Gene CPE - ENSG00000109472 | NCBI Gene ID: 1363

Details for: CPE

Gene ID: 1363

Symbol: CPE

Ensembl ID: ENSG00000109472

Description: carboxypeptidase E

Associated with

Metabolism of proteins
(R-HSA-392499)
Peptide hormone metabolism
(R-HSA-2980736)
Carboxypeptidase activity
(GO:0004180)
Cardiac left ventricle morphogenesis
(GO:0003214)
Cell adhesion molecule binding
(GO:0050839)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Insulin processing
(GO:0030070)
Metallocarboxypeptidase activity
(GO:0004181)
Neurexin family protein binding
(GO:0042043)
Neuropeptide signaling pathway
(GO:0007218)
Peptide hormone secretion
(GO:0030072)
Peptide metabolic process
(GO:0006518)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein localization to membrane
(GO:0072657)
Protein localization to secretory granule
(GO:0033366)
Protein modification process
(GO:0036211)
Protein processing
(GO:0016485)
Secretory granule membrane
(GO:0030667)
Transport vesicle membrane
(GO:0030658)
Wnt signaling pathway
(GO:0016055)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: endocrine cell (CL0000163)
Fold Change: 4.93
Marker Score: 2553
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 4.84
Marker Score: 16221
Cell Name: stellate neuron (CL0000122)
Fold Change: 4.81
Marker Score: 25831
Cell Name: mature astrocyte (CL0002627)
Fold Change: 4.51
Marker Score: 2965
Cell Name: macroglial cell (CL0000126)
Fold Change: 4.21
Marker Score: 9671
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 4.08
Marker Score: 15808
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.06
Marker Score: 4900
Cell Name: granule cell (CL0000120)
Fold Change: 3.94
Marker Score: 29710
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 3.76
Marker Score: 19719
Cell Name: Purkinje cell (CL0000121)
Fold Change: 3.69
Marker Score: 124511
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.5
Marker Score: 3301
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 3.49
Marker Score: 2625
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 3.43
Marker Score: 1183
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 3.42
Marker Score: 6942
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 3.13
Marker Score: 66892
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 3.11
Marker Score: 1627
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.08
Marker Score: 2630
Cell Name: PP cell (CL0000696)
Fold Change: 2.79
Marker Score: 629
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.76
Marker Score: 1607
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 2.72
Marker Score: 1015
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.69
Marker Score: 2562
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.57
Marker Score: 2962
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.55
Marker Score: 86915
Cell Name: supporting cell (CL0000630)
Fold Change: 2.55
Marker Score: 4793
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.55
Marker Score: 4178
Cell Name: chromaffin cell (CL0000166)
Fold Change: 2.48
Marker Score: 3486
Cell Name: astrocyte (CL0000127)
Fold Change: 2.48
Marker Score: 2145
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.47
Marker Score: 3429
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 2.42
Marker Score: 1720
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 2.42
Marker Score: 798
Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.4
Marker Score: 6859
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 2.33
Marker Score: 940
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2.3
Marker Score: 686
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 2.27
Marker Score: 1773.5
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.26
Marker Score: 1292
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.21
Marker Score: 84097.5
Cell Name: preosteoblast (CL0007010)
Fold Change: 2.17
Marker Score: 615
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.17
Marker Score: 696.5
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.15
Marker Score: 3615
Cell Name: contractile cell (CL0000183)
Fold Change: 2.14
Marker Score: 1161.5
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 2.12
Marker Score: 714
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.11
Marker Score: 19805
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 2.04
Marker Score: 8511
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.03
Marker Score: 846
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.99
Marker Score: 122407
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.98
Marker Score: 20490
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.98
Marker Score: 8267
Cell Name: keratocyte (CL0002363)
Fold Change: 1.98
Marker Score: 456
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.97
Marker Score: 7635
Cell Name: CNS interneuron (CL0000402)
Fold Change: 1.96
Marker Score: 942
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.96
Marker Score: 621
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.95
Marker Score: 14972.5
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.91
Marker Score: 18133
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.9
Marker Score: 37729
Cell Name: chondrocyte (CL0000138)
Fold Change: 1.87
Marker Score: 842
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.87
Marker Score: 2312.5
Cell Name: neuron (CL0000540)
Fold Change: 1.87
Marker Score: 7601
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.87
Marker Score: 4096
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.84
Marker Score: 15796
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.77
Marker Score: 65334
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.77
Marker Score: 992
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.76
Marker Score: 717
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.75
Marker Score: 4272
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 1.75
Marker Score: 1014
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.74
Marker Score: 8035
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.72
Marker Score: 1933
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.7
Marker Score: 1121
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.69
Marker Score: 4418
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.68
Marker Score: 427
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.67
Marker Score: 826
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.66
Marker Score: 696.5
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.61
Marker Score: 2486
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.6
Marker Score: 398
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.59
Marker Score: 4542
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.59
Marker Score: 398
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.57
Marker Score: 595
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.54
Marker Score: 488
Cell Name: pericyte (CL0000669)
Fold Change: 1.54
Marker Score: 898
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.53
Marker Score: 1655
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 1.51
Marker Score: 658
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.49
Marker Score: 2049
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.47
Marker Score: 466
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.47
Marker Score: 430
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167244
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.45
Marker Score: 8614
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.45
Marker Score: 796
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 1.43
Marker Score: 740
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.43
Marker Score: 1777
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.39
Marker Score: 2138.5
Cell Name: muscle cell (CL0000187)
Fold Change: 1.38
Marker Score: 391
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.37
Marker Score: 338
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.37
Marker Score: 18039
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.34
Marker Score: 1387
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.33
Marker Score: 13355
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 1.31
Marker Score: 359
Cell Name: acinar cell (CL0000622)
Fold Change: 1.31
Marker Score: 927
Cell Name: mesothelial cell (CL0000077)
Fold Change: 1.31
Marker Score: 527
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.29
Marker Score: 495
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.28
Marker Score: 349
Cell Name: reticular cell (CL0000432)
Fold Change: 1.26
Marker Score: 460

