker Score: 238
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.27
    Marker Score: 122
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.25
    Marker Score: 75
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.24
    Marker Score: 2053
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.23
    Marker Score: 349
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.21
    Marker Score: 888
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 94
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.21
    Marker Score: 272
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.19
    Marker Score: 1828
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.19
    Marker Score: 42
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.19
    Marker Score: 77
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.17
    Marker Score: 81
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.17
    Marker Score: 10294
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.16
    Marker Score: 111
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.15
    Marker Score: 54
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.15
    Marker Score: 5582
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.15
    Marker Score: 60
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.15
    Marker Score: 617.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.15
    Marker Score: 1383.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.15
    Marker Score: 5508
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.14
    Marker Score: 94
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.14
    Marker Score: 134
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.14
    Marker Score: 1422.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.13
    Marker Score: 65
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.13
    Marker Score: 47
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.13
    Marker Score: 231
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.13
    Marker Score: 153
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.12
    Marker Score: 119
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.12
    Marker Score: 636
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.12
    Marker Score: 62
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.12
    Marker Score: 454
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.12
    Marker Score: 272

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Other Information

**Key characteristics:** - Function: Carboxypeptidase B2 is a metallopeptidase, which means it can break down proteins into smaller peptides. - Subcellular location: The protein is found in the plasma membrane and cytoplasm of cells. - Expression: CPB2 is highly expressed in endothelial cells and hepatocytes. It is also expressed in immune cells, particularly macrophages and dendritic cells. **Pathways and functions:** - Blood coagulation: CPB2 is involved in the regulation of blood coagulation by facilitating the conversion of prothrombinogen to thrombin, which is essential for blood clot formation. - Cellular response to glucose stimulus: The protein is also involved in the cellular response to glucose stimuli, where it helps to regulate glucose metabolism and insulin signaling. - Complement cascade: CPB2 is a component of the complement cascade, a complex network of proteins involved in the immune response. It helps to activate other complement proteins and promote the formation of the membrane attack complex, which can kill infected cells. - Fibrinolysis: CPB2 is involved in the regulation of fibrinolysis, the breakdown of blood clots. It helps to control the formation of new blood vessels and maintain blood homeostasis. - Immune system: CPB2 is a component of the immune system, where it helps to regulate the inflammatory response and the activation of immune cells. - Innate immune system: The protein is expressed in macrophages and dendritic cells, which are key players in the innate immune response. - Liver regeneration: CPB2 is involved in the regulation of liver regeneration after injury or disease. - Metabolism of angiotensinogen to angiotensins: The protein is involved in the metabolism of angiotensinogen, a protein that is produced by the liver and converted to angiotensin I, which is a potent vasoconstrictor. - Metabolism of proteins: CPB2 is involved in the metabolism of various proteins, including those involved in inflammation, cell signaling, and tissue repair. - Metallocarboxypeptidase activity: The protein has metallocarboxypeptidase activity, which allows it to break down a variety of proteins, including those involved in inflammation, cell signaling, and tissue repair. - Negative regulation of fibrinolysis: CPB2 acts as a negative regulator of fibrinolysis, which is the process by which blood clots are broken down. - Negative regulation of hepatocyte proliferation: The protein is involved in the negative regulation of hepatocyte proliferation. - Negative regulation of plasminogen activation: CPB2 inhibits the activation of plasminogen, an enzyme that is involved in blood clot formation. - Peptide hormone metabolism: The protein is involved in the metabolism of various peptide hormones, including those involved in inflammation and cell growth. - Positive regulation of extracellular matrix constituent secretion: CPB2 is involved in the positive regulation of extracellular matrix constituent secretion, which is essential for the formation of new blood vessels and the maintenance of tissue integrity. - Protein catabolic process: The protein is involved in the protein catabolic process, where it breaks down proteins into smaller peptides that can be used by the body. - Proteolysis: CPB2 is involved in the proteolytic process, where it breaks down proteins into smaller peptides. - Regulation of complement cascade: CPB2 is a component of the complement cascade, which is a complex network of proteins involved in the immune response. It helps to activate other complement proteins and promote the formation of the membrane attack complex, which can kill infected cells. **Clinical significance:** Mutations in the CPB2 gene have been linked to various human diseases, including liver disease, vascular disease, and cancer. The protein is a potential therapeutic target for these diseases, as it can be used to inhibit the activity of the complement cascade and promote the formation of blood clots.

