Genular: Defining Cellular Identity and Function

Details for: Eef1a1

Gene ID: 13627

Symbol: Eef1a1

Ensembl ID: ENSMUSG00000037742

Description: eukaryotic translation elongation factor 1 alpha 1

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to heat stress
(R-MMU-3371556)
Eukaryotic translation elongation
(R-MMU-156842)
Hsf1 activation
(R-MMU-3371511)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism of proteins
(R-MMU-392499)
Neutrophil degranulation
(R-MMU-6798695)
Post-translational protein modification
(R-MMU-597592)
Protein methylation
(R-MMU-8876725)
Calmodulin binding
(GO:0005516)
Cellular response to epidermal growth factor stimulus
(GO:0071364)
Cortical actin cytoskeleton
(GO:0030864)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Heterocyclic compound binding
(GO:1901363)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Kinase binding
(GO:0019900)
Membrane
(GO:0016020)
Molecular adaptor activity
(GO:0060090)
Mrna binding
(GO:0003729)
Myelin sheath
(GO:0043209)
Nucleolus
(GO:0005730)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation by host of viral genome replication
(GO:0044829)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of d-erythro-sphingosine kinase activity
(GO:1900022)
Ribosome
(GO:0005840)
Ruffle membrane
(GO:0032587)
Translation
(GO:0006412)
Translational elongation
(GO:0006414)
Translation elongation factor activity
(GO:0003746)
Trna binding
(GO:0000049)

Other Information

Proteins

Elongation factor 1-alpha 1

Genular Protein ID: 1468629186

Symbol: EF1A1_MOUSE

Name: Elongation factor 1-alpha 1

UniProtKB Accession Codes:

P10126 Q61511 Q6ZWN2 Q8BMB8 Q8BVS8 Q99KU5

Database IDs:

Citations:

PubMed ID: 3215517

Title: Isolation and mapping of a gene for protein synthesis initiation factor 4A and its expression during differentiation of murine erythroleukemia cells.

PubMed ID: 3215517

DOI: 10.1016/0378-1119(88)90195-3

PubMed ID: 2911475

Title: The complete cDNA sequence of mouse elongation factor 1 alpha (EF 1 alpha) mRNA.

PubMed ID: 2911475

DOI: 10.1093/nar/17.1.442

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3481036

Title: Expression of a gene for mouse eucaryotic elongation factor Tu during murine erythroleukemic cell differentiation.

PubMed ID: 3481036

DOI: 10.1128/mcb.7.11.3929-3936.1987

PubMed ID: 3960725

Title: Structure of the amino-terminal end of mammalian elongation factor Tu.

PubMed ID: 3960725

DOI: 10.1093/nar/14.5.2409

PubMed ID: 2569467

Title: Murine elongation factor 1 alpha (EF-1 alpha) is posttranslationally modified by novel amide-linked ethanolamine-phosphoglycerol moieties. Addition of ethanolamine-phosphoglycerol to specific glutamic acid residues on EF-1 alpha.

PubMed ID: 2569467

DOI: 10.1016/s0021-9258(18)71682-7

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19856081

Title: The interaction between interferon-induced protein with tetratricopeptide repeats-1 and eukaryotic elongation factor-1A.

PubMed ID: 19856081

DOI: 10.1007/s11010-009-0289-9

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 28108655

Title: The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A).

PubMed ID: 28108655

DOI: 10.1093/nar/gkx002

Sequence Information:

Length: 462
Mass: 50114
Checksum: 71072871DE7405DC
Sequence:

MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG KGSFKYAWVL 
DKLKAERERG ITIDISLWKF ETSKYYVTII DAPGHRDFIK NMITGTSQAD CAVLIVAAGV 
GEFEAGISKN GQTREHALLA YTLGVKQLIV GVNKMDSTEP PYSQKRYEEI VKEVSTYIKK 
IGYNPDTVAF VPISGWNGDN MLEPSANMPW FKGWKVTRKD GSASGTTLLE ALDCILPPTR 
PTDKPLRLPL QDVYKIGGIG TVPVGRVETG VLKPGMVVTF APVNVTTEVK SVEMHHEALS 
EALPGDNVGF NVKNVSVKDV RRGNVAGDSK NDPPMEAAGF TAQVIILNHP GQISAGYAPV 
LDCHTAHIAC KFAELKEKID RRSGKKLEDG PKFLKSGDAA IVDMVPGKPM CVESFSDYPP 
LGRFAVRDMR QTVAVGVIKA VDKKAAGAGK VTKSAQKAQK AK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Eef1a1

Associated with

Other Information

Isolation and mapping of a gene for protein synthesis initiation factor 4A and its expression during differentiation of murine erythroleukemia cells. PubMed ID: 3215517

The complete cDNA sequence of mouse elongation factor 1 alpha (EF 1 alpha) mRNA. PubMed ID: 2911475

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression of a gene for mouse eucaryotic elongation factor Tu during murine erythroleukemic cell differentiation. PubMed ID: 3481036

Structure of the amino-terminal end of mammalian elongation factor Tu. PubMed ID: 3960725

Murine elongation factor 1 alpha (EF-1 alpha) is posttranslationally modified by novel amide-linked ethanolamine-phosphoglycerol moieties. Addition of ethanolamine-phosphoglycerol to specific glutamic acid residues on EF-1 alpha. PubMed ID: 2569467

Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. PubMed ID: 16139798

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The interaction between interferon-induced protein with tetratricopeptide repeats-1 and eukaryotic elongation factor-1A. PubMed ID: 19856081

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). PubMed ID: 28108655