Hover over a box to see details here...

**Key characteristics:** * CPE is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a serine protease that is expressed in both the extracellular and intracellular domains. * CPE is a key regulator of cell adhesion, migration, and differentiation. * It is involved in the processing and secretion of proteins. * It is a regulator of the insulin signaling pathway. * It is involved in the regulation of cardiac development and function. **Pathways and functions:** * CPE is involved in the regulation of cardiac development and function. * It is a key regulator of cardiac remodeling and growth. * It is involved in the regulation of myocardial fibrosis and hypertrophy. * It is involved in the regulation of cardiac inflammation. * CPE is also involved in the regulation of insulin signaling. **Clinical significance:** * Mutations in the CPE gene have been linked to a number of human diseases, including diabetes, heart failure, and cancer. * CPE inhibitors are being investigated as potential treatments for these diseases. * Understanding the role of CPE in human health and disease is important for the development of new therapeutic strategies. **Additional information:** * CPE is a conserved protein that is found in organisms from yeast to humans. * It is a highly regulated protein that is involved in many cellular processes. * CPE is a promising target for the development of new therapeutic drugs.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Carboxypeptidase E

Genular Protein ID: 4015157520

Symbol: CBPE_HUMAN

Name: Carboxypeptidase E

UniProtKB Accession Codes:

P16870 A8K4N1 B3KR42 B4DFN4 D3DP33 Q9UIU9

Database IDs:

Citations:

PubMed ID: 2334405

Title: Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro.

PubMed ID: 2334405

DOI: 10.1042/bj2670517

PubMed ID: 9662053

Title: Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity.

PubMed ID: 9662053

DOI: 10.1007/s001250050971

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21285511

Title: An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.

PubMed ID: 21285511

DOI: 10.1172/jci40433

PubMed ID: 30882370

Title:

PubMed ID: 30882370

DOI: 10.1172/jci128836

PubMed ID: 34383079

Title: BDV syndrome: An emerging syndrome with profound obesity and neurodevelopmental delay resembling Prader-Willi syndrome.

PubMed ID: 34383079

DOI: 10.1210/clinem/dgab592

PubMed ID: 32936766

Title: A new cause of obesity syndrome associated with a mutation in the carboxypeptidase gene detected in three siblings with obesity, intellectual disability and hypogonadotropic hypogonadism.

PubMed ID: 32936766

DOI: 10.4274/jcrpe.galenos.2020.2020.0101

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 476
Mass: 53151
Checksum: D561AC0285A51E86
Sequence:

MAGRGGSALL ALCGALAACG WLLGAEAQEP GAPAAGMRRR RRLQQEDGIS FEYHRYPELR 
EALVSVWLQC TAISRIYTVG RSFEGRELLV IELSDNPGVH EPGEPEFKYI GNMHGNEAVG 
RELLIFLAQY LCNEYQKGNE TIVNLIHSTR IHIMPSLNPD GFEKAASQPG ELKDWFVGRS 
NAQGIDLNRN FPDLDRIVYV NEKEGGPNNH LLKNMKKIVD QNTKLAPETK AVIHWIMDIP 
FVLSANLHGG DLVANYPYDE TRSGSAHEYS SSPDDAIFQS LARAYSSFNP AMSDPNRPPC 
RKNDDDSSFV DGTTNGGAWY SVPGGMQDFN YLSSNCFEIT VELSCEKFPP EETLKTYWED 
NKNSLISYLE QIHRGVKGFV RDLQGNPIAN ATISVEGIDH DVTSAKDGDY WRLLIPGNYK 
LTASAPGYLA ITKKVAVPYS PAAGVDFELE SFSERKEEEK EELMEWWKMM SETLNF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CPE

Associated with

Cells (max top 100)

Other Information

Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro. PubMed ID: 2334405

Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity. PubMed ID: 9662053

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers. PubMed ID: 21285511