Details for: CPE
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 86.57rCSI 85.15%PRS 93.09
-
CSI 77.81rCSI 81.52%PRS 93.15
-
CSI 51.54rCSI 70.52%PRS 84.53
-
CSI 47.73rCSI 65.26%PRS 89.83
-
CSI 37.96rCSI 84.03%PRS 91.49
-
CSI 36.48rCSI 49.84%PRS 89.86
-
CSI 35.91rCSI 53.12%PRS 92.87
-
CSI 34.32rCSI 76.95%PRS 79.87
-
CSI 33.63rCSI 54.13%PRS 84.27
-
CSI 33.28rCSI 59.8%PRS 86.94
-
CSI 32.51rCSI 83.58%PRS 88.17
-
CSI 30.07rCSI 56.44%PRS 93.1
-
CSI 29.72rCSI 27.66%PRS 92.8
-
CSI 28.92rCSI 58.07%PRS 85.86
-
CSI 28.33rCSI 36.36%PRS 87.98
-
CSI 27.13rCSI 57.8%PRS 71.27
-
CSI 27.1rCSI 39.84%PRS 86.86
-
CSI 26.85rCSI 32.07%PRS 79.57
-
CSI 26.3rCSI 33.77%PRS 84.14
-
CSI 26.04rCSI 63.29%PRS 77.39
-
CSI 25.37rCSI 95.73%PRS 77.49
-
CSI 25.14rCSI 47.08%PRS 83.77
-
CSI 25.08rCSI 20.38%PRS 90.9
-
CSI 23.89rCSI 18.88%PRS 85.11
-
CSI 23.58rCSI 51.92%PRS 93.89
-
CSI 23.39rCSI 37.61%PRS 80.49
-
CSI 22.84rCSI 31.63%PRS 88.49
-
CSI 22.58rCSI 39.59%PRS 88.25
-
CSI 22.2rCSI 39.12%PRS 87.63
-
CSI 22.07rCSI 30.17%PRS 94.22
-
CSI 21.77rCSI 25.14%PRS 84.47
-
CSI 21.67rCSI 32.21%PRS 90.36
-
CSI 21.65rCSI 49.98%PRS 83.11
-
CSI 20.78rCSI 34.23%PRS 93.13
-
CSI 20.78rCSI 84.67%PRS 84.71
-
CSI 20.66rCSI 36.48%PRS 78.95
-
CSI 20.64rCSI 32.6%PRS 92.3
-
CSI 20.52rCSI 64.13%PRS 80.87
-
CSI 19.73rCSI 24.54%PRS 77.3
-
CSI 19.57rCSI 16.87%PRS 90.99
-
CSI 19.5rCSI 77.6%PRS 94.26
-
CSI 19.07rCSI 43.51%PRS 85.54
-
CSI 18.74rCSI 45.04%PRS 92.49
-
CSI 18.63rCSI 49.63%PRS 80.2
-
CSI 18.62rCSI 32.2%PRS 86.56
-
CSI 18.59rCSI 70.26%PRS 79.75
-
CSI 18.54rCSI 66.71%PRS 77.61
-
CSI 17.32rCSI 50.14%PRS 90.78
-
CSI 17.19rCSI 42.56%PRS 92.14
-
CSI 17.12rCSI 24.27%PRS 89.57
-
CSI 16.9rCSI 21.51%PRS 94.52
-
CSI 16.88rCSI 29.77%PRS 93.9
-
CSI 16.82rCSI 37.17%PRS 81.81
-
CSI 16.75rCSI 27.43%PRS 85.14
-
CSI 16.4rCSI 56.18%PRS 79.72
-
CSI 15.67rCSI 73.06%PRS 94.48
-
CSI 15.55rCSI 20.04%PRS 80.63
-
CSI 15.48rCSI 24.73%PRS 93.51
-
CSI 15.21rCSI 51.55%PRS 87.92
-
CSI 15.05rCSI 16.49%PRS 93.02
-
CSI 14.9rCSI 38.83%PRS 85.97
-
CSI 14.79rCSI 39.39%PRS 69.42
-
CSI 14.75rCSI 35.22%PRS 93.44
-
CSI 14.49rCSI 47.01%PRS 89.81
-
CSI 14.19rCSI 53.17%PRS 87.55
-
CSI 14.19rCSI 37.45%PRS 94.84
-
CSI 14.01rCSI 12.44%PRS 89.18
-
CSI 14rCSI 30.8%PRS 75.24
-
CSI 13.84rCSI 30.03%PRS 81.15
-
CSI 13.83rCSI 11.46%PRS 92.3
-
CSI 13.8rCSI 18.81%PRS 85.56
-
CSI 13.74rCSI 40.55%PRS 90.88
-
CSI 13.38rCSI 12.88%PRS 90.07
-
CSI 13.23rCSI 39.06%PRS 91.2
-
CSI 13.18rCSI 17.62%PRS 89.02
-
CSI 13.09rCSI 37.94%PRS 83.67
-
CSI 12.82rCSI 32.44%PRS 93.54
-
CSI 12.71rCSI 17.65%PRS 89.98
-
CSI 12.52rCSI 29.86%PRS 85.97
-
