Details for: CPE

Gene ID: 1363

Symbol: CPE

Ensembl ID: ENSG00000109472

Description: carboxypeptidase E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 90.4013
    Cell Significance Index: -86.3100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 9.2568
    Cell Significance Index: 71.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 8.6696
    Cell Significance Index: 455.1900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 4.7442
    Cell Significance Index: 66.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.8618
    Cell Significance Index: 180.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.8006
    Cell Significance Index: 79.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7875
    Cell Significance Index: 559.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.0874
    Cell Significance Index: 128.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9905
    Cell Significance Index: 713.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.9752
    Cell Significance Index: 33.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8855
    Cell Significance Index: 54.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1989
    Cell Significance Index: 829.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0152
    Cell Significance Index: 68.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9222
    Cell Significance Index: 40.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9027
    Cell Significance Index: 815.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7843
    Cell Significance Index: 29.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6334
    Cell Significance Index: 402.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5940
    Cell Significance Index: 58.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2730
    Cell Significance Index: 51.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2528
    Cell Significance Index: 41.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2221
    Cell Significance Index: 418.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2160
    Cell Significance Index: 27.6900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.2043
    Cell Significance Index: 1.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2016
    Cell Significance Index: 11.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0886
    Cell Significance Index: 12.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0682
    Cell Significance Index: 30.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0209
    Cell Significance Index: 11.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0106
    Cell Significance Index: 4.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0144
    Cell Significance Index: -10.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0356
    Cell Significance Index: -1.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0741
    Cell Significance Index: -136.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0746
    Cell Significance Index: -46.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0782
    Cell Significance Index: -8.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0884
    Cell Significance Index: -136.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0963
    Cell Significance Index: -20.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0966
    Cell Significance Index: -131.3500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1065
    Cell Significance Index: -1.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1111
    Cell Significance Index: -62.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1159
    Cell Significance Index: -3.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1269
    Cell Significance Index: -93.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1284
    Cell Significance Index: -14.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1378
    Cell Significance Index: -104.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1839
    Cell Significance Index: -3.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2720
    Cell Significance Index: -46.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2795
    Cell Significance Index: -55.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3129
    Cell Significance Index: -90.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3601
    Cell Significance Index: -26.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.3610
    Cell Significance Index: -65.0700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3813
    Cell Significance Index: -9.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3841
    Cell Significance Index: -17.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3938
    Cell Significance Index: -57.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4706
    Cell Significance Index: -9.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4749
    Cell Significance Index: -54.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5826
    Cell Significance Index: -40.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.6248
    Cell Significance Index: -76.8300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6429
    Cell Significance Index: -5.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.6652
    Cell Significance Index: -85.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6715
    Cell Significance Index: -69.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6951
    Cell Significance Index: -81.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.7025
    Cell Significance Index: -71.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.7592
    Cell Significance Index: -45.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7902
    Cell Significance Index: -48.4500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8070
    Cell Significance Index: -17.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8484
    Cell Significance Index: -60.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1527
    Cell Significance Index: -36.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1586
    Cell Significance Index: -19.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1937
    Cell Significance Index: -94.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.2997
    Cell Significance Index: -99.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.3297
    Cell Significance Index: -69.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.3440
    Cell Significance Index: -63.1700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -1.3765
    Cell Significance Index: -14.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.4936
    Cell Significance Index: -41.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.5143
    Cell Significance Index: -48.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.5408
    Cell Significance Index: -33.3800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.5549
    Cell Significance Index: -26.8900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -1.5685
    Cell Significance Index: -17.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.5916
    Cell Significance Index: -52.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.6482
    Cell Significance Index: -43.3400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.7761
    Cell Significance Index: -19.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.8378
    Cell Significance Index: -95.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.8411
    Cell Significance Index: -32.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.8734
    Cell Significance Index: -65.1000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -2.0426
    Cell Significance Index: -24.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.1569
    Cell Significance Index: -75.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -2.1928
    Cell Significance Index: -102.2400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -2.2778
    Cell Significance Index: -45.7300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -2.2831
    Cell Significance Index: -26.1300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -2.3026
    Cell Significance Index: -28.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.4326
    Cell Significance Index: -62.5300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -2.4652
    Cell Significance Index: -52.7000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -2.4995
    Cell Significance Index: -53.0500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -2.5721
    Cell Significance Index: -64.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.6023
    Cell Significance Index: -95.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -2.6312
    Cell Significance Index: -71.6200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -2.6642
    Cell Significance Index: -35.5400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -2.6905
    Cell Significance Index: -26.6200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -2.7168
    Cell Significance Index: -53.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.8001
    Cell Significance Index: -75.0300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -2.8967
    Cell Significance Index: -45.9600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -2.9616
    Cell Significance Index: -30.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Carboxypeptidase activity:** CPE is a metalloprotease that catalyzes the removal of C-terminal amino acids from peptides and proteins, a process essential for protein processing and modification. 2. **Cellular localization:** CPE is primarily found in the Golgi apparatus, secretory granules, and plasma membrane, suggesting its involvement in protein secretion, modification, and localization. 3. **Protein binding:** CPE interacts with various proteins, including neurexins, insulin, and other peptides, which may regulate its activity and specificity. 4. **Cell type specificity:** CPE is expressed in diverse cell types, including endocrine cells, neurons, and astrocytes, highlighting its widespread role in the nervous system and other tissues. **Pathways and Functions:** 1. **Insulin processing:** CPE is involved in the processing and modification of insulin, which is critical for glucose homeostasis and energy metabolism. 2. **Neurotransmitter regulation:** CPE may modulate the release and activity of neurotransmitters, such as glycine and GABA, by processing and modifying their precursor peptides. 3. **Protein secretion:** CPE is essential for the secretion of various proteins, including hormones, neurotransmitters, and growth factors, which play critical roles in tissue development and homeostasis. 4. **Wnt signaling pathway:** CPE may interact with the Wnt signaling pathway, which regulates cell proliferation, differentiation, and survival in various tissues. **Clinical Significance:** 1. **Diabetes:** Dysregulation of insulin processing and secretion has been implicated in the pathogenesis of diabetes, and CPE may play a role in this process. 2. **Neurological disorders:** CPE's involvement in neurotransmitter regulation and protein secretion may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** CPE's role in protein secretion and modification may be exploited by cancer cells to promote tumor growth and metastasis. 4. **Neurodegenerative diseases:** CPE's interactions with the Wnt signaling pathway and other cellular processes may contribute to the pathogenesis of neurodegenerative diseases, such as Huntington's disease and amyotrophic lateral sclerosis (ALS). In conclusion, Carboxypeptidase E is a multifaceted enzyme that plays a critical role in various cellular processes, including protein modification, secretion, and regulation. Its involvement in insulin processing, neurotransmitter regulation, and protein secretion highlights its significance in maintaining tissue homeostasis and responding to environmental cues. Further research on CPE's structure, function, and clinical significance is necessary to elucidate its role in human disease and develop novel therapeutic strategies.

