Details for: CPD

Gene ID: 1362

Symbol: CPD

Ensembl ID: ENSG00000108582

Description: carboxypeptidase D

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.4
    Marker Score: 5462
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.26
    Marker Score: 1349
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.99
    Marker Score: 3627
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.94
    Marker Score: 67345
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.88
    Marker Score: 514
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.84
    Marker Score: 4181
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8
    Marker Score: 6950
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.79
    Marker Score: 834
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.77
    Marker Score: 872
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.76
    Marker Score: 108003
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.75
    Marker Score: 26136
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.74
    Marker Score: 12928
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.72
    Marker Score: 1530.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.66
    Marker Score: 1112
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.65
    Marker Score: 477
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.65
    Marker Score: 14159
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.62
    Marker Score: 916
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.6
    Marker Score: 4282
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.56
    Marker Score: 449.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.56
    Marker Score: 2717
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.52
    Marker Score: 11648
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.51
    Marker Score: 14312
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.47
    Marker Score: 55766
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.45
    Marker Score: 3480
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.45
    Marker Score: 6021
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.45
    Marker Score: 1007
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.43
    Marker Score: 2203
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.43
    Marker Score: 831
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.42
    Marker Score: 4062
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.41
    Marker Score: 9010
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.4
    Marker Score: 1638
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.39
    Marker Score: 1603
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.39
    Marker Score: 51267
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.38
    Marker Score: 2009
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.35
    Marker Score: 5507
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.35
    Marker Score: 1417
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.34
    Marker Score: 13819
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.33
    Marker Score: 421
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.33
    Marker Score: 338
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.32
    Marker Score: 1215
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.3
    Marker Score: 1151
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.3
    Marker Score: 11269
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.3
    Marker Score: 483
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.28
    Marker Score: 12080
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.27
    Marker Score: 641
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.26
    Marker Score: 1281
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.26
    Marker Score: 434
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.25
    Marker Score: 301
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.25
    Marker Score: 3110
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.24
    Marker Score: 462
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.23
    Marker Score: 492
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.23
    Marker Score: 1179
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.23
    Marker Score: 449
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.23
    Marker Score: 682
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.21
    Marker Score: 1556
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.19
    Marker Score: 4107
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.19
    Marker Score: 1259
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.18
    Marker Score: 25257
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.18
    Marker Score: 1068
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.17
    Marker Score: 1937
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.16
    Marker Score: 1254
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.14
    Marker Score: 22762
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.13
    Marker Score: 1010
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.13
    Marker Score: 2248
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.12
    Marker Score: 2836
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.12
    Marker Score: 470
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.12
    Marker Score: 62735
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.12
    Marker Score: 791
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.1
    Marker Score: 268
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.09
    Marker Score: 5226
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.09
    Marker Score: 562
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.08
    Marker Score: 2749
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.08
    Marker Score: 229
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.07
    Marker Score: 1581
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.07
    Marker Score: 2348
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.05
    Marker Score: 499
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.05
    Marker Score: 1992
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.05
    Marker Score: 728
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.04
    Marker Score: 1077
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.03
    Marker Score: 4780
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.01
    Marker Score: 406
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1
    Marker Score: 684
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71647
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47871
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.99
    Marker Score: 252
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.99
    Marker Score: 1654
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.98
    Marker Score: 4113
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30378
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.98
    Marker Score: 362
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.98
    Marker Score: 621
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.98
    Marker Score: 1385
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.96
    Marker Score: 586
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.96
    Marker Score: 15442
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.95
    Marker Score: 825
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.94
    Marker Score: 276
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2391
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.94
    Marker Score: 220
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.93
    Marker Score: 1004
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481

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Other Information

**Key characteristics:** * Gene name: CPD * Ensembl ID: ENSG00000108582 * Protein: CBPD_HUMAN * Protein function: Carboxypeptidase D * Cellular location: Extracellular space, Golgi associated vesicles, membrane, and cell interior * Pathways/Ontology: Extracellular exosome, Extracellular space, Golgi associated vesicle biogenesis, Membrane, Membrane trafficking, Metallocarboxypeptidase activity, Peptide metabolic process, Plasma membrane, Protein processing, Rho gtpase cycle, Rnd1 gtpase cycle, Rnd3 gtpase cycle, Serine-type carboxypeptidase activity, Signaling by rho gtpases, Signaling by rho gtpases, miro gtpases and rhobtb3, Signal transduction **Functions:** * Carboxypeptidase D is involved in the processing of various proteins, including those involved in cell signaling, cell adhesion, and extracellular matrix remodeling. * It is a key regulator of synaptic plasticity and learning and memory processes in the CNS. * It is involved in the regulation of neurogenesis, neurite outgrowth, and neuronal survival. * It is a potential therapeutic target for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. **Clinical significance:** * Mutations in the CPD gene have been linked to several neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). * Carboxypeptidase D inhibitors are being investigated as potential treatments for these diseases. * Understanding the role of CPD in neurobiology and disease pathogenesis could provide new insights for the development of novel therapeutic strategies.

