Details for: CPD

Gene ID: 1362

Symbol: CPD

Ensembl ID: ENSG00000108582

Description: carboxypeptidase D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 302.7094
    Cell Significance Index: -47.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 104.1255
    Cell Significance Index: -49.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 100.0721
    Cell Significance Index: -40.6600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 73.1272
    Cell Significance Index: -49.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.6607
    Cell Significance Index: -40.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.8051
    Cell Significance Index: -47.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.3357
    Cell Significance Index: -46.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.4345
    Cell Significance Index: -44.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1869
    Cell Significance Index: -48.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.1265
    Cell Significance Index: -26.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2602
    Cell Significance Index: 105.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.8820
    Cell Significance Index: 43.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6539
    Cell Significance Index: 328.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6466
    Cell Significance Index: 330.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4834
    Cell Significance Index: 532.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3874
    Cell Significance Index: 757.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0682
    Cell Significance Index: 964.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9320
    Cell Significance Index: 62.6700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8312
    Cell Significance Index: 574.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6772
    Cell Significance Index: 122.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6137
    Cell Significance Index: 42.4400
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.5596
    Cell Significance Index: 5.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5542
    Cell Significance Index: 90.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5294
    Cell Significance Index: 65.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5078
    Cell Significance Index: 96.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3621
    Cell Significance Index: 20.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3223
    Cell Significance Index: 31.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2973
    Cell Significance Index: 8.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2231
    Cell Significance Index: 11.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1849
    Cell Significance Index: 2.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1433
    Cell Significance Index: 11.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1284
    Cell Significance Index: 5.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1263
    Cell Significance Index: 5.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1206
    Cell Significance Index: 53.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1188
    Cell Significance Index: 16.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0967
    Cell Significance Index: 2.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0926
    Cell Significance Index: 15.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0795
    Cell Significance Index: 3.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0771
    Cell Significance Index: 145.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0651
    Cell Significance Index: 4.0000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0647
    Cell Significance Index: 1.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0452
    Cell Significance Index: 28.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0328
    Cell Significance Index: 1.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0189
    Cell Significance Index: 8.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0069
    Cell Significance Index: 0.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0046
    Cell Significance Index: 7.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0038
    Cell Significance Index: 6.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0022
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0062
    Cell Significance Index: -0.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0078
    Cell Significance Index: -10.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0106
    Cell Significance Index: -7.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0131
    Cell Significance Index: -9.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0144
    Cell Significance Index: -9.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0410
    Cell Significance Index: -31.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0531
    Cell Significance Index: -7.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0558
    Cell Significance Index: -2.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0583
    Cell Significance Index: -32.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0972
    Cell Significance Index: -9.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0977
    Cell Significance Index: -12.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1137
    Cell Significance Index: -23.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1185
    Cell Significance Index: -2.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1295
    Cell Significance Index: -2.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1428
    Cell Significance Index: -41.1000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1502
    Cell Significance Index: -2.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1653
    Cell Significance Index: -4.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1828
    Cell Significance Index: -23.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1844
    Cell Significance Index: -21.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1972
    Cell Significance Index: -14.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2465
    Cell Significance Index: -5.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2788
    Cell Significance Index: -32.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2807
    Cell Significance Index: -32.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3343
    Cell Significance Index: -23.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3696
    Cell Significance Index: -10.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3798
    Cell Significance Index: -23.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3960
    Cell Significance Index: -25.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4006
    Cell Significance Index: -41.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4042
    Cell Significance Index: -8.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4207
    Cell Significance Index: -5.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4502
    Cell Significance Index: -27.0300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4749
    Cell Significance Index: -7.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5275
    Cell Significance Index: -18.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5343
    Cell Significance Index: -42.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6004
    Cell Significance Index: -17.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6152
    Cell Significance Index: -37.7200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6380
    Cell Significance Index: -15.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6483
    Cell Significance Index: -10.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6686
    Cell Significance Index: -23.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6925
    Cell Significance Index: -18.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7003
    Cell Significance Index: -36.7700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7013
    Cell Significance Index: -8.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7020
    Cell Significance Index: -22.4900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7051
    Cell Significance Index: -4.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7843
    Cell Significance Index: -20.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8126
    Cell Significance Index: -21.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8405
    Cell Significance Index: -7.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9079
    Cell Significance Index: -33.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9588
    Cell Significance Index: -9.9300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9643
    Cell Significance Index: -18.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9918
    Cell Significance Index: -32.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0253
    Cell Significance Index: -25.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Metallocarboxypeptidase activity**: CPD possesses a zinc-dependent carboxypeptidase activity, allowing it to cleave peptides at the C-terminal end. 2. **Extracellular localization**: CPD is primarily found in the extracellular space, where it regulates the processing of peptides and modulates signaling pathways. 3. **Widespread expression**: CPD is expressed in various cell types, including immune cells, endothelial cells, and neurons, indicating its involvement in multiple cellular processes. 4. **Regulation of signaling pathways**: CPD modulates signaling pathways, including the Rho GTPase cycle, which is crucial for immune cell function and cellular migration. **Pathways and Functions:** 1. **Extracellular exosome-mediated transport**: CPD is involved in the regulation of exosome-mediated transport, which is essential for the delivery of signaling molecules between cells. 2. **Protein processing**: CPD cleaves peptides at the C-terminal end, regulating the processing of proteins and peptides involved in immune responses. 3. **Signaling by Rho GTPases**: CPD modulates the Rho GTPase cycle, which is involved in immune cell function, cellular migration, and cytoskeleton organization. 4. **Metallocarboxypeptidase activity**: CPD's metallocarboxypeptidase activity allows it to cleave peptides, regulating the processing of proteins and peptides involved in immune responses. **Clinical Significance:** Dysregulation of CPD has been implicated in various diseases, including inflammatory disorders and neurological conditions. For instance: 1. **Inflammatory disorders**: CPD dysregulation may contribute to the development of inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis. 2. **Neurological conditions**: CPD's involvement in signaling pathways and protein processing suggests its potential role in neurological conditions, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: CPD's role in regulating protein processing and signaling pathways may also contribute to cancer development and progression. In conclusion, carboxypeptidase D is a multifaceted enzyme involved in various cellular processes, including immune regulation, signaling, and protein processing. Further research is needed to fully understand the role of CPD in disease pathology and to explore its potential as a therapeutic target.