Genular Protein ID: 4015157520

Symbol: CBPE_HUMAN

Name: Carboxypeptidase E

UniProtKB Accession Codes:

P16870 A8K4N1 B3KR42 B4DFN4 D3DP33 Q9UIU9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 2 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2334405

Title: Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro.

PubMed ID: 2334405

DOI: 10.1042/bj2670517

PubMed ID: 9662053

Title: Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity.

PubMed ID: 9662053

DOI: 10.1007/s001250050971

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21285511

Title: An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.

PubMed ID: 21285511

DOI: 10.1172/jci40433

PubMed ID: 30882370

Title:

PubMed ID: 30882370

DOI: 10.1172/jci128836

PubMed ID: 34383079

Title: BDV syndrome: An emerging syndrome with profound obesity and neurodevelopmental delay resembling Prader-Willi syndrome.

PubMed ID: 34383079

DOI: 10.1210/clinem/dgab592

PubMed ID: 32936766

Title: A new cause of obesity syndrome associated with a mutation in the carboxypeptidase gene detected in three siblings with obesity, intellectual disability and hypogonadotropic hypogonadism.

PubMed ID: 32936766

DOI: 10.4274/jcrpe.galenos.2020.2020.0101

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 476
  • Mass: 53151
  • Checksum: D561AC0285A51E86
  • Sequence:
    • MAGRGGSALL ALCGALAACG WLLGAEAQEP GAPAAGMRRR RRLQQEDGIS FEYHRYPELR 
EALVSVWLQC TAISRIYTVG RSFEGRELLV IELSDNPGVH EPGEPEFKYI GNMHGNEAVG 
RELLIFLAQY LCNEYQKGNE TIVNLIHSTR IHIMPSLNPD GFEKAASQPG ELKDWFVGRS 
NAQGIDLNRN FPDLDRIVYV NEKEGGPNNH LLKNMKKIVD QNTKLAPETK AVIHWIMDIP 
FVLSANLHGG DLVANYPYDE TRSGSAHEYS SSPDDAIFQS LARAYSSFNP AMSDPNRPPC 
RKNDDDSSFV DGTTNGGAWY SVPGGMQDFN YLSSNCFEIT VELSCEKFPP EETLKTYWED 
NKNSLISYLE QIHRGVKGFV RDLQGNPIAN ATISVEGIDH DVTSAKDGDY WRLLIPGNYK 
LTASAPGYLA ITKKVAVPYS PAAGVDFELE SFSERKEEEK EELMEWWKMM SETLNF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.