Genular: Defining Cellular Identity and Function

Details for: Edn1

Gene ID: 13614

Symbol: Edn1

Ensembl ID: ENSMUSG00000021367

Description: endothelin 1

Associated with

Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Artery smooth muscle contraction
(GO:0014824)
Axon guidance
(GO:0007411)
Body fluid secretion
(GO:0007589)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Calcium-mediated signaling
(GO:0019722)
Cardiac neural crest cell migration involved in outflow tract morphogenesis
(GO:0003253)
Cell-cell signaling
(GO:0007267)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to human chorionic gonadotropin stimulus
(GO:0044751)
Cytokine activity
(GO:0005125)
Dorsal/ventral pattern formation
(GO:0009953)
Embryonic heart tube development
(GO:0035050)
Endothelin a receptor binding
(GO:0031707)
Endothelin b receptor binding
(GO:0031708)
Epithelial fluid transport
(GO:0042045)
Gene expression
(GO:0010467)
Glomerular filtration
(GO:0003094)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heart development
(GO:0007507)
Heart process
(GO:0003015)
Histamine secretion
(GO:0001821)
Hormone activity
(GO:0005179)
Intracellular calcium ion homeostasis
(GO:0006874)
Intracellular signal transduction
(GO:0035556)
In utero embryonic development
(GO:0001701)
Mapk cascade
(GO:0000165)
Middle ear morphogenesis
(GO:0042474)
Mitochondrion organization
(GO:0007005)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of smooth muscle cell apoptotic process
(GO:0034392)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural crest cell development
(GO:0014032)
Neural crest cell differentiation
(GO:0014033)
Neural crest cell fate commitment
(GO:0014034)
Neuron projection development
(GO:0031175)
Nitric oxide transport
(GO:0030185)
Noradrenergic neuron differentiation
(GO:0003357)
Peptide hormone secretion
(GO:0030072)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Phospholipase d-activating g protein-coupled receptor signaling pathway
(GO:0031583)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cell size
(GO:0045793)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of heart rate
(GO:0010460)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of odontogenesis
(GO:0042482)
Positive regulation of prostaglandin secretion
(GO:0032308)
Positive regulation of renal sodium excretion
(GO:0035815)
Positive regulation of smooth muscle contraction
(GO:0045987)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of urine volume
(GO:0035810)
Prostaglandin biosynthetic process
(GO:0001516)
Protein binding
(GO:0005515)
Protein kinase a signaling
(GO:0010737)
Protein kinase c-activating g protein-coupled receptor signaling pathway
(GO:0007205)
Protein kinase c deactivation
(GO:0042313)
Protein phosphorylation
(GO:0006468)
Receptor ligand activity
(GO:0048018)
Regulation of blood pressure
(GO:0008217)
Regulation of glucose transmembrane transport
(GO:0010827)
Regulation of ph
(GO:0006885)
Regulation of systemic arterial blood pressure by endothelin
(GO:0003100)
Regulation of vasoconstriction
(GO:0019229)
Respiratory gaseous exchange by respiratory system
(GO:0007585)
Response to amphetamine
(GO:0001975)
Response to hypoxia
(GO:0001666)
Rhythmic excitation
(GO:0043179)
Signaling receptor binding
(GO:0005102)
Skeletal system development
(GO:0001501)
Smooth muscle contraction
(GO:0006939)
Superoxide anion generation
(GO:0042554)
Thyroid gland development
(GO:0030878)
Transcription by rna polymerase ii
(GO:0006366)
Vasoconstriction
(GO:0042310)
Vein smooth muscle contraction
(GO:0014826)

Other Information

Proteins

Endothelin-1

Genular Protein ID: 2407729746

Symbol: EDN1_MOUSE

Name: Endothelin-1

UniProtKB Accession Codes:

P22387 P70203 P97338

Database IDs:

Citations:

PubMed ID: 8575440

Title: Mouse preproendothelin-1 gene. cDNA cloning, sequence analysis and determination of sites of expression during embryonic development.

PubMed ID: 8575440

DOI: 10.1111/j.1432-1033.1995.819_a.x

PubMed ID: 8688455

Title: Sequence and neuronal expression of mouse endothelin-1 cDNA.

PubMed ID: 8688455

DOI: 10.1016/0167-4781(96)00066-8

PubMed ID: 8824799

Title: Sequence analysis, chromosomal location, and developmental expression of the mouse preproendothelin-1 gene.

PubMed ID: 8824799

DOI: 10.1006/geno.1996.0029

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7883980

Title: Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter.

PubMed ID: 7883980

DOI: 10.1172/jci117784

PubMed ID: 8238383

Title: Endothelin-1 mRNA in glomerular and epithelial cells of kidney.

PubMed ID: 8238383

DOI: 10.1152/ajprenal.1993.265.4.f542

PubMed ID: 2768235

Title: A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity.

PubMed ID: 2768235

DOI: 10.1016/s0021-9258(18)63739-1

PubMed ID: 16293765

Title: Embryonic lethality in Dear gene-deficient mice: new player in angiogenesis.

PubMed ID: 16293765

DOI: 10.1152/physiolgenomics.00144.2005

Sequence Information:

Length: 202
Mass: 22809
Checksum: 3A0C1E1DFA797411
Sequence:

MDYFPVIFSL LFVTFQGAPE TAVLGAELST GAENGVQSPP PSTPWRPRRS KRCSCSSLMD 
KECVYFCHLD IIWVNTPERV VPYGLGGSSR SKRSLKDLLP NKATDQAVRC QCAHQKDKKC 
WNFCQAGKEL RAQSTMQKSL KDSKKGKPCS KLGKKCIYQQ LVEGRKLRRL EAISNSIKAS 
FRVAKLKAEL YRDQKLTHNR AH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Edn1

Associated with

Other Information

Mouse preproendothelin-1 gene. cDNA cloning, sequence analysis and determination of sites of expression during embryonic development. PubMed ID: 8575440

Sequence and neuronal expression of mouse endothelin-1 cDNA. PubMed ID: 8688455

Sequence analysis, chromosomal location, and developmental expression of the mouse preproendothelin-1 gene. PubMed ID: 8824799

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter. PubMed ID: 7883980

Endothelin-1 mRNA in glomerular and epithelial cells of kidney. PubMed ID: 8238383

A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity. PubMed ID: 2768235

Embryonic lethality in Dear gene-deficient mice: new player in angiogenesis. PubMed ID: 16293765