Genular Protein ID: 2472666290

Symbol: CBPD_HUMAN

Name: Carboxypeptidase D

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9714835

Title: Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme.

PubMed ID: 9714835

DOI: 10.1016/s0378-1119(98)00270-4

PubMed ID: 9355738

Title: Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains.

PubMed ID: 9355738

DOI: 10.1042/bj3270081

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9064476

Title: Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B virus-binding protein.

PubMed ID: 9064476

DOI: 10.1016/s0024-3205(96)00642-x

PubMed ID: 12643288

Title: Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking.

PubMed ID: 12643288

DOI: 10.1074/jbc.m209379200

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 1380
  • Mass: 152931
  • Checksum: 567EC1F0B4B7A0C8
  • Sequence:
  • MASGRDERPP WRLGRLLLLM CLLLLGSSAR AAHIKKAEAT TTTTSAGAEA AEGQFDRYYH 
    EEELESALRE AAAAGLPGLA RLFSIGRSVE GRPLWVLRLT AGLGSLIPEG DAGPDAAGPD 
    AAGPLLPGRP QVKLVGNMHG DETVSRQVLI YLARELAAGY RRGDPRLVRL LNTTDVYLLP 
    SLNPDGFERA REGDCGFGDG GPSGASGRDN SRGRDLNRSF PDQFSTGEPP ALDEVPEVRA 
    LIEWIRRNKF VLSGNLHGGS VVASYPFDDS PEHKATGIYS KTSDDEVFKY LAKAYASNHP 
    IMKTGEPHCP GDEDETFKDG ITNGAHWYDV EGGMQDYNYV WANCFEITLE LSCCKYPPAS 
    QLRQEWENNR ESLITLIEKV HIGVKGFVKD SITGSGLENA TISVAGINHN ITTGRFGDFY 
    RLLVPGTYNL TVVLTGYMPL TVTNVVVKEG PATEVDFSLR PTVTSVIPDT TEAVSTASTV 
    AIPNILSGTS SSYQPIQPKD FHHHHFPDME IFLRRFANEY PNITRLYSLG KSVESRELYV 
    MEISDNPGVH EPGEPEFKYI GNMHGNEVVG RELLLNLIEY LCKNFGTDPE VTDLVHNTRI 
    HLMPSMNPDG YEKSQEGDSI SVIGRNNSNN FDLNRNFPDQ FVQITDPTQP ETIAVMSWMK 
    SYPFVLSANL HGGSLVVNYP FDDDEQGLAT YSKSPDDAVF QQIALSYSKE NSQMFQGRPC 
    KNMYPNEYFP HGITNGASWY NVPGGMQDWN YLQTNCFEVT IELGCVKYPL EKELPNFWEQ 
    NRRSLIQFMK QVHQGVRGFV LDATDGRGIL NATISVAEIN HPVTTYKTGD YWRLLVPGTY 
    KITASARGYN PVTKNVTVKS EGAIQVNFTL VRSSTDSNNE SKKGKGASSS TNDASDPTTK 
    EFETLIKDLS AENGLESLML RSSSNLALAL YRYHSYKDLS EFLRGLVMNY PHITNLTNLG 
    QSTEYRHIWS LEISNKPNVS EPEEPKIRFV AGIHGNAPVG TELLLALAEF LCLNYKKNPA 
    VTQLVDRTRI VIVPSLNPDG RERAQEKDCT SKIGQTNARG KDLDTDFTNN ASQPETKAII 
    ENLIQKQDFS LSVALDGGSM LVTYPYDKPV QTVENKETLK HLASLYANNH PSMHMGQPSC 
    PNKSDENIPG GVMRGAEWHS HLGSMKDYSV TYGHCPEITV YTSCCYFPSA ARLPSLWADN 
    KRSLLSMLVE VHKGVHGFVK DKTGKPISKA VIVLNEGIKV QTKEGGYFHV LLAPGVHNII 
    AIADGYQQQH SQVFVHHDAA SSVVIVFDTD NRIFGLPREL VVTVSGATMS ALILTACIIW 
    CICSIKSNRH KDGFHRLRQH HDEYEDEIRM MSTGSKKSLL SHEFQDETDT EEETLYSSKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.