Genular: Defining Cellular Identity and Function

Details for: Eed

Gene ID: 13626

Symbol: Eed

Ensembl ID: ENSMUSG00000030619

Description: embryonic ectoderm development

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Chromatin modifying enzymes
(R-MMU-3247509)
Epigenetic regulation of gene expression
(R-MMU-212165)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Oxidative stress induced senescence
(R-MMU-2559580)
Pkmts methylate histone lysines
(R-MMU-3214841)
Prc2 methylates histones and dna
(R-MMU-212300)
Rna polymerase ii transcription
(R-MMU-73857)
Transcriptional regulation by e2f6
(R-MMU-8953750)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Chromatin binding
(GO:0003682)
Chromatin organization
(GO:0006325)
Chromatin silencing complex
(GO:0005677)
Chromosome
(GO:0005694)
Cytosol
(GO:0005829)
Enzyme activator activity
(GO:0008047)
Esc/e(z) complex
(GO:0035098)
Facultative heterochromatin formation
(GO:0140718)
Genomic imprinting
(GO:0071514)
Histone methyltransferase activity
(GO:0042054)
Identical protein binding
(GO:0042802)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleosome binding
(GO:0031491)
Nucleus
(GO:0005634)
Oligodendrocyte differentiation
(GO:0048709)
Plasma membrane
(GO:0005886)
Positive regulation of amide metabolic process
(GO:0034250)
Positive regulation of cellular metabolic process
(GO:0031325)
Positive regulation of lipid metabolic process
(GO:0045834)
Pronucleus
(GO:0045120)
Protein binding
(GO:0005515)
Regulation of adaxial/abaxial pattern formation
(GO:2000011)
Regulation of membrane lipid metabolic process
(GO:1905038)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sex chromatin
(GO:0001739)
Sphingomyelin phosphodiesterase activator activity
(GO:0016230)
Transcription corepressor binding
(GO:0001222)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)

Other Information

Proteins

Polycomb protein EED

Genular Protein ID: 3783390109

Symbol: EED_MOUSE

Name: Polycomb protein EED

UniProtKB Accession Codes:

Q921E6 P97462

Database IDs:

Citations:

PubMed ID: 8805699

Title: Positional cloning of a global regulator of anterior-posterior patterning in mice.

PubMed ID: 8805699

DOI: 10.1038/383250a0

PubMed ID: 8984348

Title:

PubMed ID: 8984348

DOI: 10.1038/384648a0

PubMed ID: 9234727

Title: The product of the murine homolog of the Drosophila extra sex combs gene displays transcriptional repressor activity.

PubMed ID: 9234727

DOI: 10.1128/mcb.17.8.4707

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9742080

Title: Point mutations in the WD40 domain of Eed block its interaction with Ezh2.

PubMed ID: 9742080

DOI: 10.1128/mcb.18.10.5634

PubMed ID: 11479595

Title: Imprinted X inactivation maintained by a mouse Polycomb group gene.

PubMed ID: 11479595

DOI: 10.1038/ng574

PubMed ID: 12123576

Title: Mitotically stable association of polycomb group proteins Eed and Enx1 with the inactive X chromosome in trophoblast stem cells.

PubMed ID: 12123576

DOI: 10.1016/s0960-9822(02)00892-8

PubMed ID: 12370779

Title: The mouse PcG gene Eed is required for Hox gene repression and extraembryonic development.

PubMed ID: 12370779

DOI: 10.1007/s00335-002-2182-7

PubMed ID: 12689588

Title: Establishment of histone H3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes.

PubMed ID: 12689588

DOI: 10.1016/s1534-5807(03)00068-6

PubMed ID: 12627233

Title: Genome imprinting regulated by the mouse Polycomb group protein Eed.

PubMed ID: 12627233

DOI: 10.1038/ng1125

PubMed ID: 12649488

Title: Role of histone H3 lysine 27 methylation in X inactivation.

PubMed ID: 12649488

DOI: 10.1126/science.1084274

PubMed ID: 15516932

Title: Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes.

PubMed ID: 15516932

DOI: 10.1038/ng1467

PubMed ID: 14671313

Title: Epigenetic dynamics of imprinted X inactivation during early mouse development.

PubMed ID: 14671313

DOI: 10.1126/science.1092727

PubMed ID: 14752160

Title: Reactivation of the paternal X chromosome in early mouse embryos.

PubMed ID: 14752160

DOI: 10.1126/science.1092674

PubMed ID: 15916951

Title: The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation.