CSI 12.52rCSI 44.43%PRS 92.65
-
CSI 12.48rCSI 53.04%PRS 85.16
-
CSI 12.17rCSI 11.73%PRS 87.69
-
CSI 12.06rCSI 33.24%PRS 89.13
-
CSI 12.04rCSI 21.88%PRS 85.54
-
CSI 11.93rCSI 24.21%PRS 74.85
-
CSI 11.89rCSI 39.08%PRS 80.87
-
CSI 11.82rCSI 69.61%PRS 79.99
-
CSI 11.69rCSI 14.03%PRS 90.43
-
CSI 11.57rCSI 54.43%PRS 82.38
-
CSI 11.39rCSI 62%PRS 93.64
-
CSI 10.93rCSI 61.79%PRS 81.47
-
CSI 10.74rCSI 27.76%PRS 89.12
-
CSI 10.67rCSI 22.69%PRS 85.53
-
CSI 10.48rCSI 25.07%PRS 81.95
-
CSI 10.3rCSI 33.06%PRS 91.16
-
CSI 10.13rCSI 16.09%PRS 95.21
-
CSI 10.02rCSI 45.99%PRS 93.14
-
CSI 9.93rCSI 14.18%PRS 91.55
-
CSI 9.8rCSI 15.64%PRS 84.46
-
CSI 9.58rCSI 51.53%PRS 94.83
-
CSI 0.3rCSI 6.1%PRS 95.4%
-
CSI 0.4rCSI 8.5%PRS 95.8%
-
CSI 0.5rCSI 11.4%PRS 95.4%
-
CSI 0.8rCSI 11.6%PRS 92.5%
-
CSI 0.9rCSI 2.4%PRS 94.2%
-
CSI 1.1rCSI 29.1%PRS 94.5%
-
CSI 1.2rCSI 4.1%PRS 95.0%
-
CSI 1.3rCSI 19.2%PRS 94.8%
-
CSI 1.4rCSI 15.8%PRS 93.2%
-
CSI 1.6rCSI 27.2%PRS 94.2%
-
CSI 1.7rCSI 26.5%PRS 91.9%
-
CSI 1.8rCSI 37.2%PRS 83.5%
-
CSI 2.0rCSI 1.8%PRS 83.3%
-
CSI 2.2rCSI 44.5%PRS 84.1%
-
CSI 2.2rCSI 10.1%PRS 94.5%
-
CSI 2.4rCSI 3.6%PRS 95.8%
-
CSI 2.7rCSI 38.8%PRS 84.5%
-
CSI 2.8rCSI 67.8%PRS 77.4%
-
CSI 2.9rCSI 68.4%PRS 77.3%
-
CSI 2.9rCSI 24.1%PRS 78.9%
-
CSI 3.0rCSI 25.7%PRS 84.0%
-
CSI 3.0rCSI 27.6%PRS 88.6%
-
CSI 3.0rCSI 14.9%PRS 86.6%
-
CSI 3.1rCSI 6.1%PRS 88.3%
-
CSI 3.2rCSI 26.4%PRS 89.3%
-
CSI 3.3rCSI 37.3%PRS 80.0%
-
CSI 3.4rCSI 55.4%PRS 93.0%
-
CSI 3.4rCSI 19.7%PRS 92.9%
-
CSI 3.7rCSI 6.2%PRS 79.5%
-
CSI 3.8rCSI 24.2%PRS 93.7%
-
CSI 3.8rCSI 49.8%PRS 92.5%
-
CSI 3.8rCSI 43.0%PRS 93.1%
-
CSI 4.1rCSI 31.0%PRS 92.2%
-
CSI 4.3rCSI 6.1%PRS 84.1%
-
CSI 4.3rCSI 17.5%PRS 95.4%
-
CSI 4.6rCSI 59.6%PRS 88.2%
-
CSI 4.9rCSI 35.4%PRS 95.4%
-
CSI 4.9rCSI 21.6%PRS 81.5%
-
CSI 5.0rCSI 14.5%PRS 93.5%
-
CSI 5.0rCSI 12.8%PRS 86.9%
-
CSI 5.1rCSI 16.1%PRS 82.5%
-
CSI 5.2rCSI 35.8%PRS 94.3%
-
CSI 5.2rCSI 9.5%PRS 95.5%
-
CSI 5.3rCSI 41.7%PRS 92.8%
-
CSI 5.7rCSI 19.1%PRS 79.0%
-
CSI 5.7rCSI 41.9%PRS 83.9%
-
CSI 5.8rCSI 33.8%PRS 94.4%
-
CSI 5.8rCSI 43.9%PRS 81.3%
-
CSI 5.9rCSI 27.8%PRS 93.4%
-
CSI 6.0rCSI 17.0%PRS 88.0%
-
CSI 6.0rCSI 43.2%PRS 82.7%
-
CSI 6.1rCSI 53.5%PRS 79.5%
-
CSI 6.1rCSI 14.2%PRS 96.3%
-
CSI 6.1rCSI 11.6%PRS 96.1%
-
CSI 6.2rCSI 23.5%PRS 85.5%
-
CSI 6.3rCSI 28.3%PRS 77.8%
-
CSI 6.7rCSI 34.2%PRS 96.6%
-
CSI 6.7rCSI 10.3%PRS 88.5%
-
CSI 6.9rCSI 42.3%PRS 92.0%
-
CSI 6.9rCSI 29.0%PRS 93.1%
-
CSI 7.0rCSI 27.1%PRS 94.1%
-
CSI 7.0rCSI 7.4%PRS 89.3%
-
CSI 7.1rCSI 55.3%PRS 84.6%
-
CSI 7.2rCSI 18.6%PRS 94.0%
-
CSI 7.2rCSI 46.0%PRS 85.8%
-
CSI 7.5rCSI 15.3%PRS 80.7%
-
CSI 7.7rCSI 33.7%PRS 87.2%