Genular Protein ID: 2472666290

Symbol: CBPD_HUMAN

Name: Carboxypeptidase D

UniProtKB Accession Codes:

O75976 B7Z7T9 B7ZAU4 F5GZH6 O15377 Q86SH9 Q86XE6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 CarbonylDB 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 3 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9714835

Title: Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme.

PubMed ID: 9714835

DOI: 10.1016/s0378-1119(98)00270-4

PubMed ID: 9355738

Title: Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains.

PubMed ID: 9355738

DOI: 10.1042/bj3270081

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9064476

Title: Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B virus-binding protein.

PubMed ID: 9064476

DOI: 10.1016/s0024-3205(96)00642-x

PubMed ID: 12643288

Title: Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking.

PubMed ID: 12643288

DOI: 10.1074/jbc.m209379200

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 1380
  • Mass: 152931
  • Checksum: 567EC1F0B4B7A0C8
  • Sequence:
    • MASGRDERPP WRLGRLLLLM CLLLLGSSAR AAHIKKAEAT TTTTSAGAEA AEGQFDRYYH 
EEELESALRE AAAAGLPGLA RLFSIGRSVE GRPLWVLRLT AGLGSLIPEG DAGPDAAGPD 
AAGPLLPGRP QVKLVGNMHG DETVSRQVLI YLARELAAGY RRGDPRLVRL LNTTDVYLLP 
SLNPDGFERA REGDCGFGDG GPSGASGRDN SRGRDLNRSF PDQFSTGEPP ALDEVPEVRA 
LIEWIRRNKF VLSGNLHGGS VVASYPFDDS PEHKATGIYS KTSDDEVFKY LAKAYASNHP 
IMKTGEPHCP GDEDETFKDG ITNGAHWYDV EGGMQDYNYV WANCFEITLE LSCCKYPPAS 
QLRQEWENNR ESLITLIEKV HIGVKGFVKD SITGSGLENA TISVAGINHN ITTGRFGDFY 
RLLVPGTYNL TVVLTGYMPL TVTNVVVKEG PATEVDFSLR PTVTSVIPDT TEAVSTASTV 
AIPNILSGTS SSYQPIQPKD FHHHHFPDME IFLRRFANEY PNITRLYSLG KSVESRELYV 
MEISDNPGVH EPGEPEFKYI GNMHGNEVVG RELLLNLIEY LCKNFGTDPE VTDLVHNTRI 
HLMPSMNPDG YEKSQEGDSI SVIGRNNSNN FDLNRNFPDQ FVQITDPTQP ETIAVMSWMK 
SYPFVLSANL HGGSLVVNYP FDDDEQGLAT YSKSPDDAVF QQIALSYSKE NSQMFQGRPC 
KNMYPNEYFP HGITNGASWY NVPGGMQDWN YLQTNCFEVT IELGCVKYPL EKELPNFWEQ 
NRRSLIQFMK QVHQGVRGFV LDATDGRGIL NATISVAEIN HPVTTYKTGD YWRLLVPGTY 
KITASARGYN PVTKNVTVKS EGAIQVNFTL VRSSTDSNNE SKKGKGASSS TNDASDPTTK 
EFETLIKDLS AENGLESLML RSSSNLALAL YRYHSYKDLS EFLRGLVMNY PHITNLTNLG 
QSTEYRHIWS LEISNKPNVS EPEEPKIRFV AGIHGNAPVG TELLLALAEF LCLNYKKNPA 
VTQLVDRTRI VIVPSLNPDG RERAQEKDCT SKIGQTNARG KDLDTDFTNN ASQPETKAII 
ENLIQKQDFS LSVALDGGSM LVTYPYDKPV QTVENKETLK HLASLYANNH PSMHMGQPSC 
PNKSDENIPG GVMRGAEWHS HLGSMKDYSV TYGHCPEITV YTSCCYFPSA ARLPSLWADN 
KRSLLSMLVE VHKGVHGFVK DKTGKPISKA VIVLNEGIKV QTKEGGYFHV LLAPGVHNII 
AIADGYQQQH SQVFVHHDAA SSVVIVFDTD NRIFGLPREL VVTVSGATMS ALILTACIIW 
CICSIKSNRH KDGFHRLRQH HDEYEDEIRM MSTGSKKSLL SHEFQDETDT EEETLYSSKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.