PubMed ID: 15916951

DOI: 10.1016/j.cub.2005.04.051

PubMed ID: 16007070

Title: Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte.

PubMed ID: 16007070

DOI: 10.1038/sj.embor.7400461

PubMed ID: 15684044

Title: Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation.

PubMed ID: 15684044

DOI: 10.1073/pnas.0409875102

PubMed ID: 16224021

Title: Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.

PubMed ID: 16224021

DOI: 10.1126/science.1118947

PubMed ID: 16618801

Title: Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.

PubMed ID: 16618801

DOI: 10.1101/gad.381706

PubMed ID: 16415857

Title: The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation.

PubMed ID: 16415857

DOI: 10.1038/ncb1351

PubMed ID: 17259173

Title: Developmental regulation of Eed complex composition governs a switch in global histone modification in brain.

PubMed ID: 17259173

DOI: 10.1074/jbc.m608722200

PubMed ID: 17997413

Title: Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation.

PubMed ID: 17997413

DOI: 10.1016/j.jmb.2007.10.040

PubMed ID: 18201968

Title: STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells.

PubMed ID: 18201968

DOI: 10.1074/jbc.m707275200

PubMed ID: 19026780

Title: EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.

PubMed ID: 19026780

DOI: 10.1016/j.molcel.2008.10.016

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20144788

Title: Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation.

PubMed ID: 20144788

DOI: 10.1016/j.stem.2009.12.014

PubMed ID: 23970558

Title: Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes.

PubMed ID: 23970558

DOI: 10.1126/science.1240636

PubMed ID: 17937919

Title: Structural basis of EZH2 recognition by EED.

PubMed ID: 17937919

DOI: 10.1016/j.str.2007.08.007

Sequence Information:

Length: 441
Mass: 50198
Checksum: D2E0A5BA27C0499A
Sequence:

MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT ERPDTPTNTP 
NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ FNWHSKEGDP LVFATVGSNR 
VTLYECHSQG EIRLLQSYVD ADADENFYTC AWTYDSNTSH PLLAVAGSRG IIRIINPITM 
QCIKHYVGHG NAINELKFHP RDPNLLLSVS KDHALRLWNI QTDTLVAIFG GVEGHRDEVL 
SADYDLLGEK IMSCGMDHSL KLWRINSKRM MNAIKESYDY NPNKTNRPFI SQKIHFPDFS 
TRDIHRNYVD CVRWLGDLIL SKSCENAIVC WKPGKMEDDI DKIKPSESNV TILGRFDYSQ 
CDIWYMRFSM DFWQKMLALG NQVGKLYVWD LEVEDPHKAK CTTLTHHKCG AAIRQTSFSR 
DSSILIAVCD DASIWRWDRL R

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Eed

Associated with

Other Information

Positional cloning of a global regulator of anterior-posterior patterning in mice. PubMed ID: 8805699

PubMed ID: 8984348

The product of the murine homolog of the Drosophila extra sex combs gene displays transcriptional repressor activity. PubMed ID: 9234727

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Point mutations in the WD40 domain of Eed block its interaction with Ezh2. PubMed ID: 9742080

Imprinted X inactivation maintained by a mouse Polycomb group gene. PubMed ID: 11479595

Mitotically stable association of polycomb group proteins Eed and Enx1 with the inactive X chromosome in trophoblast stem cells. PubMed ID: 12123576

The mouse PcG gene Eed is required for Hox gene repression and extraembryonic development. PubMed ID: 12370779

Establishment of histone H3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. PubMed ID: 12689588

Genome imprinting regulated by the mouse Polycomb group protein Eed. PubMed ID: 12627233

Role of histone H3 lysine 27 methylation in X inactivation. PubMed ID: 12649488

Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. PubMed ID: 15516932

Epigenetic dynamics of imprinted X inactivation during early mouse development. PubMed ID: 14671313

Reactivation of the paternal X chromosome in early mouse embryos. PubMed ID: 14752160

The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. PubMed ID: 15916951

Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte. PubMed ID: 16007070

Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. PubMed ID: 15684044

Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. PubMed ID: 16224021

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. PubMed ID: 16618801

The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. PubMed ID: 16415857

Developmental regulation of Eed complex composition governs a switch in global histone modification in brain. PubMed ID: 17259173

Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation. PubMed ID: 17997413

STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells. PubMed ID: 18201968

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. PubMed ID: 19026780

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. PubMed ID: 20144788

Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes. PubMed ID: 23970558

Structural basis of EZH2 recognition by EED. PubMed ID: 17937919