Details for: CPB2

Gene ID: 1361

Symbol: CPB2

Ensembl ID: ENSG00000080618

Description: carboxypeptidase B2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 8.2387
    Cell Significance Index: 138.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.2414
    Cell Significance Index: 643.2700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 2.9977
    Cell Significance Index: 11.2900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.3388
    Cell Significance Index: 7.7100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.6463
    Cell Significance Index: 9.5400
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.2529
    Cell Significance Index: 2.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2280
    Cell Significance Index: 157.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2227
    Cell Significance Index: 13.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0939
    Cell Significance Index: 18.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0638
    Cell Significance Index: 1.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0400
    Cell Significance Index: 0.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0353
    Cell Significance Index: 26.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0253
    Cell Significance Index: 9.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0178
    Cell Significance Index: 5.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0159
    Cell Significance Index: 0.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0040
    Cell Significance Index: 7.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0032
    Cell Significance Index: 5.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0012
    Cell Significance Index: 2.1900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0029
    Cell Significance Index: -0.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0042
    Cell Significance Index: -5.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0093
    Cell Significance Index: -0.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0121
    Cell Significance Index: -6.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0124
    Cell Significance Index: -9.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0130
    Cell Significance Index: -8.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0151
    Cell Significance Index: -9.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0156
    Cell Significance Index: -8.8200
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0219
    Cell Significance Index: -0.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0220
    Cell Significance Index: -9.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0357
    Cell Significance Index: -5.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0401
    Cell Significance Index: -8.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0418
    Cell Significance Index: -7.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0513
    Cell Significance Index: -7.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0589
    Cell Significance Index: -10.6100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0605
    Cell Significance Index: -0.5000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0612
    Cell Significance Index: -0.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0648
    Cell Significance Index: -1.8100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0700
    Cell Significance Index: -0.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0705
    Cell Significance Index: -7.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0751
    Cell Significance Index: -8.7500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0819
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0844
    Cell Significance Index: -9.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0864
    Cell Significance Index: -10.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0918
    Cell Significance Index: -6.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0943
    Cell Significance Index: -1.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0988
    Cell Significance Index: -7.5800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1023
    Cell Significance Index: -1.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1025
    Cell Significance Index: -5.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1099
    Cell Significance Index: -2.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1137
    Cell Significance Index: -11.6100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1286
    Cell Significance Index: -1.5000
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1435
    Cell Significance Index: -0.7600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1511
    Cell Significance Index: -2.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1561
    Cell Significance Index: -7.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1597
    Cell Significance Index: -5.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1635
    Cell Significance Index: -2.7500
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1652
    Cell Significance Index: -2.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1697
    Cell Significance Index: -5.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1701
    Cell Significance Index: -5.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1796
    Cell Significance Index: -8.1400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1798
    Cell Significance Index: -2.2300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1801
    Cell Significance Index: -1.2200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1813
    Cell Significance Index: -2.3800
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1820
    Cell Significance Index: -2.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1826
    Cell Significance Index: -11.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1848
    Cell Significance Index: -11.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1863
    Cell Significance Index: -8.2400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1949
    Cell Significance Index: -2.4300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1975
    Cell Significance Index: -1.6300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1997
    Cell Significance Index: -2.7700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.2000
    Cell Significance Index: -1.7300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2083
    Cell Significance Index: -1.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2144
    Cell Significance Index: -4.5500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2152
    Cell Significance Index: -2.3400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2195
    Cell Significance Index: -2.7700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2203
    Cell Significance Index: -2.7800
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.2204
    Cell Significance Index: -2.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2234
    Cell Significance Index: -8.4600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2236
    Cell Significance Index: -4.8300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2281
    Cell Significance Index: -4.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2342
    Cell Significance Index: -10.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2430
    Cell Significance Index: -8.5400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2441
    Cell Significance Index: -2.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2462
    Cell Significance Index: -5.3900
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.2508
    Cell Significance Index: -2.3500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2514
    Cell Significance Index: -6.2700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2678
    Cell Significance Index: -5.5900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2770
    Cell Significance Index: -4.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2858
    Cell Significance Index: -7.6300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2859
    Cell Significance Index: -3.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2860
    Cell Significance Index: -8.2400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2880
    Cell Significance Index: -9.1100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2888
    Cell Significance Index: -5.7100
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.2946
    Cell Significance Index: -2.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2948
    Cell Significance Index: -8.4500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2996
    Cell Significance Index: -3.5300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3086
    Cell Significance Index: -6.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3131
    Cell Significance Index: -15.8200
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.3208
    Cell Significance Index: -2.9000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3268
    Cell Significance Index: -3.7400
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.3282
    Cell Significance Index: -3.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** CPB2 is a zinc-dependent metallo-carboxypeptidase enzyme that cleaves peptides at the carboxy-terminal end, releasing amino acids. 2. **Tissue Distribution:** CPB2 is highly expressed in the liver, pancreas, retina, and other tissues, suggesting its involvement in multiple cellular processes. 3. **Cellular Localization:** CPB2 is found in various cell types, including hepatocytes, pancreatic cells, retinal bipolar neurons, and bipolar cells. **Pathways and Functions:** 1. **Blood Coagulation:** CPB2 participates in the regulation of fibrinolysis, a critical process that prevents excessive clot formation. By cleaving fibrinogen, CPB2 helps maintain the balance between coagulation and fibrinolysis. 2. **Glucose Metabolism:** CPB2 is involved in the regulation of glucose-stimulated insulin secretion from pancreatic beta cells. By cleaving glucagon-like peptide-1 (GLP-1), CPB2 modulates glucose metabolism and insulin sensitivity. 3. **Protein Degradation:** CPB2 is a key enzyme in the proteolytic processing of various proteins, including angiotensinogen, which is converted to angiotensin I and II, playing a crucial role in blood pressure regulation. 4. **Regulation of Complement Cascade:** CPB2 negatively regulates the complement cascade, a critical immune response that prevents excessive tissue damage. **Clinical Significance:** 1. **Hypertension:** Alterations in CPB2 expression or activity may contribute to the development of hypertension, as dysregulation of angiotensinogen processing can lead to increased blood pressure. 2. **Diabetes:** CPB2's role in glucose metabolism and insulin secretion makes it a potential target for the treatment of diabetes. 3. **Liver Disease:** CPB2's involvement in liver regeneration and hepatocyte proliferation suggests its potential as a biomarker or therapeutic target for liver diseases, such as cirrhosis. 4. **Retinal Disorders:** CPB2's expression in retinal cells implies its potential role in retinal diseases, such as age-related macular degeneration. In conclusion, CPB2 is a multifunctional enzyme that plays critical roles in various physiological processes, including blood coagulation, glucose metabolism, and protein degradation. Further research is needed to fully elucidate the mechanisms by which CPB2 regulates these processes and to explore its potential therapeutic applications in human disease.