-
CSI 7.8rCSI 40.8%PRS 82.2%
-
CSI 8.0rCSI 15.5%PRS 92.8%
-
CSI 8.0rCSI 44.7%PRS 92.6%
-
CSI 8.1rCSI 17.7%PRS 93.7%
-
CSI 9.1rCSI 61.9%PRS 83.9%
-
CSI 9.2rCSI 54.5%PRS 83.2%
-
CSI 9.4rCSI 15.0%PRS 87.3%
-
CSI 9.5rCSI 14.5%PRS 80.3%
-
CSI 9.5rCSI 62.9%PRS 86.0%
-
CSI 9.6rCSI 51.5%PRS 94.8%
-
CSI 9.8rCSI 15.6%PRS 84.5%
-
CSI 9.9rCSI 14.2%PRS 91.6%
-
CSI 10.0rCSI 46.0%PRS 93.1%
-
CSI 10.1rCSI 16.1%PRS 95.2%
-
CSI 10.3rCSI 33.1%PRS 91.2%
-
CSI 10.5rCSI 25.1%PRS 82.0%
-
CSI 10.7rCSI 22.7%PRS 85.5%
-
CSI 10.7rCSI 27.8%PRS 89.1%
-
CSI 10.9rCSI 61.8%PRS 81.5%
-
CSI 11.4rCSI 62.0%PRS 93.6%
-
CSI 11.6rCSI 54.4%PRS 82.4%
-
CSI 11.7rCSI 14.0%PRS 90.4%
-
CSI 11.8rCSI 69.6%PRS 80.0%
-
CSI 11.9rCSI 39.1%PRS 80.9%
-
CSI 11.9rCSI 24.2%PRS 74.9%
-
CSI 12.0rCSI 21.9%PRS 85.5%
-
CSI 12.1rCSI 33.2%PRS 89.1%
-
CSI 12.2rCSI 11.7%PRS 87.7%
-
CSI 12.5rCSI 53.0%PRS 85.2%
-
CSI 12.5rCSI 44.4%PRS 92.7%
-
CSI 12.5rCSI 29.9%PRS 86.0%
-
CSI 12.7rCSI 17.7%PRS 90.0%
-
CSI 12.8rCSI 32.4%PRS 93.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 4015157520
Symbol: CBPE_HUMAN
Name: Carboxypeptidase E
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2334405
Title: Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro.
PubMed ID: 2334405
DOI: 10.1042/bj2670517
PubMed ID: 9662053
Title: Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity.
PubMed ID: 9662053
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21285511
Title: An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.
PubMed ID: 21285511
DOI: 10.1172/jci40433
PubMed ID: 30882370
PubMed ID: 34383079
Title: BDV syndrome: An emerging syndrome with profound obesity and neurodevelopmental delay resembling Prader-Willi syndrome.
PubMed ID: 34383079
PubMed ID: 32936766
Title: A new cause of obesity syndrome associated with a mutation in the carboxypeptidase gene detected in three siblings with obesity, intellectual disability and hypogonadotropic hypogonadism.
PubMed ID: 32936766
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 476
- Mass: 53151
- Checksum: D561AC0285A51E86
- Sequence:
MAGRGGSALL ALCGALAACG WLLGAEAQEP GAPAAGMRRR RRLQQEDGIS FEYHRYPELR EALVSVWLQC TAISRIYTVG RSFEGRELLV IELSDNPGVH EPGEPEFKYI GNMHGNEAVG RELLIFLAQY LCNEYQKGNE TIVNLIHSTR IHIMPSLNPD GFEKAASQPG ELKDWFVGRS NAQGIDLNRN FPDLDRIVYV NEKEGGPNNH LLKNMKKIVD QNTKLAPETK AVIHWIMDIP FVLSANLHGG DLVANYPYDE TRSGSAHEYS SSPDDAIFQS LARAYSSFNP AMSDPNRPPC RKNDDDSSFV DGTTNGGAWY SVPGGMQDFN YLSSNCFEIT VELSCEKFPP EETLKTYWED NKNSLISYLE QIHRGVKGFV RDLQGNPIAN ATISVEGIDH DVTSAKDGDY WRLLIPGNYK LTASAPGYLA ITKKVAVPYS PAAGVDFELE SFSERKEEEK EELMEWWKMM SETLNF