Genular Protein ID: 3577744548

Symbol: CBPB2_HUMAN

Name: Carboxypeptidase B2

UniProtKB Accession Codes:

Q96IY4 A8K464 Q15114 Q5T9K1 Q5T9K2 Q9P2Y6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1939207

Title: Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma.

PubMed ID: 1939207

DOI: 10.1016/s0021-9258(18)54713-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10574983

Title: Characterization of plasmin-mediated activation of plasma procarboxypeptidase B. Modulation by glycosaminoglycans.

PubMed ID: 10574983

DOI: 10.1074/jbc.274.49.35046

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16445295

Title: Post-translational modifications of human thrombin-activatable fibrinolysis inhibitor (TAFI): evidence for a large shift in the isoelectric point and reduced solubility upon activation.

PubMed ID: 16445295

DOI: 10.1021/bi051956v

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 18559974

Title: Crystal structures of TAFI elucidate the inactivation mechanism of activated TAFI: a novel mechanism for enzyme autoregulation.

PubMed ID: 18559974

DOI: 10.1182/blood-2008-03-146001

PubMed ID: 20088943

Title: Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor.

PubMed ID: 20088943

DOI: 10.1111/j.1538-7836.2010.03740.x

Sequence Information:

  • Length: 423
  • Mass: 48424
  • Checksum: B4D20E03ECDD55EF
  • Sequence:
    • MKLCSLAVLV PIVLFCEQHV FAFQSGQVLA ALPRTSRQVQ VLQNLTTTYE IVLWQPVTAD 
LIVKKKQVHF FVNASDVDNV KAHLNVSGIP CSVLLADVED LIQQQISNDT VSPRASASYY 
EQYHSLNEIY SWIEFITERH PDMLTKIHIG SSFEKYPLYV LKVSGKEQAA KNAIWIDCGI 
HAREWISPAF CLWFIGHITQ FYGIIGQYTN LLRLVDFYVM PVVNVDGYDY SWKKNRMWRK 
NRSFYANNHC IGTDLNRNFA SKHWCEEGAS SSSCSETYCG LYPESEPEVK AVASFLRRNI 
NQIKAYISMH SYSQHIVFPY SYTRSKSKDH EELSLVASEA VRAIEKISKN TRYTHGHGSE 
TLYLAPGGGD DWIYDLGIKY SFTIELRDTG TYGFLLPERY IKPTCREAFA AVSKIAWHVI 
RNV

Genular Protein ID: 3068085381

Symbol: A0A087WSY5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WSY5

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MEROPS 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

Sequence Information:

  • Length: 386
  • Mass: 44022
  • Checksum: 76EAAED94C8E8F40
  • Sequence:
    • MKLCSLAVLV PIVLFCEQHV FAFQSGQVLA ALPRTSRQVQ VLQNLTTTYE IVLWQPVTAD 
LIVKKKQVHF FVNASDVDNV KAHLNVSGIP CSVLLADVED LIQQQISNDT VSPRASASYY 
EQYHSLNEIY SWIEFITERH PDMLTKIHIG SSFEKYPLYV LKVSGKEQAA KNAIWIDCGI 
HAREWISPAF CLWFIGHNRM WRKNRSFYAN NHCIGTDLNR NFASKHWCEE GASSSSCSET 
YCGLYPESEP EVKAVASFLR RNINQIKAYI SMHSYSQHIV FPYSYTRSKS KDHEELSLVA 
SEAVRAIEKI SKNTRYTHGH GSETLYLAPG GGDDWIYDLG IKYSFTIELR DTGTYGFLLP 
ERYIKPTCRE AFAAVSKIAW HVIRNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.