Genular Protein ID: 3577744548

Symbol: CBPB2_HUMAN

Name: Carboxypeptidase B2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1939207

Title: Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma.

PubMed ID: 1939207

DOI: 10.1016/s0021-9258(18)54713-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10574983

Title: Characterization of plasmin-mediated activation of plasma procarboxypeptidase B. Modulation by glycosaminoglycans.

PubMed ID: 10574983

DOI: 10.1074/jbc.274.49.35046

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16445295

Title: Post-translational modifications of human thrombin-activatable fibrinolysis inhibitor (TAFI): evidence for a large shift in the isoelectric point and reduced solubility upon activation.

PubMed ID: 16445295

DOI: 10.1021/bi051956v

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 18559974

Title: Crystal structures of TAFI elucidate the inactivation mechanism of activated TAFI: a novel mechanism for enzyme autoregulation.

PubMed ID: 18559974

DOI: 10.1182/blood-2008-03-146001

PubMed ID: 20088943

Title: Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor.

PubMed ID: 20088943

DOI: 10.1111/j.1538-7836.2010.03740.x

Sequence Information:

  • Length: 423
  • Mass: 48424
  • Checksum: B4D20E03ECDD55EF
  • Sequence:
  • MKLCSLAVLV PIVLFCEQHV FAFQSGQVLA ALPRTSRQVQ VLQNLTTTYE IVLWQPVTAD 
    LIVKKKQVHF FVNASDVDNV KAHLNVSGIP CSVLLADVED LIQQQISNDT VSPRASASYY 
    EQYHSLNEIY SWIEFITERH PDMLTKIHIG SSFEKYPLYV LKVSGKEQAA KNAIWIDCGI 
    HAREWISPAF CLWFIGHITQ FYGIIGQYTN LLRLVDFYVM PVVNVDGYDY SWKKNRMWRK 
    NRSFYANNHC IGTDLNRNFA SKHWCEEGAS SSSCSETYCG LYPESEPEVK AVASFLRRNI 
    NQIKAYISMH SYSQHIVFPY SYTRSKSKDH EELSLVASEA VRAIEKISKN TRYTHGHGSE 
    TLYLAPGGGD DWIYDLGIKY SFTIELRDTG TYGFLLPERY IKPTCREAFA AVSKIAWHVI 
    RNV

Genular Protein ID: 3068085381

Symbol: A0A087WSY5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 386
  • Mass: 44022
  • Checksum: 76EAAED94C8E8F40
  • Sequence:
  • MKLCSLAVLV PIVLFCEQHV FAFQSGQVLA ALPRTSRQVQ VLQNLTTTYE IVLWQPVTAD 
    LIVKKKQVHF FVNASDVDNV KAHLNVSGIP CSVLLADVED LIQQQISNDT VSPRASASYY 
    EQYHSLNEIY SWIEFITERH PDMLTKIHIG SSFEKYPLYV LKVSGKEQAA KNAIWIDCGI 
    HAREWISPAF CLWFIGHNRM WRKNRSFYAN NHCIGTDLNR NFASKHWCEE GASSSSCSET 
    YCGLYPESEP EVKAVASFLR RNINQIKAYI SMHSYSQHIV FPYSYTRSKS KDHEELSLVA 
    SEAVRAIEKI SKNTRYTHGH GSETLYLAPG GGDDWIYDLG IKYSFTIELR DTGTYGFLLP 
    ERYIKPTCRE AFAAVSKIAW HVIRNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.